Rendering of the source text

<?xml version="1.0"?>
<!--
This CellML file was generated on 19/06/2009 at 09:10:40 using:

COR (0.9.31.813)
Copyright 2002-2009 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:base="file:///people/jlaw060/Desktop/C57BL7_WT_model_version1.cellml" cmeta:id="Li_Smith_2009" name="Li_Smith_2009">

    <documentation xmlns="http://cellml.org/tmp-documentation">
        <article>
            <articleinfo>
                <title>G-Protein Specificity In Synaptic Signalling</title>
                <author>
                    <firstname>Catherine</firstname>
                    <surname>Lloyd</surname>
                    <affiliation>
                        <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
                    </affiliation>
                </author>
            </articleinfo>
            <section id="sec_status">
                <title>Model Status</title>
                <para>
This CellML model was written by the original model author and is known to be completely correct. 
                </para>
                <para> ValidateCellML confirms this model as valid CellML with consistent units</para>
            </section>
            <sect1 id="sec_structure">
                <title>Model Structure</title>

                <para>
A model of Ca<superscript>2+</superscript> dynamics in mouse ventricular myocytes from the C57BL/6 strain has been developed, based on experimental data at the same temperature and under consistent experimental conditions and protocols. 
                </para>
                <para>
Parameterisation of the NCX, SERCA and LCC formulations were done sequentially. The model of NCX, based on the Luo and Rudy 1994 formulation, was first fitted from the decay of the caffeine-induced [Ca<superscript>2+</superscript>]i transient, which allowed us to infer the flux through SERCA from the decay of the field-stimulated [Ca<superscript>2+</superscript>]i transient. Frequency-dependence of the flux through SERCA was accounted for using  Hund and Rudy 2002 formulation of Ca<superscript>2+</superscript>/calmodulin kinase II regulatory pathway, with parameters fitted to experimentally measured SERCA flux at 0.5, 1 and 3Hz pacing frequencies.  The L-type Ca<superscript>2+</superscript> channel model, with slight modifications to the Hinch 2004 formulation, was fitted to data from voltage-clamp experiments. All these component models were then incorporated into the whole-cell AP model of Bondarenko et al., with parameters of RyR adjusted to match the experimentally observed time-to-peak of the [Ca<superscript>2+</superscript>]i transient at 3Hz, and parameters
for the background Ca<superscript>2+</superscript> current and PMCA adjusted to match experimentally observed diastolic [Ca<superscript>2+</superscript>]i levels.
                </para>

                <informalfigure float="0" id="fig_reaction_diagram">
                    <mediaobject>
                        <imageobject>
                            <objectinfo>
                                <title>reaction diagram</title>
                            </objectinfo>
                            <imagedata fileref="bondarenko_2004.png"/>
                        </imageobject>
                    </mediaobject>
                    <caption>Schematic diagram of the Bondarenko 2004 model.</caption>
                </informalfigure>

                <sect2>
                    <title>
                        <emphasis>Associated data</emphasis>
                    </title>

                    <para>
                        <ulink url="Caffeine.zip">Caffeine</ulink> - Caffeine-induced Ca<superscript>2+</superscript> transients from 18 individual myocytes</para>
                    <para>Each file contains the time course of caffeine-induced Ca<superscript>2+</superscript> transients from a myocyte. The traces were exported from IonOptix for the duration of the caffeine application.</para>
                    <para>Related parameter: K<subscript>ncx</subscript>
                    </para>
                    <para>Fitting process: 1. The decay of individual transients were aligned and averaged. 
2. The rate of decay of the average transient, after taking into account of intracellular buffering, was used to calculate J<subscript>ncx</subscript>. J<subscript>ncx</subscript>  was then used to fit K<subscript>ncx</subscript> in the Luo and Rudy 1994 model.</para>


                    <para>
                        <ulink url="3Hz.zip">3Hz</ulink> - Field-stimulated Ca<superscript>2+</superscript> transients at 3Hz from 19 individual myocytes</para>
                    <para>Each file contains the time course of a Ca<superscript>2+</superscript> transient, field stimulated at 3Hz, from a myocyte. The time course was exported from IonOptix for a duration of 1s starting from the first stimulus.</para>
                    <para>Related parameter: K<subscript>m, serca</subscript>, V<subscript>serca</subscript> at 3Hz</para>
                    <para>Fitting process: 1. The individual transients were averaged. The decay of the average transient, from 70ms after-peak until the end of the period was analysed. 
2. J<subscript>ncx</subscript> was inferred from previously fitted NCX model, and the difference between the total Ca<superscript>2+</superscript> flux and J<subscript>ncx</subscript> was taken as the net SR Ca<superscript>2+</superscript> uptake J<subscript>up</subscript>. 
3 A small SR leak (0.008<superscript>2+</superscript> through SERCA J<subscript>serca</subscript> = J<subscript>up</subscript>+ J<subscript>leak</subscript>
4. J<subscript>serca</subscript> was used to fit the K<subscript>m,serca</subscript> and V<subscript>serca</subscript> at 3Hz.</para>

                    <para>
                        <ulink url="1Hz.zip">1Hz</ulink> - Field-stimulated Ca<superscript>2+</superscript> transients at 1Hz from 7 individual myocytes</para>
                    <para>Each file contains the time course of a Ca<superscript>2+</superscript> transient, field stimulated at 1Hz, from a myocyte.</para>
                    <para>Related parameter: Estimated V<subscript>serca</subscript> at 1Hz</para>
                    <para>1. The derivation of J<subscript>serca</subscript> at 1Hz is similar to above. 
