Model Mathematics

Component: environment

Component: AP1

ddtimeAP1=v_sap1GFK_agf+GF-k_dap1AP1eps

Component: pRB

ddtimepRB=v_sprb-k_pc1pRBE2F+k_pc2pRBc1-V_1pRBK_1+pRBMd+Mdp27+V_2pRBpK_2+pRBp-k_dprbpRBeps

Component: pRBc1

ddtimepRBc1=k_pc1pRBE2F-k_pc2pRBc1eps

Component: pRBp

ddtimepRBp=V_1pRBK_1+pRBMd+Mdp27-V_2pRBpK_2+pRBp-V_3pRBpK_3+pRBpMe+V_4pRBppK_4+pRBpp-k_pc3pRBpE2F+k_pc4pRBc2-k_dpRBppRBpeps

Component: pRBc2

ddtimepRBc2=k_pc3pRBpE2F-k_pc4pRBc2eps

Component: pRBpp

ddtimepRBpp=V_3pRBpK_3+pRBpMe-V_4pRBppK_4+pRBpp-k_dpRBpppRBppeps

Component: E2F

ddtimeE2F=v_se2f-k_pc1pRBE2F+k_pc2pRBc1-k_pc3pRBpE2F+k_pc4pRBc2-V_1e2fMaE2FK_1e2f+E2F+V_2e2fE2FpK_2e2f+E2Fp-k_de2fE2Feps

Component: E2Fp

ddtimeE2Fp=V_1e2fMaE2FK_1e2f+E2F-V_2e2fE2FpK_2e2f+E2Fp-k_de2fpE2Fpeps

Component: Cd

ddtimeCd=k_cd1AP1+k_cd2E2FK_i7K_i7+pRBK_i8K_i8+pRBp-k_com1CdCdk4_tot-Mdi+Md+Mdp27+k_decom1Mdi-V_ddCdK_dd+Cd-k_dddCdeps

Component: Mdi

ddtimeMdi=k_com1CdCdk4_tot-Mdi+Md+Mdp27-k_decom1Mdi+V_m2dMdK_2d+Md-V_m1dMdiK_1d+Mdieps

Component: Md

ddtimeMd=V_m1dMdiK_1d+Mdi-V_m2dMdK_2d+Md-k_c1Mdp27+k_c2Mdp27eps

Component: Mdp27

ddtimeMdp27=k_c1Mdp27-k_c2Mdp27eps

Component: Ce

ddtimeCe=k_ceE2FK_i9K_i9+pRBK_i10K_i10+pRBp-k_com2CeCdk2_tot-Mei+Me+Mep27+Mai+Ma+Map27+k_decom2Mei-V_deSkp2K_dceskp2+Skp2CeK_de+Ce-k_ddeCeeps

Component: Mei

ddtimeMei=k_com2CeCdk2_tot-Mei+Me+Mep27+Mai+Ma+Map27-k_decom2Mei+V_m2eWee1+i_b1MeK_2e+Me-V_m1ePeMeiK_1e+Meieps

Component: Me

ddtimeMe=V_m1ePeMeiK_1e+Mei-V_m2eWee1+i_b1MeK_2e+Me-k_c3Mep27+k_c4Mep27eps

Component: Skp2

ddtimeSkp2=v_sskp2-V_dskp2Skp2K_dskp2+Skp2Cdh1aK_cdh1+Cdh1a-k_ddskp2Skp2eps

Component: Mep27

ddtimeMep27=k_c3Mep27-k_c4Mep27eps

Component: Pei

ddtimePei=v_spei+V_6ex_e1+x_e2Chk1PeK_6e+Pe-V_m5eMe+a_ePeiK_5e+Pei-k_dpeiPeieps

Component: Pe

ddtimePe=V_m5eMe+a_ePeiK_5e+Pei-V_6ex_e1+x_e2Chk1PeK_6e+Pe-k_dpePeeps

Component: Ca

ddtimeCa=k_caE2FK_i11K_i11+pRBK_i12K_i12+pRBp-k_com3CaCdk2_tot-Mei+Me+Mep27+Mai+Ma+Map27+k_decom3Mai-V_daCaK_da+CaCdc20aK_acdc20+Cdc20a-k_ddaCaeps

Component: Mai

ddtimeMai=k_com3CaCdk2_tot-Mei+Me+Mep27+Mai+Ma+Map27-k_decom3Mai+V_m2aWee1+i_b2MaK_2a+Ma-V_m1aPaMaiK_1a+Maieps

