NKE knowledge page — Physiome Model Repository

About

Landing page for the sodium potassium pump NKE. Other name for these proteins: NKA, Na-K-ATPase.

NKE helps maintain resting membrane potential through helping establish the sodium and potassium concentration gradients across the membrane.

NKE is thought to be a heterodimer - made of the active alpha subunit protein, which catalyses the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This is assembled with the regulatory beta subunit.

Pictures

Subfamilies

The following list contains a portion of all subfamilies that can compose the NKE.

Variants within the human species
Channel name	Alias	Gene	Structure
ATP1A1		Uniprot A1	PDB A1
ATP1A2		Uniprot A2	SMR A2
ATP1A3		Uniprot A3	PDB A3
ATP1A4		Uniprot A4	SMR A4
ATP1B1		Uniprot B1	PDB B1
ATP1B2		Uniprot B2	SMR B2
ATP1B3		Uniprot B3	SMR B3
ATP1C	ATNG, FXYD2	Uniprot 1C	PDB 1C
FXYD3		Uniprot FXYD3	SMR FXYD3

Literature

For further reading
Title	Author
A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources	Kernik et al.
A thermodynamic framework for modelling membrane transporters	Pan et al.

Existing models

Link to other PMR workspaces or exposures
Title	Author
BG_NaK	S Fong
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death*^	C Clancy and Y Rudy
Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^	M Pan et al.
A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^	C Luo and Y Rudy

Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.

Other annotations

Item	Database
Sodium:potassium-exchanging ATPase complex	Gene Ontology Complex
P-type sodium:potassium-exchanging transporter activity	Gene Ontology activity