2. J<subscript>serca</subscript> was used to constrain V<subscript>serca</subscript> at 1Hz
                    </para>

                    <para>
                        <ulink url="0.5Hz.zip">0.5Hz</ulink> - Field-stimulated Ca<superscript>2+</superscript> transients at 0.5Hz from 7 individual myocytes</para>
                    <para>Each file contains the time course of a Ca<superscript>2+</superscript> transient, field stimulated at 0.5Hz, from a myocyte</para>
                    <para>Related parameter: Estimated V<subscript>serca</subscript> at 0.5Hz</para>
                    <para>1. The derivation of J<subscript>serca</subscript> at 0.5Hz is similar to above. 
2. J<subscript>serca</subscript> was used to constrain V<subscript>serca</subscript> at 0.5Hz</para>

                    <para>
                        <ulink url="Ica.zip">Ica</ulink> - Time courses of transmembrane currents from 5 individual myocytes.</para>
                    <para>Each file contains the time course of experimentally measured L-type Ca<superscript>2+</superscript> current from one myocyte, measured in nA. </para>
                    <para>PCaL, </para>
                    <para>Fitting process: 1. The time course of transmembrane currents individual myocytes were averaged for each test potential between -20 and 20mV (-20, -10, 0, 10, 20mV). 
2. Averaged currents were converted into current densities by division by cell membrane capacitance (138.66pF).
3. Simulated sum of late K<superscript>+</superscript> currents, from the Bondarenko et al 2004 formulation, for test potentials -20, -10, 0, 10, 20mV were subtracted from the decay phase of each current.
4. The decay of the current at each test potential, after correcting for late K<superscript>+</superscript> currents, was fitted to a single exponential function, giving a time constant of decay tau value.
5. The IV relation and tau values at each test potential were used to fit the model of LCC.
                    </para>

                    <para>
                        <ulink url="Ica.zip">Ica/IV.xls</ulink> - Experimentally measured current-voltage relation for the L-type Ca<superscript>2+</superscript> current</para>
                    <para>Average current-voltage curve.</para>
                    <para>Related parameter: PCaL, </para>
                    <para>Fitting process: as for Ica
                    </para>
                </sect2>
            </sect1>
        </article>
    </documentation>

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        <variable initial_value="1" name="Cm" public_interface="out" units="microF_per_cm2"/>
        <variable initial_value="2.2e-5" name="Vmyo" public_interface="out" units="microlitre"/>
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                                <apply>
                                    <plus/>
                                    <ci>Km_CSQN</ci>
                                    <ci>CaJSR</ci>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="calcium_fluxes">
        <variable name="J_leak" public_interface="out" units="micromolar_per_millisecond"/>
        <variable name="J_rel" public_interface="out" units="micromolar_per_millisecond"/>
        <variable name="J_serca" public_interface="out" units="micromolar_per_millisecond"/>
        <variable name="J_tr" public_interface="out" units="micromolar_per_millisecond"/>
        <variable name="J_xfer" public_interface="out" units="micromolar_per_millisecond"/>
        <variable initial_value="2.290355e-9" name="P_RyR" units="dimensionless"/>
        <variable initial_value="4.5" name="v1" units="per_millisecond"/>
        <variable initial_value="20" name="tau_tr" units="millisecond"/>
        <variable initial_value="1e-5" name="v2" units="per_millisecond"/>
        <variable initial_value="8" name="tau_xfer" units="millisecond"/>
        <variable name="CaMKb" units="dimensionless"/>
        <variable initial_value="0.08989079" name="CaMKt" units="dimensionless"/>
        <variable name="CaMKa" units="dimensionless"/>
        <variable initial_value="0.05" name="on_rate" units="per_millisecond"/>
        <variable initial_value="0.00068" name="off_rate" units="per_millisecond"/>
        <variable name="vmup" units="micromolar_per_millisecond"/>
        <variable initial_value="0.412" name="Km_up" units="micromolar"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="i_CaL_max" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
        <variable name="Cai" public_interface="in" units="micromolar"/>
        <variable name="Cass" public_interface="in" units="micromolar"/>
        <variable name="CaJSR" public_interface="in" units="micromolar"/>
        <variable name="CaNSR" public_interface="in" units="micromolar"/>
        <variable name="P_O1" public_interface="in" units="dimensionless"/>
        <variable name="P_O2" public_interface="in" units="dimensionless"/>
        <variable initial_value="0.3158" name="vmup_init" units="micromolar_per_millisecond"/>
        <variable initial_value="-0.09" name="P_ryr_const1" units="per_millisecond"/>
        <variable initial_value="-0.225" name="P_ryr_const2" units="per_millisecond"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>J_rel</ci>
                <apply>
                    <times/>
                    <ci>v1</ci>
                    <apply>
                        <plus/>
                        <ci>P_O1</ci>
                        <ci>P_O2</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>CaJSR</ci>
                        <ci>Cass</ci>
                    </apply>
                    <ci>P_RyR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_tr</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>CaNSR</ci>
                        <ci>CaJSR</ci>
                    </apply>
                    <ci>tau_tr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_xfer</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>Cass</ci>
                        <ci>Cai</ci>
                    </apply>
                    <ci>tau_xfer</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_leak</ci>
                <apply>
                    <times/>
                    <ci>v2</ci>
                    <apply>
                        <minus/>
                        <ci>CaNSR</ci>
                        <ci>Cai</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CaMKb</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.05</cn>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>CaMKt</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">0.7</cn>
                            <ci>Cass</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>CaMKt</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>on_rate</ci>
                        <ci>CaMKb</ci>
                        <apply>
                            <plus/>
                            <ci>CaMKb</ci>
                            <ci>CaMKt</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>off_rate</ci>
                        <ci>CaMKt</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CaMKa</ci>
                <apply>
                    <plus/>
                    <ci>CaMKb</ci>
                    <ci>CaMKt</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>vmup</ci>
                <apply>
                    <times/>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.1512</cn>
                                <apply>
                                    <power/>
                                    <ci>CaMKa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.2062</cn>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <apply>
                                    <power/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1588</cn>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.2062</cn>
                                </apply>
                                <apply>
                                    <power/>
                                    <ci>CaMKa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.2062</cn>
                                </apply>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                    <ci>vmup_init</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_serca</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>vmup</ci>
                        <apply>
                            <power/>
                            <ci>Cai</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <power/>
                            <ci>Km_up</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                            <power/>
                            <ci>Cai</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_RyR</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>P_ryr_const1</ci>
                        <ci>P_RyR</ci>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>P_ryr_const2</ci>
                                <ci>i_CaL</ci>
                            </apply>
                            <ci>i_CaL_max</ci>
                        </apply>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <power/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                                        </apply>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    </apply>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt2">648</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="ryanodine_receptors">