Component: Ma

ddtimeMa=V_m1aPaMaiK_1a+Mai-V_m2aWee1+i_b2MaK_2a+Ma-k_c5Map27+k_c6Map27eps

Component: Map27

ddtimeMap27=k_c5Map27-k_c6Map27eps

Component: p27

ddtimep27=v_s1p27+v_s2p27E2FK_i13K_i13+pRBK_i14K_i14+pRBp-k_c1Mdp27+k_c2Mdp27-k_c3Mep27+k_c4Mep27-k_c5Map27+k_c6Map27-k_c7Mbp27+k_c8Mbp27-V_1p27Mep27K_1p27+p27+V_2p27p27pK_2p27+p27p-k_ddp27p27eps

Component: p27p

ddtimep27p=V_1p27Mep27K_1p27+p27-V_2p27p27pK_2p27+p27p-V_dp27pSkp2K_dp27skp2+Skp2p27pK_dp27p+p27p-k_ddp27pp27peps

Component: Cdh1i

ddtimeCdh1i=V_2cdh1Cdh1aK_2cdh1+Cdh1aMa+Mb-V_1cdh1Cdh1iK_1cdh1+Cdh1i-k_dcdh1iCdh1ieps

Component: Cdh1a

ddtimeCdh1a=v_scdh1a+V_1cdh1Cdh1iK_1cdh1+Cdh1i-V_2cdh1Cdh1aK_2cdh1+Cdh1aMa+Mb-k_dcdh1aCdh1aeps

Component: Pai

ddtimePai=v_spai+V_6ax_a1+x_a2Chk1PaK_6a+Pa-V_m5aMa+a_aPaiK_5a+Pai-k_dpaiPaieps

Component: Pa

ddtimePa=V_m5aMa+a_aPaiK_5a+Pai-V_6ax_a1+x_a2Chk1PaK_6a+Pa-k_dpaPaeps

Component: Cb

ddtimeCb=v_cb-k_com4CbCdk1_tot-Mbi+Mb+Mbp27+k_decom4Mbi-V_dbCbK_db+CbCdc20aK_dbcdc20+Cdc20a+Cdh1aK_dbcdh1+Cdh1a-k_ddbCbeps

Component: Mbi

ddtimeMbi=k_com4CbCdk1_tot-Mbi+Mb+Mbp27-k_decom4Mbi+V_m2bWee1+i_b3MbK_2b+Mb-V_m1bPbMbiK_1b+Mbieps

Component: Mb

ddtimeMb=V_m1bPbMbiK_1b+Mbi-V_m2bWee1+i_b3MbK_2b+Mb-k_c7Mbp27+k_c8Mbp27eps

Component: Mbp27

ddtimeMbp27=k_c7Mbp27-k_c8Mbp27eps

Component: Cdc20i

ddtimeCdc20i=v_scdc20i-V_m3bMbCdc20iK_3b+Cdc20i+V_m4bCdc20aK_4b+Cdc20a-k_dcdc20iCdc20ieps

Component: Cdc20a

ddtimeCdc20a=V_m3bMbCdc20iK_3b+Cdc20i-V_m4bCdc20aK_4b+Cdc20a-k_dcdc20aCdc20aeps

Component: Pbi

ddtimePbi=v_spbi+V_6bx_b1+x_b2Chk1PbK_6b+Pb-V_m5bMb+a_bPbiK_5b+Pbi-k_dpbiPbieps

Component: Pb

ddtimePb=V_m5bMb+a_bPbiK_5b+Pbi-V_6bx_b1+x_b2Chk1PbK_6b+Pb-k_dpbPbeps

Component: Wee1

ddtimeWee1=v_swee1+k_swMw-V_m7bMb+i_bWee1K_7b+Wee1+V_m8bWee1pK_8b+Wee1p-k_dwee1Wee1eps

Component: Wee1p

ddtimeWee1p=V_m7bMb+i_bWee1K_7b+Wee1-V_m8bWee1pK_8b+Wee1p-k_dwee1pWee1peps

Component: Cdc45

ddtimeCdc45=V_1cdc45MeCdc45_tot-Cdc45K_1cdc45+Cdc45_tot-Cdc45-V_2cdc45Cdc45K_2cdc45+Cdc45-k_spolPol_tot-PolCdc45+k_dpolPoleps

Component: Pol

ddtimePol=k_spolPol_tot-PolCdc45-k_dpolPoleps

Component: Primer

ddtimePrimer=k_sprimPol-k_dprimPrimer-k_aatrATR_tot-ATRPrimer+k_datrATReps

Component: ATR

ddtimeATR=k_aatrATR_tot-ATRPrimer-k_datrATReps

Component: Chk1

ddtimeChk1=V_1chkATRChk1_tot-Chk1K_1chk+Chk1_tot-Chk1-V_2chkChk1K_2chk+Chk1eps

Component: Mw

ddtimeMw=v_swBNn_gerardK_iwn_gerard+BNn_gerard-v_dwMwK_dw+Mw

Component: X

ddtimeX=V_1xMaX_tot-XK_1x+X_tot-X-V_2xXK_2x+Xeps

Component: CbA

ddtimeCbA=v_cbX1-k_com4CbACdk1_tot-Mbi+Mb+Mbp27+k_decom4Mbi-V_dbCbAK_db+CbACdc20aK_dbcdc20+Cdc20a+Cdh1aK_dbcdh1+Cdh1a-k_ddbCbAeps

Component: MP

ddtimeMP=vsPBNnKAPn+BNn-vmPMPKmP+MP+kdmpMP

Component: MC

ddtimeMC=vsCBNnKACn+BNn-vmCMCKmC+MC+kdmcMC

Component: MB

ddtimeMB=vsBKIBmKIBm+RNm-vmBMBKmB+MB+kdmbMB

Component: MR

ddtimeMR=vsRBNhKARh+BNh-vmRMRKmR+MR+kdmrMR

Component: PC

ddtimePC=ksPMP+V2PPCPKdp+PCP+k4PCC-V1PPCKp+PC+k3PCCC+kdnPC

Component: CC

ddtimeCC=ksCMC+V2CCCPKdp+CCP+k4PCC-V1CCCKp+CC+k3PCCC+kdncCC

Component: RC

ddtimeRC=ksRMR+k10RN-k9RC+vdRCRCKd+RC+kdnRC

Component: PCP

ddtimePCP=V1PPCKp+PC-V2PPCPKdp+PCP+vdPCPCPKd+PCP+kdnPCP

Component: CCP

ddtimeCCP=V1CCCKp+CC-V2CCCPKdp+CCP+vdCCCCPKd+CCP+kdnCCP

Component: PCC

ddtimePCC=V2PCPCCPKdp+PCCP+k3PCCC+k2PCN-V1PCPCCKp+PCC+k4PCC+k1PCC+kdnPCC

Component: PCN

ddtimePCN=V4PCPCNPKdp+PCNP+k1PCC+k8IN-V3PCPCNKp+PCN+k2PCN+k7BNPCN+kdnPCN

Component: RN

ddtimeRN=k9RC-k10RN+vdRNRNKd+RN+kdnRN

Component: PCCP

ddtimePCCP=V1PCPCCKp+PCC-V2PCPCCPKdp+PCCP+vdPCCPCCPKd+PCCP+kdnPCCP

Component: PCNP

ddtimePCNP=V3PCPCNKp+PCN-V4PCPCNPKdp+PCNP+vdPCNPCNPKd+PCNP+kdnPCNP

Component: BC

ddtimeBC=V2BBCPKdp+BCP+k6BN+ksBMB-V1BBCKp+BC+k5BC+kdnBC

Component: BCP

ddtimeBCP=V1BBCKp+BC-V2BBCPKdp+BCP+vdBCBCPKd+BCP+kdnBCP

Component: BN

ddtimeBN=V4BBNPKdp+BNP+k5BC+k8IN-V3BBNKp+BN+k6BN+k7BNPCN+kdnBN

Component: BNP

ddtimeBNP=V3BBNKp+BN-V4BBNPKdp+BNP+vdBNBNPKd+BNP+kdnBNP

Component: IN

ddtimeIN=k7BNPCN-k8IN+vdININKd+IN+kdnIN

Component: model_parameters

Model Curation
  • Curation Status c2
  • JSim c0
  • COR c2
  • OpenCell c2
Source
Derived from workspace Gerard and Goldbeter 2009 at changeset 1befde9589f3.
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License

This work is licensed under a Creative Commons Attribution 3.0 Unported License.