/* There are a total of 68 entries in the algebraic variable array. There are a total of 17 entries in each of the rate and state variable arrays. There are a total of 47 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is R in component membrane (joule_per_mole_kelvin). * CONSTANTS[1] is T in component membrane (kelvin). * CONSTANTS[2] is F in component membrane (coulomb_per_millimole). * CONSTANTS[3] is Cm in component membrane (microF_per_cm2). * CONSTANTS[4] is V_c in component membrane (micrometre3). * ALGEBRAIC[49] is i_K1 in component inward_rectifier_potassium_current (picoA_per_picoF). * ALGEBRAIC[56] is i_to in component transient_outward_current (picoA_per_picoF). * ALGEBRAIC[50] is i_Kr in component rapid_time_dependent_potassium_current (picoA_per_picoF). * ALGEBRAIC[51] is i_Ks in component slow_time_dependent_potassium_current (picoA_per_picoF). * ALGEBRAIC[54] is i_CaL in component L_type_Ca_current (picoA_per_picoF). * ALGEBRAIC[57] is i_NaK in component sodium_potassium_pump_current (picoA_per_picoF). * ALGEBRAIC[52] is i_Na in component fast_sodium_current (picoA_per_picoF). * ALGEBRAIC[53] is i_b_Na in component sodium_background_current (picoA_per_picoF). * ALGEBRAIC[58] is i_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF). * ALGEBRAIC[55] is i_b_Ca in component calcium_background_current (picoA_per_picoF). * ALGEBRAIC[60] is i_p_K in component potassium_pump_current (picoA_per_picoF). * ALGEBRAIC[59] is i_p_Ca in component calcium_pump_current (picoA_per_picoF). * ALGEBRAIC[64] is i_Stim in component membrane (picoA_per_picoF). * ALGEBRAIC[62] is Istim in component stimulus_protocol (picoA_per_picoF). * ALGEBRAIC[0] is E_Na in component reversal_potentials (millivolt). * ALGEBRAIC[13] is E_K in component reversal_potentials (millivolt). * ALGEBRAIC[26] is E_Ks in component reversal_potentials (millivolt). * ALGEBRAIC[35] is E_Ca in component reversal_potentials (millivolt). * CONSTANTS[5] is P_kna in component reversal_potentials (nanoA_per_millimolar). * CONSTANTS[6] is K_o in component potassium_dynamics (millimolar). * CONSTANTS[7] is Na_o in component sodium_dynamics (millimolar). * STATES[1] is K_i in component potassium_dynamics (millimolar). * STATES[2] is Na_i in component sodium_dynamics (millimolar). * CONSTANTS[8] is Ca_o in component calcium_dynamics (millimolar). * STATES[3] is Ca_i in component calcium_dynamics (millimolar). * CONSTANTS[9] is g_K1 in component inward_rectifier_potassium_current (nanoS_per_picoF). * ALGEBRAIC[48] is xK1_inf in component inward_rectifier_potassium_current (dimensionless). * ALGEBRAIC[44] is alpha_K1 in component inward_rectifier_potassium_current (dimensionless). * ALGEBRAIC[47] is beta_K1 in component inward_rectifier_potassium_current (dimensionless). * CONSTANTS[10] is g_Kr in component rapid_time_dependent_potassium_current (nanoS_per_picoF). * STATES[4] is Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * STATES[5] is Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * ALGEBRAIC[1] is xr1_inf in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * ALGEBRAIC[14] is alpha_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (per_millisecond). * ALGEBRAIC[27] is beta_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (per_millisecond). * ALGEBRAIC[36] is tau_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (millisecond). * ALGEBRAIC[2] is xr2_inf in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * ALGEBRAIC[15] is alpha_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (per_millisecond). * ALGEBRAIC[28] is beta_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (per_millisecond). * ALGEBRAIC[37] is tau_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (millisecond). * CONSTANTS[11] is g_Ks in component slow_time_dependent_potassium_current (nanoS_per_picoF). * STATES[6] is Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * ALGEBRAIC[3] is xs_inf in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * ALGEBRAIC[16] is alpha_xs in component slow_time_dependent_potassium_current_Xs_gate (per_millisecond). * ALGEBRAIC[29] is beta_xs in component slow_time_dependent_potassium_current_Xs_gate (per_millisecond). * ALGEBRAIC[38] is tau_xs in component slow_time_dependent_potassium_current_Xs_gate (millisecond). * CONSTANTS[12] is g_Na in component fast_sodium_current (nanoS_per_picoF). * STATES[7] is m in component fast_sodium_current_m_gate (dimensionless). * STATES[8] is h in component fast_sodium_current_h_gate (dimensionless). * STATES[9] is j in component fast_sodium_current_j_gate (dimensionless). * ALGEBRAIC[4] is m_inf in component fast_sodium_current_m_gate (dimensionless). * ALGEBRAIC[17] is alpha_m in component fast_sodium_current_m_gate (per_millisecond). * ALGEBRAIC[30] is beta_m in component fast_sodium_current_m_gate (per_millisecond). * ALGEBRAIC[39] is tau_m in component fast_sodium_current_m_gate (millisecond). * ALGEBRAIC[5] is h_inf in component fast_sodium_current_h_gate (dimensionless). * ALGEBRAIC[18] is alpha_h in component fast_sodium_current_h_gate (per_millisecond). * ALGEBRAIC[31] is beta_h in component fast_sodium_current_h_gate (per_millisecond). * ALGEBRAIC[40] is tau_h in component fast_sodium_current_h_gate (millisecond). * ALGEBRAIC[6] is j_inf in component fast_sodium_current_j_gate (dimensionless). * ALGEBRAIC[19] is alpha_j in component fast_sodium_current_j_gate (per_millisecond). * ALGEBRAIC[32] is beta_j in component fast_sodium_current_j_gate (per_millisecond). * ALGEBRAIC[41] is tau_j in component fast_sodium_current_j_gate (millisecond). * CONSTANTS[13] is g_bna in component sodium_background_current (nanoS_per_picoF). * CONSTANTS[14] is g_CaL in component L_type_Ca_current (nanoS_per_picoF). * STATES[10] is d in component L_type_Ca_current_d_gate (dimensionless). * STATES[11] is f in component L_type_Ca_current_f_gate (dimensionless). * STATES[12] is fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[7] is d_inf in component L_type_Ca_current_d_gate (dimensionless). * ALGEBRAIC[20] is alpha_d in component L_type_Ca_current_d_gate (per_millisecond). * ALGEBRAIC[33] is beta_d in component L_type_Ca_current_d_gate (per_millisecond). * ALGEBRAIC[42] is gamma_d in component L_type_Ca_current_d_gate (per_millisecond). * ALGEBRAIC[45] is tau_d in component L_type_Ca_current_d_gate (millisecond). * ALGEBRAIC[8] is f_inf in component L_type_Ca_current_f_gate (dimensionless). * ALGEBRAIC[21] is tau_f in component L_type_Ca_current_f_gate (millisecond). * ALGEBRAIC[9] is alpha_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[22] is beta_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[34] is gama_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[43] is fCa_inf in component L_type_Ca_current_fCa_gate (dimensionless). * CONSTANTS[46] is tau_fCa in component L_type_Ca_current_fCa_gate (millisecond). * ALGEBRAIC[46] is d_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * CONSTANTS[15] is g_bca in component calcium_background_current (nanoS_per_picoF). * CONSTANTS[16] is g_to in component transient_outward_current (nanoS_per_picoF). * STATES[13] is s in component transient_outward_current_s_gate (dimensionless). * STATES[14] is r in component transient_outward_current_r_gate (dimensionless). * ALGEBRAIC[10] is s_inf in component transient_outward_current_s_gate (dimensionless). * ALGEBRAIC[23] is tau_s in component transient_outward_current_s_gate (dimensionless). * ALGEBRAIC[11] is r_inf in component transient_outward_current_r_gate (dimensionless). * ALGEBRAIC[24] is tau_r in component transient_outward_current_r_gate (millisecond). * CONSTANTS[17] is P_NaK in component sodium_potassium_pump_current (picoA_per_picoF). * CONSTANTS[18] is K_mk in component sodium_potassium_pump_current (millimolar). * CONSTANTS[19] is K_mNa in component sodium_potassium_pump_current (millimolar). * CONSTANTS[20] is K_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF). * CONSTANTS[21] is K_sat in component sodium_calcium_exchanger_current (dimensionless). * CONSTANTS[22] is alpha in component sodium_calcium_exchanger_current (dimensionless). * CONSTANTS[23] is gamma in component sodium_calcium_exchanger_current (dimensionless). * CONSTANTS[24] is Km_Ca in component sodium_calcium_exchanger_current (millimolar). * CONSTANTS[25] is Km_Nai in component sodium_calcium_exchanger_current (millimolar). * CONSTANTS[26] is g_pCa in component calcium_pump_current (nanoS_per_picoF). * CONSTANTS[27] is K_pCa in component calcium_pump_current (millimolar). * CONSTANTS[28] is g_pK in component potassium_pump_current (nanoS_per_picoF). * STATES[15] is Ca_SR in component calcium_dynamics (millimolar). * ALGEBRAIC[61] is i_rel in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[63] is i_up in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[65] is i_leak in component calcium_dynamics (millimolar_per_millisecond). * STATES[16] is g in component calcium_dynamics (dimensionless). * CONSTANTS[29] is tau_g in component calcium_dynamics (millisecond). * ALGEBRAIC[12] is g_inf in component calcium_dynamics (dimensionless). * CONSTANTS[30] is a_rel in component calcium_dynamics (millimolar_per_millisecond). * CONSTANTS[31] is b_rel in component calcium_dynamics (millimolar). * CONSTANTS[32] is c_rel in component calcium_dynamics (millimolar_per_millisecond). * CONSTANTS[33] is K_up in component calcium_dynamics (millimolar). * CONSTANTS[34] is V_leak in component calcium_dynamics (per_millisecond). * CONSTANTS[35] is Vmax_up in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[66] is Ca_i_bufc in component calcium_dynamics (millimolar). * ALGEBRAIC[67] is Ca_sr_bufsr in component calcium_dynamics (millimolar). * CONSTANTS[36] is Buf_c in component calcium_dynamics (millimolar). * CONSTANTS[37] is K_buf_c in component calcium_dynamics (millimolar). * CONSTANTS[38] is Buf_sr in component calcium_dynamics (millimolar). * CONSTANTS[39] is K_buf_sr in component calcium_dynamics (millimolar). * CONSTANTS[40] is V_sr in component calcium_dynamics (micrometre3). * ALGEBRAIC[25] is d_g in component calcium_dynamics (dimensionless). * CONSTANTS[41] is IstimStart in component stimulus_protocol (millisecond). * CONSTANTS[42] is IstimEnd in component stimulus_protocol (millisecond). * CONSTANTS[43] is IstimAmplitude in component stimulus_protocol (picoA_per_picoF). * CONSTANTS[44] is IstimPeriod in component stimulus_protocol (millisecond). * CONSTANTS[45] is IstimPulseDuration in component stimulus_protocol (millisecond). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[4] is d/dt Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * RATES[5] is d/dt Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * RATES[6] is d/dt Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * RATES[7] is d/dt m in component fast_sodium_current_m_gate (dimensionless). * RATES[8] is d/dt h in component fast_sodium_current_h_gate (dimensionless). * RATES[9] is d/dt j in component fast_sodium_current_j_gate (dimensionless). * RATES[10] is d/dt d in component L_type_Ca_current_d_gate (dimensionless). * RATES[11] is d/dt f in component L_type_Ca_current_f_gate (dimensionless). * RATES[12] is d/dt fCa in component L_type_Ca_current_fCa_gate (dimensionless). * RATES[13] is d/dt s in component transient_outward_current_s_gate (dimensionless). * RATES[14] is d/dt r in component transient_outward_current_r_gate (dimensionless). * RATES[16] is d/dt g in component calcium_dynamics (dimensionless). * RATES[3] is d/dt Ca_i in component calcium_dynamics (millimolar). * RATES[15] is d/dt Ca_SR in component calcium_dynamics (millimolar). * RATES[2] is d/dt Na_i in component sodium_dynamics (millimolar). * RATES[1] is d/dt K_i in component potassium_dynamics (millimolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -86.2; CONSTANTS[0] = 8314.472; CONSTANTS[1] = 310; CONSTANTS[2] = 96485.3415; CONSTANTS[3] = 0.185; CONSTANTS[4] = 0.016404; CONSTANTS[5] = 0.03; CONSTANTS[6] = 5.4; CONSTANTS[7] = 140; STATES[1] = 138.3; STATES[2] = 11.6; CONSTANTS[8] = 2; STATES[3] = 0.0002; CONSTANTS[9] = 5.405; CONSTANTS[10] = 0.096; STATES[4] = 0; STATES[5] = 1; CONSTANTS[11] = 0.245; STATES[6] = 0; CONSTANTS[12] = 14.838; STATES[7] = 0; STATES[8] = 0.75; STATES[9] = 0.75; CONSTANTS[13] = 0.00029; CONSTANTS[14] = 0.000175; STATES[10] = 0; STATES[11] = 1; STATES[12] = 1; CONSTANTS[15] = 0.000592; CONSTANTS[16] = 0.073; STATES[13] = 1; STATES[14] = 0; CONSTANTS[17] = 1.362; CONSTANTS[18] = 1; CONSTANTS[19] = 40; CONSTANTS[20] = 1000; CONSTANTS[21] = 0.1; CONSTANTS[22] = 2.5; CONSTANTS[23] = 0.35; CONSTANTS[24] = 1.38; CONSTANTS[25] = 87.5; CONSTANTS[26] = 0.825; CONSTANTS[27] = 0.0005; CONSTANTS[28] = 0.0146; STATES[15] = 0.2; STATES[16] = 1; CONSTANTS[29] = 2; CONSTANTS[30] = 0.016464; CONSTANTS[31] = 0.25; CONSTANTS[32] = 0.008232; CONSTANTS[33] = 0.00025; CONSTANTS[34] = 8e-5; CONSTANTS[35] = 0.000425; CONSTANTS[36] = 0.15; CONSTANTS[37] = 0.001; CONSTANTS[38] = 10; CONSTANTS[39] = 0.3; CONSTANTS[40] = 0.001094; CONSTANTS[41] = 100; CONSTANTS[42] = 50000; CONSTANTS[43] = -52; CONSTANTS[44] = 1000; CONSTANTS[45] = 1; CONSTANTS[46] = 2.00000; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/7.00000)); ALGEBRAIC[21] = 1125.00*exp(- pow(STATES[0]+27.0000, 2.00000)/240.000)+80.0000+165.000/(1.00000+exp((25.0000 - STATES[0])/10.0000)); RATES[11] = (ALGEBRAIC[8] - STATES[11])/ALGEBRAIC[21]; ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+28.0000)/5.00000)); ALGEBRAIC[23] = 1000.00*exp(- pow(STATES[0]+67.0000, 2.00000)/1000.00)+8.00000; RATES[13] = (ALGEBRAIC[10] - STATES[13])/ALGEBRAIC[23]; ALGEBRAIC[11] = 1.00000/(1.00000+exp((20.0000 - STATES[0])/6.00000)); ALGEBRAIC[24] = 9.50000*exp(- pow(STATES[0]+40.0000, 2.00000)/1800.00)+0.800000; RATES[14] = (ALGEBRAIC[11] - STATES[14])/ALGEBRAIC[24]; ALGEBRAIC[12] = (STATES[3]<0.000350000 ? 1.00000/(1.00000+pow(STATES[3]/0.000350000, 6.00000)) : 1.00000/(1.00000+pow(STATES[3]/0.000350000, 16.0000))); ALGEBRAIC[25] = (ALGEBRAIC[12] - STATES[16])/CONSTANTS[29]; RATES[16] = ( 0.0100000*ALGEBRAIC[25]>0.00000&&STATES[0]>- 60.0000 ? 0.00000 : ALGEBRAIC[25]); ALGEBRAIC[1] = 1.00000/(1.00000+exp((- 26.0000 - STATES[0])/7.00000)); ALGEBRAIC[14] = 450.000/(1.00000+exp((- 45.0000 - STATES[0])/10.0000)); ALGEBRAIC[27] = 6.00000/(1.00000+exp((STATES[0]+30.0000)/11.5000)); ALGEBRAIC[36] = ALGEBRAIC[14]*ALGEBRAIC[27]; RATES[4] = (ALGEBRAIC[1] - STATES[4])/ALGEBRAIC[36]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+88.0000)/24.0000)); ALGEBRAIC[15] = 3.00000/(1.00000+exp((- 60.0000 - STATES[0])/20.0000)); ALGEBRAIC[28] = 1.12000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[37] = ALGEBRAIC[15]*ALGEBRAIC[28]; RATES[5] = (ALGEBRAIC[2] - STATES[5])/ALGEBRAIC[37]; ALGEBRAIC[3] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/14.0000)); ALGEBRAIC[16] = 1100.00/ pow((1.00000+exp((- 10.0000 - STATES[0])/6.00000)), 1.0 / 2); ALGEBRAIC[29] = 1.00000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[38] = ALGEBRAIC[16]*ALGEBRAIC[29]; RATES[6] = (ALGEBRAIC[3] - STATES[6])/ALGEBRAIC[38]; ALGEBRAIC[4] = 1.00000/pow(1.00000+exp((- 56.8600 - STATES[0])/9.03000), 2.00000); ALGEBRAIC[17] = 1.00000/(1.00000+exp((- 60.0000 - STATES[0])/5.00000)); ALGEBRAIC[30] = 0.100000/(1.00000+exp((STATES[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((STATES[0] - 50.0000)/200.000)); ALGEBRAIC[39] = ALGEBRAIC[17]*ALGEBRAIC[30]; RATES[7] = (ALGEBRAIC[4] - STATES[7])/ALGEBRAIC[39]; ALGEBRAIC[5] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[18] = (STATES[0]<- 40.0000 ? 0.0570000*exp(- (STATES[0]+80.0000)/6.80000) : 0.00000); ALGEBRAIC[31] = (STATES[0]<- 40.0000 ? 2.70000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.348500*STATES[0]) : 0.770000/( 0.130000*(1.00000+exp((STATES[0]+10.6600)/- 11.1000)))); ALGEBRAIC[40] = 1.00000/(ALGEBRAIC[18]+ALGEBRAIC[31]); RATES[8] = (ALGEBRAIC[5] - STATES[8])/ALGEBRAIC[40]; ALGEBRAIC[6] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[19] = (STATES[0]<- 40.0000 ? ( ( - 25428.0*exp( 0.244400*STATES[0]) - 6.94800e-06*exp( - 0.0439100*STATES[0]))*(STATES[0]+37.7800))/(1.00000+exp( 0.311000*(STATES[0]+79.2300))) : 0.00000); ALGEBRAIC[32] = (STATES[0]<- 40.0000 ? ( 0.0242400*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400))) : ( 0.600000*exp( 0.0570000*STATES[0]))/(1.00000+exp( - 0.100000*(STATES[0]+32.0000)))); ALGEBRAIC[41] = 1.00000/(ALGEBRAIC[19]+ALGEBRAIC[32]); RATES[9] = (ALGEBRAIC[6] - STATES[9])/ALGEBRAIC[41]; ALGEBRAIC[7] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/7.50000)); ALGEBRAIC[20] = 1.40000/(1.00000+exp((- 35.0000 - STATES[0])/13.0000))+0.250000; ALGEBRAIC[33] = 1.40000/(1.00000+exp((STATES[0]+5.00000)/5.00000)); ALGEBRAIC[42] = 1.00000/(1.00000+exp((50.0000 - STATES[0])/20.0000)); ALGEBRAIC[45] = ALGEBRAIC[20]*ALGEBRAIC[33]+ALGEBRAIC[42]; RATES[10] = (ALGEBRAIC[7] - STATES[10])/ALGEBRAIC[45]; ALGEBRAIC[9] = 1.00000/(1.00000+pow(STATES[3]/0.000325000, 8.00000)); ALGEBRAIC[22] = 0.100000/(1.00000+exp((STATES[3] - 0.000500000)/0.000100000)); ALGEBRAIC[34] = 0.200000/(1.00000+exp((STATES[3] - 0.000750000)/0.000800000)); ALGEBRAIC[43] = (ALGEBRAIC[9]+ALGEBRAIC[22]+ALGEBRAIC[34]+0.230000)/1.46000; ALGEBRAIC[46] = (ALGEBRAIC[43] - STATES[12])/CONSTANTS[46]; RATES[12] = ( 0.0100000*ALGEBRAIC[46]>0.00000&&STATES[0]>- 60.0000 ? 