Model Mathematics

Component: environment

Component: membrane

dd time V =- i_Ca + i_K + i_KATP + i_KCa + i_Leak Cm

Component: calcium_current

i_Ca = g_Ca m_infinity V - V_Ca

Component: calcium_current_m_gate

m_infinity = 1.0 1.0 + Vm - V Sm

Component: rapidly_activating_K_current

i_K = g_K n V - V_K

Component: rapidly_activating_K_current_n_gate

dd time n = n_infinity - n tau_n n_infinity = 1.0 1.0 + Vn - V Sn

Component: Ca_activated_K_current

i_KCa = g_KCa w V - V_K

Component: Ca_activated_K_current_w_gate

w = c_SS q c_SS q + Kd q

Component: ATP_dependent_K_current

i_KATP = g_KATP V - V_K

Component: leak_current

i_Leak = g_Leak V - V_Leak

Component: calcium_concentrations

dd time c = f_CYT - alpha i_Ca + J_PMCA + J_SERCA + J_X alpha = 1.0 2.0 F V_CYT V_CYT = 25.0 V_ER V_SS = 0.4 V_CYT V_ER = 0.1 V_SS dd time c_ER = f_ER V_CYT V_ER J_SERCA - J_RELEASE dd time c_SS = f_SS V_ER V_SS J_RELEASE - V_CYT V_SS J_X

Component: calcium_fluxes

J_PMCA = k_PMCA c J_SERCA = k_SERCA c J_RELEASE = p_ER c_ER - c_SS J_X = p_X c_SS - c