        <variable initial_value="0.003825599" name="P_O1" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.835831e-8" name="P_O2" public_interface="out" units="dimensionless"/>
        <variable name="P_C1" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.3797679" name="P_C2" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.006075" name="k_plus_a" units="micromolar4_per_millisecond"/>
        <variable initial_value="0.07125" name="k_minus_a" units="per_millisecond"/>
        <variable initial_value="0.00405" name="k_plus_b" units="micromolar3_per_millisecond"/>
        <variable initial_value="0.965" name="k_minus_b" units="per_millisecond"/>
        <variable initial_value="0.009" name="k_plus_c" units="per_millisecond"/>
        <variable initial_value="0.0008" name="k_minus_c" units="per_millisecond"/>
        <variable initial_value="3" name="m" units="dimensionless"/>
        <variable initial_value="4" name="n" units="dimensionless"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="Cass" public_interface="in" units="micromolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_O1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_plus_a</ci>
                            <apply>
                                <power/>
                                <ci>Cass</ci>
                                <ci>n</ci>
                            </apply>
                            <ci>P_C1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_minus_b</ci>
                            <ci>P_O2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_minus_c</ci>
                            <ci>P_C2</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_minus_a</ci>
                            <ci>P_O1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_plus_b</ci>
                            <apply>
                                <power/>
                                <ci>Cass</ci>
                                <ci>m</ci>
                            </apply>
                            <ci>P_O1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_plus_c</ci>
                            <ci>P_O1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>P_C1</ci>
                <apply>
                    <minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>P_C2</ci>
                        <ci>P_O1</ci>
                        <ci>P_O2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_O2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>k_plus_b</ci>
                        <apply>
                            <power/>
                            <ci>Cass</ci>
                            <ci>m</ci>
                        </apply>
                        <ci>P_O1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_minus_b</ci>
                        <ci>P_O2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_C2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>k_plus_c</ci>
                        <ci>P_O1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_minus_c</ci>
                        <ci>P_C2</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="L_type_calcium_current">
        <variable name="i_CaL" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="4" name="i_CaL_max" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="19.1078" name="P_CaL" units="per_millisecond"/>
        <variable initial_value="4.373318e-6" name="O" units="dimensionless"/>
        <variable name="C" units="dimensionless"/>
        <variable initial_value="0.009171979" name="I" units="dimensionless"/>
        <variable initial_value="0.8876797" name="y_gate" units="dimensionless"/>
        <variable name="y_gate_inf" units="dimensionless"/>
        <variable name="y_gate_tau" units="millisecond"/>
        <variable name="Cass" public_interface="in" units="micromolar"/>
        <variable name="alpha_p" units="per_millisecond"/>
        <variable name="alpha_m" units="per_millisecond"/>
        <variable name="epsilon_p" units="per_micromolar_millisecond"/>
        <variable name="epsilon_m" units="per_millisecond"/>
        <variable initial_value="-2" name="V_L" units="millivolt"/>
        <variable initial_value="7.0671" name="delta_V_L" units="millivolt"/>
        <variable initial_value="1.1683" name="t_L" units="millisecond"/>
        <variable initial_value="1.6411" name="phi_L" units="dimensionless"/>
        <variable initial_value="0.07" name="a" units="dimensionless"/>
        <variable initial_value="14" name="b" units="dimensionless"/>
        <variable initial_value="972.9715" name="tau_L" units="millisecond"/>
        <variable initial_value="0.0964" name="K_L" units="micromolar"/>
        <variable name="expVL" units="dimensionless"/>
        <variable name="FVRT" units="dimensionless"/>
        <variable name="FVRT_Ca" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="Cao" public_interface="in" units="micromolar"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="Acap" public_interface="in" units="cm2"/>
        <variable name="Vss" public_interface="in" units="microlitre"/>
        <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable initial_value="6.6755" name="const5" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>FVRT</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>F</ci>
                        <ci>V</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>FVRT_Ca</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    <ci>FVRT</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>expVL</ci>
                <apply>
                    <exp/>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <ci>V</ci>
                            <ci>V_L</ci>
                        </apply>
                        <ci>delta_V_L</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_p</ci>
                <apply>
                    <divide/>
                    <ci>expVL</ci>
                    <apply>
                        <times/>
                        <ci>t_L</ci>
                        <apply>
                            <plus/>
                            <ci>expVL</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_m</ci>
                <apply>
                    <divide/>
                    <ci>phi_L</ci>
                    <ci>t_L</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>epsilon_p</ci>
                <apply>
                    <divide/>
                    <apply>
                        <plus/>
                        <ci>expVL</ci>
                        <ci>a</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>tau_L</ci>
                        <ci>K_L</ci>
                        <apply>
                            <plus/>
                            <ci>expVL</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>epsilon_m</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>b</ci>
                        <apply>
                            <plus/>
                            <ci>expVL</ci>
                            <ci>a</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>tau_L</ci>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <ci>b</ci>
                                <ci>expVL</ci>
                            </apply>
                            <ci>a</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>y_gate_inf</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.6577</cn>
                                    </apply>
                                    <ci>const5</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                        </apply>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>y_gate_tau</ci>
                <apply>
                    <plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">20</cn>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">600</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9.6</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>O</ci>
                    </apply>
                    <ci>I</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>O</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_p</ci>
                        <ci>C</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_m</ci>
                        <ci>O</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>I</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>epsilon_p</ci>
                        <ci>Cass</ci>
                        <ci>C</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>epsilon_m</ci>
                        <ci>I</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>y_gate</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>y_gate_inf</ci>
                        <ci>y_gate</ci>
                    </apply>
                    <ci>y_gate_tau</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_CaL</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <ci>P_CaL</ci>
                                            </apply>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                            <ci>Vss</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>Acap</ci>
                                            <ci>Cm</ci>
                                        </apply>
                                    </apply>
                                    <ci>O</ci>
                                    <ci>y_gate</ci>
