Model Mathematics

Component: environment

Component: membrane

ddtimeV=-IK+ICa+IKCa+IKATPCm IK=gKnV-VK IKCa=gKCa1+kdc2V-VK ICa=gCaminfV-VCa minf=11+-20+V12 ninf=11+-16+V5 ddtimen=ninf-ntaun

Component: calcium_handling

ddtimec=fcytJmem+Jer ddtimecer=-fersigmaVJer Jserca=Ksercac Jleak=pleakcer-c Jer=epserJleak-Jsercalambdaer Jmem=-alphaICa+kpmcac

Component: glycolysis

f6p=0.3g6p rgpdh=0.2fbp1 ddtimefbp=lambdapfk1-0.5rgpdh ddtimeg6p=lambdaRgk1-pfk1

Component: pfk

pfk=1pfkbascattopa16+cattopbbottom16 weight2=atp2k41 topa2=topa1 bottom2=bottom1+weight2 weight3=f6p2k31 topa3=topa2+weight3 bottom3=bottom2+weight3 weight4=f6patp2fatpk3k412 topa4=topa3+weight4 bottom4=bottom3+weight4 weight5=fbpk2 topa5=topa4 bottom5=bottom4+weight5 weight6=fbpatp2k2k4fbt1 topa6=topa5 bottom6=bottom5+weight6 weight7=fbpf6p2k2k3ffbp1 topa7=topa6+weight7 bottom7=bottom6+weight7 weight8=fbpf6p2atp2k2k3k4ffbpfbtfatp12 topa8=topa7+weight8 bottom8=bottom7+weight8 weight9=ampk1 topa9=topa8 bottom9=bottom8+weight9 weight10=ampatp2k1k4fmt1 topa10=topa9 bottom10=bottom9+weight10 weight11=ampf6p2k1k3famp1 topa11=topa10+weight11 bottom11=bottom10+weight11 weight12=ampf6p2atp2k1k3k4fampfmtfatp12 topa12=topa11+weight12 bottom12=bottom11+weight12 weight13=ampfbpk1k2 topa13=topa12 bottom13=bottom12+weight13 weight14=ampfbpatp2k1k2k4fbtfmt1 topa14=topa13 bottom14=bottom13+weight14 weight15=ampfbpf6p2k1k2k3ffbpfamp1 topa15=topa14 bottom15=bottom14+weight15 topb=weight15 weight16=ampfbpf6p2atp2k1k2k3k4ffbpfampfbtfmtfatp12 topa16=topa15+weight16 bottom16=bottom15+weight16

Component: KATP

mgadp=0.165adp adp3m=0.135adp atp4m=0.05atp topo=0.081+2mgadpkdd1+0.89mgadpkdd12 bottomo=1+mgadpkdd121+adp3mktd1+atp4mktt1 katpo=topobottomo IKATP=gkatpbarkatpoV-VK

Component: nucleotides

ddtimeadp=atp-adpfback1-cr1taua1 fback=r+y y=vgrgpdhkg+rgpdh atp=0.5atot-adp+rad1 amp=adpadpatp ratio=atpadp rad=adp-atot2-4adp21