0.00000 : ALGEBRAIC[46]); ALGEBRAIC[57] = (( (( CONSTANTS[17]*CONSTANTS[6])/(CONSTANTS[6]+CONSTANTS[18]))*STATES[2])/(STATES[2]+CONSTANTS[19]))/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[0] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[7]/STATES[2]); ALGEBRAIC[52] = CONSTANTS[12]*pow(STATES[7], 3.00000)*STATES[8]*STATES[9]*(STATES[0] - ALGEBRAIC[0]); ALGEBRAIC[53] = CONSTANTS[13]*(STATES[0] - ALGEBRAIC[0]); ALGEBRAIC[58] = ( CONSTANTS[20]*( exp(( CONSTANTS[23]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[8] - exp(( (CONSTANTS[23] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[7], 3.00000)*STATES[3]*CONSTANTS[22]))/( (pow(CONSTANTS[25], 3.00000)+pow(CONSTANTS[7], 3.00000))*(CONSTANTS[24]+CONSTANTS[8])*(1.00000+ CONSTANTS[21]*exp(( (CONSTANTS[23] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))); RATES[2] = (- (ALGEBRAIC[52]+ALGEBRAIC[53]+ 3.00000*ALGEBRAIC[57]+ 3.00000*ALGEBRAIC[58])/( CONSTANTS[4]*CONSTANTS[2]))*CONSTANTS[3]; ALGEBRAIC[13] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[6]/STATES[1]); ALGEBRAIC[44] = 0.100000/(1.00000+exp( 0.0600000*((STATES[0] - ALGEBRAIC[13]) - 200.000))); ALGEBRAIC[47] = ( 3.00000*exp( 0.000200000*((STATES[0] - ALGEBRAIC[13])+100.000))+exp( 0.100000*((STATES[0] - ALGEBRAIC[13]) - 10.0000)))/(1.00000+exp( - 0.500000*(STATES[0] - ALGEBRAIC[13]))); ALGEBRAIC[48] = ALGEBRAIC[44]/(ALGEBRAIC[44]+ALGEBRAIC[47]); ALGEBRAIC[49] = CONSTANTS[9]*ALGEBRAIC[48]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[56] = CONSTANTS[16]*STATES[14]*STATES[13]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[50] = CONSTANTS[10]* pow((CONSTANTS[6]/5.40000), 1.0 / 2)*STATES[4]*STATES[5]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[26] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[6]+ CONSTANTS[5]*CONSTANTS[7])/(STATES[1]+ CONSTANTS[5]*STATES[2])); ALGEBRAIC[51] = CONSTANTS[11]*pow(STATES[6], 2.00000)*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[54] = ( (( CONSTANTS[14]*STATES[10]*STATES[11]*STATES[12]*4.00000*STATES[0]*pow(CONSTANTS[2], 2.00000))/( CONSTANTS[0]*CONSTANTS[1]))*( STATES[3]*exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 0.341000*CONSTANTS[8]))/(exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 1.00000); ALGEBRAIC[35] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[8]/STATES[3]); ALGEBRAIC[55] = CONSTANTS[15]*(STATES[0] - ALGEBRAIC[35]); ALGEBRAIC[60] = ( CONSTANTS[28]*(STATES[0] - ALGEBRAIC[13]))/(1.00000+exp((25.0000 - STATES[0])/5.98000)); ALGEBRAIC[59] = ( CONSTANTS[26]*STATES[3])/(STATES[3]+CONSTANTS[27]); ALGEBRAIC[62] = (VOI>=CONSTANTS[41]&&VOI<=CONSTANTS[42]&&(VOI - CONSTANTS[41]) - floor((VOI - CONSTANTS[41])/CONSTANTS[44])*CONSTANTS[44]<=CONSTANTS[45] ? CONSTANTS[43] : 0.00000); ALGEBRAIC[64] = ALGEBRAIC[62]; RATES[0] = (- 1.00000/1.00000)*(ALGEBRAIC[49]+ALGEBRAIC[56]+ALGEBRAIC[50]+ALGEBRAIC[51]+ALGEBRAIC[54]+ALGEBRAIC[57]+ALGEBRAIC[52]+ALGEBRAIC[53]+ALGEBRAIC[58]+ALGEBRAIC[55]+ALGEBRAIC[60]+ALGEBRAIC[59]+ALGEBRAIC[64]); RATES[1] = (- ((ALGEBRAIC[49]+ALGEBRAIC[56]+ALGEBRAIC[50]+ALGEBRAIC[51]+ALGEBRAIC[60]+ALGEBRAIC[64]) - 2.00000*ALGEBRAIC[57])/( CONSTANTS[4]*CONSTANTS[2]))*CONSTANTS[3]; ALGEBRAIC[61] = (( CONSTANTS[30]*pow(STATES[15], 2.00000))/(pow(CONSTANTS[31], 2.00000)+pow(STATES[15], 2.00000))+CONSTANTS[32])*STATES[10]*STATES[16]; ALGEBRAIC[63] = CONSTANTS[35]/(1.00000+pow(CONSTANTS[33], 2.00000)/pow(STATES[3], 2.00000)); ALGEBRAIC[65] = CONSTANTS[34]*(STATES[15] - STATES[3]); ALGEBRAIC[66] = 1.00000/(1.00000+( CONSTANTS[36]*CONSTANTS[37])/pow(STATES[3]+CONSTANTS[37], 2.00000)); RATES[3] = ALGEBRAIC[66]*(((ALGEBRAIC[65] - ALGEBRAIC[63])+ALGEBRAIC[61]) - (((ALGEBRAIC[54]+ALGEBRAIC[55]+ALGEBRAIC[59]) - 2.00000*ALGEBRAIC[58])/( 2.00000*CONSTANTS[4]*CONSTANTS[2]))*CONSTANTS[3]); ALGEBRAIC[67] = 1.00000/(1.00000+( CONSTANTS[38]*CONSTANTS[39])/pow(STATES[15]+CONSTANTS[39], 2.00000)); RATES[15] = (( ALGEBRAIC[67]*CONSTANTS[4])/CONSTANTS[40])*(ALGEBRAIC[63] - (ALGEBRAIC[61]+ALGEBRAIC[65])); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/7.00000)); ALGEBRAIC[21] = 1125.00*exp(- pow(STATES[0]+27.0000, 2.00000)/240.000)+80.0000+165.000/(1.00000+exp((25.0000 - STATES[0])/10.0000)); ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+28.0000)/5.00000)); ALGEBRAIC[23] = 1000.00*exp(- pow(STATES[0]+67.0000, 2.00000)/1000.00)+8.00000; ALGEBRAIC[11] = 1.00000/(1.00000+exp((20.0000 - STATES[0])/6.00000)); ALGEBRAIC[24] = 9.50000*exp(- pow(STATES[0]+40.0000, 2.00000)/1800.00)+0.800000; ALGEBRAIC[12] = (STATES[3]<0.000350000 ? 1.00000/(1.00000+pow(STATES[3]/0.000350000, 6.00000)) : 1.00000/(1.00000+pow(STATES[3]/0.000350000, 16.0000))); ALGEBRAIC[25] = (ALGEBRAIC[12] - STATES[16])/CONSTANTS[29]; ALGEBRAIC[1] = 1.00000/(1.00000+exp((- 26.0000 - STATES[0])/7.00000)); ALGEBRAIC[14] = 450.000/(1.00000+exp((- 45.0000 - STATES[0])/10.0000)); ALGEBRAIC[27] = 6.00000/(1.00000+exp((STATES[0]+30.0000)/11.5000)); ALGEBRAIC[36] = ALGEBRAIC[14]*ALGEBRAIC[27]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+88.0000)/24.0000)); ALGEBRAIC[15] = 3.00000/(1.00000+exp((- 60.0000 - STATES[0])/20.0000)); ALGEBRAIC[28] = 1.12000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[37] = ALGEBRAIC[15]*ALGEBRAIC[28]; ALGEBRAIC[3] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/14.0000)); ALGEBRAIC[16] = 1100.00/ pow((1.00000+exp((- 10.0000 - STATES[0])/6.00000)), 1.0 / 2); ALGEBRAIC[29] = 1.00000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[38] = ALGEBRAIC[16]*ALGEBRAIC[29]; ALGEBRAIC[4] = 1.00000/pow(1.00000+exp((- 56.8600 - STATES[0])/9.03000), 2.00000); ALGEBRAIC[17] = 1.00000/(1.00000+exp((- 60.0000 - STATES[0])/5.00000)); ALGEBRAIC[30] = 0.100000/(1.00000+exp((STATES[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((STATES[0] - 50.0000)/200.000)); ALGEBRAIC[39] = ALGEBRAIC[17]*ALGEBRAIC[30]; ALGEBRAIC[5] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[18] = (STATES[0]<- 40.0000 ? 0.0570000*exp(- (STATES[0]+80.0000)/6.80000) : 0.00000); ALGEBRAIC[31] = (STATES[0]<- 40.0000 ? 2.70000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.348500*STATES[0]) : 0.770000/( 0.130000*(1.00000+exp((STATES[0]+10.6600)/- 11.1000)))); ALGEBRAIC[40] = 1.00000/(ALGEBRAIC[18]+ALGEBRAIC[31]); ALGEBRAIC[6] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[19] = (STATES[0]<- 40.0000 ? ( ( - 25428.0*exp( 0.244400*STATES[0]) - 6.94800e-06*exp( - 0.0439100*STATES[0]))*(STATES[0]+37.7800))/(1.00000+exp( 0.311000*(STATES[0]+79.2300))) : 0.00000); ALGEBRAIC[32] = (STATES[0]<- 40.0000 ? ( 0.0242400*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400))) : ( 0.600000*exp( 0.0570000*STATES[0]))/(1.00000+exp( - 0.100000*(STATES[0]+32.0000)))); ALGEBRAIC[41] = 1.00000/(ALGEBRAIC[19]+ALGEBRAIC[32]); ALGEBRAIC[7] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/7.50000)); ALGEBRAIC[20] = 1.40000/(1.00000+exp((- 35.0000 - STATES[0])/13.0000))+0.250000; ALGEBRAIC[33] = 1.40000/(1.00000+exp((STATES[0]+5.00000)/5.00000)); ALGEBRAIC[42] = 1.00000/(1.00000+exp((50.0000 - STATES[0])/20.0000)); ALGEBRAIC[45] = ALGEBRAIC[20]*ALGEBRAIC[33]+ALGEBRAIC[42]; ALGEBRAIC[9] = 