                                    <ci>FVRT_Ca</ci>
                                </apply>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <minus/>
                                            <ci>FVRT_Ca</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>Cao</ci>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <minus/>
                                            <ci>FVRT_Ca</ci>
                                        </apply>
                                    </apply>
                                </apply>
                                <ci>Cass</ci>
                            </apply>
                        </apply>
                        <apply>
                            <gt/>
                            <apply>
                                <abs/>
                                <ci>FVRT_Ca</ci>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <ci>P_CaL</ci>
                                            </apply>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                            <ci>Vss</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>Acap</ci>
                                            <ci>Cm</ci>
                                        </apply>
                                    </apply>
                                    <ci>O</ci>
                                    <ci>y_gate</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                                </apply>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <minus/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>Cao</ci>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <minus/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                                        </apply>
                                    </apply>
                                </apply>
                                <ci>Cass</ci>
                            </apply>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
    </component>
    <component name="calcium_pump_current">
        <variable name="i_pCa" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.9" name="i_pCa_max" units="picoA_per_picoF"/>
        <variable initial_value="0.4" name="Km_pCa" units="micromolar"/>
        <variable name="Cai" public_interface="in" units="micromolar"/>
        <variable name="J_pCa" public_interface="out" units="micromolar_per_millisecond"/>
        <variable name="Vmyo" public_interface="in" units="microlitre"/>
        <variable name="Acap" public_interface="in" units="cm2"/>
        <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_pCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>i_pCa_max</ci>
                        <apply>
                            <power/>
                            <ci>Cai</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <power/>
                            <ci>Km_pCa</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                            <power/>
                            <ci>Cai</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_pCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <ci>i_pCa</ci>
                        </apply>
                        <ci>Acap</ci>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>Vmyo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_calcium_exchange_current">
        <variable name="J_ncx" units="micromolar_per_millisecond"/>
        <variable name="i_NaCa" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="772.8991" name="k_NaCa" units="picoA_per_picoF"/>
        <variable initial_value="86500" name="K_mNa" units="micromolar"/>
        <variable initial_value="1380" name="K_mCa" units="micromolar"/>
        <variable initial_value="0.1" name="k_sat" units="dimensionless"/>
        <variable initial_value="0.35" name="eta" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Nai" public_interface="in" units="micromolar"/>
        <variable name="Nao" public_interface="in" units="micromolar"/>
        <variable name="Cai" public_interface="in" units="micromolar"/>
        <variable name="Cao" public_interface="in" units="micromolar"/>
        <variable name="Vmyo" public_interface="in" units="microlitre"/>
        <variable name="Acap" public_interface="in" units="cm2"/>
        <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_NaCa</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <ci>k_NaCa</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                        </apply>
                                        <apply>
                                            <plus/>
                                            <apply>
                                                <power/>
                                                <ci>K_mNa</ci>
                                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                            </apply>
                                            <apply>
                                                <power/>
                                                <ci>Nao</ci>
                                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                            </apply>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                </apply>
                                <apply>
                                    <plus/>
                                    <ci>K_mCa</ci>
                                    <ci>Cao</ci>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <times/>
                                <ci>k_sat</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <apply>
                                                <minus/>
                                                <ci>eta</ci>
                                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                            </apply>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <times/>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <ci>eta</ci>
                                        <ci>V</ci>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <power/>
                                <ci>Nai</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                            </apply>
                            <ci>Cao</ci>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <ci>eta</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                        </apply>
                                        <ci>V</ci>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <power/>
                                <ci>Nao</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                            </apply>
                            <ci>Cai</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_ncx</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>i_NaCa</ci>
                        <ci>Acap</ci>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>Vmyo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="calcium_background_current">
        <variable name="i_Cab" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.00088" name="g_Cab" units="milliS_per_microF"/>
        <variable name="E_CaN" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Cai" public_interface="in" units="micromolar"/>
        <variable name="Cao" public_interface="in" units="micromolar"/>
        <variable name="J_Cab" units="micromolar_per_millisecond"/>
        <variable name="Vmyo" public_interface="in" units="microlitre"/>
        <variable name="Acap" public_interface="in" units="cm2"/>
        <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Cab</ci>
                <apply>
                    <times/>
                    <ci>g_Cab</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_CaN</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_CaN</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                            <ci>F</ci>
                        </apply>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Cao</ci>
                            <ci>Cai</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_Cab</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <ci>i_Cab</ci>
                        </apply>
                        <ci>Acap</ci>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>Vmyo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_concentration">
        <variable initial_value="16522.45" name="Nai" public_interface="out" units="micromolar"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Vmyo" public_interface="in" units="microlitre"/>
        <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
        <variable name="Acap" public_interface="in" units="cm2"/>
        <variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Nab" public_interface="in" units="picoA_per_picoF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Nai</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>i_Na</ci>
                                <ci>i_Nab</ci>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                    <ci>i_NaK</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                    <ci>i_NaCa</ci>
                                </apply>
                            </apply>
                        </apply>
                        <ci>Acap</ci>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>Vmyo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="fast_sodium_current">
        <variable name="i_Na" public_interface="out" units="picoA_per_picoF"/>
