/* There are a total of 9 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 16 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is Ca_m in component Ca_m (micromolar). * ALGEBRAIC[0] is J_min in component J_min (micromolar). * ALGEBRAIC[1] is J_mout in component J_mout (micromolar). * CONSTANTS[0] is k_min in component J_min (micromolar). * STATES[1] is Ca_cyt in component Ca_cyt (micromolar). * CONSTANTS[1] is K_m in component J_min (micromolar). * CONSTANTS[2] is n in component J_min (micromolar). * CONSTANTS[3] is k_mout in component J_mout (micromolar). * ALGEBRAIC[2] is J_ERch in component J_ERch (micromolar). * ALGEBRAIC[3] is J_ERpump in component J_ERpump (micromolar). * ALGEBRAIC[4] is J_ERleak in component J_ERleak (micromolar). * ALGEBRAIC[6] is J_CaPr in component J_CaPr (micromolar). * ALGEBRAIC[8] is J_Pr in component J_Pr (micromolar). * CONSTANTS[4] is rho_m in component Ca_cyt (dimensionless). * CONSTANTS[5] is beta_m in component Ca_cyt (dimensionless). * STATES[2] is Ca_tot in component Ca_tot (micromolar). * STATES[3] is Ca_ER in component Ca_ER (micromolar). * CONSTANTS[6] is rho_ER in component Ca_ER (dimensionless). * CONSTANTS[7] is beta_ER in component Ca_ER (dimensionless). * ALGEBRAIC[5] is CaPr in component CaPr (micromolar). * CONSTANTS[8] is k_ERch in component J_ERch (micromolar). * CONSTANTS[9] is K_ch in component J_ERch (micromolar). * CONSTANTS[10] is k_ERpump in component J_ERpump (per_second). * CONSTANTS[11] is k_ERleak in component J_ERleak (per_second). * CONSTANTS[12] is k_min in component J_CaPr (per_second). * CONSTANTS[13] is k_plus in component J_Pr (per_micromolar_per_second). * ALGEBRAIC[7] is Pr in component Pr (micromolar). * CONSTANTS[14] is Ca_tot in component CaPr (micromolar). * CONSTANTS[15] is Pr_tot in component Pr (micromolar). * RATES[0] is d/dt Ca_m in component Ca_m (micromolar). * RATES[1] is d/dt Ca_cyt in component Ca_cyt (micromolar). * RATES[2] is d/dt Ca_tot in component Ca_tot (micromolar). * RATES[3] is d/dt Ca_ER in component Ca_ER (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.1; CONSTANTS[0] = 330; STATES[1] = 0.01; CONSTANTS[1] = 1.6; CONSTANTS[2] = 8; CONSTANTS[3] = 0.5; CONSTANTS[4] = 0.01; CONSTANTS[5] = 0.025; STATES[2] = 0.01; STATES[3] = 20; CONSTANTS[6] = 0.01; CONSTANTS[7] = 0.0025; CONSTANTS[8] = 0.001; CONSTANTS[9] = 5; CONSTANTS[10] = 20; CONSTANTS[11] = 0.05; CONSTANTS[12] = 0.01; CONSTANTS[13] = 0.1; CONSTANTS[14] = 90; CONSTANTS[15] = 120; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[0]*pow(STATES[1], CONSTANTS[2]))/(pow(CONSTANTS[1], CONSTANTS[2])+pow(STATES[1], CONSTANTS[2])); ALGEBRAIC[1] = ( CONSTANTS[3]*STATES[0])/1.00000; RATES[0] = ALGEBRAIC[0] - ALGEBRAIC[1]; ALGEBRAIC[2] = (( CONSTANTS[8]*pow(STATES[1], 2.00000))/(pow(CONSTANTS[9], 2.00000)+pow(STATES[1], 2.00000)))*(STATES[3] - STATES[1]); ALGEBRAIC[3] = CONSTANTS[10]*STATES[1]; ALGEBRAIC[4] = CONSTANTS[11]*(STATES[3] - STATES[1]); RATES[3] = (CONSTANTS[7]/CONSTANTS[6])*((ALGEBRAIC[3] - ALGEBRAIC[4]) - ALGEBRAIC[2])*1.00000; ALGEBRAIC[5] = CONSTANTS[14] - (STATES[1]+ (CONSTANTS[6]/CONSTANTS[7])*STATES[3]); RATES[2] = STATES[1]+ (CONSTANTS[6]/CONSTANTS[7])*STATES[3]+ (CONSTANTS[4]/CONSTANTS[5])*STATES[0]+ALGEBRAIC[5]; ALGEBRAIC[6] = CONSTANTS[12]*ALGEBRAIC[5]; ALGEBRAIC[7] = CONSTANTS[15] - ALGEBRAIC[5]; ALGEBRAIC[8] = CONSTANTS[13]*STATES[1]*ALGEBRAIC[7]; RATES[1] = ((((ALGEBRAIC[2] - ALGEBRAIC[3])+ALGEBRAIC[4]+ALGEBRAIC[6]) - ALGEBRAIC[8])+ (CONSTANTS[4]/CONSTANTS[5])*(ALGEBRAIC[1] - ALGEBRAIC[0]))*1.00000; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[0]*pow(STATES[1], CONSTANTS[2]))/(pow(CONSTANTS[1], CONSTANTS[2])+pow(STATES[1], CONSTANTS[2])); ALGEBRAIC[1] = ( CONSTANTS[3]*STATES[0])/1.00000; ALGEBRAIC[2] = (( CONSTANTS[8]*pow(STATES[1], 2.00000))/(pow(CONSTANTS[9], 2.00000)+pow(STATES[1], 2.00000)))*(STATES[3] - STATES[1]); ALGEBRAIC[3] = CONSTANTS[10]*STATES[1]; ALGEBRAIC[4] = CONSTANTS[11]*(STATES[3] - STATES[1]); ALGEBRAIC[5] = CONSTANTS[14] - (STATES[1]+ (CONSTANTS[6]/CONSTANTS[7])*STATES[3]); ALGEBRAIC[6] = CONSTANTS[12]*ALGEBRAIC[5]; ALGEBRAIC[7] = CONSTANTS[15] - ALGEBRAIC[5]; ALGEBRAIC[8] = CONSTANTS[13]*STATES[1]*ALGEBRAIC[7]; }