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Sarkar, Lauffenburger, 2003
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Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
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Model Mathematics
Component based math viewer is available
Component: environment
Component: Rs
d
d
time
Rs
=
kr
Cs
+
Vs
-
kf
L
Rs
+
keR
Rs
N
Component: Cs
d
d
time
Cs
=
-
kf
L
Cs
+
kr
Cs
+
keC
Cs
N
Component: Li
d
d
time
Li
=
kri
Ci
-
kfi
Li
Ri
1.0
NA
Ve
-
krec
Li
N
Component: Ri
d
d
time
Ri
=
kri
Ci
+
keR
Rs
-
kfi
Li
Ri
+
kdeg
Ri
N
Component: Ci
d
d
time
Ci
=
kfi
Li
Ri
+
keC
Cs
-
kri
Ci
+
kdeg
Rs
N
Component: L
d
d
time
L
=
krec
Li
Ve
NA
+
kr
Cs
-
kf
L
Rs
N
NA
-
kl_WT
L
Component: Ld
d
d
time
Ld
=
kdeg
Ci
N
Component: parameters
n
=
N
Component: N
d
d
time
n
=
Kin
1
+
emax
L
kdiwt
kd
gamma
ec50
gamma
+
L
kdiwt
kd
gamma
-
kout
n
Component: PKPD
d
d
time
L4
=
Q
V4
L
-
L4
d
d
time
n1
=
k13
n1
d
d
time
n2
=
k23
n2
Source
Derived from workspace
Sarkar, Lauffenburger, 2003
at changeset
16b09319ce42
.
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License
This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo