/* There are a total of 29 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 20 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is C_m in component environment (fF). * STATES[0] is q_K_o in component environment (fmol). * STATES[1] is q_K_i in component environment (fmol). * STATES[2] is q_r0s0_TO in component environment (fmol). * STATES[3] is q_r1s0_TO in component environment (fmol). * STATES[4] is q_r0s1_TO in component environment (fmol). * STATES[5] is q_r1s1_TO in component environment (fmol). * STATES[6] is q_mem in component environment (fC). * ALGEBRAIC[0] is Vmem in component environment (volt). * CONSTANTS[1] is R in component environment (J_per_K_per_mol). * CONSTANTS[2] is T in component environment (kelvin). * CONSTANTS[3] is F in component environment (C_per_mol). * ALGEBRAIC[20] is v_TO in component TO (fmol_per_sec). * ALGEBRAIC[26] is I_mem_TO in component TO (fA). * CONSTANTS[4] is kappa_TO in component TO_parameters (fmol_per_sec). * CONSTANTS[5] is kappa_gTO_1 in component TO_parameters (fmol_per_sec). * CONSTANTS[6] is kappa_gTO_2 in component TO_parameters (fmol_per_sec). * CONSTANTS[7] is kappa_gTO_3 in component TO_parameters (fmol_per_sec). * CONSTANTS[8] is kappa_gTO_4 in component TO_parameters (fmol_per_sec). * CONSTANTS[9] is K_K_i in component TO_parameters (per_fmol). * CONSTANTS[10] is K_K_o in component TO_parameters (per_fmol). * CONSTANTS[11] is K_r0s0_TO in component TO_parameters (per_fmol). * CONSTANTS[12] is K_r1s0_TO in component TO_parameters (per_fmol). * CONSTANTS[13] is K_r0s1_TO in component TO_parameters (per_fmol). * CONSTANTS[14] is K_r1s1_TO in component TO_parameters (per_fmol). * CONSTANTS[15] is zK in component TO_parameters (dimensionless). * CONSTANTS[16] is z_rTO_f in component TO_parameters (dimensionless). * CONSTANTS[17] is z_sTO_f in component TO_parameters (dimensionless). * CONSTANTS[18] is z_rTO_r in component TO_parameters (dimensionless). * CONSTANTS[19] is z_sTO_r in component TO_parameters (dimensionless). * ALGEBRAIC[1] is u_K_i in component TO (J_per_mol). * ALGEBRAIC[2] is u_K_o in component TO (J_per_mol). * ALGEBRAIC[3] is V_mem in component TO (J_per_C). * ALGEBRAIC[4] is Am_TO in component TO (J_per_mol). * ALGEBRAIC[18] is Af_TO in component TO (J_per_mol). * ALGEBRAIC[19] is Ar_TO in component TO (J_per_mol). * ALGEBRAIC[16] is v_r0s0_TO in component TO (fmol_per_sec). * ALGEBRAIC[27] is v_r1s0_TO in component TO (fmol_per_sec). * ALGEBRAIC[25] is v_r0s1_TO in component TO (fmol_per_sec). * ALGEBRAIC[28] is v_r1s1_TO in component TO (fmol_per_sec). * ALGEBRAIC[11] is v_gTO_1 in component TO (fmol_per_sec). * ALGEBRAIC[15] is v_gTO_3 in component TO (fmol_per_sec). * ALGEBRAIC[23] is v_gTO_2 in component TO (fmol_per_sec). * ALGEBRAIC[24] is v_gTO_4 in component TO (fmol_per_sec). * ALGEBRAIC[5] is mu_r0s0_TO in component TO (J_per_mol). * ALGEBRAIC[8] is mu_r1s0_TO in component TO (J_per_mol). * ALGEBRAIC[12] is mu_r0s1_TO in component TO (J_per_mol). * ALGEBRAIC[17] is mu_r1s1_TO in component TO (J_per_mol). * ALGEBRAIC[6] is Af_gTO_1 in component TO (J_per_mol). * ALGEBRAIC[9] is Ar_gTO_1 in component TO (J_per_mol). * ALGEBRAIC[7] is Af_gTO_3 in component TO (J_per_mol). * ALGEBRAIC[13] is Ar_gTO_3 in component TO (J_per_mol). * ALGEBRAIC[14] is Af_gTO_2 in component TO (J_per_mol). * ALGEBRAIC[21] is Ar_gTO_2 in component TO (J_per_mol). * ALGEBRAIC[10] is