/* There are a total of 12 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 20 entries in the constant variable array. */ /* * VOI is time in component environment (day). * ALGEBRAIC[6] is rel_LH_E2_P4_RP_LH in component RP_LH (microg_day). * STATES[0] is RP_LH in component RP_LH (microg). * ALGEBRAIC[10] is syn_LH_E2_P4 in component RP_LH (microg_day). * CONSTANTS[0] is V0_LH in component RP_LH (microg_day). * CONSTANTS[1] is V1_LH in component RP_LH (microg_day). * CONSTANTS[2] is h in component RP_LH (dimensionless). * CONSTANTS[3] is Km_LH in component RP_LH (ng_L). * CONSTANTS[4] is Ki_LHP in component RP_LH (nmol_L). * CONSTANTS[5] is kLH_rel in component RP_LH (first_order_rate_constant). * CONSTANTS[6] is CLH_P in component RP_LH (L_nmol). * CONSTANTS[7] is CLH_E in component RP_LH (L_ng). * ALGEBRAIC[3] is E2 in component E2 (ng_L). * ALGEBRAIC[4] is E2_dE in component E2_dE (ng_L). * ALGEBRAIC[5] is P4 in component P4 (nmol_L). * ALGEBRAIC[8] is P4_dP in component P4_dP (nmol_L). * STATES[1] is LH in component LH (microg_l). * CONSTANTS[8] is v_dis in component LH (litre). * ALGEBRAIC[0] is clear_LH in component LH (microg_l_day). * CONSTANTS[9] is kLH_cl in component LH (first_order_rate_constant). * ALGEBRAIC[7] is rel_FSH_E2_P4_RP_FSH in component RP_FSH (microg_day). * STATES[2] is RP_FSH in component RP_FSH (microg). * ALGEBRAIC[11] is syn_FSH_Ih in component RP_FSH (microg_day). * CONSTANTS[10] is V_FSH in component RP_FSH (microg_day). * CONSTANTS[11] is Ki_FSH_Ih in component RP_FSH (U_L). * CONSTANTS[12] is kFSH_rel in component RP_FSH (first_order_rate_constant). * CONSTANTS[13] is CFSH_P in component RP_FSH (L_nmol). * CONSTANTS[14] is CFSH_E in component RP_FSH (L_ng2). * ALGEBRAIC[9] is Ih_dIh in component Ih_dIh (U_L). * STATES[3] is FSH in component FSH (microg_l). * CONSTANTS[15] is v_dis in component FSH (litre). * ALGEBRAIC[2] is clear_FSH in component FSH (microg_l_day). * CONSTANTS[16] is kFSH_cl in component FSH (first_order_rate_constant). * CONSTANTS[17] is dE in component E2_dE (day). * CONSTANTS[18] is dP in component P4_dP (day). * ALGEBRAIC[1] is Ih in component Ih (U_L). * CONSTANTS[19] is dIh in component Ih_dIh (day). * RATES[0] is d/dt RP_LH in component RP_LH (microg). * RATES[1] is d/dt LH in component LH (microg_l). * RATES[2] is d/dt RP_FSH in component RP_FSH (microg). * RATES[3] is d/dt FSH in component FSH (microg_l). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 467.0; CONSTANTS[0] = 1400.0; CONSTANTS[1] = 95900.0; CONSTANTS[2] = 8.0; CONSTANTS[3] = 360.0; CONSTANTS[4] = 26.0; CONSTANTS[5] = 3.0; CONSTANTS[6] = 0.024; CONSTANTS[7] = 0.008; STATES[1] = 40.0; CONSTANTS[8] = 2.5; CONSTANTS[9] = 14.0; STATES[2] = 0.0; CONSTANTS[10] = 4400.0; CONSTANTS[11] = 1176.5; CONSTANTS[12] = 45.0; CONSTANTS[13] = 3.0; CONSTANTS[14] = 0.005; STATES[3] = 