Rendering of the source text

<?xml version='1.0'?>
<model cmeta:id="clancy_rudy_2002" name="clancy_rudy_2002" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Na<superscript>+</superscript> Channel Mutation That Causes Both Brugada and Long-QT Syndrome Phenotypes: A Simulation Study of Mechanism</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This CellML model represents the INa1795insD M cell.  For more details on the curation status of this model please see this <ulink url="Clancy_Rudy_Mutations.pdf">separate notes document</ulink>.
</para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
ABSTRACT: BACKGROUND: Complex physiological interactions determine the functional consequences of gene abnormalities and make mechanistic interpretation of phenotypes extremely difficult. A recent example is a single mutation in the C terminus of the cardiac Na(+) channel, 1795insD. The mutation causes two distinct clinical syndromes, long QT (LQT) and Brugada, leading to life-threatening cardiac arrhythmias. Coexistence of these syndromes is seemingly paradoxical; LQT is associated with enhanced Na(+) channel function, and Brugada with reduced function. METHODS AND RESULTS: Using a computational approach, we demonstrate that the 1795insD mutation exerts variable effects depending on the myocardial substrate. We develop Markov models of the wild-type and 1795insD cardiac Na(+) channels. By incorporating the models into a virtual transgenic cell, we elucidate the mechanism by which 1795insD differentially disrupts cellular electrical behavior in epicardial and midmyocardial cell types. We provide a cellular mechanistic basis for the ECG abnormalities observed in patients carrying the 1795insD gene mutation. CONCLUSIONS: We demonstrate that the 1795insD mutation can cause both LQT and Brugada syndromes through interaction with the heterogeneous myocardium in a rate-dependent manner. The results highlight the complexity and multiplicity of genotype-phenotype relationships, and the usefulness of computational approaches in establishing a mechanistic link between genetic defects and functional abnormalities.  
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Na<superscript>+</superscript> Channel Mutation That Causes Both Brugada and Long-QT Syndrome Phenotypes: A Simulation Study of Mechanism, Colleen E. Clancy and Yoram Rudy, 2002, 
            <emphasis>Circulation</emphasis>
          , 105, 1208-1213. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11889015&amp;dopt=Abstract">PubMed ID: 11889015</ulink>
</para>


<informalfigure float="0" id="fig_cell_diagram1">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram</title>
    </objectinfo>
    <imagedata fileref="clancy_2002a.png"/>
  </imageobject>
</mediaobject>
<caption>A Markovian model for the wild-type cardiac Na<superscript>+</superscript> channel, embedded within an updated version of the Luo-Rudy dynamic model.  C, indicates a closed channel state; IC, a closed-inactivation state; IF, a fast inactivation state; IM, an intermediate inactivation state, and O, an open state.</caption>
</informalfigure>

<informalfigure float="0" id="fig_cell_diagram2">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram2</title>
    </objectinfo>
    <imagedata fileref="clancy_2002b.png"/>
  </imageobject>
</mediaobject>
<caption>A Markovian model for the mutant 1795insD cardiac Na<superscript>+</superscript> channel, embedded within an updated version of the Luo-Rudy dynamic model.  U (upper) indicates background mode of gating; L (lower), represents a small population of bursting channels which fail to inactivate.</caption>
</informalfigure>

</sect1>
</article>
</documentation>

    <units name="per_second">
        <unit exponent="-1" units="second"/>
    </units>
    <units name="millivolt">
        <unit prefix="milli" units="volt"/>
    </units>
    <units name="per_millivolt">
        <unit exponent="-1" prefix="milli" units="volt"/>
    </units>
    <units name="per_millivolt_second">
        <unit exponent="-1" units="millivolt"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="milliS_per_microF">
        <unit prefix="milli" units="siemens"/>
        <unit exponent="-1" prefix="milli" units="farad"/>
    </units>
    <units name="milliS_per_cm2">
        <unit prefix="milli" units="siemens"/>
        <unit exponent="-2" prefix="centi" units="metre"/>
    </units>
    <units name="nanoS_per_cm2">
        <unit prefix="nano" units="siemens"/>
        <unit exponent="-2" prefix="centi" units="metre"/>
    </units>
    <units name="microF">
        <unit prefix="micro" units="farad"/>
    </units>
    <units name="microA_per_microF">
        <unit prefix="micro" units="ampere"/>
        <unit exponent="-1" prefix="micro" units="farad"/>
    </units>
    <units name="millimolar_per_second">
        <unit prefix="milli" units="mole"/>
        <unit exponent="-1" units="litre"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="millimolar">
        <unit prefix="milli" units="mole"/>
        <unit exponent="-1" units="litre"/>
    </units>
    <units name="micromolar">
        <unit prefix="micro" units="mole"/>
        <unit exponent="-1" units="litre"/>
    </units>
    <units name="joule_per_kilomole_kelvin">
        <unit units="joule"/>
        <unit exponent="-1" prefix="kilo" units="mole"/>
        <unit exponent="-1" units="kelvin"/>
    </units>
    <units name="coulomb_per_mole">
        <unit units="coulomb"/>
        <unit exponent="-1" units="mole"/>
    </units>
    <units name="cm_per_second">
        <unit prefix="centi" units="metre"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="mm">
        <unit prefix="milli" units="metre"/>
    </units>
    <units name="mm2">
        <unit exponent="2" prefix="milli" units="metre"/>
    </units>
    <units name="micro_litre">
        <unit prefix="micro" units="litre"/>
    </units>
    <component name="environment">
        <variable name="time" public_interface="out" units="second"/>
    </component>
    <component name="membrane">
        <variable initial_value="-88.998" name="V" public_interface="out" units="millivolt"/>
        <variable initial_value="8314" name="R" public_interface="out" units="joule_per_kilomole_kelvin"/>
        <variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
        <variable initial_value="96485" name="F" public_interface="out" units="coulomb_per_mole"/>
        <variable initial_value="0.001" name="Cm" units="microF"/>
        <variable name="I_st" units="microA_per_microF"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="i_Na" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ca_T" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Kr" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ks" public_interface="in" units="microA_per_microF"/>
        <variable name="i_K_Na" public_interface="in" units="microA_per_microF"/>
        <variable name="i_K_ATP" public_interface="in" units="microA_per_microF"/>
        <variable name="i_to" public_interface="in" units="microA_per_microF"/>
        <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
        <variable name="i_K1" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Kp" public_interface="in" units="microA_per_microF"/>
        <variable name="i_p_Ca" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Na_b" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
        <variable name="i_NaK" public_interface="in" units="microA_per_microF"/>
        <variable name="i_ns_Ca" public_interface="in" units="microA_per_microF"/>
        <variable name="dVdt" public_interface="out" units="dimensionless"/>
        <variable initial_value="3" name="stim_start" units="second"/>
        <variable initial_value="9" name="stim_end" units="second"/>
        <variable initial_value="1" name="stim_period" units="dimensionless"/>
        <variable initial_value="0.002" name="stim_duration" units="second"/>
        <variable initial_value="-50" name="stim_amplitude" units="microA_per_microF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_st</ci>
                <piecewise>
                    <piece>
                        <ci>stim_amplitude</ci>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <ci>time</ci>
                                <ci>stim_start</ci>
                            </apply>
                            <apply>
                                <leq/>
                                <ci>time</ci>
                                <ci>stim_end</ci>
                            </apply>
                            <apply>
                                <leq/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>time</ci>
                                        <ci>stim_start</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <floor/>
                                            <apply>
                                                <divide/>
                                                <apply>
                                                    <minus/>
                                                    <ci>time</ci>
                                                    <ci>stim_start</ci>
                                                </apply>
                                                <ci>stim_period</ci>
                                            </apply>
                                        </apply>
                                        <ci>stim_period</ci>
                                    </apply>
                                </apply>
                                <ci>stim_duration</ci>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="microA_per_microF">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>V</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_Ca_L</ci>
                        <ci>i_Ca_T</ci>
                        <ci>i_Kr</ci>
                        <ci>i_Ks</ci>
                        <ci>i_K_Na</ci>
                        <ci>i_K_ATP</ci>
                        <ci>i_to</ci>
                        <ci>i_K1</ci>
                        <ci>i_Kp</ci>
                        <ci>i_NaCa</ci>
                        <ci>i_p_Ca</ci>
                        <ci>i_Na_b</ci>
                        <ci>i_Ca_b</ci>
                        <ci>i_NaK</ci>
                        <ci>i_ns_Ca</ci>
                        <ci>I_st</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dVdt</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                        </apply>
                        <ci>Cm</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_Ca_L</ci>
                        <ci>i_Ca_T</ci>
                        <ci>i_Kr</ci>
                        <ci>i_Ks</ci>
                        <ci>i_K_Na</ci>
                        <ci>i_K_ATP</ci>
                        <ci>i_to</ci>
                        <ci>i_K1</ci>
                        <ci>i_Kp</ci>
                        <ci>i_NaCa</ci>
                        <ci>i_p_Ca</ci>
                        <ci>i_Na_b</ci>
                        <ci>i_Ca_b</ci>
                        <ci>i_NaK</ci>
                        <ci>i_ns_Ca</ci>
                        <ci>I_st</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="fast_sodium_current">
        <variable name="i_Na" public_interface="out" units="microA_per_microF"/>
        <variable name="E_Na" public_interface="out" units="millivolt"/>
        <variable initial_value="23.5" name="g_Na" units="milliS_per_microF"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="P_O_Na" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Na</ci>
                <apply>
                    <times/>
                    <ci>g_Na</ci>
                    <ci>P_O_Na</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Na</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_Na</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Nao</ci>
                            <ci>Nai</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Na_channel_states">
        <variable name="P_O_Na" public_interface="out" units="dimensionless"/>
        <variable initial_value="4.37e-17" name="P_LO" units="dimensionless"/>
        <variable initial_value="4.15e-13" name="P_UO" units="dimensionless"/>
        <variable initial_value="5.68e-14" name="P_LC1" units="dimensionless"/>
        <variable initial_value="1.2e-11" name="P_LC2" units="dimensionless"/>
        <variable initial_value="9.535e-10" name="P_LC3" units="dimensionless"/>
        <variable initial_value="2.25e-10" name="P_UIF" units="dimensionless"/>
        <variable initial_value="5.399e-10" name="P_UC1" units="dimensionless"/>
        <variable initial_value="1.14e-7" name="P_UC2" units="dimensionless"/>
        <variable initial_value="9.06e-6" name="P_UC3" units="dimensionless"/>
        <variable initial_value="3.778e-6" name="P_UIC3" units="dimensionless"/>
        <variable initial_value="4.758e-8" name="P_UIC2" units="dimensionless"/>
        <variable initial_value="6.49e-11" name="P_UIM1" units="dimensionless"/>
        <variable initial_value="1.075e-12" name="P_UIM2" units="dimensionless"/>
        <variable name="alpha_11" units="per_second"/>
        <variable name="beta_11" units="per_second"/>
        <variable name="alpha_12" units="per_second"/>
        <variable name="beta_12" units="per_second"/>
        <variable name="alpha_13" units="per_second"/>
        <variable name="beta_13" units="per_second"/>
        <variable name="alpha_2" units="per_second"/>
        <variable name="beta_2" units="per_second"/>
        <variable name="alpha_3" units="per_second"/>
        <variable name="beta_3" units="per_second"/>
        <variable name="alpha_4" units="per_second"/>
        <variable name="beta_4" units="per_second"/>
        <variable name="alpha_5" units="per_second"/>
        <variable name="beta_5" units="per_second"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>P_O_Na</ci>
                <apply>
                    <plus/>
                    <ci>P_LO</ci>
                    <ci>P_UO</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_LC3</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                                <ci>alpha_11</ci>
                            </apply>
                        </apply>
                        <ci>P_LC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                        <ci>P_UC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_11</ci>
                        <ci>P_LC2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_LC2</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_11</ci>
                                <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                                <ci>alpha_12</ci>
                            </apply>
                        </apply>
                        <ci>P_LC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_11</ci>
                        <ci>P_LC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_12</ci>
                        <ci>P_LC1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                        <ci>P_UC2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_LC1</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_12</ci>
                                <ci>alpha_13</ci>
                                <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                            </apply>
                        </apply>
                        <ci>P_LC1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_12</ci>
