/* There are a total of 0 entries in the algebraic variable array. There are a total of 13 entries in each of the rate and state variable arrays. There are a total of 24 entries in the constant variable array. */ /* * VOI is t in component environment (s). * CONSTANTS[0] is kf1 in component EGF_EGFRtoEGFEGFR (per_um_s). * CONSTANTS[1] is kb1 in component EGF_EGFRtoEGFEGFR (per_s). * CONSTANTS[2] is kf2 in component EGF_EGFRtoEGFEGFR (per_s). * CONSTANTS[3] is kb2 in component EGF_EGFRtoEGFEGFR (per_s). * STATES[0] is EGF in component EGF_EGFRtoEGFEGFR (um). * STATES[1] is EGFR in component EGF_EGFRtoEGFEGFR (um). * STATES[2] is EGF_EGFR in component EGF_EGFRtoEGFEGFR (um). * STATES[3] is EGF_EGFR_INTERNAL in component EGF_EGFRtoEGFEGFR (um). * CONSTANTS[4] is km3 in component SHCtoSHCStar (um). * CONSTANTS[5] is kf4 in component SHCtoSHCStar (per_s). * CONSTANTS[6] is kb4 in component SHCtoSHCStar (per_s). * CONSTANTS[7] is kf5 in component SHCtoSHCStar (per_um_s). * CONSTANTS[8] is kb5 in component SHCtoSHCStar (per_s). * CONSTANTS[9] is kf6 in component SHCtoSHCStar (per_um_s). * CONSTANTS[10] is kb6 in component SHCtoSHCStar (per_s). * CONSTANTS[11] is kf8 in component SHCtoSHCStar (per_s). * CONSTANTS[12] is kb8 in component SHCtoSHCStar (per_s). * CONSTANTS[13] is kf10 in component SHCtoSHCStar (per_um_s). * CONSTANTS[14] is kb10 in component SHCtoSHCStar (per_s). * CONSTANTS[15] is km7 in component SHCtoSHCStar (um). * CONSTANTS[16] is km9 in component SHCtoSHCStar (um). * CONSTANTS[17] is Vmax7 in component SHCtoSHCStar (per_s). * CONSTANTS[18] is Vmax3 in component SHCtoSHCStar (per_s). * CONSTANTS[19] is Vmax9 in component SHCtoSHCStar (per_s). * STATES[4] is SHC in component SHCtoSHCStar (um). * STATES[5] is SHCstar in component SHCtoSHCStar (um). * STATES[6] is SHCstar_SOS_GRB2 in component SHCtoSHCStar (um). * STATES[7] is SOS_GRB2 in component SHCtoSHCStar (um). * STATES[8] is SOS in component SHCtoSHCStar (um). * CONSTANTS[20] is GRB2 in component SHCtoSHCStar (um). * CONSTANTS[21] is MAPK in component SHCtoSHCStar (um). * STATES[9] is SOSstar in component SHCtoSHCStar (um). * STATES[10] is SOSstar_GRB2 in component SHCtoSHCStar (um). * CONSTANTS[22] is km7 in component GDPrasToGTPras (um). * CONSTANTS[23] is Vmax7 in component GDPrasToGTPras (per_s). * STATES[11] is GDP_ras in component GDPrasToGTPras (um). * STATES[12] is GTP_ras in component GDPrasToGTPras (um). * RATES[0] is d/dt EGF in component EGF_EGFRtoEGFEGFR (um). * RATES[1] is d/dt EGFR in component EGF_EGFRtoEGFEGFR (um). * RATES[2] is d/dt EGF_EGFR in component EGF_EGFRtoEGFEGFR (um). * RATES[3] is d/dt EGF_EGFR_INTERNAL in component EGF_EGFRtoEGFEGFR (um). * RATES[5] is d/dt SHCstar in component SHCtoSHCStar (um). * RATES[4] is d/dt SHC in component SHCtoSHCStar (um). * RATES[6] is d/dt SHCstar_SOS_GRB2 in component SHCtoSHCStar (um). * RATES[7] is d/dt SOS_GRB2 in component SHCtoSHCStar (um). * RATES[8] is d/dt SOS in component SHCtoSHCStar (um). * RATES[9] is d/dt SOSstar in component SHCtoSHCStar (um). * RATES[10] is d/dt SOSstar_GRB2 in component SHCtoSHCStar (um). * RATES[11] is d/dt GDP_ras in component GDPrasToGTPras (um). * RATES[12] is d/dt GTP_ras in component GDPrasToGTPras (um). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.000007; CONSTANTS[1] = 0.25; CONSTANTS[2] = 0.002; CONSTANTS[3] = 0.00033; STATES[0] = 0.16667; STATES[1] = 0.16667; STATES[2] = 0; STATES[3] = 0; CONSTANTS[4] = 0.83333333333; CONSTANTS[5] = 0.0016667; CONSTANTS[6] = 0; CONSTANTS[7] = 0.000000041667; CONSTANTS[8] = 0.0168; CONSTANTS[9] = 0.0000008333; CONSTANTS[10] = 0.1; CONSTANTS[11] = 0.001; CONSTANTS[12] = 0; CONSTANTS[13] = 0.000000041667; CONSTANTS[14] = 0.0168; CONSTANTS[15] = 0.40404; CONSTANTS[16] = 2.564166667; CONSTANTS[17] = 0.02; CONSTANTS[18] = 0.2; CONSTANTS[19] = 10; STATES[4] = 0.5; STATES[5] = 0; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0.1; CONSTANTS[20] = 1; CONSTANTS[21] = 0.36; STATES[9] = 0; STATES[10] = 0; CONSTANTS[22] = 0.50505; CONSTANTS[23] = 0.02; STATES[11] = 1; STATES[12] = 0; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[5] = 0.1001; RATES[4] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[8] = 0.1001; RATES[9] = 0.1001; RATES[10] = 0.1001; RATES[11] = 0.1001; RATES[12] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - - CONSTANTS[0]*STATES[0]*STATES[1]+ CONSTANTS[1]*STATES[2]; resid[1] = RATES[1] - - CONSTANTS[0]*STATES[0]*STATES[1]+ CONSTANTS[1]*STATES[2]; resid[2] = RATES[2] - (( CONSTANTS[0]*STATES[0]*STATES[1] - CONSTANTS[1]*STATES[2]) - CONSTANTS[2]*STATES[2])+ CONSTANTS[3]*STATES[3]; resid[3] = RATES[3] - CONSTANTS[2]*STATES[2] - CONSTANTS[3]*STATES[3]; resid[4] = RATES[5] - (( STATES[2]*CONSTANTS[18]*STATES[4])/(CONSTANTS[4]+STATES[4]) - CONSTANTS[9]*STATES[5]*STATES[7])+ CONSTANTS[10]*STATES[6]; resid[5] = RATES[4] - ( CONSTANTS[5]*STATES[5] - CONSTANTS[6]*STATES[4]) - ( STATES[2]*CONSTANTS[18]*STATES[4])/(CONSTANTS[4]+STATES[4]); resid[6] = RATES[6] - CONSTANTS[9]*STATES[5]*STATES[7] - CONSTANTS[10]*STATES[6]; resid[7] = RATES[7] - (( - CONSTANTS[9]*STATES[5]*STATES[7]+ CONSTANTS[10]*STATES[6]) - CONSTANTS[8]*STATES[7])+ CONSTANTS[7]*STATES[8]*CONSTANTS[20]; resid[8] = RATES[8] - ( CONSTANTS[11]*STATES[9] - CONSTANTS[12]*STATES[8]) - ( CONSTANTS[21]*CONSTANTS[19]*STATES[8])/(CONSTANTS[16]+STATES[8]); resid[9] = RATES[9] - (( - CONSTANTS[11]*STATES[9]+ CONSTANTS[12]*STATES[8]+( CONSTANTS[21]*CONSTANTS[19]*STATES[8])/(CONSTANTS[16]+STATES[8])) - CONSTANTS[13]*STATES[9]*CONSTANTS[20])+ CONSTANTS[14]*STATES[10]; resid[10] = RATES[10] - CONSTANTS[13]*STATES[9]*CONSTANTS[20] - CONSTANTS[14]*STATES[10]; resid[11] = RATES[11] - ( - STATES[10]*CONSTANTS[23]*STATES[11])/(CONSTANTS[22]+STATES[11]); resid[12] = RATES[12] - ( STATES[10]*CONSTANTS[23]*STATES[11])/(CONSTANTS[22]+STATES[11]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; SI[11] = 1.0; SI[12] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }