/* There are a total of 18 entries in the algebraic variable array. There are a total of 8 entries in each of the rate and state variable arrays. There are a total of 10 entries in the constant variable array. */ /* * VOI is time in component environment (ms). * STATES[0] is V in component membrane (mV). * CONSTANTS[0] is C in component membrane (uF_per_mm2). * ALGEBRAIC[0] is i_Na in component sodium_current (uA_per_mm2). * ALGEBRAIC[14] is i_s in component slow_inward_current (uA_per_mm2). * ALGEBRAIC[15] is i_x1 in component time_dependent_outward_current (uA_per_mm2). * ALGEBRAIC[16] is i_K1 in component time_independent_outward_current (uA_per_mm2). * ALGEBRAIC[17] is Istim in component stimulus_protocol (uA_per_mm2). * CONSTANTS[1] is g_Na in component sodium_current (mS_per_mm2). * CONSTANTS[2] is E_Na in component sodium_current (mV). * CONSTANTS[3] is g_Nac in component sodium_current (mS_per_mm2). * STATES[1] is m in component sodium_current_m_gate (dimensionless). * STATES[2] is h in component sodium_current_h_gate (dimensionless). * STATES[3] is j in component sodium_current_j_gate (dimensionless). * ALGEBRAIC[1] is alpha_m in component sodium_current_m_gate (per_ms). * ALGEBRAIC[8] is beta_m in component sodium_current_m_gate (per_ms). * ALGEBRAIC[2] is alpha_h in component sodium_current_h_gate (per_ms). * ALGEBRAIC[9] is beta_h in component sodium_current_h_gate (per_ms). * ALGEBRAIC[3] is alpha_j in component sodium_current_j_gate (per_ms). * ALGEBRAIC[10] is beta_j in component sodium_current_j_gate (per_ms). * CONSTANTS[4] is g_s in component slow_inward_current (mS_per_mm2). * ALGEBRAIC[7] is E_s in component slow_inward_current (mV). * STATES[4] is Cai in component slow_inward_current (concentration_units). * STATES[5] is d in component slow_inward_current_d_gate (dimensionless). * STATES[6] is f in component slow_inward_current_f_gate (dimensionless). * ALGEBRAIC[4] is alpha_d in component slow_inward_current_d_gate (per_ms). * ALGEBRAIC[11] is beta_d in component slow_inward_current_d_gate (per_ms). * ALGEBRAIC[5] is alpha_f in component slow_inward_current_f_gate (per_ms). * ALGEBRAIC[12] is beta_f in component slow_inward_current_f_gate (per_ms). * STATES[7] is x1 in component time_dependent_outward_current_x1_gate (dimensionless). * ALGEBRAIC[6] is alpha_x1 in component time_dependent_outward_current_x1_gate (per_ms). * ALGEBRAIC[13] is beta_x1 in component time_dependent_outward_current_x1_gate (per_ms). * CONSTANTS[5] is IstimStart in component stimulus_protocol (ms). * CONSTANTS[6] is IstimEnd in component stimulus_protocol (ms). * CONSTANTS[7] is IstimAmplitude in component stimulus_protocol (uA_per_mm2). * CONSTANTS[8] is IstimPeriod in component stimulus_protocol (ms). * CONSTANTS[9] is IstimPulseDuration in component stimulus_protocol (ms). * RATES[0] is d/dt V in component membrane (mV). * RATES[1] is d/dt m in component sodium_current_m_gate (dimensionless). * RATES[2] is d/dt h in component sodium_current_h_gate (dimensionless). * RATES[3] is d/dt j in component sodium_current_j_gate (dimensionless). * RATES[4] is d/dt Cai in component slow_inward_current (concentration_units). * RATES[5] is d/dt d in component slow_inward_current_d_gate (dimensionless). * RATES[6] is d/dt f in component slow_inward_current_f_gate (dimensionless). * RATES[7] is d/dt x1 in component time_dependent_outward_current_x1_gate (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -84.624; CONSTANTS[0] = 0.01; CONSTANTS[1] = 4e-2; CONSTANTS[2] = 50; CONSTANTS[3] = 3e-5; STATES[1] = 0.011; STATES[2] = 0.988; STATES[3] = 0.975; CONSTANTS[4] = 9e-4; STATES[4] = 1e-4; STATES[5] = 0.003; STATES[6] = 0.994; STATES[7] = 0.0001; CONSTANTS[5] = 10; CONSTANTS[6] = 50000; CONSTANTS[7] = 0.5; CONSTANTS[8] = 1000; CONSTANTS[9] = 1; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = ( - 1.00000*(STATES[0]+47.0000))/(exp( - 0.100000*(STATES[0]+47.0000)) - 1.00000); ALGEBRAIC[8] = 40.0000*exp( - 0.0560000*(STATES[0]+72.0000)); RATES[1] = ALGEBRAIC[1]*(1.00000 - STATES[1]) - ALGEBRAIC[8]*STATES[1]; ALGEBRAIC[2] = 0.126000*exp( - 0.250000*(STATES[0]+77.0000)); ALGEBRAIC[9] = 1.70000/(exp( - 0.0820000*(STATES[0]+22.5000))+1.00000); RATES[2] = ALGEBRAIC[2]*(1.00000 - STATES[2]) - ALGEBRAIC[9]*STATES[2]; ALGEBRAIC[3] = ( 0.0550000*exp( - 0.250000*(STATES[0]+78.0000)))/(exp( - 0.200000*(STATES[0]+78.0000))+1.00000); ALGEBRAIC[10] = 0.300000/(exp( - 0.100000*(STATES[0]+32.0000))+1.00000); RATES[3] = ALGEBRAIC[3]*(1.00000 - STATES[3]) - ALGEBRAIC[10]*STATES[3]; ALGEBRAIC[4] = ( 0.0950000*exp(- (STATES[0] - 5.00000)/100.000))/(1.00000+exp(- (STATES[0] - 5.00000)/13.8900)); ALGEBRAIC[11] = ( 0.0700000*exp(- (STATES[0]+44.0000)/59.0000))/(1.00000+exp((STATES[0]+44.0000)/20.0000)); RATES[5] = ALGEBRAIC[4]*(1.00000 - STATES[5]) - ALGEBRAIC[11]*STATES[5]; ALGEBRAIC[5] = ( 0.0120000*exp(- (STATES[0]+28.0000)/125.000))/(1.00000+exp((STATES[0]+28.0000)/6.67000)); ALGEBRAIC[12] = ( 0.00650000*exp(- (STATES[0]+30.0000)/50.0000))/(1.00000+exp(- (STATES[0]+30.0000)/5.00000)); RATES[6] = ALGEBRAIC[5]*(1.00000 - STATES[6]) - ALGEBRAIC[12]*STATES[6]; ALGEBRAIC[6] = ( 0.000500000*exp((STATES[0]+50.0000)/12.1000))/(1.00000+exp((STATES[0]+50.0000)/17.5000)); ALGEBRAIC[13] = ( 0.00130000*exp(- (STATES[0]+20.0000)/16.6700))/(1.00000+exp(- (STATES[0]+20.0000)/25.0000)); RATES[7] = ALGEBRAIC[6]*(1.00000 - STATES[7]) - ALGEBRAIC[13]*STATES[7]; ALGEBRAIC[7] = - 82.3000 - 13.0287*log( STATES[4]*0.00100000); ALGEBRAIC[14] = CONSTANTS[4]*STATES[5]*STATES[6]*(STATES[0] - ALGEBRAIC[7]); RATES[4] = ( - 0.0100000*ALGEBRAIC[14])/1.00000+ 