Model Mathematics

Component: environment

Component: mass

ddtimemass=masskg

Component: Cln2

ddtimeCln2=ks_n2_+ks_n2__SBFmass-kd_n2Cln2

Component: Clb5

ddtimeClb5=ks_b5_+ks_b5__MBFmass+kd3_c1C5P+kdi_b5C5+kd3_f6F5P+kdi_f5F5-Vd_b5+kas_b5Sic1+kas_f5Cdc6Clb5

Component: Clb2

ddtimeClb2=ks_b2_+ks_b2__Mcm1mass+kd3_c1C2P+kdi_b2C2+kd3_f6F2P+kdi_f2F2-Vd_b2+kas_b2Sic1+kas_f2Cdc6Clb2

Component: Sic1

ddtimeSic1=ks_c1_+ks_c1__Swi5+Vd_b2+kdi_b2C2+Vd_b5+kdi_b5C5+kpp_c1Cdc14Sic1P-kas_b2Clb2+kas_b5Clb5+Vkp_c1Sic1

Component: Sic1P

ddtimeSic1P=Vkp_c1Sic1-kpp_c1Cdc14+kd3_c1Sic1P+Vd_b2C2P+Vd_b5C5P

Component: C2

ddtimeC2=kas_b2Clb2Sic1+kpp_c1Cdc14C2P-kdi_b2+Vd_b2+Vkp_c1C2

Component: C5

ddtimeC5=kas_b5Clb5Sic1+kpp_c1Cdc14C5P-kdi_b5+Vd_b5+Vkp_c1C5

Component: C2P

ddtimeC2P=Vkp_c1C2-kpp_c1Cdc14+kd3_c1+Vd_b2C2P

Component: C5P

ddtimeC5P=Vkp_c1C5-kpp_c1Cdc14+kd3_c1+Vd_b5C5P

Component: Cdc6

ddtimeCdc6=ks_f6_+ks_f6__Swi5+ks_f6___SBF+Vd_b2+kdi_f2F2+Vd_b5+kdi_f5F5+kpp_f6Cdc14Cdc6P-kas_f2Clb2+kas_f5Clb5+Vkp_f6Cdc6

Component: Cdc6P

ddtimeCdc6P=Vkp_f6Cdc6-kpp_f6Cdc14+kd3_f6Cdc6P+Vd_b2F2P+Vd_b5F5P

Component: F2

ddtimeF2=kas_f2Clb2Cdc6+kpp_f6Cdc14F2P-kdi_f2+Vd_b2+Vkp_f6F2

Component: Pds1

ddtimePds1=ks_pds_+ks1_pds__SBF+ks2_pds__Mcm1+kdi_espPE-Vd_pds+kas_espEsp1Pds1

Component: Esp1

ddtimeEsp1=-kas_espPds1Esp1+kdi_esp+Vd_pdsPE

Component: ORI

ddtimeORI=ks_oriepsilon_ori_b5Clb5+epsilon_ori_b2Clb2-kd_oriORI

Component: BUD

ddtimeBUD=ks_budepsilon_bud_n2Cln2+epsilon_bud_n3Cln3+epsilon_bud_b5Clb5-kd_budBUD

Component: SPN

ddtimeSPN=ks_spnClb2Jspn+Clb2-kd_spnSPN

Component: G_sbf

G_sbf=2Ji_sbfVa_sbfVi_sbf+Ja_sbfVi_sbf+Ji_sbfVa_sbf+Vi_sbf+Ja_sbfVi_sbf+Ji_sbfVa_sbf-Va_sbf2-4Vi_sbf-Va_sbfJi_sbfVa_sbf-Va_sbf

Component: G_mcm

G_mcm=2Ji_mcmka_mcmClb2ki_mcm+Ja_mcmki_mcm+Ji_mcmka_mcmClb2+ki_mcm+Ja_mcmki_mcm+Ji_mcmka_mcmClb2-ka_mcmClb22-4ki_mcm-ka_mcmClb2Ji_mcmka_mcmClb2-ka_mcmClb2

