Model Mathematics

\frac{d}{d time} (Cdc13T) = k1 M - ((k2_+ k2__Ste9 + k2___Slp1) Cdc13T)

\frac{d}{d time} (preMPF) = kwee (Cdc13T - preMPF) - (k25 preMPF) - ((k2_+ k2__Ste9 + k2___Slp1) preMPF) kwee = kwee_+ \frac{(kwee__- kwee_) 2 Vawee Jiwee}{(Viwee MPF - Vawee) + Viwee MPF Jawee + Vawee Jiwee + \sqrt{{((Viwee MPF - Vawee) + Viwee MPF Jawee + Vawee Jiwee)}^{2} - (4 Vawee Jiwee (Viwee MPF - Vawee))}} k25 = k25_+ \frac{(k25__- k25_) 2 Va25 MPF Ji25}{(Vi25 - (Va25 MPF)) + Vi25 Ja25 + Va25 MPF Ji25 + \sqrt{{((Vi25 - (Va25 MPF)) + Vi25 Ja25 + Va25 MPF Ji25)}^{2} - (4 Va25 MPF Ji25 (Vi25 - (Va25 MPF)))}}

\frac{d}{d time} (Ste9) = \frac{(k3_+ k3__Slp1) (1 - Ste9)}{J3 + 1 - Ste9} - (\frac{(k4_SK + k4 MPF) Ste9}{J4 + Ste9})

\frac{d}{d time} (Slp1T) = k5_+ \frac{k5__{MPF}^{4}}{{J5}^{4} + {MPF}^{4}} - (k6 Slp1T)

\frac{d}{d time} (Slp1) = \frac{k7 IEP (Slp1T - Slp1)}{J7 + Slp1T - Slp1} - (\frac{k8 Slp1}{J8 + Slp1} + k6 Slp1)

\frac{d}{d time} (IEP) = \frac{k9 MPF (1 - IEP)}{J9 + 1 - IEP} - (\frac{k10 IEP}{J10 + IEP})

\frac{d}{d time} (Rum1T) = k11 - ((k12 + k12_SK + k12__MPF) Rum1T)

\frac{d}{d time} (SK) = k13 TF - (k14 SK)

\frac{d}{d time} (M) = mu M

Trimer = \frac{2 Cdc13T Rum1T}{sum + \sqrt{{sum}^{2} - (4 Cdc13T Rum1T)}} sum = Cdc13T + Rum1T + Kdiss

MPF = \frac{(Cdc13T - preMPF) (Cdc13T - Trimer)}{Cdc13T}

TF = \frac{2 k15 M J16}{(k16_+ k16__MPF - (k15 M)) + (k16_+ k16__MPF) J15 + k15 M J16 + \sqrt{{((k16_+ k16__MPF - (k15 M)) + (k16_+ k16__MPF) J15 + k15 M J16)}^{2} - (4 k15 M J16 (k16_+ k16__MPF - (k15 M)))}}