/* There are a total of 9 entries in the algebraic variable array. There are a total of 8 entries in each of the rate and state variable arrays. There are a total of 20 entries in the constant variable array. */ /* * VOI is time in component environment (day). * CONSTANTS[0] is mu_T in component uninfected_CD4 (per_day). * CONSTANTS[1] is r in component uninfected_CD4 (per_day). * STATES[0] is T_1 in component latently_infected_CD4 (per_micro_L). * CONSTANTS[2] is T_max in component uninfected_CD4 (per_micro_L). * CONSTANTS[3] is k_1 in component HIV1 (micro_L_per_day). * STATES[1] is V in component HIV1 (per_micro_L). * CONSTANTS[4] is k_1_ in component hybrid_HIV1 (micro_L_per_day). * STATES[2] is V_ in component hybrid_HIV1 (per_micro_L). * CONSTANTS[5] is s_0 in component uninfected_CD4 (per_micro_L_day). * CONSTANTS[6] is theta in component uninfected_CD4 (per_micro_L). * ALGEBRAIC[0] is s_V in component uninfected_CD4 (per_micro_L_day). * STATES[3] is T in component uninfected_CD4 (per_micro_L). * CONSTANTS[7] is k_2 in component latently_infected_CD4 (per_day). * CONSTANTS[8] is k_1D in component actively_infected_CD4 (micro_L_per_day). * ALGEBRAIC[1] is D in component DIV (per_micro_L). * CONSTANTS[9] is mu_b in component actively_infected_CD4 (per_day). * STATES[4] is T_2 in component actively_infected_CD4 (per_micro_L). * CONSTANTS[10] is k_s in component actively_coinfected_CD4 (per_day). * CONSTANTS[11] is mu_bD in component actively_coinfected_CD4 (per_day). * STATES[5] is T_D2 in component actively_coinfected_CD4 (per_micro_L). * CONSTANTS[12] is mu_TD in component stably_coinfected_CD4 (per_day). * STATES[6] is T_D1 in component stably_coinfected_CD4 (per_micro_L). * ALGEBRAIC[4] is N_D_t in component DIV (dimensionless). * ALGEBRAIC[5] is pi_D_t in component DIV (per_day). * CONSTANTS[13] is mu_D in component DIV (per_day). * ALGEBRAIC[2] is N_t in component production_function (dimensionless). * CONSTANTS[14] is t_DIV in component DIV (day). * STATES[7] is D_ode in component DIV (per_micro_L). * CONSTANTS[15] is D_0 in component DIV (per_micro_L). * ALGEBRAIC[6] is N_2_t in component HIV1 (dimensionless). * CONSTANTS[16] is mu_V in component HIV1 (per_day). * ALGEBRAIC[7] is N_t_ in component hybrid_HIV1 (dimensionless). * ALGEBRAIC[8] is pi_t_ in component hybrid_HIV1 (per_day). * CONSTANTS[17] is N_0 in component production_function (dimensionless). * CONSTANTS[18] is gamma in component production_function (dimensionless). * CONSTANTS[19] is t_c in component production_function (day). * ALGEBRAIC[3] is T_tot in component cell_population (per_micro_L). * RATES[3] is d/dt T in component uninfected_CD4 (per_micro_L). * RATES[0] is d/dt T_1 in component latently_infected_CD4 (per_micro_L). * RATES[4] is d/dt T_2 in component actively_infected_CD4 (per_micro_L). * RATES[5] is d/dt T_D2 in component actively_coinfected_CD4 (per_micro_L). * RATES[6] is d/dt T_D1 in component stably_coinfected_CD4 (per_micro_L). * RATES[7] is d/dt D_ode in component DIV (per_micro_L). * RATES[1] is d/dt V in component HIV1 (per_micro_L). * RATES[2] is d/dt V_ in component hybrid_HIV1 (per_micro_L). * There are a total of 2 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.02; CONSTANTS[1] = 0.03; STATES[0] = 0; CONSTANTS[2] = 1500; CONSTANTS[3] = 2.4E-5; STATES[1] = 1E-3; CONSTANTS[4] = 2.4E-7; STATES[2] = 0; CONSTANTS[5] = 10; CONSTANTS[6] = 1; STATES[3] = 1000; CONSTANTS[7] = 0.017; CONSTANTS[8] = 2.4E-5; CONSTANTS[9] = 0.24; STATES[4] = 0; CONSTANTS[10] = 0.48; CONSTANTS[11] = 0.12; STATES[5] = 0; CONSTANTS[12] = 0.02; STATES[6] = 0; CONSTANTS[13] = 0.76; CONSTANTS[14] = 2557; STATES[7] = 0; CONSTANTS[15] = 0.1; CONSTANTS[16] = 2.4; CONSTANTS[17] = 300; CONSTANTS[18] = 25; CONSTANTS[19] = 7305; RATES[3] = 0.1001; RATES[0] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[3] - (((ALGEBRAIC[0] - CONSTANTS[0]*STATES[3])+ CONSTANTS[1]*STATES[3]*(1.00000 - (STATES[3]+STATES[0])/CONSTANTS[2])) - CONSTANTS[3]*STATES[1]*STATES[3]) - CONSTANTS[4]*STATES[2]*STATES[3]; resid[1] = RATES[0] - (( CONSTANTS[3]*STATES[1]*STATES[3]+ CONSTANTS[4]*STATES[2]*STATES[3]) - CONSTANTS[0]*STATES[0]) - CONSTANTS[7]*STATES[0]; resid[2] = RATES[4] - ( CONSTANTS[7]*STATES[0] - CONSTANTS[8]*ALGEBRAIC[1]*STATES[4]) - CONSTANTS[9]*STATES[4]; resid[3] = RATES[5] - ( CONSTANTS[8]*ALGEBRAIC[1]*STATES[4] - CONSTANTS[10]*STATES[5]) - CONSTANTS[11]*STATES[5]; resid[4] = RATES[6] - CONSTANTS[10]*STATES[5] - CONSTANTS[12]*STATES[6]; resid[5] = RATES[7] - (CONDVAR[1]<0.00000 ? CONSTANTS[15]/CONSTANTS[14] : ( ALGEBRAIC[4]*CONSTANTS[11]*STATES[5]+ ALGEBRAIC[5]*STATES[6]) - CONSTANTS[13]*STATES[7]); resid[6] = RATES[1] - (( ALGEBRAIC[2]*CONSTANTS[9]*STATES[4]+ ALGEBRAIC[6]*CONSTANTS[11]*STATES[5]) - CONSTANTS[3]*STATES[1]*STATES[3]) - CONSTANTS[16]*STATES[1]; resid[7] = RATES[2] - (( ALGEBRAIC[7]*CONSTANTS[11]*STATES[5]+ ALGEBRAIC[8]*STATES[6]) - CONSTANTS[16]*STATES[2]) - CONSTANTS[4]*STATES[3]*STATES[2]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = STATES[3]+STATES[0]+STATES[4]+STATES[5]+STATES[6]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[5]*CONSTANTS[6])/(CONSTANTS[6]+STATES[1]); ALGEBRAIC[1] = (CONDVAR[0]<0.00000 ? 0.00000 : STATES[7]); ALGEBRAIC[2] = CONSTANTS[17]*(1.00000+ CONSTANTS[18]*(pow(VOI, 2.00000)/(pow(VOI, 2.00000)+pow(CONSTANTS[19], 2.00000)))); ALGEBRAIC[4] = 0.200000*ALGEBRAIC[2]; ALGEBRAIC[5] = 0.500000*CONSTANTS[9]*ALGEBRAIC[2]; ALGEBRAIC[6] = 0.100000*ALGEBRAIC[2]; ALGEBRAIC[7] = 0.100000*ALGEBRAIC[2]; ALGEBRAIC[8] = 0.0100000*CONSTANTS[9]*ALGEBRAIC[2]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[14]; CONDVAR[1] = VOI - CONSTANTS[14]; }