function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =17; end % There are a total of 5 entries in each of the rate and state variable arrays. % There are a total of 20 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (second)'); LEGEND_CONSTANTS(:,1) = strpad('C_m in component model_parameters (uF_per_cm2)'); LEGEND_STATES(:,1) = strpad('V_s in component soma_compartment (mV)'); LEGEND_CONSTANTS(:,2) = strpad('V_Na in component soma_compartment (mV)'); LEGEND_CONSTANTS(:,3) = strpad('V_K in component soma_compartment (mV)'); LEGEND_STATES(:,2) = strpad('V_D in component dendritic_compartment (mV)'); LEGEND_ALGEBRAIC(:,14) = strpad('I_Na in component soma_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,16) = strpad('I_soma in component soma_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,1) = strpad('I_h in component soma_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,7) = strpad('I_K_DR in component soma_compartment (uA_per_cm2)'); LEGEND_CONSTANTS(:,4) = strpad('g_K_DR in component soma_compartment (mS_per_cm2)'); LEGEND_CONSTANTS(:,5) = strpad('g_Na in component soma_compartment (mS_per_cm2)'); LEGEND_CONSTANTS(:,6) = strpad('g_c in component model_parameters (mS_per_cm2)'); LEGEND_CONSTANTS(:,7) = strpad('g_h in component soma_compartment (mS_per_cm2)'); LEGEND_CONSTANTS(:,8) = strpad('p in component model_parameters (dimensionless)'); LEGEND_STATES(:,3) = strpad('n in component gating_variables (dimensionless)'); LEGEND_STATES(:,4) = strpad('h in component gating_variables (dimensionless)'); LEGEND_ALGEBRAIC(:,11) = strpad('m_infinity in component gating_variables (dimensionless)'); LEGEND_CONSTANTS(:,9) = strpad('V_L in component dendritic_compartment (mV)'); LEGEND_ALGEBRAIC(:,17) = strpad('I_D in component dendritic_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,12) = strpad('I_L in component dendritic_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,8) = strpad('I_pump in component dendritic_compartment (uA_per_cm2)'); LEGEND_CONSTANTS(:,20) = strpad('I_pump_ss in component dendritic_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,15) = strpad('I_NMDA in component dendritic_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,13) = strpad('I_Na_NMDA in component dendritic_compartment (uA_per_cm2)'); LEGEND_CONSTANTS(:,15) = strpad('R_pump in component dendritic_compartment (uA_per_cm2)'); LEGEND_ALGEBRAIC(:,2) = strpad('f_NMDA in component dendritic_compartment (dimensionless)'); LEGEND_CONSTANTS(:,10) = strpad('alpha in component dendritic_compartment (mMcm2_per_uAs)'); LEGEND_CONSTANTS(:,16) = strpad('g_NMDA in component dendritic_compartment (mS_per_cm2)'); LEGEND_CONSTANTS(:,17) = strpad('g_Na_NMDA in component dendritic_compartment (mS_per_cm2)'); LEGEND_CONSTANTS(:,18) = strpad('g_L in component dendritic_compartment (mS_per_cm2)'); LEGEND_STATES(:,5) = strpad('Na in component dendritic_compartment (mM)'); LEGEND_CONSTANTS(:,11) = strpad('Na_eq in component dendritic_compartment (mM)'); LEGEND_CONSTANTS(:,12) = strpad('K_p in component dendritic_compartment (mM)'); LEGEND_CONSTANTS(:,13) = strpad('K_Na in component dendritic_compartment (mM)'); LEGEND_CONSTANTS(:,14) = strpad('q in component dendritic_compartment (mV)'); LEGEND_ALGEBRAIC(:,3) = strpad('n_infinity in component gating_variables (dimensionless)'); LEGEND_ALGEBRAIC(:,4) = strpad('h_infinity in component gating_variables (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('r_infinity in component gating_variables (dimensionless)'); LEGEND_ALGEBRAIC(:,9) = strpad('tau_h in component gating_variables (second)'); LEGEND_ALGEBRAIC(:,10) = strpad('tau_n in component gating_variables (second)'); LEGEND_ALGEBRAIC(:,6) = strpad('tau_mL in component gating_variables (second)'); LEGEND_CONSTANTS(:,19) = strpad('tau_r in component gating_variables (second)'); LEGEND_RATES(:,1) = strpad('d/dt V_s in component soma_compartment (mV)'); LEGEND_RATES(:,2) = strpad('d/dt V_D in component dendritic_compartment (mV)'); LEGEND_RATES(:,5) = strpad('d/dt Na in component dendritic_compartment (mM)'); LEGEND_RATES(:,4) = strpad('d/dt h in component gating_variables (dimensionless)'); LEGEND_RATES(:,3) = strpad('d/dt n in component gating_variables (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 1; STATES(:,1) = -64; CONSTANTS(:,2) = 55; CONSTANTS(:,3) = -85; STATES(:,2) = -77; CONSTANTS(:,4) = 3.2; CONSTANTS(:,5) = 3.2; CONSTANTS(:,6) = 0.1; CONSTANTS(:,7) = 0.1; CONSTANTS(:,8) = 0.5; STATES(:,3) = 0.002; STATES(:,4) = 1; CONSTANTS(:,9) = -50; CONSTANTS(:,10) = 0.173; STATES(:,5) = 5.09; CONSTANTS(:,11) = 8; CONSTANTS(:,12) = 15; CONSTANTS(:,13) = 15; CONSTANTS(:,14) = 12.5; CONSTANTS(:,15) = 18.0000.*(CONSTANTS(:,8)./(1.00000 - CONSTANTS(:,8))); CONSTANTS(:,16) = 1.25000.*(CONSTANTS(:,8)./(1.00000 - CONSTANTS(:,8))); CONSTANTS(:,17) = 1.00000.*(CONSTANTS(:,8)./(1.00000 - CONSTANTS(:,8))); CONSTANTS(:,18) = 0.180000.*(CONSTANTS(:,8)./(1.00000 - CONSTANTS(:,8))); CONSTANTS(:,19) = 190.000; CONSTANTS(:,20) = ( (( CONSTANTS(:,15).*CONSTANTS(:,8))./(1.00000 - CONSTANTS(:,8))).*power(CONSTANTS(:,11), 3.00000))./(power(CONSTANTS(:,13), 3.00000)+power(CONSTANTS(:,11), 3.00000)); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,4) = 1.00000./(1.00000+exp((STATES(:,1)+30.0000)./8.30000)); ALGEBRAIC(:,9) = 0.430000+0.860000./(1.00000+exp((STATES(:,1)+25.0000)./5.00000)); RATES(:,4) = (ALGEBRAIC(:,4) - STATES(:,4))./ALGEBRAIC(:,9); ALGEBRAIC(:,3) = 1.00000./(1.00000+exp( - (STATES(:,1)+31.0000)./5.30000)); ALGEBRAIC(:,10) = (0.800000+1.60000./(1.00000+exp( 0.100000.*(STATES(:,1)+25.0000))))./(1.00000+exp( - 0.100000.*(STATES(:,1)+70.0000))); RATES(:,3) = (ALGEBRAIC(:,3) - STATES(:,3))./ALGEBRAIC(:,10); ALGEBRAIC(:,8) = ( (( CONSTANTS(:,15).*CONSTANTS(:,8))./(1.00000 - CONSTANTS(:,8))).*power( STATES(:,2).*1.00000+STATES(:,5), 3.00000))./(power(CONSTANTS(:,12), 3.00000)+power( STATES(:,2).