                        <ci>P_LC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_13</ci>
                        <ci>P_LO</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                        <ci>P_UC1</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_LO</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                                <ci>beta_13</ci>
                            </apply>
                        </apply>
                        <ci>P_LO</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                        <ci>P_UO</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_13</ci>
                        <ci>P_LC1</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UIF</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_2</ci>
                                <ci>alpha_3</ci>
                                <ci>alpha_4</ci>
                                <ci>beta_12</ci>
                            </apply>
                        </apply>
                        <ci>P_UIF</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_3</ci>
                        <ci>P_UC1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_4</ci>
                        <ci>P_UIM1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_2</ci>
                        <ci>P_UO</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_12</ci>
                        <ci>P_UIC2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UIC3</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>alpha_3</ci>
                                <ci>alpha_11</ci>
                            </apply>
                        </apply>
                        <ci>P_UIC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_3</ci>
                        <ci>P_UC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_11</ci>
                        <ci>P_UIC2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UIC2</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>alpha_3</ci>
                                <ci>alpha_12</ci>
                                <ci>beta_11</ci>
                            </apply>
                        </apply>
                        <ci>P_UIC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_3</ci>
                        <ci>P_UC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_12</ci>
                        <ci>P_UIF</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_11</ci>
                        <ci>P_UIC3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UIM1</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>alpha_5</ci>
                                <ci>beta_4</ci>
                            </apply>
                        </apply>
                        <ci>P_UIM1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_5</ci>
                        <ci>P_UIM2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_4</ci>
                        <ci>P_UIF</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UIM2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_5</ci>
                        <ci>P_UIM1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_5</ci>
                        <ci>P_UIM2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UC3</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_3</ci>
                                <ci>alpha_11</ci>
                                <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                            </apply>
                        </apply>
                        <ci>P_UC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_3</ci>
                        <ci>P_UIC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_11</ci>
                        <ci>P_UC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                        <ci>P_LC3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UC2</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_11</ci>
                                <ci>beta_3</ci>
                                <ci>alpha_12</ci>
                                <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                            </apply>
                        </apply>
                        <ci>P_UC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_11</ci>
                        <ci>P_UC3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_12</ci>
                        <ci>P_UC1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_3</ci>
                        <ci>P_UIC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                        <ci>P_LC2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UC1</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_12</ci>
                                <ci>alpha_13</ci>
                                <ci>beta_3</ci>
                                <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                            </apply>
                        </apply>
                        <ci>P_UC1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_12</ci>
                        <ci>P_UC2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_13</ci>
                        <ci>P_UO</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_3</ci>
                        <ci>P_UIF</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                        <ci>P_LC1</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_UO</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>alpha_2</ci>
                                <ci>beta_13</ci>
                                <cn cellml:units="per_second" type="e-notation">1<sep/>-4</cn>
                            </apply>
                        </apply>
                        <ci>P_UO</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_2</ci>
                        <ci>P_UIF</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_13</ci>
                        <ci>P_UC1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">9.5<sep/>-1</cn>
                        <ci>P_LO</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_11</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">3802</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.1027</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">17</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.2</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">150</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_12</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">3802</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.1027</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">15</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.23</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">150</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_13</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">3802</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.1027</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">12</cn>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.25</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">150</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_11</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">191.7</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                            </apply>
                            <cn cellml:units="millivolt">20.3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_12</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">200</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">5</cn>
                                </apply>
                            </apply>
                            <cn cellml:units="millivolt">20.3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_13</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">220</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <minus/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">10</cn>
                                </apply>
                            </apply>
                            <cn cellml:units="millivolt">20.3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_2</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">9178</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <ci>V</ci>
                            <cn cellml:units="millivolt">29.68</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_2</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>alpha_13</ci>
                        <ci>alpha_2</ci>
                        <ci>alpha_3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_13</ci>
                        <ci>beta_3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_3</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second" type="e-notation">3.7933<sep/>-4</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                </apply>
                                <cn cellml:units="millivolt">7.7</cn>
                            </apply>
                        </apply>
                    </apply>
                    <cn cellml:units="dimensionless">2.5</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_3</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="per_second">8.4</cn>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.02</cn>
                        <ci>V</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_4</ci>
                <apply>
                    <divide/>
                    <ci>alpha_2</ci>
                    <cn cellml:units="dimensionless">100</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_4</ci>
                <ci>alpha_3</ci>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_5</ci>
                <apply>
                    <divide/>
                    <ci>alpha_2</ci>
                    <cn cellml:units="dimensionless" type="e-notation">3.5<sep/>4</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_5</ci>
                <apply>
                    <divide/>
                    <ci>alpha_3</ci>
                    <cn cellml:units="dimensionless">20</cn>
                </apply>
            </apply>
        </math>
    </component>
    <component name="L_type_Ca_channel">
        <variable name="i_Ca_L" public_interface="out" units="microA_per_microF"/>
        <variable name="i_CaCa" public_interface="out" units="microA_per_microF"/>
        <variable name="i_CaK" public_interface="out" units="microA_per_microF"/>
        <variable name="i_CaNa" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.75" name="gamma_Nai" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.75" name="gamma_Nao" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.75" name="gamma_Ki" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.75" name="gamma_Ko" public_interface="out" units="dimensionless"/>
        <variable name="I_CaCa" units="microA_per_microF"/>
        <variable name="I_CaK" units="microA_per_microF"/>
        <variable name="I_CaNa" units="microA_per_microF"/>
        <variable initial_value="0.00054" name="P_Ca" units="cm_per_second"/>
        <variable initial_value="6.75e-7" name="P_Na" units="cm_per_second"/>
        <variable initial_value="1.93e-7" name="P_K" units="cm_per_second"/>
        <variable initial_value="1" name="gamma_Cai" units="dimensionless"/>
        <variable initial_value="0.341" name="gamma_Cao" units="dimensionless"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="d" private_interface="in" units="dimensionless"/>
        <variable name="f" private_interface="in" units="dimensionless"/>
        <variable name="f_Ca" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_CaCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>P_Ca</ci>
                                <apply>
                                    <power/>
                                    <cn cellml:units="dimensionless">2</cn>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                                <ci>V</ci>
                                <apply>
                                    <power/>
                                    <ci>F</ci>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>R</ci>
                                <ci>T</ci>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>gamma_Cai</ci>
                                <ci>Cai</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="dimensionless">2</cn>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>gamma_Cao</ci>
                                <ci>Cao</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2</cn>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_CaNa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>P_Na</ci>
                                <apply>
                                    <power/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                                <ci>V</ci>
                                <apply>
                                    <power/>
                                    <ci>F</ci>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>R</ci>
                                <ci>T</ci>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>gamma_Nai</ci>
                                <ci>Nai</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="dimensionless">1</cn>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>gamma_Nao</ci>
                                <ci>Nao</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_CaK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>P_K</ci>
                                <apply>
                                    <power/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                                <ci>V</ci>
                                <apply>
                                    <power/>
                                    <ci>F</ci>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>R</ci>
                                <ci>T</ci>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>gamma_Ki</ci>
                                <ci>Ki</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="dimensionless">1</cn>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>gamma_Ko</ci>
                                <ci>Ko</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_CaCa</ci>
                <apply>
                    <times/>
                    <ci>d</ci>
                    <ci>f</ci>
                    <ci>f_Ca</ci>
                    <ci>I_CaCa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_CaNa</ci>
                <apply>
                    <times/>
                    <ci>d</ci>
                    <ci>f</ci>
                    <ci>f_Ca</ci>
                    <ci>I_CaNa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_CaK</ci>
                <apply>
                    <times/>
                    <ci>d</ci>
                    <ci>f</ci>
                    <ci>f_Ca</ci>
                    <ci>I_CaK</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Ca_L</ci>
                <apply>
                    <plus/>
                    <ci>i_CaCa</ci>
                    <ci>i_CaK</ci>
                    <ci>i_CaNa</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="L_type_Ca_channel_d_gate">
        <variable initial_value="3.176e-6" name="d" public_interface="out" units="dimensionless"/>
        <variable name="alpha_d" units="per_second"/>
        <variable name="beta_d" units="per_second"/>
        <variable name="d_infinity" units="dimensionless"/>
        <variable name="tau_d" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="E0_d" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>E0_d</ci>
                <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="millivolt">10</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>d_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <ci>E0_d</ci>
                                </apply>
                                <cn cellml:units="millivolt">6.24</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_d</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <divide/>
                            <cn cellml:units="second">0.001</cn>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.035</cn>
                                <cn cellml:units="dimensionless">6.24</cn>
                            </apply>
                        </apply>
                        <apply>
                            <lt/>
                            <apply>
                                <abs/>
                                <ci>E0_d</ci>
                            </apply>
                            <cn cellml:units="millivolt" type="e-notation">1<sep/>-5</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.001</cn>
                                <ci>d_infinity</ci>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <apply>
                                                <minus/>
                                                <ci>E0_d</ci>
                                            </apply>
                                            <cn cellml:units="millivolt">6.24</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="per_millivolt_second">0.035</cn>
                                <ci>E0_d</ci>
                            </apply>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_d</ci>
                <apply>
                    <divide/>
                    <ci>d_infinity</ci>
                    <ci>tau_d</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_d</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>d_infinity</ci>
                    </apply>
                    <ci>tau_d</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>d</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_d</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>d</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_d</ci>
                        <ci>d</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="L_type_Ca_channel_f_gate">
        <variable initial_value="0.99977" name="f" public_interface="out" units="dimensionless"/>
        <variable name="alpha_f" units="per_second"/>
        <variable name="beta_f" units="per_second"/>
        <variable name="f_infinity" units="dimensionless"/>
        <variable name="tau_f" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>f_infinity</ci>
                <apply>
                    <plus/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">32</cn>
                                    </apply>
                                    <cn cellml:units="millivolt">8</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">0.6</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <minus/>
                                        <cn cellml:units="millivolt">50</cn>
                                        <ci>V</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">20</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_f</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="second">0.001</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.0197</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <power/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="per_millivolt">0.0337</cn>
                                            <apply>
                                                <plus/>
                                                <ci>V</ci>
                                                <cn cellml:units="millivolt">10</cn>
                                            </apply>
                                        </apply>
                                        <cn cellml:units="dimensionless">2</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">0.02</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_f</ci>
                <apply>
                    <divide/>
                    <ci>f_infinity</ci>
                    <ci>tau_f</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_f</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>f_infinity</ci>
                    </apply>
                    <ci>tau_f</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>f</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>alpha_f</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>f</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_f</ci>
                        <ci>f</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="L_type_Ca_channel_f_Ca_gate">
        <variable name="f_Ca" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.0006" name="Km_Ca" units="millimolar"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>f_Ca</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <ci>Cai</ci>
                            <ci>Km_Ca</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="T_type_Ca_channel">
        <variable name="i_Ca_T" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.05" name="g_CaT" units="milliS_per_microF"/>
        <variable name="E_Ca" public_interface="in" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="b" private_interface="in" units="dimensionless"/>
        <variable name="g" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Ca_T</ci>
                <apply>
                    <times/>
                    <ci>g_CaT</ci>
                    <ci>b</ci>
                    <ci>b</ci>
                    <ci>g</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Ca</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="T_type_Ca_channel_b_gate">
        <variable initial_value="0.00096" name="b" public_interface="out" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="b_inf" units="dimensionless"/>
        <variable name="tau_b" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>b_inf</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">14</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">10.8</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_b</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="second">0.0037</cn>
                    <apply>
                        <divide/>
                        <cn cellml:units="second">0.0061</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">25</cn>
                                    </apply>
                                    <cn cellml:units="millivolt">4.5</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>b</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>b_inf</ci>
                        <ci>b</ci>
                    </apply>
                    <ci>tau_b</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="T_type_Ca_channel_g_gate">
        <variable initial_value="0.9944" name="g" public_interface="out" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="g_inf" units="dimensionless"/>
        <variable name="tau_g" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>g_inf</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">60</cn>
                                </apply>
                                <cn cellml:units="millivolt">5.6</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_g</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="second">0.000875</cn>
                                </apply>
                                <ci>V</ci>
                            </apply>
                            <cn cellml:units="second">0.012</cn>
                        </apply>
                        <apply>
                            <leq/>
                            <ci>V</ci>
                            <cn cellml:units="millivolt">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="second">0.012</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>g</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>g_inf</ci>
                        <ci>g</ci>
                    </apply>
                    <ci>tau_g</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="rapid_delayed_rectifier_potassium_current">
        <variable name="i_Kr" public_interface="out" units="microA_per_microF"/>
        <variable name="g_Kr" units="milliS_per_microF"/>
        <variable name="E_Kr" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="Ko" private_interface="out" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="P_O" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Kr</ci>
                <apply>
                    <times/>
                    <ci>g_Kr</ci>
                    <ci>P_O</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Kr</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>g_Kr</ci>
                <apply>
                    <times/>
                    <cn cellml:units="milliS_per_microF">0.0135</cn>
                    <apply>
                        <power/>
                        <ci>Ko</ci>
                        <cn cellml:units="dimensionless">0.59</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_Kr</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <ci>Ki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Kr_channel_states">
        <variable initial_value="1.064e-10" name="P_O" public_interface="out" units="dimensionless"/>
        <variable initial_value="3.341e-8" name="P_C1" units="dimensionless"/>
        <variable initial_value="1.6567e-8" name="P_C2" units="dimensionless"/>
        <variable initial_value="4.95e-6" name="P_C3" units="dimensionless"/>
        <variable initial_value="3.2457e-11" name="P_I" units="dimensionless"/>
        <variable name="alpha" units="per_second"/>
        <variable name="beta" units="per_second"/>
        <variable initial_value="2172" name="alpha_in" units="per_second"/>
        <variable initial_value="1077" name="beta_in" units="per_second"/>
        <variable name="alpha_alpha" units="per_second"/>
        <variable name="beta_beta" units="per_second"/>
        <variable name="alpha_i" units="per_second"/>
        <variable name="beta_i" units="per_second"/>
        <variable name="mu" units="per_second"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_C3</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>beta</ci>
                        <ci>P_C2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha</ci>
                        <ci>P_C3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_C2</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta</ci>
                                <ci>alpha_in</ci>
                            </apply>
                        </apply>
                        <ci>P_C2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha</ci>
                        <ci>P_C3</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_in</ci>
                        <ci>P_C1</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_C1</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_in</ci>
                                <ci>alpha_alpha</ci>
                                <ci>alpha_alpha</ci>
                            </apply>
                        </apply>
                        <ci>P_C1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_in</ci>
                        <ci>P_C2</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_beta</ci>
                        <ci>P_O</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>mu</ci>
                        <ci>P_I</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_O</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>beta_beta</ci>
                                <ci>beta_i</ci>
                            </apply>
                        </apply>
                        <ci>P_O</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_alpha</ci>
                        <ci>P_C1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_i</ci>
                        <ci>P_I</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>P_I</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>mu</ci>
                                <ci>alpha_i</ci>
                            </apply>
                        </apply>
                        <ci>P_I</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_alpha</ci>
                        <ci>P_C1</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>beta_i</ci>
                        <ci>P_O</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">55.5</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.05547153</cn>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">12</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">2.357</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">0.036588</cn>
                            </apply>
                            <ci>V</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_alpha</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">65.5</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.05547153</cn>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="millivolt">36</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_beta</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_second">2.9357</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">0.02158</cn>
                            </apply>
                            <ci>V</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_i</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second">439</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">0.02352</cn>
                                </apply>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">25</cn>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="millimolar">4.5</cn>
                    </apply>
                    <ci>Ko</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_i</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second">656</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.000942</cn>
                                <ci>V</ci>
                            </apply>
                        </apply>
                        <apply>
                            <power/>
                            <cn cellml:units="millimolar">4.5</cn>
                            <cn cellml:units="dimensionless">0.3</cn>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <ci>Ko</ci>
                        <cn cellml:units="dimensionless">0.3</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>alpha_i</ci>
                        <ci>beta_beta</ci>
                        <ci>alpha_alpha</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>alpha_alpha</ci>
                        <ci>beta_i</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="slow_delayed_rectifier_potassium_current">
        <variable name="i_Ks" public_interface="out" units="microA_per_microF"/>
        <variable name="g_Ks" units="milliS_per_microF"/>
        <variable name="E_Ks" units="millivolt"/>
        <variable initial_value="0.01833" name="PNaK" units="dimensionless"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <variable name="xs1" private_interface="in" units="dimensionless"/>
        <variable name="xs2" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>E_Ks</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <apply>
                                <plus/>
                                <ci>Ko</ci>
                                <apply>
                                    <times/>
                                    <ci>PNaK</ci>
