Rendering of the source text

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<!--  FILE :  heyd_model_2003.xml

CREATED :  25th November 2003

LAST MODIFIED : 25th November 2003

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Heyd and Drew's mathematical model for elongation of a peptide chain.
CHANGES:  
  
-->

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<article>
  <articleinfo>
  <title>A mathematical model for elongation of a peptide chain</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
           This CellML model runs in both OpenCell and COR. The units have been checked and they are consistent. We are unsure as to whether or not this CellML model recreates the results of the original model as there are no simple concentration against time simulation figures in the published paper to compare it with. 
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
ABSTRACT: A mathematical model is presented for the steps in the elongation process, and the steady-state elongation rate as a function of the amino acid concentrations is found. In addition, the reset sub-process of the elongation process is modeled. The rate of elongation of peptide chains is found to be a function of the concentration of the amino acid to be bound and the concentration of all other amino acids. In addition, the overall elongation rate depends on the concentrations of elongation factors.</para>

<para>
The original paper reference is cited below:
</para>

<para>
A Mathematical Model for Elongation of a Peptide Chain, Andrew Heyd and Donald A. Drew, 2003, <emphasis>Bulletin of Mathematical Biology</emphasis>, 65, 1095-1109. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/14607290">PubMed ID: 14607290</ulink>
</para>

<informalfigure float="0" id="fig_reaction_diagram">
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      <title>reaction diagram</title>
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    <imagedata fileref="heyd_2003.png"/>
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<caption>A schematic diagram displaying the reaction steps described by the mathematical model.</caption>
</informalfigure>

</sect1>
</article>
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