C C There are a total of 29 entries in the algebraic variable array. C There are a total of 9 entries in each of the rate and state variable arrays. C There are a total of 45 entries in the constant variable array. C C C VOI is time in component environment (millisecond). C CONSTS(1) is RT in component parameters (joule_per_mole). C STATES(1) is V_m in component membrane (millivolt). C CONSTS(2) is C_m in component membrane (picofarad). C ALGBRC(17) is I_Na in component I_Na (picoampere). C ALGBRC(19) is I_T in component I_T (picoampere). C ALGBRC(21) is I_KCa in component I_KCa (picoampere). C ALGBRC(26) is I_Ca in component I_Ca (picoampere). C ALGBRC(27) is I_L in component I_L (picoampere). C ALGBRC(29) is I_K in component I_K (picoampere). C ALGBRC(14) is I_stim in component I_stim (picoampere). C CONSTS(3) is I_mag in component I_stim (picoampere). C CONSTS(4) is t_0 in component I_stim (millisecond). C CONSTS(5) is t_1 in component I_stim (millisecond). C ALGBRC(4) is H_0 in component I_stim (dimensionless). C ALGBRC(10) is H_1 in component I_stim (dimensionless). C CONSTS(6) is g_Na in component I_Na (nanosiemens). C CONSTS(7) is E_Na in component I_Na (millivolt). C STATES(2) is m in component m (dimensionless). C STATES(3) is h in component h (dimensionless). C CONSTS(8) is E_m in component m (millivolt). C CONSTS(9) is V_alpha_m in component m (millivolt). C CONSTS(10) is V_beta_m in component m (millivolt). C ALGBRC(1) is alpha_m in component m (per_millisecond). C ALGBRC(7) is beta_m in component m (per_millisecond). C CONSTS(11) is alpha_m_max in component m (per_millivolt_per_millisecond). C CONSTS(12) is beta_m_max in component m (per_millisecond). C CONSTS(13) is E_h in component h (millivolt). C CONSTS(14) is V_alpha_h in component h (millivolt). C CONSTS(15) is V_beta_h in component h (millivolt). C ALGBRC(2) is alpha_h in component h (per_millisecond). C ALGBRC(8) is beta_h in component h (per_millisecond). C CONSTS(16) is alpha_h_max in component h (per_millisecond). C CONSTS(17) is beta_h_max in component h (per_millisecond). C CONSTS(18) is R_s in component I_T (per_nanosiemens). C CONSTS(19) is C_t in component I_T (picofarad). C STATES(4) is V_T in component V_T (millivolt). C CONSTS(20) is g_KCa in component I_KCa (nanosiemens). C CONSTS(21) is E_K in component I_K (millivolt). C STATES(5) is o in component o (dimensionless). C ALGBRC(20) is w in component w (dimensionless). C STATES(6) is c in component calcium_handling (dimensionless). C ALGBRC(16) is o_oinf in component o (dimensionless). C ALGBRC(3) is alpha_Vm in component o (per_millisecond). C ALGBRC(9) is beta_Vm in component o (per_millisecond). C ALGBRC(13) is tau_Vm in component o (millisecond). C