                                    <ci>Nao</ci>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <ci>Ki</ci>
                                <apply>
                                    <times/>
                                    <ci>PNaK</ci>
                                    <ci>Nai</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>g_Ks</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.866</cn>
                    <cn cellml:units="milliS_per_cm2">0.433</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <cn cellml:units="dimensionless">0.6</cn>
                            <apply>
                                <plus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <power/>
                                    <apply>
                                        <divide/>
                                        <cn cellml:units="millimolar" type="e-notation">3.8<sep/>-5</cn>
                                        <ci>Cai</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">1.4</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Ks</ci>
                <apply>
                    <times/>
                    <ci>g_Ks</ci>
                    <ci>xs1</ci>
                    <ci>xs2</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Ks</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="slow_delayed_rectifier_potassium_current_xs1_gate">
        <variable initial_value="0.004412" name="xs1" public_interface="out" units="dimensionless"/>
        <variable name="xs1_infinity" units="dimensionless"/>
        <variable name="tau_xs1" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>xs1_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">1.5</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">16.7</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_xs1</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="second">0.001</cn>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless" type="e-notation">7.19<sep/>-5</cn>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">30</cn>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">0.148</cn>
                                        </apply>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">30</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.000131</cn>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">30</cn>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">0.0687</cn>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">30</cn>
                                        </apply>
                                    </apply>
                                </apply>
                                <cn cellml:units="dimensionless">1</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>xs1</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>xs1_infinity</ci>
                        <ci>xs1</ci>
                    </apply>
                    <ci>tau_xs1</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="slow_delayed_rectifier_potassium_current_xs2_gate">
        <variable initial_value="0.004413" name="xs2" public_interface="out" units="dimensionless"/>
        <variable name="xs2_infinity" units="dimensionless"/>
        <variable name="tau_xs2" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>xs2_infinity</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">1.5</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">16.7</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_xs2</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">4</cn>
                        <cn cellml:units="second">0.001</cn>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless" type="e-notation">7.19<sep/>-5</cn>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">30</cn>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">0.148</cn>
                                        </apply>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">30</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">0.000131</cn>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">30</cn>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">0.0687</cn>
                                        <apply>
                                            <plus/>
                                            <ci>V</ci>
                                            <cn cellml:units="millivolt">30</cn>
                                        </apply>
                                    </apply>
                                </apply>
                                <cn cellml:units="dimensionless">1</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>xs2</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>xs2_infinity</ci>
                        <ci>xs2</ci>
                    </apply>
                    <ci>tau_xs2</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="time_independent_potassium_current">
        <variable name="i_K1" public_interface="out" units="microA_per_microF"/>
        <variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
        <variable name="g_K1" units="milliS_per_cm2"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="K1_infinity" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>g_K1</ci>
                <apply>
                    <times/>
                    <cn cellml:units="milliS_per_microF">0.75</cn>
                    <apply>
                        <root/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <cn cellml:units="millimolar">5.4</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>E_K</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <ci>Ki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_K1</ci>
                <apply>
                    <times/>
                    <ci>g_K1</ci>
                    <ci>K1_infinity</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="time_independent_potassium_current_K1_gate">
        <variable name="K1_infinity" public_interface="out" units="dimensionless"/>
        <variable name="alpha_K1" units="per_second"/>
        <variable name="beta_K1" units="per_second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>alpha_K1</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">1020</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn cellml:units="per_millivolt">0.2385</cn>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <ci>E_K</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">59.215</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_K1</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">1000</cn>
                        <apply>
                            <plus/>
                            <apply>
                                <times/>
                                <cn cellml:units="per_second">0.49124</cn>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">0.08032</cn>
                                        <apply>
                                            <plus/>
                                            <apply>
                                                <minus/>
                                                <ci>V</ci>
                                                <ci>E_K</ci>
                                            </apply>
                                            <cn cellml:units="millivolt">5.476</cn>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <exp/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.06175</cn>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                            <ci>E_K</ci>
                                        </apply>
                                        <cn cellml:units="millivolt">594.31</cn>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="per_millivolt">0.5143</cn>
                                </apply>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <ci>V</ci>
                                        <ci>E_K</ci>
                                    </apply>
                                    <cn cellml:units="millivolt">4.753</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>K1_infinity</ci>
                <apply>
                    <divide/>
                    <ci>alpha_K1</ci>
                    <apply>
                        <plus/>
                        <ci>alpha_K1</ci>
                        <ci>beta_K1</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="plateau_potassium_current">
        <variable name="i_Kp" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.00552" name="g_Kp" units="milliS_per_microF"/>
        <variable name="Kp" units="dimensionless"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>Kp</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="millivolt">7.488</cn>
                                    <ci>V</ci>
                                </apply>
                                <cn cellml:units="millivolt">5.98</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Kp</ci>
                <apply>
                    <times/>
                    <ci>g_Kp</ci>
                    <ci>Kp</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_activated_potassium_current">
        <variable name="i_K_Na" public_interface="out" units="microA_per_microF"/>
        <variable name="g_K_Na" units="milliS_per_microF"/>
        <variable initial_value="2.8" name="nKNa" units="dimensionless"/>
        <variable name="pona" units="dimensionless"/>
        <variable name="pov" units="dimensionless"/>
        <variable initial_value="66" name="kdKNa" units="millimolar"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>g_K_Na</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0</cn>
                    <cn cellml:units="milliS_per_microF">0.12848</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pona</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">0.85</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <power/>
                            <apply>
                                <divide/>
                                <ci>kdKNa</ci>
                                <ci>Nai</ci>
                            </apply>
                            <ci>nKNa</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pov</ci>
                <apply>
                    <minus/>
                    <cn cellml:units="dimensionless">0.8</cn>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">0.65</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">125</cn>
                                    </apply>
                                    <cn cellml:units="millivolt">15</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_K_Na</ci>
                <apply>
                    <times/>
                    <ci>g_K_Na</ci>
                    <ci>pona</ci>
                    <ci>pov</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="ATP_sensitive_potassium_current">
        <variable name="i_K_ATP" public_interface="out" units="microA_per_microF"/>
        <variable name="g_K_ATP" units="milliS_per_microF"/>
        <variable initial_value="1" name="i_K_ATP_on" units="dimensionless"/>
        <variable initial_value="0.24" name="nATP" units="dimensionless"/>
        <variable initial_value="5e-5" name="nicholsarea" units="dimensionless"/>
        <variable initial_value="3" name="ATPi" units="millimolar"/>
        <variable initial_value="2" name="hATP" units="dimensionless"/>
        <variable initial_value="0.00025" name="kATP" units="millimolar"/>
        <variable name="pATP" units="dimensionless"/>
        <variable name="GKbaraATP" units="milliS_per_microF"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>g_K_ATP</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>i_K_ATP_on</ci>
                        <cn cellml:units="milliS_per_microF">0.000193</cn>
                    </apply>
                    <ci>nicholsarea</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>pATP</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <power/>
                            <apply>
                                <divide/>
                                <ci>ATPi</ci>
                                <ci>kATP</ci>
                            </apply>
                            <ci>hATP</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>GKbaraATP</ci>
                <apply>
                    <times/>
                    <ci>g_K_ATP</ci>
                    <ci>pATP</ci>
                    <apply>
                        <power/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <cn cellml:units="dimensionless">4</cn>
                        </apply>
                        <ci>nATP</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_K_ATP</ci>
                <apply>
                    <times/>
                    <ci>GKbaraATP</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="transient_outward_current">
        <variable name="i_to" public_interface="out" units="microA_per_microF"/>
        <variable name="g_to" units="milliS_per_microF"/>
        <variable name="E_K" public_interface="in" units="millivolt"/>
        <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
        <variable name="time" private_interface="out" public_interface="in" units="second"/>
        <variable name="rvdv" units="dimensionless"/>
        <variable name="zdv" private_interface="in" units="dimensionless"/>
        <variable name="ydv" private_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>g_to</ci>
                <cn cellml:units="milliS_per_microF">0.5</cn>
            </apply>
            <apply>
                <eq/>
                <ci>rvdv</ci>
                <apply>
                    <exp/>
                    <apply>
                        <divide/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">100</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_to</ci>
                <apply>
                    <times/>
                    <ci>g_to</ci>
                    <apply>
                        <power/>
                        <ci>zdv</ci>
                        <cn cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>ydv</ci>
                    <ci>rvdv</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="transient_outward_current_zdv_gate">
        <variable initial_value="0.01152" name="zdv" public_interface="out" units="dimensionless"/>
        <variable name="alpha_zdv" units="per_second"/>
        <variable name="beta_zdv" units="per_second"/>
        <variable name="tau_zdv" units="second"/>
        <variable name="zdv_ss" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>alpha_zdv</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second">10000</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">40</cn>
                                </apply>
                                <cn cellml:units="millivolt">25</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">40</cn>
                                </apply>
                                <cn cellml:units="millivolt">25</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_zdv</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second">10000</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">90</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">25</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>V</ci>
                                        <cn cellml:units="millivolt">90</cn>
                                    </apply>
                                </apply>
                                <cn cellml:units="millivolt">25</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_zdv</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_zdv</ci>
                        <ci>beta_zdv</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>zdv_ss</ci>
                <apply>
                    <divide/>
                    <ci>alpha_zdv</ci>
                    <apply>
                        <plus/>
                        <ci>alpha_zdv</ci>
                        <ci>beta_zdv</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>zdv</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>zdv_ss</ci>
                        <ci>zdv</ci>
                    </apply>
                    <ci>tau_zdv</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="transient_outward_current_ydv_gate">
        <variable initial_value="0.99998" name="ydv" public_interface="out" units="dimensionless"/>
        <variable name="alpha_ydv" units="per_second"/>
        <variable name="beta_ydv" units="per_second"/>
        <variable name="tau_ydv" units="second"/>
        <variable name="ydv_ss" units="dimensionless"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>alpha_ydv</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="per_second">15</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">60</cn>
                                </apply>
                                <cn cellml:units="millivolt">5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_ydv</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="per_second">100</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">25</cn>
                                </apply>
                                <cn cellml:units="millivolt">5</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">25</cn>
                                </apply>
                                <cn cellml:units="millivolt">5</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>tau_ydv</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>alpha_ydv</ci>
                        <ci>beta_ydv</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ydv_ss</ci>
                <apply>
                    <divide/>
                    <ci>alpha_ydv</ci>
                    <apply>
                        <plus/>
                        <ci>alpha_ydv</ci>
                        <ci>beta_ydv</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>ydv</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>ydv_ss</ci>
                        <ci>ydv</ci>
                    </apply>
                    <ci>tau_ydv</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sarcolemmal_calcium_pump">
        <variable name="i_p_Ca" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.0005" name="K_mpCa" units="millimolar"/>
        <variable initial_value="1.15" name="I_pCa" units="microA_per_microF"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_p_Ca</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_pCa</ci>
                        <ci>Cai</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>K_mpCa</ci>
                        <ci>Cai</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_background_current">
        <variable name="i_Na_b" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.004" name="g_Nab" units="milliS_per_microF"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="E_Na" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_Na_b</ci>
                <apply>
                    <times/>
                    <ci>g_Nab</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Na</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="calcium_background_current">
        <variable name="i_Ca_b" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.003016" name="g_Cab" units="milliS_per_microF"/>
        <variable name="E_Ca" public_interface="out" units="millivolt"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>E_Ca</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">2</cn>
                            <ci>F</ci>
                        </apply>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Cao</ci>
                            <ci>Cai</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Ca_b</ci>
                <apply>
                    <times/>
                    <ci>g_Cab</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Ca</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="sodium_potassium_pump">
        <variable name="i_NaK" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="2.25" name="I_NaK" units="microA_per_microF"/>
        <variable name="f_NaK" units="dimensionless"/>
        <variable initial_value="10" name="K_mNai" units="millimolar"/>
        <variable initial_value="1.5" name="K_mKo" units="millimolar"/>
        <variable name="sigma" units="dimensionless"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>sigma</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <cn cellml:units="dimensionless">7</cn>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Nao</ci>
                                <cn cellml:units="dimensionless">67.3</cn>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>f_NaK</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.1245</cn>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <cn cellml:units="dimensionless">0.1</cn>
                                        </apply>
                                        <ci>V</ci>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">0.0365</cn>
                            <ci>sigma</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <ci>V</ci>
                                        </apply>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_NaK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>I_NaK</ci>
                                <ci>f_NaK</ci>
                                <cn cellml:units="dimensionless">1</cn>
                            </apply>
                            <apply>
                                <plus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <apply>
                                    <power/>
                                    <apply>
                                        <divide/>
                                        <ci>K_mNai</ci>
                                        <ci>Nai</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                        </apply>
                        <ci>Ko</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <ci>K_mKo</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="non_specific_calcium_activated_current">
        <variable name="i_ns_Ca" public_interface="out" units="microA_per_microF"/>
        <variable name="i_ns_Na" public_interface="out" units="microA_per_microF"/>
        <variable name="i_ns_K" public_interface="out" units="microA_per_microF"/>
        <variable name="P_ns_Ca" units="cm_per_second"/>
        <variable name="gamma_Nai" public_interface="in" units="dimensionless"/>
        <variable name="gamma_Nao" public_interface="in" units="dimensionless"/>
        <variable name="gamma_Ki" public_interface="in" units="dimensionless"/>
        <variable name="gamma_Ko" public_interface="in" units="dimensionless"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Ko" public_interface="in" units="millimolar"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Ki" public_interface="in" units="millimolar"/>
        <variable name="I_ns_Na" units="microA_per_microF"/>
        <variable name="I_ns_K" units="microA_per_microF"/>
        <variable initial_value="0.0012" name="K_m_ns_Ca" units="millimolar"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>P_ns_Ca</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0</cn>
                    <cn cellml:units="cm_per_second" type="e-notation">1.75<sep/>-7</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_ns_Na</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>P_ns_Ca</ci>
                                <apply>
                                    <power/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                                <ci>V</ci>
                                <apply>
                                    <power/>
                                    <ci>F</ci>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>R</ci>
                                <ci>T</ci>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>gamma_Nai</ci>
                                <ci>Nai</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="dimensionless">1</cn>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>gamma_Nao</ci>
                                <ci>Nao</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_ns_K</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>P_ns_Ca</ci>
                                <apply>
                                    <power/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                                <ci>V</ci>
                                <apply>
                                    <power/>
                                    <ci>F</ci>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>R</ci>
                                <ci>T</ci>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>gamma_Ki</ci>
                                <ci>Ki</ci>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="dimensionless">1</cn>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <ci>gamma_Ko</ci>
                                <ci>Ko</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_ns_Na</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_ns_Na</ci>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <power/>
                            <apply>
                                <divide/>
                                <ci>K_m_ns_Ca</ci>
                                <ci>Cai</ci>
                            </apply>
                            <cn cellml:units="dimensionless">3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_ns_K</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_ns_K</ci>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <power/>
                            <apply>
                                <divide/>
                                <ci>K_m_ns_Ca</ci>
                                <ci>Cai</ci>
                            </apply>
                            <cn cellml:units="dimensionless">3</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_ns_Ca</ci>
                <apply>
                    <plus/>
                    <ci>i_ns_Na</ci>
                    <ci>i_ns_K</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="Na_Ca_exchanger">
        <variable name="i_NaCa" public_interface="out" units="microA_per_microF"/>
        <variable initial_value="0.00025" name="c1" units="microA_per_microF"/>
        <variable initial_value="0.0001" name="c2" units="millimolar"/>
        <variable initial_value="0.15" name="gamma" units="dimensionless"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="V" public_interface="in" units="millivolt"/>
        <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="Nai" public_interface="in" units="millimolar"/>
        <variable name="Nao" public_interface="in" units="millimolar"/>
        <variable name="Cai" public_interface="in" units="millimolar"/>
        <variable name="Cao" public_interface="in" units="millimolar"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>i_NaCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>c1</ci>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <ci>gamma</ci>
                                        <cn cellml:units="dimensionless">1</cn>
                                    </apply>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <apply>
                                    <exp/>
                                    <apply>
                                        <divide/>
                                        <apply>
                                            <times/>
                                            <ci>V</ci>
                                            <ci>F</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <ci>R</ci>
                                            <ci>T</ci>
                                        </apply>
                                    </apply>
                                </apply>
                                <apply>
                                    <power/>
                                    <ci>Nai</ci>
                                    <cn cellml:units="dimensionless">3</cn>
                                </apply>
                                <ci>Cao</ci>
                            </apply>
                            <apply>
                                <times/>
                                <apply>
                                    <power/>
                                    <ci>Nao</ci>
                                    <cn cellml:units="dimensionless">3</cn>
                                </apply>
                                <ci>Cai</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <times/>
                            <ci>c2</ci>
                            <apply>
                                <exp/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <times/>
                                        <apply>
                                            <minus/>
                                            <ci>gamma</ci>
                                            <cn cellml:units="dimensionless">1</cn>
                                        </apply>
                                        <ci>V</ci>
                                        <ci>F</ci>
                                    </apply>
                                    <apply>
                                        <times/>
                                        <ci>R</ci>
                                        <ci>T</ci>
                                    </apply>
                                </apply>
                            </apply>
                            <apply>
                                <plus/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <exp/>
                                        <apply>
                                            <divide/>
                                            <apply>
                                                <times/>
                                                <ci>V</ci>
                                                <ci>F</ci>
                                            </apply>
                                            <apply>
                                                <times/>
                                                <ci>R</ci>
                                                <ci>T</ci>
                                            </apply>
                                        </apply>
                                    </apply>
                                    <apply>
                                        <power/>
                                        <ci>Nai</ci>
                                        <cn cellml:units="dimensionless">3</cn>
                                    </apply>
                                    <ci>Cao</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <apply>
                                        <power/>
                                        <ci>Nao</ci>
                                        <cn cellml:units="dimensionless">3</cn>
                                    </apply>
                                    <ci>Cai</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="calcium_dynamics">
        <variable name="i_rel" public_interface="out" units="millimolar_per_second"/>
        <variable name="i_up" public_interface="out" units="millimolar_per_second"/>
