function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =18; end % There are a total of 8 entries in each of the rate and state variable arrays. % There are a total of 10 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (ms)'); LEGEND_STATES(:,1) = strpad('V in component membrane (mV)'); LEGEND_CONSTANTS(:,1) = strpad('C in component membrane (uF_per_mm2)'); LEGEND_ALGEBRAIC(:,1) = strpad('i_Na in component sodium_current (uA_per_mm2)'); LEGEND_ALGEBRAIC(:,15) = strpad('i_s in component slow_inward_current (uA_per_mm2)'); LEGEND_ALGEBRAIC(:,16) = strpad('i_x1 in component time_dependent_outward_current (uA_per_mm2)'); LEGEND_ALGEBRAIC(:,17) = strpad('i_K1 in component time_independent_outward_current (uA_per_mm2)'); LEGEND_ALGEBRAIC(:,18) = strpad('Istim in component stimulus_protocol (uA_per_mm2)'); LEGEND_CONSTANTS(:,2) = strpad('g_Na in component sodium_current (mS_per_mm2)'); LEGEND_CONSTANTS(:,3) = strpad('E_Na in component sodium_current (mV)'); LEGEND_CONSTANTS(:,4) = strpad('g_Nac in component sodium_current (mS_per_mm2)'); LEGEND_STATES(:,2) = strpad('m in component sodium_current_m_gate (dimensionless)'); LEGEND_STATES(:,3) = strpad('h in component sodium_current_h_gate (dimensionless)'); LEGEND_STATES(:,4) = strpad('j in component sodium_current_j_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,2) = strpad('alpha_m in component sodium_current_m_gate (per_ms)'); LEGEND_ALGEBRAIC(:,9) = strpad('beta_m in component sodium_current_m_gate (per_ms)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha_h in component sodium_current_h_gate (per_ms)'); LEGEND_ALGEBRAIC(:,10) = strpad('beta_h in component sodium_current_h_gate (per_ms)'); LEGEND_ALGEBRAIC(:,4) = strpad('alpha_j in component sodium_current_j_gate (per_ms)'); LEGEND_ALGEBRAIC(:,11) = strpad('beta_j in component sodium_current_j_gate (per_ms)'); LEGEND_CONSTANTS(:,5) = strpad('g_s in component slow_inward_current (mS_per_mm2)'); LEGEND_ALGEBRAIC(:,8) = strpad('E_s in component slow_inward_current (mV)'); LEGEND_STATES(:,5) = strpad('Cai in component slow_inward_current (concentration_units)'); LEGEND_STATES(:,6) = strpad('d in component slow_inward_current_d_gate (dimensionless)'); LEGEND_STATES(:,7) = strpad('f in component slow_inward_current_f_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('alpha_d in component slow_inward_current_d_gate (per_ms)'); LEGEND_ALGEBRAIC(:,12) = strpad('beta_d in component slow_inward_current_d_gate (per_ms)'); LEGEND_ALGEBRAIC(:,6) = strpad('alpha_f in component slow_inward_current_f_gate (per_ms)'); LEGEND_ALGEBRAIC(:,13) = strpad('beta_f in component slow_inward_current_f_gate (per_ms)'); LEGEND_STATES(:,8) = strpad('x1 in component time_dependent_outward_current_x1_gate (dimensionless)'); LEGEND_ALGEBRAIC(:,7) = strpad('alpha_x1 in component time_dependent_outward_current_x1_gate (per_ms)'); LEGEND_ALGEBRAIC(:,14) = strpad('beta_x1 in component time_dependent_outward_current_x1_gate (per_ms)'); LEGEND_CONSTANTS(:,6) = strpad('IstimStart in component stimulus_protocol (ms)'); LEGEND_CONSTANTS(:,7) = strpad('IstimEnd in component stimulus_protocol (ms)'); LEGEND_CONSTANTS(:,8) = strpad('IstimAmplitude in component stimulus_protocol (uA_per_mm2)'); LEGEND_CONSTANTS(:,9) = strpad('IstimPeriod in component stimulus_protocol (ms)'); LEGEND_CONSTANTS(:,10) = strpad('IstimPulseDuration in component stimulus_protocol (ms)'); LEGEND_RATES(:,1) = strpad('d/dt V in component membrane (mV)'); LEGEND_RATES(:,2) = strpad('d/dt m in component sodium_current_m_gate (dimensionless)'); LEGEND_RATES(:,3) = strpad('d/dt h in component sodium_current_h_gate (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt j in component sodium_current_j_gate (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt Cai in component slow_inward_current (concentration_units)'); LEGEND_RATES(:,6) = strpad('d/dt d in component slow_inward_current_d_gate (dimensionless)'); LEGEND_RATES(:,7) = strpad('d/dt f in component slow_inward_current_f_gate (dimensionless)'); LEGEND_RATES(:,8) = strpad('d/dt x1 in component time_dependent_outward_current_x1_gate (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = -84.624; CONSTANTS(:,1) = 0.01; CONSTANTS(:,2) = 4e-2; CONSTANTS(:,3) = 50; CONSTANTS(:,4) = 3e-5; STATES(:,2) = 0.011; STATES(:,3) = 0.988; STATES(:,4) = 0.975; CONSTANTS(:,5) = 9e-4; STATES(:,5) = 1e-4; STATES(:,6) = 0.003; STATES(:,7) = 0.994; STATES(:,8) = 0.0001; CONSTANTS(:,6) = 10; CONSTANTS(:,7) = 50000; CONSTANTS(:,8) = 0.5; CONSTANTS(:,9) = 1000; CONSTANTS(:,10) = 1; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,2) = ( - 1.00000.*(STATES(:,1)+47.0000))./(exp( - 0.100000.*(STATES(:,1)+47.0000)) - 1.00000); ALGEBRAIC(:,9) = 40.0000.*exp( - 0.0560000.*(STATES(:,1)+72.0000)); RATES(:,2) = ALGEBRAIC(:,2).*(1.00000 - STATES(:,2)) - ALGEBRAIC(:,9).*STATES(:,2); ALGEBRAIC(:,3) = 0.126000.*exp( - 0.250000.*(STATES(:,1)+77.0000)); ALGEBRAIC(:,10) = 1.70000./(exp( - 0.0820000.*(STATES(:,1)+22.5000))+1.00000); RATES(:,3) = ALGEBRAIC(:,3).*(1.00000 - STATES(:,3)) - ALGEBRAIC(:,10).*STATES(:,3); ALGEBRAIC(:,4) = ( 0.0550000.*exp( - 0.250000.*(STATES(:,1)+78.0000)))./(exp( - 0.200000.*(STATES(:,1)+78.0000))+1.00000); ALGEBRAIC(:,11) = 0.300000./(exp( - 0.100000.*(STATES(:,1)+32.0000))+1.00000); RATES(:,4) = ALGEBRAIC(:,4).*(1.00000 - STATES(:,4)) - ALGEBRAIC(:,11).*STATES(:,4); ALGEBRAIC(:,5) = ( 0.0950000.*exp( - (STATES(:,1) - 5.00000)./100.000))./(1.00000+exp( - (STATES(:,1) - 5.00000)./13.8900)); ALGEBRAIC(:,12) = ( 0.0700000.*exp( - (STATES(:,1)+44.0000)./59.0000))./(1.00000+exp((STATES(:,1)+44.0000)./20.0000)); RATES(:,6) = ALGEBRAIC(:,5).*(1.00000 - STATES(:,6)) - ALGEBRAIC(:,12).*STATES(:,6); ALGEBRAIC(:,6) = ( 0.0120000.*exp( - (STATES(:,1)+28.0000)./125.000))./(1.00000+exp((STATES(:,1)+28.0000)./6.67000)); ALGEBRAIC(:,13) = ( 0.00650000.*exp( - (STATES(:,1)+30.0000)./50.0000))./(1.00000+exp( - (STATES(:,1)+30.0000)./5.00000)); RATES(:,7) = ALGEBRAIC(:,6).*(1.00000 - STATES(:,7)) - ALGEBRAIC(:,13).*STATES(:,7); ALGEBRAIC(:,7) = ( 0.000500000.*exp((STATES(:,1)+50.0000)./12.1000))./(1.00000+exp((STATES(:,1)+50.0000)./17.5000)); ALGEBRAIC(:,14) = ( 0.00130000.*exp( - (STATES(:,1)+20.0000)./16.6700))./(1.00000+exp( - (STATES(:,1)+20.0000)./25.0000)); RATES(:,8) = ALGEBRAIC(:,7).*(1.00000 - STATES(:,8)) - ALGEBRAIC(:,14).*STATES(:,8); ALGEBRAIC(:,8) = - 82.3000 - 13.0287.*log( STATES(:,5).*0.00100000); ALGEBRAIC(:,15) = CONSTANTS(:,5).*STATES(:,6).*STATES(:,7).