Model Mathematics

Component: environment

Component: subspace

dd time Ca_SS = J_release + J_DHPR + J_efflux + J_buf J_DHPR =- I_DHPR 2.0 F V_SS J_release = RyR_open J_RyR J_RyR = D_RyR Ca_lumen - Ca_SS RyR_open = 0.0 if i = 0.0 1.0 otherwise dd time Ca_B_SR = k_on_SR Ca_SS Ca_B_SR - k_off_SR Ca_B_SR_tot - Ca_B_SR dd time Ca_B_trpnC = k_on_trpnC Ca_SS Ca_B_trpnC - k_off_trpnC Ca_B_trpnC_tot - Ca_B_trpnC dd time Ca_B_CaM = k_on_CaM Ca_SS Ca_B_CaM - k_off_CaM Ca_B_CaM_tot - Ca_B_CaM dd time Ca_B_SL = k_on_SL Ca_SS Ca_B_SL - k_off_SL Ca_B_SL_tot - Ca_B_SL J_buf = k_on_CaM Ca_SS Ca_B_CaM - k_off_CaM Ca_B_CaM_tot - Ca_B_CaM + k_on_trpnC Ca_SS Ca_B_trpnC - k_off_trpnC Ca_B_trpnC_tot - Ca_B_trpnC + k_on_SR Ca_SS Ca_B_SR - k_off_SR Ca_B_SR_tot - Ca_B_SR + k_on_SL Ca_SS Ca_B_SL - k_off_SL Ca_B_SL_tot - Ca_B_SL J_efflux = Ca_myo + Ca_SS tau_efflux

Component: lumen

dd time Ca_lumen = beta_JSR - J_RyR V_SS V_JSR + J_refill J_refill = Ca_NSR - Ca_lumen tau_refill beta_JSR = 1.0 + CSQ_tot K_CSQ CSQ + K_CSQ 2.0 -1.0

Component: RyR_receptor_gating

k_close = CF_close 480.0 k_open = CF_open 30000.0 Ca_SS 4.0 Ca_SS 4.0 + K_m 4.0 K_m = 6.0 - 0.0024 Ca_lumen CF_open = 1.0 + N_open + 1.0 N_open + N_closed CF_close = k_coop 1.0 + N_closed + 1.0 N_open + N_closed

Component: spark_model

dd time Ca = DC Ca + J_dye + J_buf + J_pump + J_leak + J_RyR dd time Ca_F = DF Ca_F - J_dye J_dye =- k_F_plus Ca F_T - Ca_F + k_F_minus Ca_F J_pump = Vmax_pump Ca m Km_pump + Ca m J_leak =- Vmax_pump C_infinity m Km_pump + C_infinity m