        <variable name="E_Na" public_interface="out" units="millivolt"/>
        <variable initial_value="13" name="g_Na" units="milliS_per_microF"/>
        <variable initial_value="2.639399e-7" name="O_Na" units="dimensionless"/>
        <variable initial_value="0.0001581035" name="C_Na1" units="dimensionless"/>
        <variable initial_value="0.01702105" name="C_Na2" units="dimensionless"/>
        <variable name="C_Na3" units="dimensionless"/>
        <variable initial_value="0.00001799179" name="I1_Na" units="dimensionless"/>
        <variable initial_value="0.000005460299" name="I2_Na" units="dimensionless"/>
        <variable initial_value="0.0000556206" name="IF_Na" units="dimensionless"/>
        <variable initial_value="0.005985434" name="IC_Na2" units="dimensionless"/>
        <variable initial_value="0.2543133" name="IC_Na3" units="dimensionless"/>
        <variable name="alpha_Na11" units="per_millisecond"/>
        <variable name="beta_Na11" units="per_millisecond"/>
        <variable name="alpha_Na12" units="per_millisecond"/>
        <variable name="beta_Na12" units="per_millisecond"/>
        <variable name="alpha_Na13" units="per_millisecond"/>
        <variable name="beta_Na13" units="per_millisecond"/>
        <variable name="alpha_Na3" units="per_millisecond"/>
        <variable name="beta_Na3" units="per_millisecond"/>
        <variable name="alpha_Na2" units="per_millisecond"/>
        <variable name="beta_Na2" units="per_millisecond"/>
        <variable name="alpha_Na4" units="per_millisecond"/>
        <variable name="beta_Na4" units="per_millisecond"/>
        <variable name="alpha_Na5" units="per_millisecond"/>
        <variable name="beta_Na5" units="per_millisecond"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Nao" public_interface="in" units="micromolar"/>
        <variable name="Nai" public_interface="in" units="micromolar"/>
        <variable name="Ko" public_interface="in" units="micromolar"/>
        <variable name="Ki" public_interface="in" units="micromolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Na</ci>
                <apply>
                    <times/>
                    <ci>g_Na</ci>
                    <ci>O_Na</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Na</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_Na</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                                    <ci>Nao</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                                    <ci>Ko</ci>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                                    <ci>Nai</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                                    <ci>Ki</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C_Na3</ci>
                <apply>
                    <minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>O_Na</ci>
                        <ci>C_Na1</ci>
                        <ci>C_Na2</ci>
                        <ci>IF_Na</ci>
                        <ci>I1_Na</ci>
                        <ci>I2_Na</ci>
                        <ci>IC_Na2</ci>
                        <ci>IC_Na3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_Na2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na11</ci>
                            <ci>C_Na3</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na12</ci>
                            <ci>C_Na1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na3</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na11</ci>
                            <ci>C_Na2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na12</ci>
                            <ci>C_Na2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na3</ci>
                            <ci>C_Na2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_Na1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na12</ci>
                            <ci>C_Na2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na13</ci>
                            <ci>O_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na3</ci>
                            <ci>IF_Na</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na12</ci>
                            <ci>C_Na1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na13</ci>
                            <ci>C_Na1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na3</ci>
                            <ci>C_Na1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>O_Na</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na13</ci>
                            <ci>C_Na1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na2</ci>
                            <ci>IF_Na</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na13</ci>
                            <ci>O_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na2</ci>
                            <ci>O_Na</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>IF_Na</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na2</ci>
                            <ci>O_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na3</ci>
                            <ci>C_Na1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na4</ci>
                            <ci>I1_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na12</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na2</ci>
                            <ci>IF_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na3</ci>
                            <ci>IF_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na4</ci>
                            <ci>IF_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na12</ci>
                            <ci>IF_Na</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>I1_Na</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na4</ci>
                            <ci>IF_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na5</ci>
                            <ci>I2_Na</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na4</ci>
                            <ci>I1_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na5</ci>
                            <ci>I1_Na</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>I2_Na</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_Na5</ci>
                        <ci>I1_Na</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_Na5</ci>
                        <ci>I2_Na</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>IC_Na2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na11</ci>
                            <ci>IC_Na3</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na12</ci>
                            <ci>IF_Na</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na3</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na11</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na12</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na3</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>IC_Na3</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_Na11</ci>
                            <ci>IC_Na2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_Na3</ci>
                            <ci>C_Na3</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_Na11</ci>
                            <ci>IC_Na3</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_Na3</ci>
                            <ci>IC_Na3</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na11</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.802</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na12</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.802</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.23</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na13</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">3.802</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1027</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">150</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na11</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.1917</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na12</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.2</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na13</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.22</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.5</cn>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20.3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na3</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millisecond">7<sep/>-7</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                                </apply>
                            </apply>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.7</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na3</ci>
                <apply>
                    <plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0084</cn>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00002</cn>
                        <apply>
                            <plus/>
                            <ci>V</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na2</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">1</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.188495</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.6</cn>