        <variable name="i_leak" public_interface="out" units="millimolar_per_second"/>
        <variable name="i_tr" public_interface="out" units="millimolar_per_second"/>
        <variable name="G_rel" units="per_second"/>
        <variable initial_value="60000" name="G_rel_max" units="per_second"/>
        <variable initial_value="4000" name="G_rel_overload" units="per_second"/>
        <variable initial_value="0.18" name="tau_tr" units="second"/>
        <variable initial_value="0.0008" name="K_mrel" units="millimolar"/>
        <variable initial_value="0.00018" name="delta_Ca_ith" units="millimolar"/>
        <variable initial_value="10" name="CSQN_max" units="millimolar"/>
        <variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
        <variable initial_value="0.00092" name="K_mup" units="millimolar"/>
        <variable name="K_leak" units="per_second"/>
        <variable initial_value="8.75" name="I_up" units="millimolar_per_second"/>
        <variable initial_value="15" name="Ca_NSR_max" units="millimolar"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable initial_value="0.000114" name="Cai" public_interface="out" units="millimolar"/>
        <variable initial_value="1.8" name="Cao" public_interface="out" units="millimolar"/>
        <variable initial_value="1.643" name="Ca_JSR" public_interface="out" units="millimolar"/>
        <variable initial_value="1.645" name="Ca_NSR" public_interface="out" units="millimolar"/>
        <variable name="V_myo" public_interface="in" units="micro_litre"/>
        <variable name="A_cap" public_interface="in" units="mm2"/>
        <variable name="V_JSR" units="micro_litre"/>
        <variable name="V_NSR" units="micro_litre"/>
        <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
        <variable name="i_CaCa" public_interface="in" units="microA_per_microF"/>
        <variable name="i_p_Ca" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ca_T" public_interface="in" units="microA_per_microF"/>
        <variable initial_value="0.0005" name="K_mTn" units="millimolar"/>
        <variable initial_value="0.00238" name="K_mCMDN" units="millimolar"/>
        <variable initial_value="0.07" name="Tn_max" units="millimolar"/>
        <variable initial_value="0.05" name="CMDN_max" units="millimolar"/>
        <variable name="dVdt" public_interface="in" units="dimensionless"/>
        <variable initial_value="0" name="APtrack" units="dimensionless"/>
        <variable initial_value="0" name="APtrack2" units="dimensionless"/>
        <variable initial_value="0" name="APtrack3" units="dimensionless"/>
        <variable initial_value="0" name="Cainfluxtrack" units="dimensionless"/>
        <variable initial_value="0" name="OVRLDtrack" units="dimensionless"/>
        <variable initial_value="0" name="OVRLDtrack2" units="dimensionless"/>
        <variable initial_value="0" name="OVRLDtrack3" units="dimensionless"/>
        <variable initial_value="0.7" name="CSQNthresh" units="millimolar"/>
        <variable initial_value="0.98" name="Logicthresh" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>V_JSR</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">0.0048</cn>
                        <cn cellml:units="dimensionless">0.68</cn>
                    </apply>
                    <ci>V_myo</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>V_NSR</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">0.0552</cn>
                        <cn cellml:units="dimensionless">0.68</cn>
                    </apply>
                    <ci>V_myo</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>APtrack</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">100000</cn>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>APtrack</ci>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">500</cn>
                                <ci>APtrack</ci>
                            </apply>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>dVdt</ci>
                            <cn cellml:units="dimensionless">150000</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">500</cn>
                            </apply>
                            <ci>APtrack</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>APtrack2</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">100000</cn>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>APtrack2</ci>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">500</cn>
                                <ci>APtrack2</ci>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>APtrack</ci>
                                <cn cellml:units="dimensionless">0.2</cn>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>APtrack</ci>
                                <cn cellml:units="dimensionless">0.18</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">500</cn>
                            </apply>
                            <ci>APtrack2</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>APtrack3</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">100000</cn>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <ci>APtrack3</ci>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">500</cn>
                                <ci>APtrack3</ci>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <lt/>
                                <ci>APtrack</ci>
                                <cn cellml:units="dimensionless">0.2</cn>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>APtrack</ci>
                                <cn cellml:units="dimensionless">0.18</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">10</cn>
                            </apply>
                            <ci>APtrack3</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Cainfluxtrack</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>A_cap</ci>
                                </apply>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>i_CaCa</ci>
                                            <ci>i_Ca_T</ci>
                                        </apply>
                                        <ci>i_NaCa</ci>
                                    </apply>
                                    <ci>i_p_Ca</ci>
                                    <ci>i_Ca_b</ci>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">2</cn>
                                <ci>V_myo</ci>
                                <ci>F</ci>
                            </apply>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>APtrack</ci>
                            <cn cellml:units="dimensionless">0.2</cn>
                        </apply>
                    </piece>
                    <piece>
                        <cn cellml:units="dimensionless">0</cn>
                        <apply>
                            <and/>
                            <apply>
                                <gt/>
                                <ci>APtrack2</ci>
                                <cn cellml:units="dimensionless">0.01</cn>
                            </apply>
                            <apply>
                                <leq/>
                                <ci>APtrack</ci>
                                <cn cellml:units="dimensionless">0.2</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">500</cn>
                            </apply>
                            <ci>Cainfluxtrack</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>OVRLDtrack</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">50000</cn>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>OVRLDtrack</ci>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <gt/>
                                <apply>
                                    <divide/>
                                    <cn cellml:units="dimensionless">1</cn>
                                    <apply>
                                        <plus/>
                                        <cn cellml:units="dimensionless">1</cn>
                                        <apply>
                                            <divide/>
                                            <ci>K_mCSQN</ci>
                                            <ci>Ca_NSR</ci>
                                        </apply>
                                    </apply>
                                </apply>
                                <ci>CSQNthresh</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>OVRLDtrack3</ci>
                                <cn cellml:units="dimensionless">0.37</cn>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>APtrack3</ci>
                                <cn cellml:units="dimensionless">0.37</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">500</cn>
                            </apply>
                            <ci>OVRLDtrack</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>OVRLDtrack2</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">50000</cn>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>OVRLDtrack2</ci>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <gt/>
                                <ci>OVRLDtrack</ci>
                                <ci>Logicthresh</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>OVRLDtrack2</ci>
                                <ci>Logicthresh</ci>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">500</cn>
                            </apply>
                            <ci>OVRLDtrack2</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>OVRLDtrack3</ci>
                </apply>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">50000</cn>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>OVRLDtrack3</ci>
                            </apply>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <gt/>
                                <ci>OVRLDtrack</ci>
                                <ci>Logicthresh</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>OVRLDtrack3</ci>
                                <ci>Logicthresh</ci>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">10</cn>
                            </apply>
                            <ci>OVRLDtrack3</ci>
                        </apply>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>G_rel</ci>
                <piecewise>
                    <piece>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>G_rel_max</ci>
                                    <apply>
                                        <minus/>
                                        <ci>Cainfluxtrack</ci>
                                        <ci>delta_Ca_ith</ci>
                                    </apply>
                                </apply>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>K_mrel</ci>
                                        <ci>Cainfluxtrack</ci>
                                    </apply>
                                    <ci>delta_Ca_ith</ci>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>APtrack2</ci>
                            </apply>
                            <ci>APtrack2</ci>
                        </apply>
                        <apply>
                            <gt/>
                            <ci>Cainfluxtrack</ci>
                            <ci>delta_Ca_ith</ci>
                        </apply>
                    </piece>
                    <piece>
                        <apply>
                            <times/>
                            <ci>G_rel_overload</ci>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>OVRLDtrack2</ci>
                            </apply>
                            <ci>OVRLDtrack2</ci>
                        </apply>
                        <apply>
                            <and/>
                            <apply>
                                <leq/>
                                <ci>Cainfluxtrack</ci>
                                <ci>delta_Ca_ith</ci>
                            </apply>
                            <apply>
                                <gt/>
                                <ci>OVRLDtrack2</ci>
                                <cn cellml:units="dimensionless">0</cn>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="dimensionless">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>i_rel</ci>
                <apply>
                    <times/>
                    <ci>G_rel</ci>
                    <apply>
                        <minus/>
                        <ci>Ca_JSR</ci>
                        <ci>Cai</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_up</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>I_up</ci>
                        <ci>Cai</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>Cai</ci>
                        <ci>K_mup</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>K_leak</ci>
                <apply>
                    <divide/>
                    <ci>I_up</ci>
                    <ci>Ca_NSR_max</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_leak</ci>
                <apply>
                    <times/>
                    <ci>K_leak</ci>
                    <ci>Ca_NSR</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_tr</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>Ca_NSR</ci>
                        <ci>Ca_JSR</ci>
                    </apply>
                    <ci>tau_tr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_JSR</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>CSQN_max</ci>
                                    <ci>K_mCSQN</ci>
                                </apply>
                                <apply>
                                    <power/>
                                    <apply>
                                        <plus/>
                                        <ci>K_mCSQN</ci>
                                        <ci>Ca_JSR</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>i_tr</ci>
                        <ci>i_rel</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ca_NSR</ci>
                </apply>
                <apply>
                    <plus/>
                    <apply>
                        <minus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>i_tr</ci>
                                </apply>
                                <ci>V_JSR</ci>
                            </apply>
                            <ci>V_NSR</ci>
                        </apply>
                        <ci>i_leak</ci>
                    </apply>
                    <ci>i_up</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Cai</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>CMDN_max</ci>
                                    <ci>K_mCMDN</ci>
                                </apply>
                                <apply>
                                    <power/>
                                    <apply>
                                        <plus/>
                                        <ci>K_mCMDN</ci>
                                        <ci>Cai</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>Tn_max</ci>
                                    <ci>K_mTn</ci>
                                </apply>
                                <apply>
                                    <power/>
                                    <apply>
                                        <plus/>
                                        <ci>K_mTn</ci>
                                        <ci>Cai</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>A_cap</ci>
                                </apply>
                                <apply>
                                    <plus/>
                                    <apply>
