Model Mathematics

Component: environment

Component: geometry

Component: NFAT_Cycling_interface

nuclearNFAT=NFATN_n+NFATp_n

Component: calcium

ms_in_pulse=1000t-tperiodperiod baseline=93ifperiod0.121121+period1000-16-9.8846otherwise stimGradient=1121-baseline16 CaBeat=ms_in_pulsestimGradient+baselineifms_in_pulse16ms_in_pulse-16-9.8846+1121ifms_in_pulse>16ms_in_pulse120baselineotherwise Ca=CaBeat+CaSigTrans

Component: calcineurin

act_N=CanCan+K_mNn1+K_dNM

Component: NFAT_Cycling

J1=k_f1NFATp_cNtotact_N-k_r1NFATN_c1-act_N J2=k_f2NFATN_c J3=k_f3NFATN_n1-act_N-k_r3NFATp_nNtotact_N J4=k_f4NFATp_n ddtNFATp_c=J4Ccn-J1 ddtNFATN_c=J1-J2 ddtNFATN_n=J2Ccn-J3 ddtNFATp_n=J3-J4