/* There are a total of 2 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 18 entries in the constant variable array. */ /* * VOI is time in component environment (min). * STATES[0] is Z in component Ca (uM). * STATES[1] is Y in component Ca (uM). * CONSTANTS[17] is V_in in component V_in (uM_per_min). * ALGEBRAIC[0] is V_2 in component V_2 (uM_per_min). * ALGEBRAIC[1] is V_3 in component V_3 (uM_per_min). * CONSTANTS[0] is K_f in component Ca (per_min). * CONSTANTS[1] is K in component Ca (per_min). * CONSTANTS[2] is beta in component Ca_flux (dimensionless). * CONSTANTS[3] is v_0 in component V_in (uM_per_min). * CONSTANTS[4] is v_1 in component V_in (uM_per_min). * CONSTANTS[5] is V_M2 in component V_2 (uM_per_min). * CONSTANTS[6] is K_2 in component V_2 (uM). * STATES[2] is A in component A (uM). * CONSTANTS[7] is K_y in component V_3 (uM). * CONSTANTS[8] is K_z in component V_3 (uM). * CONSTANTS[9] is K_a in component V_3 (uM). * CONSTANTS[10] is V_M3 in component V_3 (uM_per_min). * CONSTANTS[11] is upsilon_p in component A (uM_per_min). * CONSTANTS[12] is upsilon_d in component A (uM_per_min). * CONSTANTS[13] is K_p in component A (uM). * CONSTANTS[14] is K_d in component A (uM). * CONSTANTS[15] is n in component A (dimensionless). * CONSTANTS[16] is epsilon in component A (per_min). * RATES[0] is d/dt Z in component Ca (uM). * RATES[1] is d/dt Y in component Ca (uM). * RATES[2] is d/dt A in component A (uM). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.1; STATES[1] = 1.0; CONSTANTS[0] = 1; CONSTANTS[1] = 10; CONSTANTS[2] = 0.5; CONSTANTS[3] = 2; CONSTANTS[4] = 1; CONSTANTS[5] = 6.5; CONSTANTS[6] = 0.1; STATES[2] = 0.5; CONSTANTS[7] = 0.2; CONSTANTS[8] = 0.3; CONSTANTS[9] = 0.2; CONSTANTS[10] = 19.5; CONSTANTS[11] = 2.5; CONSTANTS[12] = 80; CONSTANTS[13] = 1; CONSTANTS[14] = 0.4; CONSTANTS[15] = 4; CONSTANTS[16] = 0.1; CONSTANTS[17] = CONSTANTS[3]+ CONSTANTS[4]*CONSTANTS[2]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[2] = ( CONSTANTS[2]*CONSTANTS[11] - CONSTANTS[12]*(pow(STATES[2], 2.00000)/(pow(CONSTANTS[13], 2.00000)+pow(STATES[2], 2.00000)))*(pow(STATES[0], CONSTANTS[15])/(pow(CONSTANTS[14], CONSTANTS[15])+pow(STATES[0], CONSTANTS[15])))) - CONSTANTS[16]*STATES[2]; ALGEBRAIC[0] = CONSTANTS[5]*(pow(STATES[0], 2.00000)/(pow(CONSTANTS[6], 2.00000)+pow(STATES[0], 2.00000))); ALGEBRAIC[1] = CONSTANTS[10]*(pow(STATES[2], 4.00000)/(pow(CONSTANTS[9], 4.00000)+pow(STATES[2], 4.00000)))*(pow(STATES[1], 2.00000)/(pow(CONSTANTS[7], 2.00000)+pow(STATES[1], 2.00000)))*(pow(STATES[0], 4.00000)/(pow(CONSTANTS[8], 4.00000)+pow(STATES[0], 4.00000))); RATES[0] = (CONSTANTS[17] - ALGEBRAIC[0])+ALGEBRAIC[1]+( CONSTANTS[0]*STATES[1] - CONSTANTS[1]*STATES[0]); RATES[1] = (ALGEBRAIC[0] - ALGEBRAIC[1]) - CONSTANTS[0]*STATES[1]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[5]*(pow(STATES[0], 2.00000)/(pow(CONSTANTS[6], 2.00000)+pow(STATES[0], 2.00000))); ALGEBRAIC[1] = CONSTANTS[10]*(pow(STATES[2], 4.00000)/(pow(CONSTANTS[9], 4.00000)+pow(STATES[2], 4.00000)))*(pow(STATES[1], 2.00000)/(pow(CONSTANTS[7], 2.00000)+pow(STATES[1], 2.00000)))*(pow(STATES[0], 4.00000)/(pow(CONSTANTS[8], 4.00000)+pow(STATES[0], 4.00000))); }