C C There are a total of 21 entries in the algebraic variable array. C There are a total of 8 entries in each of the rate and state variable arrays. C There are a total of 55 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is Vm in component membrane (millivolt). C ALGBRC(9) is I_iCa in component membrane (picoampere). C ALGBRC(12) is I_iNa in component membrane (picoampere). C CONSTS(1) is Cm in component membrane (picofarad). C ALGBRC(3) is I_Ca in component I_Ca (picoampere). C ALGBRC(10) is I_Na in component I_Na (picoampere). C ALGBRC(5) is I_NSCC_Ca in component I_NSCC_Ca (picoampere). C ALGBRC(8) is I_PM in component I_PM (picoampere). C ALGBRC(7) is I_NSCC_Na in component I_NSCC_Na (picoampere). C CONSTS(2) is gCa in component I_Ca (picosiemens). C ALGBRC(1) is ECa in component I_Ca (millivolt). C CONSTS(3) is T in component model_parameters (kelvin). C CONSTS(4) is R in component model_parameters (attojoule_per_zeptomole_kelvin). C CONSTS(5) is F in component model_parameters (femtocoulomb_per_zeptomole). C CONSTS(6) is CO in component model_parameters (micromolar). C STATES(2) is CS1 in component CS1 (micromolar). C CONSTS(7) is gNSCC_Ca_ in component I_NSCC_Ca (picosiemens). C ALGBRC(4) is gNSCC_Ca in component I_NSCC_Ca (picosiemens). C CONSTS(8) is hNSCC in component model_parameters (dimensionless). C CONSTS(9) is ENSCC in component model_parameters (millivolt). C CONSTS(10) is KNSCC in component model_parameters (micromolar). C CONSTS(11) is gNSCC_Na_ in component I_NSCC_Na (picosiemens). C ALGBRC(6) is gNSCC_Na in component I_NSCC_Na (picosiemens). C CONSTS(12) is gPM in component I_PM (femtoampere). C CONSTS(13) is KPM in component I_PM (micromolar). C CONSTS(14) is gNa in component I_Na (femtoampere). C CONSTS(15) is KNa in component I_Na (micromolar). C CONSTS(16) is hNa in component I_Na (dimensionless). C STATES(3) is NS1 in component NS1 (micromolar). C ALGBRC(11) is JSERCA in component JSERCA (flux). C CONSTS(17) is VSERCA in component JSERCA (first_order_rate_constant). C CONSTS(18) is A2 in component JSERCA (dimensionless). C CONSTS(19) is A4 in component JSERCA (per_micromolar). C CONSTS(20) is A5 in component JSERCA (per_micromolar). C CONSTS(21) is A6 in component JSERCA (per_micromolar2). C STATES(4) is CER in component CER (micromolar). C ALGBRC(14) is JMCU in component JMCU (flux). C CONSTS(22) is VMCU in component JMCU (flux). C CONSTS(23) is KMCU in component JMCU (micromolar). C ALGBRC(13) is epsilon_INH in component JMCU (dimensionless). C CONSTS(24) is KINH in component JMCU (micromolar). C CONSTS(25) is hINH in component JMCU (dimensionless). C STATES(5) is CS2 in component CS2 (micromolar). C STATES(6) is CMT in component CMT (micromolar). C ALGBRC(15) is JNCX in component JNCX (flux). C CONSTS(26) is VNCX in component JNCX (flux). C CONSTS(27) is KNCX in component JNCX (micromolar). C ALGBRC(16) is JS1S2 in component JS1S2 (flux). C CONSTS(28) is mu_S1S2 in component JS1S2 (first_order_rate_constant). C ALGBRC(20) is JIPR in component JIPR (flux). C CONSTS(29) is kIPR in component JIPR (first_order_rate_constant). C CONSTS(30) is k_1 in component JIPR (flux). C CONSTS(31) is k1 in component JIPR (first_order_rate_constant). C CONSTS(32) is k2 in component JIPR (first_order_rate_constant). C CONSTS(33) is r2 in component JIPR (first_order_rate_constant). C CONSTS(34) is r_2 in component JIPR (flux). C CONSTS(35) is r4 in component JIPR (first_order_rate_constant). C CONSTS(36) is R1 in component JIPR (micromolar). C CONSTS(37) is R3 in component JIPR (micromolar). C ALGBRC(18) is phi1 in component JIPR (first_order_rate_constant). C ALGBRC(19) is phi_1 in component JIPR (flux). C ALGBRC(21) is phi2 in component JIPR (first_order_rate_constant). C STATES(7) is phi3 in component JIPR (first_order_rate_constant). C STATES(8) is H in component JIPR (dimensionless). C CONSTS(38) is g_beta in component JIPR (first_order_rate_constant). C CONSTS(39) is h_beta in component JIPR (dimensionless). C CONSTS(40) is g_alpha in component JIPR (per_second_squared). C CONSTS(41) is K_beta in component JIPR (micromolar). C CONSTS(51) is alpha_phi3 in component JIPR (per_second_squared). C ALGBRC(2) is beta_phi3 in component JIPR (first_order_rate_constant). C CONSTS(42) is P in component model_parameters (micromolar). C CONSTS(50) is lambda_MT_S1 in component CS1 (dimensionless). C CONSTS(52) is lambda_ER_S1 in component CS1 (dimensionless). C CONSTS(43) is delta_s in component model_parameters (micromolar_coulomb). C CONSTS(44) is gamma_S1 in component model_parameters (dimensionless). C CONSTS(45) is gamma_MT in component model_parameters (dimensionless). C CONSTS(46) is gamma_ER in component model_parameters (dimensionless). C CONSTS(53) is lambda_MT_S2 in component CS2 (dimensionless). C CONSTS(54) is lambda_ER_S2 in component CS2 (dimensionless). C CONSTS(55) is lambda_S1_S2 in component CS2 (dimensionless). C CONSTS(47) is gamma_S2 in component model_parameters (dimensionless). C ALGBRC(17) is fm in component CMT (dimensionless). C CONSTS(48) is Km in component CMT (micromolar). C CONSTS(49) is Bm in component CMT (micromolar). C RATES(1) is d/dt Vm in component membrane (millivolt). C RATES(8) is d/dt H in component JIPR (dimensionless). C RATES(7) is d/dt phi3 in component JIPR (first_order_rate_constant). C RATES(2) is d/dt CS1 in component CS1 (micromolar). C RATES(5) is d/dt CS2 in component CS2 (micromolar). C RATES(4) is d/dt CER in component CER (micromolar). C RATES(6) is d/dt CMT in component CMT (micromolar). C RATES(3) is d/dt NS1 in component NS1 (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -70.1 CONSTS(1) = 20.0 CONSTS(2) = 0.01 CONSTS(3) = 310.16 CONSTS(4) = 8.314E-3 CONSTS(5) = 0.09649 CONSTS(6) = 1.8E3 STATES(2) = 0.120 CONSTS(7) = 0.12 CONSTS(8) = 3.0 CONSTS(9) = 0.0 CONSTS(10) = 0.12 CONSTS(11) = 220.0 CONSTS(12) = 420.0 CONSTS(13) = 1.0 CONSTS(14) = 1.5E4 CONSTS(15) = 1.0E4 CONSTS(16) = 4.0 STATES(3) = 1.01E4 CONSTS(17) = 1.0E5 CONSTS(18) = 6E-4 CONSTS(19) = 3.57 CONSTS(20) = 2.7E-5 CONSTS(21) = 2.31E-5 STATES(4) = 203.0 CONSTS(22) = 800.0 CONSTS(23) = 10.0 CONSTS(24) = 10.0 CONSTS(25) = 4.0 STATES(5) = 0.023 STATES(6) = 0.220 CONSTS(26) = 0.5 CONSTS(27) = 0.3 CONSTS(28) = 0.04 CONSTS(29) = 2000.0 CONSTS(30) = 6.4 CONSTS(31) = 0.0 CONSTS(32) = 4.0 CONSTS(33) = 200.0 CONSTS(34) = 0.0 CONSTS(35) = 750.0 CONSTS(36) = 36.0 CONSTS(37) = 300.0 STATES(7) = 0.306 STATES(8) = 0.787 CONSTS(38) = 300.0 CONSTS(39) = 2.0 CONSTS(40) = 0.02 CONSTS(41) = 2.0 CONSTS(42) = 1.0 CONSTS(43) = 26.0 CONSTS(44) = 100.0 CONSTS(45) = 200.0 CONSTS(46) = 20.0 CONSTS(47) = 1.0 CONSTS(48) = 0.01 CONSTS(49) = 100.0 CONSTS(50) = CONSTS(45)/CONSTS(44) CONSTS(51) = CONSTS(40) CONSTS(52) = CONSTS(46)/CONSTS(44) CONSTS(53) = CONSTS(45)/CONSTS(47) CONSTS(54) = CONSTS(46)/CONSTS(47) CONSTS(55) = CONSTS(44)/CONSTS(47) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(38)*(STATES(5) ** CONSTS(39)/(CONSTS(41) ** CONSTS(39)+STATES(5) ** CONSTS(39))) RATES(7) = CONSTS(51) - ALGBRC(2)*STATES(7) ALGBRC(1) = (( CONSTS(4)*CONSTS(3))/( 2.00000*CONSTS(5)))*log(CONSTS(6)/STATES(2)) ALGBRC(3) = CONSTS(2)*(STATES(1) - ALGBRC(1)) ALGBRC(4) = CONSTS(7)*(CONSTS(10) ** CONSTS(8)/(CONSTS(10) ** CONSTS(8)+STATES(2) ** CONSTS(8))) ALGBRC(5) = ALGBRC(4)*(STATES(1) - CONSTS(9)) ALGBRC(8) = CONSTS(12)*(STATES(2) ** 2.00000/(CONSTS(13) ** 2.00000+STATES(2) ** 2.00000)) ALGBRC(9) = ALGBRC(3)+ALGBRC(5)+ALGBRC(8) ALGBRC(10) = CONSTS(14)*(STATES(3) ** CONSTS(16)/(CONSTS(15) ** CONSTS(16)+STATES(3) ** CONSTS(16))) ALGBRC(6) = CONSTS(11)*(CONSTS(10) ** CONSTS(8)/(CONSTS(10) ** CONSTS(8)+STATES(2) ** CONSTS(8))) ALGBRC(7) = ALGBRC(6)*(STATES(1) - CONSTS(9)) ALGBRC(12) = ALGBRC(7)+ALGBRC(10) RATES(1) = - ((ALGBRC(9)+ALGBRC(12))/CONSTS(1)) RATES(3) = - (CONSTS(43)/1.00000)*ALGBRC(12) ALGBRC(11) = ( CONSTS(17)*(STATES(2) - CONSTS(18)*STATES(4)))/(1.00000+ CONSTS(19)*STATES(2)+ CONSTS(20)*STATES(4)+ CONSTS(21)*STATES(2)*STATES(4)) ALGBRC(15) = CONSTS(26)*(STATES(6)/(STATES(6)+CONSTS(27))) ALGBRC(16) = CONSTS(28)*(STATES(5) - STATES(2)) RATES(2) = (ALGBRC(16)+ CONSTS(50)*ALGBRC(15)) - ( (CONSTS(43)/2.00000)*ALGBRC(9)+ CONSTS(52)*ALGBRC(11)) ALGBRC(13) = CONSTS(24) ** CONSTS(25)/(CONSTS(24) ** CONSTS(25)+STATES(6) ** CONSTS(25)) ALGBRC(14) = CONSTS(22)*(STATES(5) ** 2.00000/(CONSTS(23) ** 2.00000+STATES(5) ** 2.00000))*ALGBRC(13) ALGBRC(17) = 1.00000/(1.00000+( CONSTS(48)*CONSTS(49))/CONSTS(48)+STATES(6) ** 2.00000) RATES(6) = ALGBRC(17)*(ALGBRC(14) - ALGBRC(15)) ALGBRC(18) = ( CONSTS(31)*CONSTS(36)+ CONSTS(33)*STATES(5))/(CONSTS(36)+STATES(5)) ALGBRC(19) = ( (CONSTS(30)+CONSTS(34))*CONSTS(37))/(CONSTS(37)+STATES(5)) ALGBRC(21) = ( CONSTS(32)*CONSTS(37)+ CONSTS(35)*STATES(5))/(CONSTS(37)+STATES(5)) RATES(8) = STATES(7)*(1.00000 - STATES(8)) - (( CONSTS(42)*ALGBRC(18)*ALGBRC(21))/( CONSTS(42)*ALGBRC(18)+ALGBRC(19)))*STATES(8) ALGBRC(20) = CONSTS(29)*( CONSTS(42)*ALGBRC(18)*STATES(8))/( CONSTS(42)*ALGBRC(18)+ALGBRC(19)) ** 4.00000*(STATES(4) - STATES(5)) RATES(5) = CONSTS(54)*ALGBRC(20) - ( CONSTS(55)*ALGBRC(16)+ CONSTS(53)*ALGBRC(14)) RATES(4) = ALGBRC(11) - ALGBRC(20) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(38)*(STATES(5) ** CONSTS(39)/(CONSTS(41) ** CONSTS(39)+STATES(5) ** CONSTS(39))) ALGBRC(1) = (( CONSTS(4)*CONSTS(3))/( 2.00000*CONSTS(5)))*log(CONSTS(6)/STATES(2)) ALGBRC(3) = CONSTS(2)*(STATES(1) - ALGBRC(1)) ALGBRC(4) = CONSTS(7)*(CONSTS(10) ** CONSTS(8)/(CONSTS(10) ** CONSTS(8)+STATES(2) ** CONSTS(8))) ALGBRC(5) = ALGBRC(4)*(STATES(1) - CONSTS(9)) ALGBRC(8) = CONSTS(12)*(STATES(2) ** 2.00000/(CONSTS(13) ** 2.00000+STATES(2) ** 2.00000)) ALGBRC(9) = ALGBRC(3)+ALGBRC(5)+ALGBRC(8) ALGBRC(10) = CONSTS(14)*(STATES(3) ** CONSTS(16)/(CONSTS(15) ** CONSTS(16)+STATES(3) ** CONSTS(16))) ALGBRC(6) = CONSTS(11)*(CONSTS(10) ** CONSTS(8)/(CONSTS(10) ** CONSTS(8)+STATES(2) ** CONSTS(8))) ALGBRC(7) = ALGBRC(6)*(STATES(1) - CONSTS(9)) ALGBRC(12) = ALGBRC(7)+ALGBRC(10) ALGBRC(11) = ( CONSTS(17)*(STATES(2) - CONSTS(18)*STATES(4)))/(1.00000+ CONSTS(19)*STATES(2)+ CONSTS(20)*STATES(4)+ CONSTS(21)*STATES(2)*STATES(4)) ALGBRC(15) = CONSTS(26)*(STATES(6)/(STATES(6)+CONSTS(27))) ALGBRC(16) = CONSTS(28)*(STATES(5) - STATES(2)) ALGBRC(13) = CONSTS(24) ** CONSTS(25)/(CONSTS(24) ** CONSTS(25)+STATES(6) ** CONSTS(25)) ALGBRC(14) = CONSTS(22)*(STATES(5) ** 2.00000/(CONSTS(23) ** 2.00000+STATES(5) ** 2.00000))*ALGBRC(13) ALGBRC(17) = 1.00000/(1.00000+( CONSTS(48)*CONSTS(49))/CONSTS(48)+STATES(6) ** 2.00000) ALGBRC(18) = ( CONSTS(31)*CONSTS(36)+ CONSTS(33)*STATES(5))/(CONSTS(36)+STATES(5)) ALGBRC(19) = ( (CONSTS(30)+CONSTS(34))*CONSTS(37))/(CONSTS(37)+STATES(5)) ALGBRC(21) = ( CONSTS(32)*CONSTS(37)+ CONSTS(35)*STATES(5))/(CONSTS(37)+STATES(5)) ALGBRC(20) = CONSTS(29)*( CONSTS(42)*ALGBRC(18)*STATES(8))/( CONSTS(42)*ALGBRC(18)+ALGBRC(19)) ** 4.00000*(STATES(4) - STATES(5)) RETURN END