function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =14; end % There are a total of 7 entries in each of the rate and state variable arrays. % There are a total of 24 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (second)'); LEGEND_ALGEBRAIC(:,1) = strpad('Vm in component membrane (millivolt)'); LEGEND_CONSTANTS(:,1) = strpad('Cm in component membrane (microfarad)'); LEGEND_ALGEBRAIC(:,12) = strpad('I_b in component I_b (nanoampere)'); LEGEND_ALGEBRAIC(:,3) = strpad('I_Kir in component I_Kir (nanoampere)'); LEGEND_ALGEBRAIC(:,10) = strpad('I_Shkr in component I_Shkr (nanoampere)'); LEGEND_ALGEBRAIC(:,14) = strpad('I_stim in component I_stim (nanoampere)'); LEGEND_STATES(:,1) = strpad('VmReal in component membrane (millivolt)'); LEGEND_CONSTANTS(:,2) = strpad('GKir in component I_Kir (microsiemens)'); LEGEND_CONSTANTS(:,3) = strpad('aKir in component I_Kir (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('bKir in component I_Kir (dimensionless)'); LEGEND_CONSTANTS(:,24) = strpad('EK in component I_Kir (millivolt)'); LEGEND_ALGEBRAIC(:,2) = strpad('OKir in component I_Kir (dimensionless)'); LEGEND_CONSTANTS(:,5) = strpad('R in component model_parameters (millijoule_per_kelvin_mole)'); LEGEND_CONSTANTS(:,6) = strpad('T in component model_parameters (kelvin)'); LEGEND_CONSTANTS(:,7) = strpad('F in component model_parameters (coulomb_per_mole)'); LEGEND_CONSTANTS(:,8) = strpad('Ko in component model_parameters (millimolar)'); LEGEND_CONSTANTS(:,9) = strpad('Ki in component model_parameters (millimolar)'); LEGEND_CONSTANTS(:,10) = strpad('PShkr in component I_Shkr (microlitre_per_second)'); LEGEND_STATES(:,2) = strpad('C0ShkrReal in component I_Shkr (dimensionless)'); LEGEND_STATES(:,3) = strpad('C1ShkrReal in component I_Shkr (dimensionless)'); LEGEND_STATES(:,4) = strpad('C2ShkrReal in component I_Shkr (dimensionless)'); LEGEND_STATES(:,5) = strpad('C3ShkrReal in component I_Shkr (dimensionless)'); LEGEND_STATES(:,6) = strpad('C4ShkrReal in component I_Shkr (dimensionless)'); LEGEND_STATES(:,7) = strpad('OShkrReal in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,4) = strpad('C0Shkr in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('C1Shkr in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,6) = strpad('C2Shkr in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,7) = strpad('C3Shkr in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,8) = strpad('C4Shkr in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,9) = strpad('OShkr in component I_Shkr (dimensionless)'); LEGEND_ALGEBRAIC(:,11) = strpad('kv in component I_Shkr (first_order_rate_constant)'); LEGEND_ALGEBRAIC(:,13) = strpad('k_v in component I_Shkr (first_order_rate_constant)'); LEGEND_CONSTANTS(:,11) = strpad('kv0 in component I_Shkr (first_order_rate_constant)'); LEGEND_CONSTANTS(:,12) = strpad('zv in component I_Shkr (dimensionless)'); LEGEND_CONSTANTS(:,13) = strpad('k_v0 in component I_Shkr (first_order_rate_constant)'); LEGEND_CONSTANTS(:,14) = strpad('z_v in component I_Shkr (dimensionless)'); LEGEND_CONSTANTS(:,15) = strpad('ko in component I_Shkr (first_order_rate_constant)'); LEGEND_CONSTANTS(:,16) = strpad('k_o in component I_Shkr (first_order_rate_constant)'); LEGEND_CONSTANTS(:,17) = strpad('Gb in component I_b (microsiemens)'); LEGEND_CONSTANTS(:,18) = strpad('Eb