                                </apply>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.393956</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na2</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>alpha_Na13</ci>
                        <ci>alpha_Na2</ci>
                        <ci>alpha_Na3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_Na13</ci>
                        <ci>beta_Na3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na4</ci>
                <apply>
                    <divide/>
                    <ci>alpha_Na2</ci>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na4</ci>
                <ci>alpha_Na3</ci>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_Na5</ci>
                <apply>
                    <divide/>
                    <ci>alpha_Na2</ci>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">95000</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_Na5</ci>
                <apply>
                    <divide/>
                    <ci>alpha_Na3</ci>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">50</cn>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_background_current">
        <variable name="i_Nab" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.0026" name="g_Nab" units="milliS_per_microF"/>
        <variable name="E_Na" public_interface="in" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Nab</ci>
                <apply>
                    <times/>
                    <ci>g_Nab</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Na</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="potassium_concentration">
        <variable initial_value="141474" name="Ki" public_interface="out" units="micromolar"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Vmyo" public_interface="in" units="microlitre"/>
        <variable name="Cm" public_interface="in" units="microF_per_cm2"/>
        <variable name="Acap" public_interface="in" units="cm2"/>
        <variable name="i_Kto_f" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Kto_s" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Kss" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Kur" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
        <variable name="i_Stim" public_interface="in" units="picoA_per_picoF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ki</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <minus/>
                                <apply>
                                    <plus/>
                                    <ci>i_Stim</ci>
                                    <ci>i_Kto_f</ci>
                                    <ci>i_Kto_s</ci>
                                    <ci>i_K1</ci>
                                    <ci>i_Ks</ci>
                                    <ci>i_Kss</ci>
                                    <ci>i_Kur</ci>
                                    <ci>i_Kr</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    <ci>i_NaK</ci>
                                </apply>
                            </apply>
                        </apply>
                        <ci>Acap</ci>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>Vmyo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="fast_transient_outward_K_I">
        <variable name="i_Kto_f" public_interface="out" units="picoA_per_picoF"/>
        <variable name="E_K" public_interface="out" units="millivolt"/>
        <variable initial_value="0.4067" name="g_Kto_f" units="milliS_per_microF"/>
        <variable initial_value="0.001937245" name="ato_f" units="dimensionless"/>
        <variable initial_value="0.9999985" name="ito_f" units="dimensionless"/>
        <variable name="alpha_a" units="per_millisecond"/>
        <variable name="beta_a" units="per_millisecond"/>
        <variable name="alpha_i" units="per_millisecond"/>
        <variable name="beta_i" units="per_millisecond"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Ki" public_interface="in" units="micromolar"/>
        <variable name="Ko" public_interface="in" units="micromolar"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kto_f</ci>
                <apply>
                    <times/>
                    <ci>g_Kto_f</ci>
                    <apply>
                        <power/>
                        <ci>ato_f</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>ito_f</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_K</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <ci>Ki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>ato_f</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_a</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>ato_f</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_a</ci>
                        <ci>ato_f</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>ito_f</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_i</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>ito_f</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_i</ci>
                        <ci>ito_f</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_a</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.18064</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_a</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.3956</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06237</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_i</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.000152</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.5</cn>
                                    </apply>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0067083</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                                        </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                                </apply>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_i</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.00095</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.051335</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">33.5</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                                </apply>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="slow_transient_outward_K_I">
        <variable name="i_Kto_s" public_interface="out" units="picoA_per_picoF"/>
        <variable name="ass" public_interface="out" units="dimensionless"/>
        <variable name="iss" public_interface="out" units="dimensionless"/>
        <variable initial_value="0" name="g_Kto_s" units="milliS_per_microF"/>
        <variable initial_value="0.02000568" name="ato_s" units="dimensionless"/>
        <variable initial_value="0.9308568" name="ito_s" units="dimensionless"/>
        <variable name="tau_ta_s" units="millisecond"/>
        <variable name="tau_ti_s" units="millisecond"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kto_s</ci>
                <apply>
                    <times/>
                    <ci>g_Kto_s</ci>
                    <ci>ato_s</ci>
                    <ci>ito_s</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>ato_s</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>ass</ci>
                        <ci>ato_s</ci>
                    </apply>
                    <ci>tau_ta_s</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>ito_s</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>iss</ci>
                        <ci>ito_s</ci>
                    </apply>
                    <ci>tau_ti_s</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ass</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.5</cn>
                                    </apply>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.7</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>iss</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_ta_s</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.493</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0629</cn>
                                </apply>
                                <ci>V</ci>
                            </apply>
                        </apply>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2.058</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_ti_s</ci>
                <apply>
                    <plus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">270</cn>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1050</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="time_independent_K_I">
        <variable name="i_K1" public_interface="out" units="picoA_per_picoF"/>
        <variable name="Ko" public_interface="in" units="micromolar"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable initial_value="0.2938" name="g_K1" units="milliS_per_microF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_K1</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>g_K1</ci>
                                <ci>Ko</ci>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>Ko</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">210</cn>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <ci>V</ci>
                            <ci>E_K</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0896</cn>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_K</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="slow_delayed_rectifier_K_I">
        <variable name="i_Ks" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.00575" name="g_Ks" units="milliS_per_microF"/>
        <variable initial_value="0.002206261" name="nKs" units="dimensionless"/>
        <variable name="alpha_n" units="per_millisecond"/>
        <variable name="beta_n" units="per_millisecond"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Ks</ci>
                <apply>
                    <times/>
                    <ci>g_Ks</ci>
                    <apply>
                        <power/>
                        <ci>nKs</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>nKs</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_n</ci>
                        <apply>
                            <minus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <ci>nKs</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_n</ci>
                        <ci>nKs</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_n</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_millisecond">0.00000481333</cn>
                        <apply>
                            <plus/>
                            <ci>V</ci>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.128</cn>
                                </apply>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_n</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0000953333</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.038</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="ultra_rapidly_activating_delayed_rectifier_K_I">
        <variable name="i_Kur" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.16" name="g_Kur" units="milliS_per_microF"/>
        <variable initial_value="0.02000568" name="aur" units="dimensionless"/>
        <variable initial_value="0.9822006" name="iur" units="dimensionless"/>
        <variable name="tau_aur" units="millisecond"/>
        <variable name="tau_iur" units="millisecond"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="ass" public_interface="in" units="dimensionless"/>
        <variable name="iss" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kur</ci>
                <apply>
                    <times/>
                    <ci>g_Kur</ci>
                    <ci>aur</ci>
                    <ci>iur</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>aur</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>ass</ci>
                        <ci>aur</ci>
                    </apply>
                    <ci>tau_aur</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>iur</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>iss</ci>
                        <ci>iur</ci>
                    </apply>
                    <ci>tau_iur</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_aur</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">0.493</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0629</cn>
                                </apply>
                                <ci>V</ci>
                            </apply>
                        </apply>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">2.058</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_iur</ci>
                <apply>
                    <minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">1200</cn>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">170</cn>
                        <apply>
                            <plus/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.2</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.7</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="non_inactivating_steady_state_K_I">
        <variable name="i_Kss" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.05" name="g_Kss" units="milliS_per_microF"/>
        <variable initial_value="0.8883113" name="aKss" units="dimensionless"/>
        <variable initial_value="1" name="iKss" units="dimensionless"/>
        <variable name="tau_Kss" units="millisecond"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="ass" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kss</ci>
                <apply>
                    <times/>
                    <ci>g_Kss</ci>
                    <ci>aKss</ci>
                    <ci>iKss</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>aKss</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>ass</ci>
                        <ci>aKss</ci>
                    </apply>
                    <ci>tau_Kss</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>iKss</ci>
                </apply>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0</cn>
            </apply>
            <apply>
                <eq/>
                <ci>tau_Kss</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">39.3</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0862</cn>
                                </apply>
                                <ci>V</ci>
                            </apply>
                        </apply>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millisecond">13.17</cn>
                </apply>
            </apply>
        </math>
    </component>
    <component name="rapid_delayed_rectifier_K_I">
        <variable name="i_Kr" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="0.078" name="g_Kr" units="milliS_per_microF"/>
        <variable initial_value="0.0004858865" name="O_K" units="dimensionless"/>
        <variable initial_value="0.0007799137" name="C_K1" units="dimensionless"/>
        <variable initial_value="0.0005301217" name="C_K2" units="dimensionless"/>
        <variable name="C_K0" units="dimensionless"/>
        <variable initial_value="0.00007519518" name="I_K" units="dimensionless"/>
        <variable name="alpha_a0" units="per_millisecond"/>
        <variable name="beta_a0" units="per_millisecond"/>
        <variable initial_value="0.036778" name="kb" units="per_millisecond"/>
        <variable initial_value="0.023761" name="kf" units="per_millisecond"/>
        <variable name="alpha_a1" units="per_millisecond"/>
        <variable name="beta_a1" units="per_millisecond"/>
        <variable name="alpha_i" units="per_millisecond"/>
        <variable name="beta_i" units="per_millisecond"/>
        <variable name="time" public_interface="in" units="millisecond"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Nao" public_interface="in" units="micromolar"/>
        <variable name="Nai" public_interface="in" units="micromolar"/>
        <variable name="Ko" public_interface="in" units="micromolar"/>
        <variable name="Ki" public_interface="in" units="micromolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kr</ci>
                <apply>
                    <times/>
                    <ci>g_Kr</ci>
                    <ci>O_K</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                                <ci>F</ci>
                            </apply>
                            <apply>
                                <ln/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <apply>
                                            <times/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.98</cn>
                                            <ci>Ko</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                                            <ci>Nao</ci>
                                        </apply>
                                    </apply>
                                    <apply>
                                        <plus/>
                                        <apply>
                                            <times/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.98</cn>
                                            <ci>Ki</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                                            <ci>Nai</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C_K0</ci>
                <apply>
                    <minus/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>C_K1</ci>
                        <ci>C_K2</ci>
                        <ci>O_K</ci>
                        <ci>I_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_K2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>kf</ci>
                            <ci>C_K1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_a1</ci>
                            <ci>O_K</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>kb</ci>
                            <ci>C_K2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_a1</ci>
                            <ci>C_K2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_K1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_a0</ci>
                            <ci>C_K0</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kb</ci>
                            <ci>C_K2</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_a0</ci>
                            <ci>C_K1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>kf</ci>
                            <ci>C_K1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>O_K</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>alpha_a1</ci>
                            <ci>C_K2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>beta_i</ci>
                            <ci>I_K</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>beta_a1</ci>
                            <ci>O_K</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>alpha_i</ci>
                            <ci>O_K</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>I_K</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_i</ci>