150.0; CONSTANTS[15] = 2.5; CONSTANTS[16] = 8.21; CONSTANTS[17] = 0.42; CONSTANTS[18] = 2.9; CONSTANTS[19] = 2.0; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = (300.000 - ( 240.000*pow(VOI+1.00000, 2.00000))/(3.00000+pow(VOI+1.00000, 2.00000)))+ 90.0000*exp(- (pow(VOI - 8.00000, 2.00000)/10.0000)); ALGEBRAIC[5] = 52.0000*exp(- (pow(VOI - 7.00000, 2.00000)/18.0000)); ALGEBRAIC[6] = ( CONSTANTS[5]*(1.00000+ CONSTANTS[6]*ALGEBRAIC[5])*STATES[0])/(1.00000+ CONSTANTS[7]*ALGEBRAIC[3]); ALGEBRAIC[0] = CONSTANTS[9]*STATES[1]; RATES[1] = ALGEBRAIC[6]/CONSTANTS[8] - ALGEBRAIC[0]; ALGEBRAIC[7] = ( CONSTANTS[12]*(1.00000+ CONSTANTS[13]*ALGEBRAIC[5])*STATES[2])/(1.00000+ CONSTANTS[14]*pow(ALGEBRAIC[3], 2.00000)); ALGEBRAIC[2] = CONSTANTS[16]*STATES[3]; RATES[3] = ALGEBRAIC[7]/CONSTANTS[15] - ALGEBRAIC[2]; ALGEBRAIC[4] = (300.000 - ( 240.000*pow((VOI+1.00000) - CONSTANTS[17], 2.00000))/(3.00000+pow((VOI+1.00000) - CONSTANTS[17], 2.00000)))+ 90.0000*exp(- (pow(VOI - (CONSTANTS[17]+8.00000), 2.00000)/10.0000)); ALGEBRAIC[8] = 52.0000*exp(- (pow(VOI - (CONSTANTS[18]+7.00000), 2.00000)/18.0000)); ALGEBRAIC[10] = (CONSTANTS[0]+( CONSTANTS[1]*pow(ALGEBRAIC[4], CONSTANTS[2]))/(pow(CONSTANTS[3], CONSTANTS[2])+pow(ALGEBRAIC[4], CONSTANTS[2])))/(1.00000+ALGEBRAIC[8]/CONSTANTS[4]); RATES[0] = ALGEBRAIC[10] - ALGEBRAIC[6]; ALGEBRAIC[9] = 300.000+ 1330.00*exp(- (pow(VOI - (7.00000+CONSTANTS[19]), 2.00000)/19.0000)); ALGEBRAIC[11] = CONSTANTS[10]/(1.00000+ALGEBRAIC[9]/CONSTANTS[11]); RATES[2] = ALGEBRAIC[11] - ALGEBRAIC[7]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = (300.000 - ( 240.000*pow(VOI+1.00000, 2.00000))/(3.00000+pow(VOI+1.00000, 2.00000)))+ 90.0000*exp(- (pow(VOI - 8.00000, 2.00000)/10.0000)); ALGEBRAIC[5] = 52.0000*exp(- (pow(VOI - 7.00000, 2.00000)/18.0000)); ALGEBRAIC[6] = ( CONSTANTS[5]*(1.00000+ CONSTANTS[6]*ALGEBRAIC[5])*STATES[0])/(1.00000+ CONSTANTS[7]*ALGEBRAIC[3]); ALGEBRAIC[0] = CONSTANTS[9]*STATES[1]; ALGEBRAIC[7] = ( CONSTANTS[12]*(1.00000+ CONSTANTS[13]*ALGEBRAIC[5])*STATES[2])/(1.00000+ CONSTANTS[14]*pow(ALGEBRAIC[3], 2.00000)); ALGEBRAIC[2] = CONSTANTS[16]*STATES[3]; ALGEBRAIC[4] = (300.000 - ( 240.000*pow((VOI+1.00000) - CONSTANTS[17], 2.00000))/(3.00000+pow((VOI+1.00000) - CONSTANTS[17], 2.00000)))+ 90.0000*exp(- (pow(VOI - (CONSTANTS[17]+8.00000), 2.00000)/10.0000)); ALGEBRAIC[8] = 52.0000*exp(- (pow(VOI - (CONSTANTS[18]+7.00000), 2.00000)/18.0000)); ALGEBRAIC[10] = (CONSTANTS[0]+( CONSTANTS[1]*pow(ALGEBRAIC[4], CONSTANTS[2]))/(pow(CONSTANTS[3], CONSTANTS[2])+pow(ALGEBRAIC[4], CONSTANTS[2])))/(1.00000+ALGEBRAIC[8]/CONSTANTS[4]); ALGEBRAIC[9] = 300.000+ 1330.00*exp(- (pow(VOI - (7.00000+CONSTANTS[19]), 2.00000)/19.0000)); ALGEBRAIC[11] = CONSTANTS[10]/(1.00000+ALGEBRAIC[9]/CONSTANTS[11]); ALGEBRAIC[1] = 300.000+ 1330.00*exp(- (pow(VOI - 7.00000, 2.00000)/19.0000)); }