Component: SBF_MBF

SBF=MBFMBF=G_sbf

Component: Mcm1

Mcm1=G_mcm

Component: Cln3

Cln3=C0Dn3massJn3+Dn3mass

Component: Bck2

Bck2=B0mass

Component: Clb5_T

Clb5_T=Clb5+C5+C5P+F5+F5P

Component: Clb2_T

Clb2_T=Clb2+C2+C2P+F2+F2P

Component: Sic1_T

Sic1_T=Sic1+Sic1P+C2+C2P+C5+C5P

Component: F5

ddtimeF5=kas_f5Clb5Cdc6+kpp_f6Cdc14F5P-kdi_f5+Vd_b5+Vkp_f6F5

Component: F2P

ddtimeF2P=Vkp_f6F2-kpp_f6Cdc14+kd3_f6+Vd_b2F2P

Component: F5P

ddtimeF5P=Vkp_f6F5-kpp_f6Cdc14+kd3_f6+Vd_b5F5P

Component: Swi5_T

ddtimeSwi5_T=ks_swi_+ks_swi__Mcm1-kd_swiSwi5_T

Component: Swi5

ddtimeSwi5=ks_swi_+ks_swi__Mcm1+ka_swiCdc14Swi5_T-Swi5-kd_swi+ki_swiClb2Swi5

Component: APC_P

ddtimeAPC_P=ka_apcClb21-APC_PJa_apc+1-APC_P-ki_apcAPC_PJi_apc+APC_P

Component: Cdc20_T

ddtimeCdc20_T=ks_20_+ks_20__Mcm1-kd_20Cdc20_T

Component: Cdc20_A

ddtimeCdc20_A=ka_20_+ka_20__APC_PCdc20_T-Cdc20_A-kmad2+kd_20Cdc20_A

Component: Cdh1_T

ddtimeCdh1_T=ks_cdh-kd_cdhCdh1_T

Component: Cdh1

ddtimeCdh1=ks_cdh+Va_cdhCdh1_T-Cdh1Ja_cdh+Cdh1_T-Cdh1-kd_cdhCdh1+Vi_cdhCdh1Ji_cdh+Cdh1

Component: Tem1

ddtimeTem1=klte1Tem1_T-Tem1Ja_tem+Tem1_T-Tem1-kbub2Tem1Ji_tem+Tem1

Component: Cdc15

ddtimeCdc15=ka_15_Tem1_T-Tem1+ka_15__Tem1+ka_15___Cdc14Cdc15_T-Cdc15-ki_15Cdc15

Component: Cdc14_T

ddtimeCdc14_T=ks_14-kd_14Cdc14_T

Component: Cdc14

ddtimeCdc14=ks_14+kd_netRENT+RENTP+kdi_rentRENT+kdi_rentpRENTP-kd_14Cdc14+kas_rentNet1+kas_rentpNet1PCdc14

Component: Net1_T

ddtimeNet1_T=ks_net-kd_netNet1_T

Component: Cdc6_T

Cdc6_T=Cdc6+Cdc6P+F2+F2P+F5+F5P

Component: CKI_T

CKI_T=Sic1_T+Cdc6_T

Component: RENTP

RENTP=Cdc14_T-RENT+Cdc14

Component: Net1P

Net1P=Net1_T+Cdc14-Net1+Cdc14_T

Component: PE

PE=Esp1_T-Esp1

Component: Vd_b5

Vd_b5=kd_b5_+kd_b5__Cdc20_A

Component: Vd_b2

Vd_b2=kd_b2_+kd_b2__Cdh1+kd_b2pCdc20_A

Component: Va_sbf

Va_sbf=ka_sbfepsilon_sbf_n2Cln2+epsilon_sbf_n3Cln3+Bck2+epsilon_sbf_b5Clb5

Component: Vi_sbf

Vi_sbf=ki_sbf_+ki_sbf__Clb2

Component: Vkp_c1

Vkp_c1=kd1_c1+kd2_c1epsilon_c1_n3Cln3+epsilon_c1_k2Bck2+epsilon_c1_n2Cln2+epsilon_c1_b5Clb5+epsilon_c1_b2Clb2Jd2_c1+Sic1_T

Component: Vkp_f6

Vkp_f6=kd1_f6+kd2_f6epsilon_f6_n3Cln3+epsilon_f6_k2Bck2+epsilon_f6_n2Cln2+epsilon_f6_b5Clb5+epsilon_f6_b2Clb2Jd2_f6+Cdc6_T

Component: Va_cdh

Va_cdh=ka_cdh_+ka_cdh__Cdc14

Component: Vi_cdh

Vi_cdh=ki_cdh_+ki_cdh__epsilon_cdh_n3Cln3+epsilon_cdh_n2Cln2+epsilon_cdh_b5Clb5+epsilon_cdh_b2Clb2

Component: Vpp_net

Vpp_net=kpp_net_+kpp_net__PPX

Component: Vkp_net

Vkp_net=kkp_net_+kkp_net__Cdc15mass

Component: Net1

ddtimeNet1=ks_net+kd_14RENT+kdi_rentRENT+Vpp_netNet1P-kd_netNet1+kas_rentCdc14Net1+Vkp_netNet1

Component: RENT

ddtimeRENT=kas_rentCdc14Net1+Vpp_netRENTP-kd_14+kd_netRENT+kdi_rentRENT+Vkp_netRENT

Component: PPX

ddtimePPX=ks_ppx-Vd_ppxPPX

Component: Vd_ppx

Vd_ppx=kd_ppx_+kd_ppx__J20_ppx+Cdc20_AJpdsJpds+Pds1

Component: Vd_pds

Vd_pds=kd1_pds_+kd2_pds__Cdc20_A+kd3_pds__Cdh1

Component: model_parameters

kmad2=8ifORI>1SPN<10.01otherwisekbub2=1ifORI>1SPN<10.2otherwiseklte1=1ifSPN>1Clb2>Kez0.1otherwise