1.00000/(1.00000+pow(STATES[3]/0.000325000, 8.00000)); ALGEBRAIC[22] = 0.100000/(1.00000+exp((STATES[3] - 0.000500000)/0.000100000)); ALGEBRAIC[34] = 0.200000/(1.00000+exp((STATES[3] - 0.000750000)/0.000800000)); ALGEBRAIC[43] = (ALGEBRAIC[9]+ALGEBRAIC[22]+ALGEBRAIC[34]+0.230000)/1.46000; ALGEBRAIC[46] = (ALGEBRAIC[43] - STATES[12])/CONSTANTS[46]; ALGEBRAIC[57] = (( (( CONSTANTS[17]*CONSTANTS[6])/(CONSTANTS[6]+CONSTANTS[18]))*STATES[2])/(STATES[2]+CONSTANTS[19]))/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[0] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[7]/STATES[2]); ALGEBRAIC[52] = CONSTANTS[12]*pow(STATES[7], 3.00000)*STATES[8]*STATES[9]*(STATES[0] - ALGEBRAIC[0]); ALGEBRAIC[53] = CONSTANTS[13]*(STATES[0] - ALGEBRAIC[0]); ALGEBRAIC[58] = ( CONSTANTS[20]*( exp(( CONSTANTS[23]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[8] - exp(( (CONSTANTS[23] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[7], 3.00000)*STATES[3]*CONSTANTS[22]))/( (pow(CONSTANTS[25], 3.00000)+pow(CONSTANTS[7], 3.00000))*(CONSTANTS[24]+CONSTANTS[8])*(1.00000+ CONSTANTS[21]*exp(( (CONSTANTS[23] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))); ALGEBRAIC[13] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[6]/STATES[1]); ALGEBRAIC[44] = 0.100000/(1.00000+exp( 0.0600000*((STATES[0] - ALGEBRAIC[13]) - 200.000))); ALGEBRAIC[47] = ( 3.00000*exp( 0.000200000*((STATES[0] - ALGEBRAIC[13])+100.000))+exp( 0.100000*((STATES[0] - ALGEBRAIC[13]) - 10.0000)))/(1.00000+exp( - 0.500000*(STATES[0] - ALGEBRAIC[13]))); ALGEBRAIC[48] = ALGEBRAIC[44]/(ALGEBRAIC[44]+ALGEBRAIC[47]); ALGEBRAIC[49] = CONSTANTS[9]*ALGEBRAIC[48]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[56] = CONSTANTS[16]*STATES[14]*STATES[13]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[50] = CONSTANTS[10]* pow((CONSTANTS[6]/5.40000), 1.0 / 2)*STATES[4]*STATES[5]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[26] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[6]+ CONSTANTS[5]*CONSTANTS[7])/(STATES[1]+ CONSTANTS[5]*STATES[2])); ALGEBRAIC[51] = CONSTANTS[11]*pow(STATES[6], 2.00000)*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[54] = ( (( CONSTANTS[14]*STATES[10]*STATES[11]*STATES[12]*4.00000*STATES[0]*pow(CONSTANTS[2], 2.00000))/( CONSTANTS[0]*CONSTANTS[1]))*( STATES[3]*exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 0.341000*CONSTANTS[8]))/(exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 1.00000); ALGEBRAIC[35] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[8]/STATES[3]); ALGEBRAIC[55] = CONSTANTS[15]*(STATES[0] - ALGEBRAIC[35]); ALGEBRAIC[60] = ( CONSTANTS[28]*(STATES[0] - ALGEBRAIC[13]))/(1.00000+exp((25.0000 - STATES[0])/5.98000)); ALGEBRAIC[59] = ( CONSTANTS[26]*STATES[3])/(STATES[3]+CONSTANTS[27]); ALGEBRAIC[62] = (VOI>=CONSTANTS[41]&&VOI<=CONSTANTS[42]&&(VOI - CONSTANTS[41]) - floor((VOI - CONSTANTS[41])/CONSTANTS[44])*CONSTANTS[44]<=CONSTANTS[45] ? CONSTANTS[43] : 0.00000); ALGEBRAIC[64] = ALGEBRAIC[62]; ALGEBRAIC[61] = (( CONSTANTS[30]*pow(STATES[15], 2.00000))/(pow(CONSTANTS[31], 2.00000)+pow(STATES[15], 2.00000))+CONSTANTS[32])*STATES[10]*STATES[16]; ALGEBRAIC[63] = CONSTANTS[35]/(1.00000+pow(CONSTANTS[33], 2.00000)/pow(STATES[3], 2.00000)); ALGEBRAIC[65] = CONSTANTS[34]*(STATES[15] - STATES[3]); ALGEBRAIC[66] = 1.00000/(1.00000+( CONSTANTS[36]*CONSTANTS[37])/pow(STATES[3]+CONSTANTS[37], 2.00000)); ALGEBRAIC[67] = 1.00000/(1.00000+( CONSTANTS[38]*CONSTANTS[39])/pow(STATES[15]+CONSTANTS[39], 2.00000)); }