                                        <minus/>
                                        <apply>
                                            <plus/>
                                            <ci>i_CaCa</ci>
                                            <ci>i_Ca_T</ci>
                                        </apply>
                                        <apply>
                                            <times/>
                                            <cn cellml:units="dimensionless">2</cn>
                                            <ci>i_NaCa</ci>
                                        </apply>
                                    </apply>
                                    <ci>i_p_Ca</ci>
                                    <ci>i_Ca_b</ci>
                                </apply>
                            </apply>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">2</cn>
                                <ci>V_myo</ci>
                                <ci>F</ci>
                            </apply>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>i_rel</ci>
                                <ci>V_JSR</ci>
                            </apply>
                            <ci>V_myo</ci>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>i_leak</ci>
                                    <ci>i_up</ci>
                                </apply>
                                <ci>V_NSR</ci>
                            </apply>
                            <ci>V_myo</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="ionic_concentrations">
        <variable initial_value="11.54" name="Nai" public_interface="out" units="millimolar"/>
        <variable initial_value="132" name="Nao" public_interface="out" units="millimolar"/>
        <variable initial_value="140.28" name="Ki" public_interface="out" units="millimolar"/>
        <variable initial_value="4.5" name="Ko" public_interface="out" units="millimolar"/>
        <variable initial_value="1.434e-7" name="A_cap" public_interface="out" units="mm2"/>
        <variable initial_value="0.001" name="preplength" units="mm"/>
        <variable initial_value="1.1e-4" name="radius" units="mm"/>
        <variable name="volume" units="micro_litre"/>
        <variable name="V_myo" public_interface="out" units="micro_litre"/>
        <variable name="time" public_interface="in" units="second"/>
        <variable name="F" public_interface="in" units="coulomb_per_mole"/>
        <variable name="i_Na" public_interface="in" units="microA_per_microF"/>
        <variable name="i_CaNa" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Na_b" public_interface="in" units="microA_per_microF"/>
        <variable name="i_ns_Na" public_interface="in" units="microA_per_microF"/>
        <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
        <variable name="i_NaK" public_interface="in" units="microA_per_microF"/>
        <variable name="i_CaK" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Kr" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Ks" public_interface="in" units="microA_per_microF"/>
        <variable name="i_K1" public_interface="in" units="microA_per_microF"/>
        <variable name="i_Kp" public_interface="in" units="microA_per_microF"/>
        <variable name="i_K_Na" public_interface="in" units="microA_per_microF"/>
        <variable name="i_K_ATP" public_interface="in" units="microA_per_microF"/>
        <variable name="i_ns_K" public_interface="in" units="microA_per_microF"/>
        <variable name="i_to" public_interface="in" units="microA_per_microF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>volume</ci>
                <apply>
                    <times/>
                    <pi/>
                    <ci>preplength</ci>
                    <apply>
                        <power/>
                        <ci>radius</ci>
                        <cn cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>V_myo</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.68</cn>
                    <ci>volume</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Nai</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>i_Na</ci>
                                <ci>i_CaNa</ci>
                                <ci>i_Na_b</ci>
                                <ci>i_ns_Na</ci>
                                <apply>
                                    <times/>
                                    <ci>i_NaCa</ci>
                                    <cn cellml:units="dimensionless">3</cn>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>i_NaK</ci>
                                    <cn cellml:units="dimensionless">3</cn>
                                </apply>
                            </apply>
                        </apply>
                        <ci>A_cap</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>V_myo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ki</ci>
                </apply>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <apply>
                                <plus/>
                                <ci>i_CaK</ci>
                                <ci>i_Kr</ci>
                                <ci>i_Ks</ci>
                                <ci>i_K1</ci>
                                <ci>i_Kp</ci>
                                <ci>i_K_Na</ci>
                                <ci>i_K_ATP</ci>
                                <ci>i_to</ci>
                                <ci>i_ns_K</ci>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <ci>i_NaK</ci>
                                    </apply>
                                    <cn cellml:units="dimensionless">2</cn>
                                </apply>
                            </apply>
                        </apply>
                        <ci>A_cap</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>V_myo</ci>
                        <ci>F</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <group>
        <relationship_ref relationship="containment"/>
        <component_ref component="membrane">
            <component_ref component="fast_sodium_current">
                <component_ref component="Na_channel_states"/>
            </component_ref>
            <component_ref component="L_type_Ca_channel">
                <component_ref component="L_type_Ca_channel_d_gate"/>
                <component_ref component="L_type_Ca_channel_f_gate"/>
                <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
            </component_ref>
            <component_ref component="T_type_Ca_channel">
                <component_ref component="T_type_Ca_channel_b_gate"/>
                <component_ref component="T_type_Ca_channel_g_gate"/>
            </component_ref>
            <component_ref component="rapid_delayed_rectifier_potassium_current">
                <component_ref component="Kr_channel_states"/>
            </component_ref>
            <component_ref component="slow_delayed_rectifier_potassium_current">
                <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
                <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
            </component_ref>
            <component_ref component="time_independent_potassium_current">
                <component_ref component="time_independent_potassium_current_K1_gate"/>
            </component_ref>
            <component_ref component="transient_outward_current">
                <component_ref component="transient_outward_current_zdv_gate"/>
                <component_ref component="transient_outward_current_ydv_gate"/>
            </component_ref>
            <component_ref component="Na_Ca_exchanger"/>
            <component_ref component="plateau_potassium_current"/>
            <component_ref component="sodium_activated_potassium_current"/>
            <component_ref component="ATP_sensitive_potassium_current"/>
            <component_ref component="sarcolemmal_calcium_pump"/>
            <component_ref component="sodium_background_current"/>
            <component_ref component="calcium_background_current"/>
            <component_ref component="sodium_potassium_pump"/>
            <component_ref component="non_specific_calcium_activated_current"/>
            <component_ref component="ionic_concentrations"/>
            <component_ref component="calcium_dynamics"/>
        </component_ref>
    </group>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="fast_sodium_current">
            <component_ref component="Na_channel_states"/>
        </component_ref>
        <component_ref component="L_type_Ca_channel">
            <component_ref component="L_type_Ca_channel_d_gate"/>
            <component_ref component="L_type_Ca_channel_f_gate"/>
            <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
        </component_ref>
        <component_ref component="T_type_Ca_channel">
            <component_ref component="T_type_Ca_channel_b_gate"/>
            <component_ref component="T_type_Ca_channel_g_gate"/>
        </component_ref>
        <component_ref component="rapid_delayed_rectifier_potassium_current">
            <component_ref component="Kr_channel_states"/>
        </component_ref>
        <component_ref component="slow_delayed_rectifier_potassium_current">
            <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
            <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
        </component_ref>
        <component_ref component="time_independent_potassium_current">
            <component_ref component="time_independent_potassium_current_K1_gate"/>
        </component_ref>
        <component_ref component="transient_outward_current">
            <component_ref component="transient_outward_current_zdv_gate"/>
            <component_ref component="transient_outward_current_ydv_gate"/>
        </component_ref>
    </group>
    <connection>
        <map_components component_1="membrane" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="fast_sodium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="T_type_Ca_channel" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="time_independent_potassium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="transient_outward_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="Na_Ca_exchanger" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="plateau_potassium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="sarcolemmal_calcium_pump" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="sodium_background_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="calcium_background_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="sodium_potassium_pump" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="sodium_activated_potassium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="ATP_sensitive_potassium_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="ionic_concentrations" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="calcium_dynamics" component_2="environment"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="fast_sodium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Na" variable_2="i_Na"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="L_type_Ca_channel"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="T_type_Ca_channel"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="rapid_delayed_rectifier_potassium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="slow_delayed_rectifier_potassium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="sodium_activated_potassium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_K_Na" variable_2="i_K_Na"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="ATP_sensitive_potassium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_K_ATP" variable_2="i_K_ATP"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="transient_outward_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_to" variable_2="i_to"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="time_independent_potassium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_K1" variable_2="i_K1"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="plateau_potassium_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="sarcolemmal_calcium_pump"/>
        <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="sodium_background_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="calcium_background_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="sodium_potassium_pump"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="non_specific_calcium_activated_current"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="R" variable_2="R"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="i_ns_Ca" variable_2="i_ns_Ca"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="ionic_concentrations"/>
        <map_variables variable_1="F" variable_2="F"/>
    </connection>
    <connection>
        <map_components component_1="membrane" component_2="calcium_dynamics"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="dVdt" variable_2="dVdt"/>
    </connection>
    <connection>
        <map_components component_1="fast_sodium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="i_Na" variable_2="i_Na"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
    </connection>
    <connection>
        <map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
        <map_variables variable_1="E_Na" variable_2="E_Na"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="i_CaNa" variable_2="i_CaNa"/>
        <map_variables variable_1="i_CaK" variable_2="i_CaK"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="calcium_dynamics"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
        <map_variables variable_1="i_CaCa" variable_2="i_CaCa"/>
    </connection>
    <connection>
        <map_components component_1="T_type_Ca_channel" component_2="calcium_dynamics"/>
        <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
    </connection>
    <connection>
        <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
        <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
    </connection>
    <connection>
        <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="calcium_dynamics"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
    </connection>
    <connection>
        <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
    </connection>
    <connection>
        <map_components component_1="transient_outward_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="i_to" variable_2="i_to"/>
    </connection>
    <connection>
        <map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
    </connection>
    <connection>
        <map_components component_1="Na_Ca_exchanger" component_2="calcium_dynamics"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
        <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
    </connection>
    <connection>
        <map_components component_1="time_independent_potassium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="i_K1" variable_2="i_K1"/>
    </connection>
    <connection>
        <map_components component_1="sodium_activated_potassium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
        <map_variables variable_1="i_K_Na" variable_2="i_K_Na"/>
    </connection>
    <connection>
        <map_components component_1="ATP_sensitive_potassium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="i_K_ATP" variable_2="i_K_ATP"/>
    </connection>
    <connection>