                        <ci>O_K</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_i</ci>
                        <ci>I_K</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_a0</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.022348</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01176</cn>
                            <ci>V</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_a0</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.047002</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0631</cn>
                            </apply>
                            <ci>V</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_a1</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.013733</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.038198</cn>
                            <ci>V</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_a1</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.0000689</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04178</cn>
                            </apply>
                            <ci>V</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_i</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.090821</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.023391</cn>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_i</ci>
                <apply>
                    <times/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millisecond">0.006497</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03268</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>V</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_potassium_pump_current">
        <variable name="i_NaK" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="1.66" name="i_NaK_max" units="picoA_per_picoF"/>
        <variable initial_value="21000" name="Km_Nai" units="micromolar"/>
        <variable initial_value="1500" name="Km_Ko" units="micromolar"/>
        <variable name="f_NaK" units="dimensionless"/>
        <variable name="sigma" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Nai" public_interface="in" units="micromolar"/>
        <variable name="Nao" public_interface="in" units="micromolar"/>
        <variable name="Ko" public_interface="in" units="micromolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_NaK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>i_NaK_max</ci>
                                <ci>f_NaK</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                <apply>
                                    <power/>
                                    <apply>
                                        <divide/>
                                        <ci>Km_Nai</ci>
                                        <ci>Nai</ci>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                                </apply>
                            </apply>
                        </apply>
                        <ci>Ko</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <ci>Km_Ko</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>f_NaK</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                                        </apply>
                                        <ci>V</ci>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                            <ci>sigma</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                        </apply>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>sigma</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Nao</ci>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="micromolar">67300</cn>
                            </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="calcium_activated_chloride_current">
        <variable name="i_ClCa" public_interface="out" units="picoA_per_picoF"/>
        <variable initial_value="10" name="g_ClCa" units="milliS_per_microF"/>
        <variable name="O_ClCa" units="dimensionless"/>
        <variable initial_value="-40" name="E_Cl" units="millivolt"/>
        <variable initial_value="10" name="Km_Cl" units="micromolar"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="Cai" public_interface="in" units="micromolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_ClCa</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>g_ClCa</ci>
                            <ci>O_ClCa</ci>
                            <ci>Cai</ci>
                        </apply>
                        <apply>
                            <plus/>
                            <ci>Cai</ci>
                            <ci>Km_Cl</ci>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Cl</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>O_ClCa</ci>
                <apply>
                    <divide/>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                    <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">46.7</cn>
                                    </apply>
                                </apply>
                                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.8</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="transmembrane_currents"/>
    <component name="intracellular_currents"/>
    <component name="Ions_n_reversal_potentials"/>
    <group>
        <relationship_ref relationship="containment"/>
        <component_ref component="membrane">
            <component_ref component="transmembrane_currents">
                <component_ref component="L_type_calcium_current"/>
                <component_ref component="calcium_pump_current"/>
                <component_ref component="sodium_calcium_exchange_current"/>
                <component_ref component="calcium_background_current"/>
                <component_ref component="fast_sodium_current"/>
                <component_ref component="sodium_background_current"/>
                <component_ref component="fast_transient_outward_K_I"/>
                <component_ref component="slow_transient_outward_K_I"/>
                <component_ref component="time_independent_K_I"/>
                <component_ref component="slow_delayed_rectifier_K_I"/>
                <component_ref component="ultra_rapidly_activating_delayed_rectifier_K_I"/>
                <component_ref component="non_inactivating_steady_state_K_I"/>
                <component_ref component="rapid_delayed_rectifier_K_I"/>
                <component_ref component="sodium_potassium_pump_current"/>
                <component_ref component="calcium_activated_chloride_current"/>
            </component_ref>
            <component_ref component="Ions_n_reversal_potentials">
                <component_ref component="calcium_concentration"/>
                <component_ref component="sodium_concentration"/>
                <component_ref component="potassium_concentration"/>
            </component_ref>
            <component_ref component="intracellular_currents">
                <component_ref component="ryanodine_receptors"/>
                <component_ref component="calcium_fluxes"/>
            </component_ref>
        </component_ref>
    </group>
    <connection>
        <map_components component_1="membrane" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="calcium_concentration" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="calcium_fluxes" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="ryanodine_receptors" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="L_type_calcium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="sodium_concentration" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="fast_sodium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="potassium_concentration" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="fast_transient_outward_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="slow_transient_outward_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="slow_delayed_rectifier_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="time_independent_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="ultra_rapidly_activating_delayed_rectifier_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="non_inactivating_steady_state_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="rapid_delayed_rectifier_K_I" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="L_type_calcium_current"/>
        <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="Vss" variable_2="Vss"/>
        <map_variables variable_1="Acap" variable_2="Acap"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="Cm" variable_2="Cm"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="calcium_pump_current"/>
        <map_variables variable_1="i_pCa" variable_2="i_pCa"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
        <map_variables variable_1="Acap" variable_2="Acap"/>
        <map_variables variable_1="Cm" variable_2="Cm"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="sodium_calcium_exchange_current"/>
        <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
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        <map_variables variable_1="Acap" variable_2="Acap"/>
        <map_variables variable_1="Cm" variable_2="Cm"/>
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Source
Derived from workspace Li, Smith, 2009 at changeset b4c2308e064c.
Collaboration
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License

This work is licensed under a Creative Commons Attribution 3.0 Unported License.