*1.00000+STATES(:,5), 3.00000)); ALGEBRAIC(:,2) = 1.00000./(1.00000+ 0.141000.*exp( - STATES(:,2)./CONSTANTS(:,14))); ALGEBRAIC(:,13) = CONSTANTS(:,17).*ALGEBRAIC(:,2).*(STATES(:,2) - CONSTANTS(:,2)); RATES(:,5) = CONSTANTS(:,10).*( - ALGEBRAIC(:,13) - 3.00000.*(ALGEBRAIC(:,8) - CONSTANTS(:,20))); ALGEBRAIC(:,11) = 1.00000./(1.00000+exp( - (STATES(:,1)+35.0000)./6.20000)); ALGEBRAIC(:,14) = CONSTANTS(:,5).*STATES(:,4).*(STATES(:,1) - CONSTANTS(:,2)).*power(ALGEBRAIC(:,11), 3.00000); ALGEBRAIC(:,1) = CONSTANTS(:,7).*STATES(:,4).*(STATES(:,1)+30.0000); ALGEBRAIC(:,7) = CONSTANTS(:,4).*(STATES(:,1) - CONSTANTS(:,3)).*power(STATES(:,3), 2.00000); ALGEBRAIC(:,16) = ALGEBRAIC(:,14)+ALGEBRAIC(:,7)+ALGEBRAIC(:,1); RATES(:,1) = ( - ALGEBRAIC(:,16) - (CONSTANTS(:,6)./CONSTANTS(:,8)).*(STATES(:,2) - STATES(:,1)))./CONSTANTS(:,1); ALGEBRAIC(:,12) = CONSTANTS(:,18).*(STATES(:,2) - CONSTANTS(:,9)); ALGEBRAIC(:,15) = CONSTANTS(:,16).*ALGEBRAIC(:,2).*STATES(:,2); ALGEBRAIC(:,17) = ((ALGEBRAIC(:,15)+ALGEBRAIC(:,8)) - CONSTANTS(:,20))+ALGEBRAIC(:,12); RATES(:,2) = ( - ALGEBRAIC(:,17)+ (CONSTANTS(:,6)./(1.00000 - CONSTANTS(:,8))).*(STATES(:,1) - STATES(:,2)))./CONSTANTS(:,1); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,4) = 1.00000./(1.00000+exp((STATES(:,1)+30.0000)./8.30000)); ALGEBRAIC(:,9) = 0.430000+0.860000./(1.00000+exp((STATES(:,1)+25.0000)./5.00000)); ALGEBRAIC(:,3) = 1.00000./(1.00000+exp( - (STATES(:,1)+31.0000)./5.30000)); ALGEBRAIC(:,10) = (0.800000+1.60000./(1.00000+exp( 0.100000.*(STATES(:,1)+25.0000))))./(1.00000+exp( - 0.100000.*(STATES(:,1)+70.0000))); ALGEBRAIC(:,8) = ( (( CONSTANTS(:,15).*CONSTANTS(:,8))./(1.00000 - CONSTANTS(:,8))).*power( STATES(:,2).*1.00000+STATES(:,5), 3.00000))./(power(CONSTANTS(:,12), 3.00000)+power( STATES(:,2).*1.00000+STATES(:,5), 3.00000)); ALGEBRAIC(:,2) = 1.00000./(1.00000+ 0.141000.*exp( - STATES(:,2)./CONSTANTS(:,14))); ALGEBRAIC(:,13) = CONSTANTS(:,17).*ALGEBRAIC(:,2).*(STATES(:,2) - CONSTANTS(:,2)); ALGEBRAIC(:,11) = 1.00000./(1.00000+exp( - (STATES(:,1)+35.0000)./6.20000)); ALGEBRAIC(:,14) = CONSTANTS(:,5).*STATES(:,4).*(STATES(:,1) - CONSTANTS(:,2)).*power(ALGEBRAIC(:,11), 3.00000); ALGEBRAIC(:,1) = CONSTANTS(:,7).*STATES(:,4).*(STATES(:,1)+30.0000); ALGEBRAIC(:,7) = CONSTANTS(:,4).*(STATES(:,1) - CONSTANTS(:,3)).*power(STATES(:,3), 2.00000); ALGEBRAIC(:,16) = ALGEBRAIC(:,14)+ALGEBRAIC(:,7)+ALGEBRAIC(:,1); ALGEBRAIC(:,12) = CONSTANTS(:,18).*(STATES(:,2) - CONSTANTS(:,9)); ALGEBRAIC(:,15) = CONSTANTS(:,16).*ALGEBRAIC(:,2).*STATES(:,2); ALGEBRAIC(:,17) = ((ALGEBRAIC(:,15)+ALGEBRAIC(:,8)) - CONSTANTS(:,20))+ALGEBRAIC(:,12); ALGEBRAIC(:,5) = 1.00000./(1.00000+exp((STATES(:,1)+80.0000)./8.00000)); ALGEBRAIC(:,6) = 0.400000./( 5.00000.*exp( - (STATES(:,2)+11.0000)./8.30000)+( - (STATES(:,2)+11.0000)./8.30000)./(exp( - (STATES(:,2)+11.0000)./8.30000) - 1.00000)); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end