in component I_b (millivolt)'); LEGEND_CONSTANTS(:,19) = strpad('stim_start in component I_stim (second)'); LEGEND_CONSTANTS(:,20) = strpad('stim_end in component I_stim (second)'); LEGEND_CONSTANTS(:,21) = strpad('stim_period in component I_stim (second)'); LEGEND_CONSTANTS(:,22) = strpad('stim_duration in component I_stim (second)'); LEGEND_CONSTANTS(:,23) = strpad('stim_amplitude in component I_stim (nanoampere)'); LEGEND_RATES(:,1) = strpad('d/dt VmReal in component membrane (millivolt)'); LEGEND_RATES(:,2) = strpad('d/dt C0ShkrReal in component I_Shkr (dimensionless)'); LEGEND_RATES(:,3) = strpad('d/dt C1ShkrReal in component I_Shkr (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt C2ShkrReal in component I_Shkr (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt C3ShkrReal in component I_Shkr (dimensionless)'); LEGEND_RATES(:,6) = strpad('d/dt C4ShkrReal in component I_Shkr (dimensionless)'); LEGEND_RATES(:,7) = strpad('d/dt OShkrReal in component I_Shkr (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 4.5e-6; STATES(:,1) = -58.00; CONSTANTS(:,2) = 1e-3; CONSTANTS(:,3) = 0.94; CONSTANTS(:,4) = 1.26; CONSTANTS(:,5) = 8310; CONSTANTS(:,6) = 295; CONSTANTS(:,7) = 9.65e4; CONSTANTS(:,8) = 5; CONSTANTS(:,9) = 140; CONSTANTS(:,10) = 5.4e-9; STATES(:,2) = 9.11e-1; STATES(:,3) = 8.57e-2; STATES(:,4) = 3.02e-3; STATES(:,5) = 4.74e-5; STATES(:,6) = 2.79e-7; STATES(:,7) = 0; CONSTANTS(:,11) = 30; CONSTANTS(:,12) = 1.28; CONSTANTS(:,13) = 2; CONSTANTS(:,14) = -1.53; CONSTANTS(:,15) = 77; CONSTANTS(:,16) = 18; CONSTANTS(:,17) = 6.9e-6; CONSTANTS(:,18) = 0; CONSTANTS(:,19) = 0.1; CONSTANTS(:,20) = 10; CONSTANTS(:,21) = 1; CONSTANTS(:,22) = 0.001; CONSTANTS(:,23) = 0.1; CONSTANTS(:,24) = (( CONSTANTS(:,5).*CONSTANTS(:,6))./CONSTANTS(:,7)).*log(CONSTANTS(:,8)./CONSTANTS(:,9)); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,8) = piecewise({STATES(:,6)<0.00000, 0.00000 , STATES(:,6)>1.00000, 1.00000 }, STATES(:,6)); ALGEBRAIC(:,9) = piecewise({STATES(:,7)<0.00000, 0.00000 , STATES(:,7)>1.00000, 1.00000 }, STATES(:,7)); RATES(:,7) = CONSTANTS(:,15).*ALGEBRAIC(:,8) - CONSTANTS(:,16).*ALGEBRAIC(:,9); ALGEBRAIC(:,4) = piecewise({STATES(:,2)<0.00000, 0.00000 , STATES(:,2)>1.00000, 1.00000 }, STATES(:,2)); ALGEBRAIC(:,5) = piecewise({STATES(:,3)<0.00000, 0.00000 , STATES(:,3)>1.00000, 1.00000 }, STATES(:,3)); ALGEBRAIC(:,1) = piecewise({abs(STATES(:,1))<1.00000e-07, 1.00000e-07 }, STATES(:,1)); ALGEBRAIC(:,11) = CONSTANTS(:,11).*exp(( ALGEBRAIC(:,1).*CONSTANTS(:,12).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6))); ALGEBRAIC(:,13) = CONSTANTS(:,13).*exp(( ALGEBRAIC(:,1).*CONSTANTS(:,14).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6))); RATES(:,2) = ALGEBRAIC(:,13).*ALGEBRAIC(:,5) - 4.00000.*ALGEBRAIC(:,11).*ALGEBRAIC(:,4); ALGEBRAIC(:,6) = piecewise({STATES(:,4)<0.00000, 0.00000 , STATES(:,4)>1.00000, 1.00000 }, STATES(:,4)); RATES(:,3) = ( 2.00000.*ALGEBRAIC(:,13).*ALGEBRAIC(:,6)+ 4.00000.*ALGEBRAIC(:,11).*ALGEBRAIC(:,4)) - ( 3.00000.*ALGEBRAIC(:,11)+ALGEBRAIC(:,13)).*ALGEBRAIC(:,5); ALGEBRAIC(:,7) = piecewise({STATES(:,5)<0.00000, 0.00000 , STATES(:,5)>1.00000, 1.00000 }, STATES(:,5)); RATES(:,4) = ( 3.00000.*ALGEBRAIC(:,13).*ALGEBRAIC(:,7)+ 3.00000.*ALGEBRAIC(:,11).*ALGEBRAIC(:,5)) - ( 2.00000.*ALGEBRAIC(:,11)+ 2.00000.*ALGEBRAIC(:,13)).