CONSTS(22) is d_1 in component o (dimensionless). C CONSTS(23) is d_2 in component o (dimensionless). C CONSTS(24) is k_1 in component o (dimensionless). C CONSTS(25) is k_2 in component o (dimensionless). C CONSTS(26) is a_bar in component o (per_millisecond). C CONSTS(27) is b_bar in component o (per_millisecond). C CONSTS(28) is kd in component w (dimensionless). C STATES(7) is cer in component calcium_handling (dimensionless). C ALGBRC(28) is j_mem in component calcium_handling (picoampere). C ALGBRC(22) is j_leak in component calcium_handling (picoampere). C ALGBRC(23) is j_serca in component calcium_handling (picoampere). C ALGBRC(24) is j_er in component calcium_handling (picoampere). C CONSTS(29) is alpha in component calcium_handling (dimensionless). C CONSTS(30) is k_pmca in component calcium_handling (dimensionless). C CONSTS(31) is k_serca in component calcium_handling (picoampere). C CONSTS(32) is p_leak in component calcium_handling (picoampere). C CONSTS(33) is f_er in component calcium_handling (per_picoampere_per_millisecond). C CONSTS(34) is f_cyt in component calcium_handling (per_picoampere_per_millisecond). C CONSTS(35) is v_cytver in component calcium_handling (dimensionless). C STATES(8) is d in component d (dimensionless). C ALGBRC(25) is g_Ca in component I_Ca (nanosiemens). C CONSTS(36) is g_Ca0 in component I_Ca (nanosiemens_per_millivolt). C CONSTS(37) is E_Ca in component I_Ca (millivolt). C ALGBRC(15) is alpha_d in component d (per_millisecond). C ALGBRC(18) is beta_d in component d (per_millisecond). C ALGBRC(11) is tau_d in component d (millisecond). C ALGBRC(5) is d_infinity in component d (dimensionless). C CONSTS(38) is E_L in component I_L (millivolt). C CONSTS(39) is g_Lmax in component I_L (nanosiemens). C STATES(9) is n in component n (dimensionless). C CONSTS(40) is g_K in component I_K (nanosiemens). C CONSTS(41) is E_n in component n (millivolt). C CONSTS(42) is V_alpha_n in component n (millivolt). C CONSTS(43) is V_beta_n in component n (millivolt). C ALGBRC(6) is alpha_n in component n (per_millisecond). C ALGBRC(12) is beta_n in component n (per_millisecond). C CONSTS(44) is alpha_n_max in component n (per_millivolt_per_millisecond). C CONSTS(45) is beta_n_max in component n (per_millisecond). C RATES(1) is d/dt V_m in component membrane (millivolt). C RATES(2) is d/dt m in component m (dimensionless). C RATES(3) is d/dt h in component h (dimensionless). C RATES(4) is d/dt V_T in component V_T (millivolt). C RATES(5) is d/dt o in component o (dimensionless). C RATES(6) is d/dt c in component calcium_handling (dimensionless). C RATES(7) is d/dt cer in component calcium_handling (dimensionless). C RATES(8) is d/dt d in component d (dimensionless). C RATES(9) is d/dt n in component n (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 2577 STATES(1) = -75 CONSTS(2) = 0.009 CONSTS(3) = 2 CONSTS(4) = 5 CONSTS(5) = 6 CONSTS(6) = 0.45 CONSTS(7) = 50 STATES(2) = 0 STATES(3) = 1 CONSTS(8) = -42 CONSTS(9) = 10 CONSTS(10) = 18 CONSTS(11) = 0.208 CONSTS(12) = 2.081 CONSTS(13) = -41 CONSTS(14) = 14.7 CONSTS(15) = 7.6 CONSTS(16) = 0.0156 CONSTS(17) = 3.382 CONSTS(18) = 15 CONSTS(19) = 0.04 STATES(4) = -70 CONSTS(20) = 0.5 CONSTS(21) = -70 STATES(5) = 0.15 STATES(6) = 0.15 CONSTS(22) = 0.84 CONSTS(23) = 1 CONSTS(24) = 0.18 CONSTS(25) = 0.011 CONSTS(26) = 0.48 CONSTS(27) = 0.28 CONSTS(28) = 0.18 STATES(7) = 200 CONSTS(29) = 4.5e-6 CONSTS(30) = 0.2 CONSTS(31) = 0.4 CONSTS(32) = 0.0005 CONSTS(33) = 0.01 CONSTS(34) = 0.01 CONSTS(35) = 5 STATES(8) = 0 CONSTS(36) = 0.05 CONSTS(37) = 50 CONSTS(38) = -75 CONSTS(39) = 0.0024 STATES(9) = 0 CONSTS(40) = 0.415 CONSTS(41) = -40 CONSTS(42) = 7 CONSTS(43) = 40 CONSTS(44) = 0.0229 CONSTS(45) = 0.09616 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(4) = (STATES(1) - STATES(4))/( CONSTS(18)*CONSTS(19)) ALGBRC(1) = ( CONSTS(11)*(STATES(1) - CONSTS(8)))/(1.00000 - EXP((CONSTS(8) - STATES(1))/CONSTS(9))) ALGBRC(7) = CONSTS(12)*EXP((CONSTS(8) - STATES(1))/CONSTS(10)) RATES(2) = ALGBRC(1)*(1.00000 - STATES(2)) - ALGBRC(7)*STATES(2) ALGBRC(2) = CONSTS(16)*EXP((STATES(1) - CONSTS(13))/CONSTS(14)) ALGBRC(8) = CONSTS(17)/(1.00000+EXP((CONSTS(13) - STATES(1))/CONSTS(15))) RATES(3) = ALGBRC(2)*(1.00000 - STATES(3)) - ALGBRC(8)*STATES(3) ALGBRC(6) = ( CONSTS(44)*(STATES(1) - CONSTS(41)))/(1.00000 - EXP((CONSTS(41) - STATES(1))/CONSTS(42))) ALGBRC(12) = CONSTS(45)*EXP((CONSTS(41) - STATES(1))/CONSTS(43)) RATES(9) = ALGBRC(6)*(1.00000 - STATES(9)) - ALGBRC(12)*STATES(9) ALGBRC(3) = CONSTS(26)/(1.00000+ CONSTS(24)*EXP(( - 2.00000*CONSTS(22)*96.4850*STATES(1))/( CONSTS(1)*STATES(6)))) ALGBRC(9) = CONSTS(27)/(1.00000+STATES(6)/( CONSTS(25)*EXP(( - 2.00000*CONSTS(23)*96.4850*STATES(1))/CONSTS(1)))) ALGBRC(13) = 1.00000/(ALGBRC(3)+ALGBRC(9)) ALGBRC(16) = ALGBRC(3)*ALGBRC(13) RATES(5) = (ALGBRC(16) - STATES(5))/ALGBRC(13) ALGBRC(11) = ( 80.0000*1.00000)/cosh( - 0.0310000*(STATES(1)+37.1000)) ALGBRC(5) = 1.00000/(1.00000+EXP((- 24.6000 - STATES(1))/11.3000)) ALGBRC(15) = ALGBRC(5)/ALGBRC(11) ALGBRC(18) = (1.00000 - ALGBRC(5))/ALGBRC(11) RATES(8) = ALGBRC(15)*(1.00000 - STATES(8)) - ALGBRC(18)*STATES(8) ALGBRC(22) = CONSTS(32)*(STATES(7) - STATES(6)) ALGBRC(23) = CONSTS(31)*STATES(6) ALGBRC(24) = ALGBRC(22) - ALGBRC(23) RATES(7) = - CONSTS(33)*CONSTS(35)*ALGBRC(24) ALGBRC(25) = ( - CONSTS(36)*STATES(1))/(EXP( 0.117000*STATES(1)) - 1.00000) ALGBRC(26) = ALGBRC(25)*STATES(8) ** 