Af_gTO_4 in component TO (J_per_mol). * ALGEBRAIC[22] is Ar_gTO_4 in component TO (J_per_mol). * RATES[1] is d/dt q_K_i in component environment (fmol). * RATES[0] is d/dt q_K_o in component environment (fmol). * RATES[6] is d/dt q_mem in component environment (fC). * RATES[2] is d/dt q_r0s0_TO in component environment (fmol). * RATES[3] is d/dt q_r1s0_TO in component environment (fmol). * RATES[4] is d/dt q_r0s1_TO in component environment (fmol). * RATES[5] is d/dt q_r1s1_TO in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1.0e6; STATES[0] = 0.116325; STATES[1] = 3.65002; STATES[2] = 3.1966124E-07; STATES[3] = 3.1966124E-07; STATES[4] = 3.1966124E-07; STATES[5] = 3.1966124E-07; STATES[6] = -8.5e4; CONSTANTS[1] = 8.31; CONSTANTS[2] = 310; CONSTANTS[3] = 96500; CONSTANTS[4] = 1.91513; CONSTANTS[5] = 10.0063; CONSTANTS[6] = 0.053573; CONSTANTS[7] = 0.0622138; CONSTANTS[8] = 0.0155957; CONSTANTS[9] = 0.0402291; CONSTANTS[10] = 0.267055; CONSTANTS[11] = 0.00553253; CONSTANTS[12] = 0.0220702; CONSTANTS[13] = 1.03336; CONSTANTS[14] = 4.12222; CONSTANTS[15] = 1; CONSTANTS[16] = 2.28623234372134; CONSTANTS[17] = -1.51477720975217; CONSTANTS[18] = -0.131848324558065; CONSTANTS[19] = 1.75042355789096; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = STATES[6]/CONSTANTS[0]; ALGEBRAIC[5] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[11]*STATES[2]); ALGEBRAIC[6] = ALGEBRAIC[5]+ CONSTANTS[16]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[8] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[12]*STATES[3]); ALGEBRAIC[9] = ALGEBRAIC[8]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[11] = CONSTANTS[5]*(exp(ALGEBRAIC[6]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[9]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[7] = ALGEBRAIC[5]+ CONSTANTS[17]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[12] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[13]*STATES[4]); ALGEBRAIC[13] = ALGEBRAIC[12]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[15] = CONSTANTS[7]*(exp(ALGEBRAIC[7]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[13]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[16] = - ALGEBRAIC[11]+ALGEBRAIC[15]; RATES[2] = ALGEBRAIC[16]; ALGEBRAIC[4] = CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[1] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[9]*STATES[1]); ALGEBRAIC[17] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[14]*STATES[5]); ALGEBRAIC[18] = ALGEBRAIC[17]+ALGEBRAIC[1]+ALGEBRAIC[4]; ALGEBRAIC[2] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[10]*STATES[0]); ALGEBRAIC[19] = ALGEBRAIC[17]+ALGEBRAIC[2]; ALGEBRAIC[20] = (ALGEBRAIC[4]==0.00000 ? 1.00000*CONSTANTS[4]*(exp(ALGEBRAIC[18]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2]))) : ((( 1.00000*CONSTANTS[4]*ALGEBRAIC[4])/( CONSTANTS[1]*CONSTANTS[2]))/(exp(ALGEBRAIC[4]/( CONSTANTS[1]*CONSTANTS[2])) - 1.00000))*(exp(ALGEBRAIC[18]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2])))); RATES[1] = - ALGEBRAIC[20]; RATES[0] = ALGEBRAIC[20]; ALGEBRAIC[14] = ALGEBRAIC[12]+ CONSTANTS[16]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[21] = ALGEBRAIC[17]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[23] = CONSTANTS[6]*(exp(ALGEBRAIC[14]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[21]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[25] = - ALGEBRAIC[23]+ALGEBRAIC[15]; RATES[4] = ALGEBRAIC[25]; ALGEBRAIC[10] = ALGEBRAIC[8]+ CONSTANTS[17]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[22] = ALGEBRAIC[17]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[24] = CONSTANTS[8]*(exp(ALGEBRAIC[10]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[22]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[26] = CONSTANTS[3]*( - CONSTANTS[15]*ALGEBRAIC[20]+ (ALGEBRAIC[11]+ALGEBRAIC[23])*(CONSTANTS[18] - CONSTANTS[16])+ (ALGEBRAIC[15]+ALGEBRAIC[24])*(CONSTANTS[19] - CONSTANTS[17])); RATES[6] = ALGEBRAIC[26]; ALGEBRAIC[27] = ALGEBRAIC[11] - ALGEBRAIC[24]; RATES[3] = ALGEBRAIC[27]; ALGEBRAIC[28] = ALGEBRAIC[23]+ALGEBRAIC[24]; RATES[5] = ALGEBRAIC[28]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = STATES[6]/CONSTANTS[0]; ALGEBRAIC[5] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[11]*STATES[2]); ALGEBRAIC[6] = ALGEBRAIC[5]+ CONSTANTS[16]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[8] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[12]*STATES[3]); ALGEBRAIC[9] = ALGEBRAIC[8]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[11] = CONSTANTS[5]*(exp(ALGEBRAIC[6]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[9]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[7] = ALGEBRAIC[5]+ CONSTANTS[17]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[12] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[13]*STATES[4]); ALGEBRAIC[13] = ALGEBRAIC[12]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[15] = CONSTANTS[7]*(exp(ALGEBRAIC[7]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[13]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[16] = - ALGEBRAIC[11]+ALGEBRAIC[15]; ALGEBRAIC[4] = CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[1] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[9]*STATES[1]); ALGEBRAIC[17] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[14]*STATES[5]); ALGEBRAIC[18] = ALGEBRAIC[17]+ALGEBRAIC[1]+ALGEBRAIC[4]; ALGEBRAIC[2] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[10]*STATES[0]); ALGEBRAIC[19] = ALGEBRAIC[17]+ALGEBRAIC[2]; ALGEBRAIC[20] = (ALGEBRAIC[4]==0.00000 ? 1.00000*CONSTANTS[4]*(exp(ALGEBRAIC[18]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2]))) : ((( 1.00000*CONSTANTS[4]*ALGEBRAIC[4])/( CONSTANTS[1]*CONSTANTS[2]))/(exp(ALGEBRAIC[4]/( CONSTANTS[1]*CONSTANTS[2])) - 1.00000))*(exp(ALGEBRAIC[18]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2])))); ALGEBRAIC[14] = ALGEBRAIC[12]+ CONSTANTS[16]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[21] = ALGEBRAIC[17]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[23] = CONSTANTS[6]*(exp(ALGEBRAIC[14]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[21]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[25] = - ALGEBRAIC[23]+ALGEBRAIC[15]; ALGEBRAIC[10] = ALGEBRAIC[8]+ CONSTANTS[17]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[22] = ALGEBRAIC[17]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[3]; ALGEBRAIC[24] = CONSTANTS[8]*(exp(ALGEBRAIC[10]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[22]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[26] = CONSTANTS[3]*( - CONSTANTS[15]*ALGEBRAIC[20]+ (ALGEBRAIC[11]+ALGEBRAIC[23])*(CONSTANTS[18] - CONSTANTS[16])+ (ALGEBRAIC[15]+ALGEBRAIC[24])*(CONSTANTS[19] - CONSTANTS[17])); ALGEBRAIC[27] = ALGEBRAIC[11] - ALGEBRAIC[24]; ALGEBRAIC[28] = ALGEBRAIC[23]+ALGEBRAIC[24]; ALGEBRAIC[0] = STATES[6]/CONSTANTS[0]; }