/* There are a total of 16 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 16 entries in the constant variable array. */ /* * CONSTANTS[0] is T in component parameters (kelvin). * CONSTANTS[1] is K in component parameters_propagation (per_ms). * CONSTANTS[2] is V_initial in component initial_conditions (mV). * VOI is time in component time (ms). * ALGEBRAIC[6] is INa in component INa (uA_per_cmsq). * ALGEBRAIC[11] is IK in component IK (uA_per_cmsq). * ALGEBRAIC[13] is Ileak in component Ileak (uA_per_cmsq). * ALGEBRAIC[14] is Ii in component propagated_AP (uA_per_cmsq). * ALGEBRAIC[0] is Im in component propagated_AP (uA_per_cmsq). * ALGEBRAIC[15] is I in component propagated_AP (uA_per_cmsq). * ALGEBRAIC[12] is g in component propagated_AP (mS_per_cmsq). * ALGEBRAIC[10] is gK in component IK (mS_per_cmsq). * ALGEBRAIC[1] is gNa in component INa (mS_per_cmsq). * STATES[0] is V in component propagated_AP (mV). * ALGEBRAIC[2] is minus_V in component propagated_AP (mV). * STATES[2] is X in component hh_gating_variable (dimensionless). * STATES[3] is X in component hh_gating_variable (dimensionless). * STATES[4] is X in component hh_gating_variable (dimensionless). * CONSTANTS[3] is n_initial in component initial_conditions (dimensionless). * CONSTANTS[4] is m_initial in component initial_conditions (dimensionless). * CONSTANTS[5] is h_initial in component initial_conditions (dimensionless). * CONSTANTS[6] is VNa in component parameters (mV). * CONSTANTS[7] is VK in component parameters (mV). * CONSTANTS[8] is Vleak in component parameters (mV). * CONSTANTS[9] is gNa_max in component parameters (mS_per_cmsq). * CONSTANTS[10] is gK_max in component parameters (mS_per_cmsq). * CONSTANTS[11] is gleak_max in component parameters (mS_per_cmsq). * CONSTANTS[12] is Cm in component parameters (uF_per_cmsq). * CONSTANTS[13] is V_initial in component initial_conditions (mV). * ALGEBRAIC[3] is alpha in component alpha_m (per_ms). * CONSTANTS[14] is phi in component temperature_factor (dimensionless). * ALGEBRAIC[7] is beta in component beta_m (per_ms). * ALGEBRAIC[4] is alpha in component alpha_h (per_ms). * ALGEBRAIC[8] is beta in component beta_h (per_ms). * ALGEBRAIC[5] is alpha in component alpha_n (per_ms). * CONSTANTS[15] is phi in component temperature_factor (dimensionless). * ALGEBRAIC[9] is beta in component beta_n (per_ms). * STATES[1] is d/dt V in component propagated_AP (mV). * RATES[1] is d^2/dtV in component propagated_AP (mV). * RATES[3] is d/dt X in component hh_gating_variable (dimensionless). * RATES[2] is d/dt X in component hh_gating_variable (dimensionless). * RATES[4] is d/dt X in component hh_gating_variable (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 18.5; CONSTANTS[1] = 10.47; CONSTANTS[2] = 0; STATES[1] = 0.0; CONSTANTS[3] = 0.315; CONSTANTS[4] = 0.042; CONSTANTS[5] = 0.608; CONSTANTS[6] = -115.0; CONSTANTS[7] = 12.0; CONSTANTS[8] = -10.613; CONSTANTS[9] = 120.0; CONSTANTS[10] = 36.0; CONSTANTS[11] = 0.3; CONSTANTS[12] = 1.0; CONSTANTS[13] = 0.0; CONSTANTS[14] = pow(3.00000, (CONSTANTS[0] - 6.30000)/10.0000); CONSTANTS[15] = pow(3.00000, (CONSTANTS[0] - 6.30000)/10.0000); STATES[0] = CONSTANTS[2]; STATES[2] = CONSTANTS[5]; STATES[3] = CONSTANTS[4]; STATES[4] = CONSTANTS[3]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = (( 0.100000*(STATES[0]+25.0000))/(exp((STATES[0]+25.0000)/10.0000) - 1.00000))*CONSTANTS[14]; ALGEBRAIC[7] = 4.00000*exp(STATES[0]/18.0000)*CONSTANTS[14]; RATES[3] = ALGEBRAIC[3]*(1.00000 - STATES[3]) - ALGEBRAIC[7]*STATES[3]; ALGEBRAIC[4] = 0.0700000*exp(STATES[0]/20.0000)*CONSTANTS[14]; ALGEBRAIC[8] = (1.00000/(exp((STATES[0]+30.0000)/10.0000)+1.00000))*CONSTANTS[14]; RATES[2] = ALGEBRAIC[4]*(1.00000 - STATES[2]) - ALGEBRAIC[8]*STATES[2]; ALGEBRAIC[5] = (( 0.0100000*(STATES[0]+10.0000))/(exp((STATES[0]+10.0000)/10.0000) - 1.00000))*CONSTANTS[15]; ALGEBRAIC[9] = 0.125000*exp(STATES[0]/80.0000)*CONSTANTS[15]; RATES[4] = ALGEBRAIC[5]*(1.00000 - STATES[4]) - ALGEBRAIC[9]*STATES[4]; ALGEBRAIC[1] = CONSTANTS[9]*pow(STATES[3], 3.00000)*STATES[2]; ALGEBRAIC[6] = ALGEBRAIC[1]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[10] = CONSTANTS[10]*pow(STATES[4], 4.00000); ALGEBRAIC[11] = ALGEBRAIC[10]*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[13] = CONSTANTS[11]*(STATES[0] - CONSTANTS[8]); ALGEBRAIC[14] = ALGEBRAIC[6]+ALGEBRAIC[11]+ALGEBRAIC[13]; RATES[1] = CONSTANTS[1]*(STATES[1]+ (1.00000/CONSTANTS[12])*ALGEBRAIC[14]); RATES[0] = STATES[1]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = (( 0.100000*(STATES[0]+25.0000))/(exp((STATES[0]+25.0000)/10.0000) - 1.00000))*CONSTANTS[14]; ALGEBRAIC[7] = 4.00000*exp(STATES[0]/18.0000)*CONSTANTS[14]; ALGEBRAIC[4] = 0.0700000*exp(STATES[0]/20.0000)*CONSTANTS[14]; ALGEBRAIC[8] = (1.00000/(exp((STATES[0]+30.0000)/10.0000)+1.00000))*CONSTANTS[14]; ALGEBRAIC[5] = (( 0.0100000*(STATES[0]+10.0000))/(exp((STATES[0]+10.0000)/10.0000) - 1.00000))*CONSTANTS[15]; ALGEBRAIC[9] = 0.125000*exp(STATES[0]/80.0000)*CONSTANTS[15]; ALGEBRAIC[1] = CONSTANTS[9]*pow(STATES[3], 3.00000)*STATES[2]; ALGEBRAIC[6] = ALGEBRAIC[1]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[10] = CONSTANTS[10]*pow(STATES[4], 4.00000); ALGEBRAIC[11] = ALGEBRAIC[10]*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[13] = CONSTANTS[11]*(STATES[0] - CONSTANTS[8]); ALGEBRAIC[14] = ALGEBRAIC[6]+ALGEBRAIC[11]+ALGEBRAIC[13]; ALGEBRAIC[0] = - CONSTANTS[12]*STATES[1]; ALGEBRAIC[2] = - STATES[0]; ALGEBRAIC[12] = ALGEBRAIC[10]+ALGEBRAIC[1]+CONSTANTS[11]; ALGEBRAIC[15] = (CONSTANTS[12]/CONSTANTS[1])*RATES[1]; }