Model Mathematics

Component: environment

Component: GLCo

Component: GLCi

dd time GLCi = v_GLT - v_GLK

Component: G6P

ddtimeG6P= v_GLK - v_PGI + 2.0 v_trehalose + v_glycogen

Component: F6P

ddtimeF6P=v_PGI-v_PFK

Component: F16P

ddtimeF16P=v_PFK-v_ALD

Component: F26P

Component: TRIO

ddtimeTRIO= 2.0 v_ALD - v_GAPDH + v_G3PDH

Component: BPG

ddtimeBPG=v_GAPDH-v_PGK

Component: P3G

ddtimeP3G=v_PGK-v_PGM

Component: P2G

ddtimeP2G=v_PGM-v_ENO

Component: PEP

ddtimePEP=v_ENO-v_PYK

Component: PYR

ddtimePYR=v_PYK-v_PDC

Component: ACE

ddtimeACE=v_PDC-v_ADH+ 2.0 v_succinate

Component: P

ddtimeP= v_PGK + v_PYK - v_GLK + v_PFK + v_ATP + v_trehalose + v_glycogen + 4.0 v_succinate

Component: NADH

ddtimeNADH=v_GAPDH+ 3.0 v_succinate-v_ADH+v_G3PDH

Component: NAD

ddtimeNAD=v_ADH+v_G3PDH-v_GAPDH+ 3.0 v_succinate

Component: DHAP

DHAP=TRIO 1.0 +Keq_TPI

Component: GAP

GAP=TRIOKeq_TPI 1.0 +Keq_TPI

Component: ADP

ADP=SUM_P-P 2 1.0 - 4.0 Keq_AK+ 2 SUM_PP 4.0 Keq_AK- 1.0 +SUM_P 2 1.0 - 4.0 Keq_AK

Component: ATP

ATP=P-ADP 2

Component: AMP

AMP=SUM_P-ATP+ADP

Component: ETOH

Component: GLY

Component: v_PGI

v_PGI = v_max Km_G6P G6P - F6P Keq_PGI 1.0 + G6P Km_G6P + F6P Km_F6P

Component: v_PGM

v_PGM = v_max Km_P3G P3G - P2G Keq_PGM 1.0 + P3G Km_P3G + P2G Km_P2G

Component: v_ENO

v_ENO = v_max Km_P2G P2G - PEP Keq_ENO 1.0 + P2G Km_P2G + PEP Km_PEP

Component: v_GLK

v_GLK = v_max Km_GLCi Km_ATP GLCi ATP - G6P ADP Keq_GLK 1.0 + GLCi Km_GLCi + G6P Km_G6P 1.0 + ATP Km_ATP + ADP Km_ADP

Component: v_GAPDH

v_GAPDH = v_max_f Keq_TPI 1.0 + Keq_TPI TRIO NAD Km_GAP Km_NAD - v_max_r BPG NADH Km_BPG Km_NADH 1.0 + Keq_TPI 1.0 + Keq_TPI TRIO Km_GAP + BPG Km_BPG 1.0 + NAD Km_NAD + NADH Km_NADH

Component: v_PGK

v_PGK = v_max Km_P3G Km_ATP Keq_PGK BPG ADP - P3G ATP 1.0 + BPG Km_BPG + P3G Km_P3G 1.0 + ATP Km_ATP + ADP Km_ADP

Component: v_PYK

v_PYK = v_max Km_PEP Km_ADP PEP ADP - PYR ATP Keq_PYK 1.0 + PEP Km_PEP + PYR Km_PYR 1.0 + ATP Km_ATP + ADP Km_ADP

Component: v_GLT

v_GLT = v_max GLCo - GLCi Keq_Glc Km_Glco 1.0 + GLCo Km_Glco + GLCi Km_Glci + 0.91 GLCo GLCi Km_Glci Km_Glco

Component: v_ALD

v_ALD = v_max Km_F16P F16P - Keq_TPI 1.0 + Keq_TPI TRIO 1.0 1.0 + Keq_TPI TRIO Keq_ALD 1.0 + F16P Km_F16P + Keq_TPI 1.0 + Keq_TPI TRIO Km_GAP + 1.0 1.0 + Keq_TPI TRIO Km_DHAP + Keq_TPI 1.0 + Keq_TPI TRIO 1.0 1.0 + Keq_TPI TRIO Km_GAP Km_DHAP + F16P Keq_TPI 1.0 + Keq_TPI TRIO Km_GAPi Km_F16P

Component: v_PDC

v_PDC = v_max PYR nPDC Km_PYR nPDC 1.0 + PYR nPDC Km_PYR nPDC

Component: v_ADH

v_ADH =- v_max Ki_NAD Km_ETOH NAD ETOH - NADH ACE Keq_ADH 1.0 + NAD Ki_NAD + Km_NAD ETOH Ki_NAD Km_ETOH + Km_NADH ACE Ki_NADH Km_ACE + NADH Ki_NADH + NAD ETOH Ki_NAD Km_ETOH + Km_NADH NAD ACE Ki_NAD Ki_NADH Km_ACE + Km_NAD ETOH NADH Ki_NAD Km_ETOH Ki_NADH + NADH ACE Ki_NADH Km_ACE + NAD ETOH ACE Ki_NAD Km_ETOH Ki_ACE + ETOH NADH ACE Ki_ETOH Ki_NADH Km_ACE

Component: v_ATP

v_ATP = Km_ATPase ATP

Component: v_PFK

v_PFK = v_max gR F6P Km_F6P ATP Km_ATP R R 2 + L T 2 R = 1.0 + F6P Km_F6P + ATP Km_ATP + gR F6P Km_F6P ATP Km_ATP L = L0 1.0 + Ci_ATP ATP Ki_ATP 1.0 + ATP Ki_ATP 2.0 1.0 + CAMP AMP Km_AMP 1.0 + AMP Km_AMP 2.0 1.0 + CF26BP F26P Km_F26BP + CF16BP F16P Km_F16BP 1.0 + F26P Km_F26BP + F16P Km_F16BP 2 T = 1.0 + CATP ATP Km_ATP

Component: v_G3PDH

v_G3PDH= v_max Km_DHAP Km_NADH 1.0 1.0 + Keq_TPI TRIO NADH - GLY NAD Keq_G3PDH 1.0 + 1.0 1.0 + Keq_TPI TRIO Km_DHAP + GLY Km_GLY 1.0 + NADH Km_NADH + NAD Km_NAD

Component: v_succinate

v_succinate= Km_succinate ACE

Component: v_glycogen

Component: v_trehalose