*(STATES(:,1) - ALGEBRAIC(:,8)); RATES(:,5) = ( - 0.0100000.*ALGEBRAIC(:,15))./1.00000+ 0.0700000.*(0.000100000 - STATES(:,5)); ALGEBRAIC(:,1) = ( CONSTANTS(:,2).*power(STATES(:,2), 3.00000).*STATES(:,3).*STATES(:,4)+CONSTANTS(:,4)).*(STATES(:,1) - CONSTANTS(:,3)); ALGEBRAIC(:,16) = ( STATES(:,8).*0.00800000.*(exp( 0.0400000.*(STATES(:,1)+77.0000)) - 1.00000))./exp( 0.0400000.*(STATES(:,1)+35.0000)); ALGEBRAIC(:,17) = 0.00350000.*(( 4.00000.*(exp( 0.0400000.*(STATES(:,1)+85.0000)) - 1.00000))./(exp( 0.0800000.*(STATES(:,1)+53.0000))+exp( 0.0400000.*(STATES(:,1)+53.0000)))+( 0.200000.*(STATES(:,1)+23.0000))./(1.00000 - exp( - 0.0400000.*(STATES(:,1)+23.0000)))); ALGEBRAIC(:,18) = piecewise({VOI>=CONSTANTS(:,6)&VOI<=CONSTANTS(:,7)&(VOI - CONSTANTS(:,6)) - floor((VOI - CONSTANTS(:,6))./CONSTANTS(:,9)).*CONSTANTS(:,9)<=CONSTANTS(:,10), CONSTANTS(:,8) }, 0.00000); RATES(:,1) = (ALGEBRAIC(:,18) - (ALGEBRAIC(:,1)+ALGEBRAIC(:,15)+ALGEBRAIC(:,16)+ALGEBRAIC(:,17)))./CONSTANTS(:,1); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,2) = ( - 1.00000.*(STATES(:,1)+47.0000))./(exp( - 0.100000.*(STATES(:,1)+47.0000)) - 1.00000); ALGEBRAIC(:,9) = 40.0000.*exp( - 0.0560000.*(STATES(:,1)+72.0000)); ALGEBRAIC(:,3) = 0.126000.*exp( - 0.250000.*(STATES(:,1)+77.0000)); ALGEBRAIC(:,10) = 1.70000./(exp( - 0.0820000.*(STATES(:,1)+22.5000))+1.00000); ALGEBRAIC(:,4) = ( 0.0550000.*exp( - 0.250000.*(STATES(:,1)+78.0000)))./(exp( - 0.200000.*(STATES(:,1)+78.0000))+1.00000); ALGEBRAIC(:,11) = 0.300000./(exp( - 0.100000.*(STATES(:,1)+32.0000))+1.00000); ALGEBRAIC(:,5) = ( 0.0950000.*exp( - (STATES(:,1) - 5.00000)./100.000))./(1.00000+exp( - (STATES(:,1) - 5.00000)./13.8900)); ALGEBRAIC(:,12) = ( 0.0700000.*exp( - (STATES(:,1)+44.0000)./59.0000))./(1.00000+exp((STATES(:,1)+44.0000)./20.0000)); ALGEBRAIC(:,6) = ( 0.0120000.*exp( - (STATES(:,1)+28.0000)./125.000))./(1.00000+exp((STATES(:,1)+28.0000)./6.67000)); ALGEBRAIC(:,13) = ( 0.00650000.*exp( - (STATES(:,1)+30.0000)./50.0000))./(1.00000+exp( - (STATES(:,1)+30.0000)./5.00000)); ALGEBRAIC(:,7) = ( 0.000500000.*exp((STATES(:,1)+50.0000)./12.1000))./(1.00000+exp((STATES(:,1)+50.0000)./17.5000)); ALGEBRAIC(:,14) = ( 0.00130000.*exp( - (STATES(:,1)+20.0000)./16.6700))./(1.00000+exp( - (STATES(:,1)+20.0000)./25.0000)); ALGEBRAIC(:,8) = - 82.3000 - 13.0287.*log( STATES(:,5).*0.00100000); ALGEBRAIC(:,15) = CONSTANTS(:,5).*STATES(:,6).*STATES(:,7).*(STATES(:,1) - ALGEBRAIC(:,8)); ALGEBRAIC(:,1) = ( CONSTANTS(:,2).*power(STATES(:,2), 3.00000).*STATES(:,3).*STATES(:,4)+CONSTANTS(:,4)).*(STATES(:,1) - CONSTANTS(:,3)); ALGEBRAIC(:,16) = ( STATES(:,8).*0.00800000.*(exp( 0.0400000.*(STATES(:,1)+77.0000)) - 1.00000))./exp( 0.0400000.*(STATES(:,1)+35.0000)); ALGEBRAIC(:,17) = 0.00350000.*(( 4.00000.*(exp( 0.0400000.*(STATES(:,1)+85.0000)) - 1.00000))./(exp( 0.0800000.*(STATES(:,1)+53.0000))+exp( 0.0400000.*(STATES(:,1)+53.0000)))+( 0.200000.*(STATES(:,1)+23.0000))./(1.00000 - exp( - 0.0400000.*(STATES(:,1)+23.0000)))); ALGEBRAIC(:,18) = piecewise({VOI>=CONSTANTS(:,6)&VOI<=CONSTANTS(:,7)&(VOI - CONSTANTS(:,6)) - floor((VOI - CONSTANTS(:,6))./CONSTANTS(:,9)).*CONSTANTS(:,9)<=CONSTANTS(:,10), CONSTANTS(:,8) }, 0.00000); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end