0.0700000*(0.000100000 - STATES[4]); ALGEBRAIC[0] = ( CONSTANTS[1]*pow(STATES[1], 3.00000)*STATES[2]*STATES[3]+CONSTANTS[3])*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[15] = ( STATES[7]*0.00800000*(exp( 0.0400000*(STATES[0]+77.0000)) - 1.00000))/exp( 0.0400000*(STATES[0]+35.0000)); ALGEBRAIC[16] = 0.00350000*(( 4.00000*(exp( 0.0400000*(STATES[0]+85.0000)) - 1.00000))/(exp( 0.0800000*(STATES[0]+53.0000))+exp( 0.0400000*(STATES[0]+53.0000)))+( 0.200000*(STATES[0]+23.0000))/(1.00000 - exp( - 0.0400000*(STATES[0]+23.0000)))); ALGEBRAIC[17] = (VOI>=CONSTANTS[5]&&VOI<=CONSTANTS[6]&&(VOI - CONSTANTS[5]) - floor((VOI - CONSTANTS[5])/CONSTANTS[8])*CONSTANTS[8]<=CONSTANTS[9] ? CONSTANTS[7] : 0.00000); RATES[0] = (ALGEBRAIC[17] - (ALGEBRAIC[0]+ALGEBRAIC[14]+ALGEBRAIC[15]+ALGEBRAIC[16]))/CONSTANTS[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = ( - 1.00000*(STATES[0]+47.0000))/(exp( - 0.100000*(STATES[0]+47.0000)) - 1.00000); ALGEBRAIC[8] = 40.0000*exp( - 0.0560000*(STATES[0]+72.0000)); ALGEBRAIC[2] = 0.126000*exp( - 0.250000*(STATES[0]+77.0000)); ALGEBRAIC[9] = 1.70000/(exp( - 0.0820000*(STATES[0]+22.5000))+1.00000); ALGEBRAIC[3] = ( 0.0550000*exp( - 0.250000*(STATES[0]+78.0000)))/(exp( - 0.200000*(STATES[0]+78.0000))+1.00000); ALGEBRAIC[10] = 0.300000/(exp( - 0.100000*(STATES[0]+32.0000))+1.00000); ALGEBRAIC[4] = ( 0.0950000*exp(- (STATES[0] - 5.00000)/100.000))/(1.00000+exp(- (STATES[0] - 5.00000)/13.8900)); ALGEBRAIC[11] = ( 0.0700000*exp(- (STATES[0]+44.0000)/59.0000))/(1.00000+exp((STATES[0]+44.0000)/20.0000)); ALGEBRAIC[5] = ( 0.0120000*exp(- (STATES[0]+28.0000)/125.000))/(1.00000+exp((STATES[0]+28.0000)/6.67000)); ALGEBRAIC[12] = ( 0.00650000*exp(- (STATES[0]+30.0000)/50.0000))/(1.00000+exp(- (STATES[0]+30.0000)/5.00000)); ALGEBRAIC[6] = ( 0.000500000*exp((STATES[0]+50.0000)/12.1000))/(1.00000+exp((STATES[0]+50.0000)/17.5000)); ALGEBRAIC[13] = ( 0.00130000*exp(- (STATES[0]+20.0000)/16.6700))/(1.00000+exp(- (STATES[0]+20.0000)/25.0000)); ALGEBRAIC[7] = - 82.3000 - 13.0287*log( STATES[4]*0.00100000); ALGEBRAIC[14] = CONSTANTS[4]*STATES[5]*STATES[6]*(STATES[0] - ALGEBRAIC[7]); ALGEBRAIC[0] = ( CONSTANTS[1]*pow(STATES[1], 3.00000)*STATES[2]*STATES[3]+CONSTANTS[3])*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[15] = ( STATES[7]*0.00800000*(exp( 0.0400000*(STATES[0]+77.0000)) - 1.00000))/exp( 0.0400000*(STATES[0]+35.0000)); ALGEBRAIC[16] = 0.00350000*(( 4.00000*(exp( 0.0400000*(STATES[0]+85.0000)) - 1.00000))/(exp( 0.0800000*(STATES[0]+53.0000))+exp( 0.0400000*(STATES[0]+53.0000)))+( 0.200000*(STATES[0]+23.0000))/(1.00000 - exp( - 0.0400000*(STATES[0]+23.0000)))); ALGEBRAIC[17] = (VOI>=CONSTANTS[5]&&VOI<=CONSTANTS[6]&&(VOI - CONSTANTS[5]) - floor((VOI - CONSTANTS[5])/CONSTANTS[8])*CONSTANTS[8]<=CONSTANTS[9] ? CONSTANTS[7] : 0.00000); }