C C There are a total of 6 entries in the algebraic variable array. C There are a total of 12 entries in each of the rate and state variable arrays. C There are a total of 43 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is Asp in component Asp (millimolar). C ALGBRC(1) is vAKI in component vAKI (flux). C ALGBRC(5) is vAKIII in component vAKIII (flux). C STATES(2) is aspp in component aspp (millimolar). C ALGBRC(2) is vASD in component vASD (flux). C STATES(3) is ASA in component ASA (millimolar). C ALGBRC(3) is vHDH in component vHDH (flux). C STATES(4) is hs in component hs (millimolar). C ALGBRC(4) is vHK in component vHK (flux). C STATES(5) is hsp in component hsp (millimolar). C ALGBRC(6) is vTS in component vTS (flux). C STATES(6) is Thr in component Thr (millimolar). C STATES(7) is ATP in component ATP (millimolar). C STATES(8) is ADP in component ADP (millimolar). C STATES(9) is NADPH in component NADPH (millimolar). C STATES(10) is NADP in component NADP (millimolar). C STATES(11) is Pi in component Pi (millimolar). C STATES(12) is Lys in component Lys (millimolar). C CONSTS(1) is K_asp in component vAKI (millimolar). C CONSTS(2) is K_ATP in component vAKI (millimolar). C CONSTS(3) is K_aspp in component vAKI (millimolar). C CONSTS(4) is K_ADP in component vAKI (millimolar). C CONSTS(5) is K_iThr in component vAKI (millimolar). C CONSTS(6) is alpha in component vAKI (dimensionless). C CONSTS(7) is h_Thr in component vAKI (dimensionless). C CONSTS(8) is K_eq in component vAKI (dimensionless). C CONSTS(9) is V_max_AK_I in component vAKI (flux). C CONSTS(10) is K_aspp in component vASD (millimolar). C CONSTS(11) is K_NADPH in component vASD (millimolar). C CONSTS(12) is K_ASA in component vASD (millimolar). C CONSTS(13) is K_NADP in component vASD (millimolar). C CONSTS(14) is K_Pi in component vASD (millimolar). C CONSTS(15) is K_eq in component vASD (millimolar). C CONSTS(16) is V_max_ASD in component vASD (flux). C CONSTS(17) is K_ASA in component vHDH (millimolar). C CONSTS(18) is K_NADPH in component vHDH (millimolar). C CONSTS(19) is K_hs in component vHDH (millimolar). C CONSTS(20) is K_NADP in component vHDH (millimolar). C CONSTS(21) is K_iThr in component vHDH (millimolar). C CONSTS(22) is alpha in component vHDH (dimensionless). C CONSTS(23) is h in component vHDH (dimensionless). C CONSTS(24) is K_eq in component vHDH (dimensionless). C CONSTS(25) is V_max_HDH in component vHDH (flux). C CONSTS(26) is K_hs in component vHK (millimolar). C CONSTS(27) is K_ATP in component vHK (millimolar). C CONSTS(28) is K_iThr in component vHK (millimolar). C CONSTS(29) is K_iLys in component vHK (millimolar). C CONSTS(30) is K_ihs in component vHK (millimolar). C CONSTS(31) is K_iATP in component vHK (millimolar). C CONSTS(32) is V_max_HK in component vHK (flux). C CONSTS(33) is K_hsp in component vTS (millimolar). C CONSTS(34) is V_max_TS in component vTS (flux). C CONSTS(35) is K_asp in component vAKIII (millimolar). C CONSTS(36) is K_ATP in component vAKIII (millimolar). C CONSTS(37) is K_aspp in component vAKIII (millimolar). C CONSTS(38) is K_ADP in component vAKIII (millimolar). C CONSTS(39) is K_iLys in component vAKIII (millimolar). C CONSTS(40) is h_Lys in component vAKIII (dimensionless). C CONSTS(41) is K_eq in component vAKIII (dimensionless). C CONSTS(42) is V_max_AK_III in component vAKIII (flux). C RATES(1) is d/dt Asp in component Asp (millimolar). C RATES(2) is d/dt aspp in component aspp (millimolar). C RATES(3) is d/dt ASA in component ASA (millimolar). C RATES(4) is d/dt hs in component hs (millimolar). C RATES(5) is d/dt hsp in component hsp (millimolar). C RATES(6) is d/dt Thr in component Thr (millimolar). C RATES(7) is d/dt ATP in component ATP (millimolar). C RATES(8) is d/dt ADP in component ADP (millimolar). C RATES(9) is d/dt NADPH in component NADPH (millimolar). C RATES(10) is d/dt NADP in component NADP (millimolar). C RATES(11) is d/dt Pi in component Pi (millimolar). C RATES(12) is d/dt Lys in component Lys (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 10 STATES(2) = 0 STATES(3) = 0 STATES(4) = 0 STATES(5) = 0 STATES(6) = 0 STATES(7) = 30 STATES(8) = 0 STATES(9) = 0 STATES(10) = 0 STATES(11) = 0 STATES(12) = 0 CONSTS(1) = 0.97 CONSTS(2) = 0.98 CONSTS(3) = 0.017 CONSTS(4) = 0.25 CONSTS(5) = 0.167 CONSTS(6) = 2.47 CONSTS(7) = 4.09 CONSTS(8) = 0.00064 CONSTS(9) = 463 CONSTS(10) = 0.022 CONSTS(11) = 0.029 CONSTS(12) = 0.11 CONSTS(13) = 0.144 CONSTS(14) = 10.2 CONSTS(15) = 284000 CONSTS(16) = 598 CONSTS(17) = 0.24 CONSTS(18) = 0.037 CONSTS(19) = 3.39 CONSTS(20) = 0.067 CONSTS(21) = 0.097 CONSTS(22) = 3.93 CONSTS(23) = 1.41 CONSTS(24) = 100000000000 CONSTS(25) = 2585 CONSTS(26) = 0.11 CONSTS(27) = 0.072 CONSTS(28) = 1.09 CONSTS(29) = 9.45 CONSTS(30) = 4.7 CONSTS(31) = 4.35 CONSTS(32) = 483 CONSTS(33) = 0.31 CONSTS(34) = 208 CONSTS(35) = 0.32 CONSTS(36) = 0.22 CONSTS(37) = 0.017 CONSTS(38) = 0.25 CONSTS(39) = 0.391 CONSTS(40) = 2.8 CONSTS(41) = 0.00064 CONSTS(42) = 299 CONSTS(42) = 0.00000 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(12) = CONSTS(42) ALGBRC(2) = ( CONSTS(16)*( STATES(2)*STATES(9) - ( STATES(3)*STATES(10)*STATES(11))/CONSTS(15)))/( ( CONSTS(10)*(1.00000+STATES(3)/CONSTS(12))*(1.00000+STATES(11)/CONSTS(14))+STATES(2))*( CONSTS(11)*(1.00000+STATES(10)/CONSTS(13))+STATES(9))) ALGBRC(3) = ( CONSTS(25)*( STATES(3)*STATES(9) - ( STATES(4)*STATES(10))/CONSTS(24)))/( ((1.00000+STATES(6)/CONSTS(21) ** CONSTS(23))/(1.00000+STATES(6)/( CONSTS(22)*CONSTS(21)) ** CONSTS(23)))*(CONSTS(17)+( STATES(4)*CONSTS(17))/CONSTS(19)+STATES(3))*( CONSTS(18)*(1.00000+STATES(10)/CONSTS(20))+STATES(9))) RATES(3) = ALGBRC(2) - ALGBRC(3) RATES(9) = - ALGBRC(2) - ALGBRC(3) RATES(10) = ALGBRC(2)+ALGBRC(3) ALGBRC(4) = ( CONSTS(32)*STATES(4)*STATES(7))/( (( CONSTS(26)*(1.00000+STATES(7)/CONSTS(31)))/(1.00000+STATES(6)/CONSTS(28))+STATES(4))*( CONSTS(27)*(1.00000+STATES(4)/CONSTS(30))+STATES(7))*(1.00000+STATES(12)/CONSTS(29))) RATES(4) = ALGBRC(3) - ALGBRC(4) ALGBRC(1) = ( CONSTS(9)*( STATES(1)*STATES(7) - ( STATES(2)*STATES(8))/CONSTS(8)))/( (( CONSTS(1)*(1.00000+STATES(6)/CONSTS(5) ** CONSTS(7)))/(1.00000+STATES(6)/( CONSTS(5)*CONSTS(6)) ** CONSTS(7))+( STATES(2)*CONSTS(1))/CONSTS(3)+STATES(1))*( CONSTS(2)*(1.00000+STATES(8)/CONSTS(4))+STATES(7))) ALGBRC(5) = ( CONSTS(42)*( STATES(1)*STATES(7) - ( STATES(2)*STATES(8))/CONSTS(41)))/( (1.00000+STATES(12)/CONSTS(39) ** CONSTS(40))*( CONSTS(35)*(1.00000+STATES(2)/CONSTS(37))+STATES(1))*( CONSTS(36)*(1.00000+STATES(8)/CONSTS(38))+STATES(7))) RATES(1) = - ALGBRC(1) - ALGBRC(5) RATES(2) = (ALGBRC(1)+ALGBRC(5)) - ALGBRC(2) ALGBRC(6) = ( CONSTS(34)*STATES(5))/(CONSTS(33)+STATES(5)) RATES(5) = ALGBRC(4)+ALGBRC(6) RATES(6) = ALGBRC(6) RATES(7) = (- ALGBRC(1) - ALGBRC(5)) - ALGBRC(4) RATES(8) = ALGBRC(1)+ALGBRC(5)+ALGBRC(4) RATES(11) = ALGBRC(2)+ALGBRC(6) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = ( CONSTS(16)*( STATES(2)*STATES(9) - ( STATES(3)*STATES(10)*STATES(11))/CONSTS(15)))/( ( CONSTS(10)*(1.00000+STATES(3)/CONSTS(12))*(1.00000+STATES(11)/CONSTS(14))+STATES(2))*( CONSTS(11)*(1.00000+STATES(10)/CONSTS(13))+STATES(9))) ALGBRC(3) = ( CONSTS(25)*( STATES(3)*STATES(9) - ( STATES(4)*STATES(10))/CONSTS(24)))/( ((1.00000+STATES(6)/CONSTS(21) ** CONSTS(23))/(1.00000+STATES(6)/( CONSTS(22)*CONSTS(21)) ** CONSTS(23)))*(CONSTS(17)+( STATES(4)*CONSTS(17))/CONSTS(19)+STATES(3))*( CONSTS(18)*(1.00000+STATES(10)/CONSTS(20))+STATES(9))) ALGBRC(4) = ( CONSTS(32)*STATES(4)*STATES(7))/( (( CONSTS(26)*(1.00000+STATES(7)/CONSTS(31)))/(1.00000+STATES(6)/CONSTS(28))+STATES(4))*( CONSTS(27)*(1.00000+STATES(4)/CONSTS(30))+STATES(7))*(1.00000+STATES(12)/CONSTS(29))) ALGBRC(1) = ( CONSTS(9)*( STATES(1)*STATES(7) - ( STATES(2)*STATES(8))/CONSTS(8)))/( (( CONSTS(1)*(1.00000+STATES(6)/CONSTS(5) ** CONSTS(7)))/(1.00000+STATES(6)/( CONSTS(5)*CONSTS(6)) ** CONSTS(7))+( STATES(2)*CONSTS(1))/CONSTS(3)+STATES(1))*( CONSTS(2)*(1.00000+STATES(8)/CONSTS(4))+STATES(7))) ALGBRC(5) = ( CONSTS(42)*( STATES(1)*STATES(7) - ( STATES(2)*STATES(8))/CONSTS(41)))/( (1.00000+STATES(12)/CONSTS(39) ** CONSTS(40))*( CONSTS(35)*(1.00000+STATES(2)/CONSTS(37))+STATES(1))*( CONSTS(36)*(1.00000+STATES(8)/CONSTS(38))+STATES(7))) ALGBRC(6) = ( CONSTS(34)*STATES(5))/(CONSTS(33)+STATES(5)) RETURN END