2.00000*(STATES(1) - CONSTS(37)) ALGBRC(28) = - CONSTS(29)*ALGBRC(26)*CONSTS(30)*STATES(6) RATES(6) = CONSTS(34)*(ALGBRC(28)+ALGBRC(24)) ALGBRC(17) = CONSTS(6)*STATES(2) ** 3.00000*STATES(3)*(STATES(1) - CONSTS(7)) ALGBRC(19) = (STATES(1) - STATES(4))/CONSTS(18) ALGBRC(20) = STATES(6) ** 5.00000/(STATES(6) ** 5.00000+CONSTS(28) ** 5.00000) ALGBRC(21) = CONSTS(20)*STATES(5)*ALGBRC(20)*(STATES(1) - CONSTS(21)) ALGBRC(27) = CONSTS(39)*(STATES(1) - CONSTS(38)) ALGBRC(29) = CONSTS(40)*STATES(9) ** 4.00000*(STATES(1) - CONSTS(21)) ALGBRC(4) = TERNRY(VOI.LT.CONSTS(4), 0.00000, 1.00000) ALGBRC(10) = TERNRY(VOI.LT.CONSTS(5), 0.00000, 1.00000) ALGBRC(14) = CONSTS(3)*(ALGBRC(4) - ALGBRC(10)) RATES(1) = (ALGBRC(14) - (ALGBRC(17)+ALGBRC(26)+ALGBRC(29)+ALGBRC(27)+ALGBRC(19)+ALGBRC(21)))/CONSTS(2) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( CONSTS(11)*(STATES(1) - CONSTS(8)))/(1.00000 - EXP((CONSTS(8) - STATES(1))/CONSTS(9))) ALGBRC(7) = CONSTS(12)*EXP((CONSTS(8) - STATES(1))/CONSTS(10)) ALGBRC(2) = CONSTS(16)*EXP((STATES(1) - CONSTS(13))/CONSTS(14)) ALGBRC(8) = CONSTS(17)/(1.00000+EXP((CONSTS(13) - STATES(1))/CONSTS(15))) ALGBRC(6) = ( CONSTS(44)*(STATES(1) - CONSTS(41)))/(1.00000 - EXP((CONSTS(41) - STATES(1))/CONSTS(42))) ALGBRC(12) = CONSTS(45)*EXP((CONSTS(41) - STATES(1))/CONSTS(43)) ALGBRC(3) = CONSTS(26)/(1.00000+ CONSTS(24)*EXP(( - 2.00000*CONSTS(22)*96.4850*STATES(1))/( CONSTS(1)*STATES(6)))) ALGBRC(9) = CONSTS(27)/(1.00000+STATES(6)/( CONSTS(25)*EXP(( - 2.00000*CONSTS(23)*96.4850*STATES(1))/CONSTS(1)))) ALGBRC(13) = 1.00000/(ALGBRC(3)+ALGBRC(9)) ALGBRC(16) = ALGBRC(3)*ALGBRC(13) ALGBRC(11) = ( 80.0000*1.00000)/cosh( - 0.0310000*(STATES(1)+37.1000)) ALGBRC(5) = 1.00000/(1.00000+EXP((- 24.6000 - STATES(1))/11.3000)) ALGBRC(15) = ALGBRC(5)/ALGBRC(11) ALGBRC(18) = (1.00000 - ALGBRC(5))/ALGBRC(11) ALGBRC(22) = CONSTS(32)*(STATES(7) - STATES(6)) ALGBRC(23) = CONSTS(31)*STATES(6) ALGBRC(24) = ALGBRC(22) - ALGBRC(23) ALGBRC(25) = ( - CONSTS(36)*STATES(1))/(EXP( 0.117000*STATES(1)) - 1.00000) ALGBRC(26) = ALGBRC(25)*STATES(8) ** 2.00000*(STATES(1) - CONSTS(37)) ALGBRC(28) = - CONSTS(29)*ALGBRC(26)*CONSTS(30)*STATES(6) ALGBRC(17) = CONSTS(6)*STATES(2) ** 3.00000*STATES(3)*(STATES(1) - CONSTS(7)) ALGBRC(19) = (STATES(1) - STATES(4))/CONSTS(18) ALGBRC(20) = STATES(6) ** 5.00000/(STATES(6) ** 5.00000+CONSTS(28) ** 5.00000) ALGBRC(21) = CONSTS(20)*STATES(5)*ALGBRC(20)*(STATES(1) - CONSTS(21)) ALGBRC(27) = CONSTS(39)*(STATES(1) - CONSTS(38)) ALGBRC(29) = CONSTS(40)*STATES(9) ** 4.00000*(STATES(1) - CONSTS(21)) ALGBRC(4) = TERNRY(VOI.LT.CONSTS(4), 0.00000, 1.00000) ALGBRC(10) = TERNRY(VOI.LT.CONSTS(5), 0.00000, 1.00000) ALGBRC(14) = CONSTS(3)*(ALGBRC(4) - ALGBRC(10)) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END