Model Mathematics

Component: environment

Component: membrane

ddtime Vm =- I_iCa + I_iNa Cm I_iCa = I_Ca + I_NSCC_Ca + I_PM I_iNa = I_NSCC_Na + I_Na

Component: I_Ca

ECa = R T 2.0 F ln CO CS1 I_Ca = gCa Vm - ECa

Component: I_NSCC_Ca

gNSCC_Ca = gNSCC_Ca_ KNSCC hNSCC KNSCC hNSCC + CS1 hNSCC I_NSCC_Ca = gNSCC_Ca Vm - ENSCC

Component: I_NSCC_Na

gNSCC_Na = gNSCC_Na_ KNSCC hNSCC KNSCC hNSCC + CS1 hNSCC I_NSCC_Na = gNSCC_Na Vm - ENSCC

Component: I_PM

I_PM = gPM CS1 2.0 KPM 2.0 + CS1 2.0

Component: I_Na

I_Na = gNa NS1 hNa KNa hNa + NS1 hNa

Component: JSERCA

JSERCA = VSERCA CS1 - A2 CER 1.0 + A4 CS1 + A5 CER + A6 CS1 CER

Component: JMCU

JMCU = VMCU CS2 2.0 KMCU 2.0 + CS2 2.0 epsilon_INH epsilon_INH = KINH hINH KINH hINH + CMT hINH

Component: JNCX

JNCX = VNCX CMT CMT + KNCX

Component: JS1S2

JS1S2 = mu_S1S2 CS2 - CS1

Component: JIPR

ddtime H = phi3 1.0 - H - P phi1 phi2 P phi1 + phi_1 H JIPR = kIPR P phi1 H P phi1 + phi_1 4.0 CER - CS2 phi1 = k1 R1 + r2 CS2 R1 + CS2 phi_1 = k_1 + r_2 R3 R3 + CS2 phi2 = k2 R3 + r4 CS2 R3 + CS2 ddtime phi3 = alpha_phi3 - beta_phi3 phi3 alpha_phi3 = g_alpha beta_phi3 = g_beta CS2 h_beta K_beta h_beta + CS2 h_beta

Component: CS1

ddtime CS1 = JS1S2 + lambda_MT_S1 JNCX - delta_s 2.0 I_iCa + lambda_ER_S1 JSERCA lambda_MT_S1 = gamma_MT gamma_S1 lambda_ER_S1 = gamma_ER gamma_S1

Component: CS2

ddtime CS2 = lambda_ER_S2 JIPR - lambda_S1_S2 JS1S2 + lambda_MT_S2 JMCU lambda_MT_S2 = gamma_MT gamma_S2 lambda_ER_S2 = gamma_ER gamma_S2 lambda_S1_S2 = gamma_S1 gamma_S2

Component: CER

ddtime CER = JSERCA - JIPR

Component: CMT

ddtime CMT = fm JMCU - JNCX fm = 1.0 1.0 + Km Bm Km + CMT 2.0

Component: NS1

ddtime NS1 =- delta_s 1.0 I_iNa

Component: model_parameters