*ALGEBRAIC(:,6); RATES(:,5) = ( 4.00000.*ALGEBRAIC(:,13).*ALGEBRAIC(:,8)+ 2.00000.*ALGEBRAIC(:,11).*ALGEBRAIC(:,6)) - (ALGEBRAIC(:,11)+ 3.00000.*ALGEBRAIC(:,13)).*ALGEBRAIC(:,7); RATES(:,6) = ( CONSTANTS(:,16).*ALGEBRAIC(:,9)+ ALGEBRAIC(:,11).*ALGEBRAIC(:,7)) - (CONSTANTS(:,15)+ 4.00000.*ALGEBRAIC(:,13)).*ALGEBRAIC(:,8); ALGEBRAIC(:,12) = CONSTANTS(:,17).*(ALGEBRAIC(:,1) - CONSTANTS(:,18)); ALGEBRAIC(:,2) = 1.00000./(CONSTANTS(:,3)+exp(( CONSTANTS(:,4).*(ALGEBRAIC(:,1) - CONSTANTS(:,24)).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6)))); ALGEBRAIC(:,3) = CONSTANTS(:,2).*ALGEBRAIC(:,2).*power(( CONSTANTS(:,8).*0.00100000), 1.0 ./ 2).*(ALGEBRAIC(:,1) - CONSTANTS(:,24)); ALGEBRAIC(:,10) = ( (( CONSTANTS(:,10).*ALGEBRAIC(:,9).*ALGEBRAIC(:,1).*power(CONSTANTS(:,7), 2.00000))./( CONSTANTS(:,5).*CONSTANTS(:,6))).*(CONSTANTS(:,9) - CONSTANTS(:,8).*exp(( - ALGEBRAIC(:,1).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6)))))./(1.00000 - exp(( - ALGEBRAIC(:,1).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6)))); ALGEBRAIC(:,14) = piecewise({VOI>=CONSTANTS(:,19)&(VOI<=CONSTANTS(:,20)&(VOI - CONSTANTS(:,19)) - floor((VOI - CONSTANTS(:,19))./CONSTANTS(:,21)).*CONSTANTS(:,21)<=CONSTANTS(:,22)), CONSTANTS(:,23) }, 0.00000); RATES(:,1) = - ((ALGEBRAIC(:,3)+ALGEBRAIC(:,10)+ALGEBRAIC(:,12)) - ALGEBRAIC(:,14))./CONSTANTS(:,1); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,8) = piecewise({STATES(:,6)<0.00000, 0.00000 , STATES(:,6)>1.00000, 1.00000 }, STATES(:,6)); ALGEBRAIC(:,9) = piecewise({STATES(:,7)<0.00000, 0.00000 , STATES(:,7)>1.00000, 1.00000 }, STATES(:,7)); ALGEBRAIC(:,4) = piecewise({STATES(:,2)<0.00000, 0.00000 , STATES(:,2)>1.00000, 1.00000 }, STATES(:,2)); ALGEBRAIC(:,5) = piecewise({STATES(:,3)<0.00000, 0.00000 , STATES(:,3)>1.00000, 1.00000 }, STATES(:,3)); ALGEBRAIC(:,1) = piecewise({abs(STATES(:,1))<1.00000e-07, 1.00000e-07 }, STATES(:,1)); ALGEBRAIC(:,11) = CONSTANTS(:,11).*exp(( ALGEBRAIC(:,1).*CONSTANTS(:,12).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6))); ALGEBRAIC(:,13) = CONSTANTS(:,13).*exp(( ALGEBRAIC(:,1).*CONSTANTS(:,14).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6))); ALGEBRAIC(:,6) = piecewise({STATES(:,4)<0.00000, 0.00000 , STATES(:,4)>1.00000, 1.00000 }, STATES(:,4)); ALGEBRAIC(:,7) = piecewise({STATES(:,5)<0.00000, 0.00000 , STATES(:,5)>1.00000, 1.00000 }, STATES(:,5)); ALGEBRAIC(:,12) = CONSTANTS(:,17).*(ALGEBRAIC(:,1) - CONSTANTS(:,18)); ALGEBRAIC(:,2) = 1.00000./(CONSTANTS(:,3)+exp(( CONSTANTS(:,4).*(ALGEBRAIC(:,1) - CONSTANTS(:,24)).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6)))); ALGEBRAIC(:,3) = CONSTANTS(:,2).*ALGEBRAIC(:,2).*power(( CONSTANTS(:,8).*0.00100000), 1.0 ./ 2).*(ALGEBRAIC(:,1) - CONSTANTS(:,24)); ALGEBRAIC(:,10) = ( (( CONSTANTS(:,10).*ALGEBRAIC(:,9).*ALGEBRAIC(:,1).*power(CONSTANTS(:,7), 2.00000))./( CONSTANTS(:,5).*CONSTANTS(:,6))).*(CONSTANTS(:,9) - CONSTANTS(:,8).*exp(( - ALGEBRAIC(:,1).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6)))))./(1.00000 - exp(( - ALGEBRAIC(:,1).*CONSTANTS(:,7))./( CONSTANTS(:,5).*CONSTANTS(:,6)))); ALGEBRAIC(:,14) = piecewise({VOI>=CONSTANTS(:,19)&(VOI<=CONSTANTS(:,20)&(VOI - CONSTANTS(:,19)) - floor((VOI - CONSTANTS(:,19))./CONSTANTS(:,21)).*CONSTANTS(:,21)<=CONSTANTS(:,22)), CONSTANTS(:,23) }, 0.00000); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end