        <map_components component_1="plateau_potassium_current" component_2="time_independent_potassium_current"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="sodium_activated_potassium_current" component_2="time_independent_potassium_current"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="ATP_sensitive_potassium_current" component_2="time_independent_potassium_current"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="transient_outward_current" component_2="time_independent_potassium_current"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
    </connection>
    <connection>
        <map_components component_1="plateau_potassium_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
    </connection>
    <connection>
        <map_components component_1="sarcolemmal_calcium_pump" component_2="calcium_dynamics"/>
        <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
    </connection>
    <connection>
        <map_components component_1="T_type_Ca_channel" component_2="calcium_background_current"/>
        <map_variables variable_1="E_Ca" variable_2="E_Ca"/>
    </connection>
    <connection>
        <map_components component_1="sodium_background_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
    </connection>
    <connection>
        <map_components component_1="calcium_background_current" component_2="calcium_dynamics"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
        <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
    </connection>
    <connection>
        <map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
    </connection>
    <connection>
        <map_components component_1="non_specific_calcium_activated_current" component_2="ionic_concentrations"/>
        <map_variables variable_1="Nao" variable_2="Nao"/>
        <map_variables variable_1="Nai" variable_2="Nai"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="i_ns_Na" variable_2="i_ns_Na"/>
        <map_variables variable_1="i_ns_K" variable_2="i_ns_K"/>
    </connection>
    <connection>
        <map_components component_1="non_specific_calcium_activated_current" component_2="calcium_dynamics"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="non_specific_calcium_activated_current"/>
        <map_variables variable_1="gamma_Nao" variable_2="gamma_Nao"/>
        <map_variables variable_1="gamma_Nai" variable_2="gamma_Nai"/>
        <map_variables variable_1="gamma_Ko" variable_2="gamma_Ko"/>
        <map_variables variable_1="gamma_Ki" variable_2="gamma_Ki"/>
    </connection>
    <connection>
        <map_components component_1="fast_sodium_current" component_2="Na_channel_states"/>
        <map_variables variable_1="P_O_Na" variable_2="P_O_Na"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
        <map_variables variable_1="d" variable_2="d"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
        <map_variables variable_1="f" variable_2="f"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_Ca_gate"/>
        <map_variables variable_1="f_Ca" variable_2="f_Ca"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_b_gate"/>
        <map_variables variable_1="b" variable_2="b"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_g_gate"/>
        <map_variables variable_1="g" variable_2="g"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="Kr_channel_states"/>
        <map_variables variable_1="P_O" variable_2="P_O"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
    </connection>
    <connection>
        <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="slow_delayed_rectifier_potassium_current_xs1_gate"/>
        <map_variables variable_1="xs1" variable_2="xs1"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="slow_delayed_rectifier_potassium_current_xs2_gate"/>
        <map_variables variable_1="xs2" variable_2="xs2"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
        <map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
        <map_variables variable_1="E_K" variable_2="E_K"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="transient_outward_current" component_2="transient_outward_current_ydv_gate"/>
        <map_variables variable_1="ydv" variable_2="ydv"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="transient_outward_current" component_2="transient_outward_current_zdv_gate"/>
        <map_variables variable_1="zdv" variable_2="zdv"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="calcium_dynamics" component_2="ionic_concentrations"/>
        <map_variables variable_1="V_myo" variable_2="V_myo"/>
        <map_variables variable_1="A_cap" variable_2="A_cap"/>
    </connection>
    <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
        <rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9a2484a4-5347-4c2a-ae56-1ba2ecf92d03">
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">cardiac</rdf:li>
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">Brugada Syndrome</rdf:li>
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">Long QT Syndrome</rdf:li>
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">electrophysiology</rdf:li>
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">na channel</rdf:li>
        </rdf:Bag>
        <rdf:Seq xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b962ed3b-3bf1-42c2-abc2-1f84f04fb6ea">
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="rdf:#81fab56d-f9f6-4aea-941e-aee79bacbeac"/>
            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="rdf:#c94a6f50-ae93-4b96-b843-c19a09ad2a42"/>
        </rdf:Seq>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
            <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Na Channel Mutation That Causes Both Brugada Syndrome and Long-QT Syndrome Phenotypes: A Simulation Study of Mechanism (INa1795insD Mutant Midmyocardial Cell)</dc:title>
            <dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/">The University of Auckland, The Bioengineering Institute</dc:publisher>
            <cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#429d3bf8-0794-4a0c-b7a5-6d166003caad" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#b117ebec-647a-46a3-9edd-e49c3395f906" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#0fb0a047-5a98-4065-adf8-d6911d94e680" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <cmeta:modification xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#a1af5d01-f40f-466a-815e-306d5f32c684" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <cmeta:modification xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#a7e90d23-4aba-4e14-bc88-ef643aa6f9d1" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d803aa7b-3f78-413b-9645-1513adc20163">
            <vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
            <vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The Bioengineering Institute</vCard:Orgunit>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#a1af5d01-f40f-466a-815e-306d5f32c684">
            <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#38ab0814-528a-468a-a1a1-e3135f1e5378" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">updated curation status,&#xd;
removed publication link in documentation</rdf:value>
            <cmeta:modifier xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#0a232fa0-1166-4841-9e92-e410fd7aa7e3" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#3d57aa7e-c598-40f4-af54-f697ee73a61a">
            <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James Lawson</vCard:FN>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0e44e421-22d5-49a9-b0dc-318da090e7f5">
            <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-08-16T12:26:07+12:00</dcterms:W3CDTF>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#326f5b39-4f3f-4c91-9da8-e2971653de10">
            <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#7116e19a-7428-4133-a01f-84ac727bb597" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c94a6f50-ae93-4b96-b843-c19a09ad2a42">
            <rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
            <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#513baec9-a0ad-4aa2-b9be-20f1063a4fc3" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#962d2037-80ad-4491-8af5-93d26147c7d9">
            <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#9909b67a-6358-4108-963f-36e9aa21ac6b" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">This is the CellML description of Clancy and Rudy's 2002 mathematical model of a Na channel mutation that causes both Brugada and long-QT syndrome phenotypes.</rdf:value>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#429d3bf8-0794-4a0c-b7a5-6d166003caad">
            <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#3d57aa7e-c598-40f4-af54-f697ee73a61a" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">This model is currently unable to be supported due to its dependence on the Luo Rudy 1994 model, which contains delay elements in its model of the CIRC, which can not yet be represented in CellML (as of CellML 1.1). Therefore this model is unconstrained and does not load or run in any simulator.</rdf:value>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#c843dd26-2775-4b51-92fa-bd8aeb634811">
            <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Colleen</vCard:Given>
            <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Clancy</vCard:Family>
            <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">E</vCard:Other>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9909b67a-6358-4108-963f-36e9aa21ac6b">
            <vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#a7e90d23-4aba-4e14-bc88-ef643aa6f9d1">
            <dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#0e44e421-22d5-49a9-b0dc-318da090e7f5" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">Added value of 1.5e-2 to variable I_NaK (note, not i_NaK) in component "sodium_potassium_pump". This value was obtained from the LR94 dynamic model</rdf:value>
            <cmeta:modifier xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#326f5b39-4f3f-4c91-9da8-e2971653de10" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#23be2508-0213-45bb-aff9-43137aad7c76">
            <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine</vCard:Given>
            <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lloyd</vCard:Family>
            <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">May</vCard:Other>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0fb0a047-5a98-4065-adf8-d6911d94e680">
            <vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#d803aa7b-3f78-413b-9645-1513adc20163" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#9309aa54-9b93-48fb-b079-55c23c7df3c4" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#23be2508-0213-45bb-aff9-43137aad7c76" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#5bf86eff-6b70-42d1-9a5c-e25c4c5c07e1">
            <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Circulation</dc:title>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#59c594fa-5e91-4d2d-a791-81bf15642db7">
            <bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">11889015</bqs:Pubmed_id>
            <bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#4c104ab4-076c-46ba-abd2-90da15384de7" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#eb59ab39-f2f9-4915-8fe6-62f3520a35b3">
            <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2002-03-12</dcterms:W3CDTF>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7116e19a-7428-4133-a01f-84ac727bb597">
            <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
            <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lawson</vCard:Family>
            <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#513baec9-a0ad-4aa2-b9be-20f1063a4fc3">
            <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Yoram</vCard:Given>
            <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Rudy</vCard:Family>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#clancy_rudy_2002">
            <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">The Clancy and Rudy's 2002 mathematical model of a Na channel mutation that causes both Brugada and long-QT syndrome phenotypes.</dc:title>
            <cmeta:bio_entity xmlns:cmeta="http://www.cellml.org/metadata/1.0#">Ventricular Myocyte</cmeta:bio_entity>
            <cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#962d2037-80ad-4491-8af5-93d26147c7d9" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#59c594fa-5e91-4d2d-a791-81bf15642db7" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#b30107f9-bf91-467f-a6b6-fbab92afc3fb" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <cmeta:species xmlns:cmeta="http://www.cellml.org/metadata/1.0#">Mammalia</cmeta:species>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4c104ab4-076c-46ba-abd2-90da15384de7">
            <dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#b962ed3b-3bf1-42c2-abc2-1f84f04fb6ea" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Na Channel Mutation That Causes Both Brugada Syndrome and Long-QT Syndrome Phenotypes: A Simulation Study of Mechanism</dc:title>
            <bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">105</bqs:volume>
            <bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">1208</bqs:first_page>
            <bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#5bf86eff-6b70-42d1-9a5c-e25c4c5c07e1" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#eb59ab39-f2f9-4915-8fe6-62f3520a35b3" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
            <bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">1213</bqs:last_page>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#81fab56d-f9f6-4aea-941e-aee79bacbeac">
            <rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
            <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#c843dd26-2775-4b51-92fa-bd8aeb634811" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d60448dc-e2e6-4c7f-b97e-d986d1e40c9b">
            <bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="rdf:#9a2484a4-5347-4c2a-ae56-1ba2ecf92d03"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b30107f9-bf91-467f-a6b6-fbab92afc3fb">
            <dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#d60448dc-e2e6-4c7f-b97e-d986d1e40c9b" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9309aa54-9b93-48fb-b079-55c23c7df3c4">
            <rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:resource="http://imc.org/vCard/3.0#internet"/>
            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">c.lloyd@auckland.ac.nz</rdf:value>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#38ab0814-528a-468a-a1a1-e3135f1e5378">
            <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2009-06-05T15:14:35+12:00</dcterms:W3CDTF>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#23a1cbd8-03b0-4701-a21a-7431792c7bf0">
            <vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James</vCard:Given>
            <vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lawson</vCard:Family>
            <vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Richard</vCard:Other>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#b117ebec-647a-46a3-9edd-e49c3395f906">
            <dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2003-08-20T00:00:00+00:00</dcterms:W3CDTF>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0a232fa0-1166-4841-9e92-e410fd7aa7e3">
            <vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#23a1cbd8-03b0-4701-a21a-7431792c7bf0" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"/>
        </rdf:Description>
    </rdf:RDF>
</model>