function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =31; end % There are a total of 16 entries in each of the rate and state variable arrays. % There are a total of 72 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (millisecond)'); LEGEND_STATES(:,1) = strpad('V in component membrane (millivolt)'); LEGEND_CONSTANTS(:,1) = strpad('C in component membrane (uF)'); LEGEND_ALGEBRAIC(:,1) = strpad('i_Na in component sodium_current (nanoA)'); LEGEND_ALGEBRAIC(:,16) = strpad('i_NaP in component persistent_sodium_current (nanoA)'); LEGEND_ALGEBRAIC(:,23) = strpad('i_K in component delayed_rectifier_current (nanoA)'); LEGEND_ALGEBRAIC(:,24) = strpad('i_leak in component leak_current (nanoA)'); LEGEND_ALGEBRAIC(:,25) = strpad('i_T in component LVA_calcium_current (nanoA)'); LEGEND_ALGEBRAIC(:,26) = strpad('i_N in component N_HVA_calcium_current (nanoA)'); LEGEND_ALGEBRAIC(:,27) = strpad('i_P in component P_HVA_calcium_current (nanoA)'); LEGEND_ALGEBRAIC(:,28) = strpad('i_SK in component calcium_dependent_potassium_current (nanoA)'); LEGEND_ALGEBRAIC(:,29) = strpad('i_A in component fast_transient_potassium_current (nanoA)'); LEGEND_ALGEBRAIC(:,30) = strpad('i_H in component hyperpolarization_activated_current (nanoA)'); LEGEND_ALGEBRAIC(:,31) = strpad('i_app in component stimulus_protocol (nanoA)'); LEGEND_CONSTANTS(:,2) = strpad('g_Na in component sodium_current (uS)'); LEGEND_CONSTANTS(:,3) = strpad('E_Na in component sodium_current (millivolt)'); LEGEND_STATES(:,2) = strpad('m in component sodium_current_m_gate (dimensionless)'); LEGEND_STATES(:,3) = strpad('h in component sodium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('theta_h in component sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,5) = strpad('sigma_h in component sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,6) = strpad('theta_1 in component sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,7) = strpad('sigma_1 in component sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,8) = strpad('sigma_2 in component sodium_current_h_gate (millivolt)'); LEGEND_ALGEBRAIC(:,2) = strpad('tau_h in component sodium_current_h_gate (millisecond)'); LEGEND_ALGEBRAIC(:,17) = strpad('h_infinity in component sodium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,9) = strpad('theta_m in component sodium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,10) = strpad('sigma_m in component sodium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,11) = strpad('tau_m in component sodium_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,3) = strpad('m_infinity in component sodium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,12) = strpad('g_NaP in component persistent_sodium_current (uS)'); LEGEND_STATES(:,4) = strpad('m in component persistent_sodium_current_m_gate (dimensionless)'); LEGEND_STATES(:,5) = strpad('h in component persistent_sodium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,13) = strpad('theta_h in component persistent_sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,14) = strpad('sigma_h in component persistent_sodium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,15) = strpad('tau_h in component persistent_sodium_current_h_gate (millisecond)'); LEGEND_ALGEBRAIC(:,4) = strpad('h_infinity in component persistent_sodium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,16) = strpad('theta_m in component persistent_sodium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,17) = strpad('sigma_m in component persistent_sodium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,18) = strpad('tau_m in component persistent_sodium_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,5) = strpad('m_infinity in component persistent_sodium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,19) = strpad('g_K in component delayed_rectifier_current (uS)'); LEGEND_CONSTANTS(:,20) = strpad('E_K in component delayed_rectifier_current (millivolt)'); LEGEND_STATES(:,6) = strpad('n in component delayed_rectifier_current_n_gate (dimensionless)'); LEGEND_CONSTANTS(:,21) = strpad('theta_n in component delayed_rectifier_current_n_gate (millivolt)'); LEGEND_CONSTANTS(:,22) = strpad('sigma_n in component delayed_rectifier_current_n_gate (millivolt)'); LEGEND_CONSTANTS(:,23) = strpad('theta_1 in component delayed_rectifier_current_n_gate (millivolt)'); LEGEND_CONSTANTS(:,24) = strpad('sigma_1 in component delayed_rectifier_current_n_gate (millivolt)'); LEGEND_CONSTANTS(:,25) = strpad('sigma_2 in component delayed_rectifier_current_n_gate (millivolt)'); LEGEND_ALGEBRAIC(:,6) = strpad('tau_n in component delayed_rectifier_current_n_gate (millisecond)'); LEGEND_ALGEBRAIC(:,18) = strpad('n_infinity in component delayed_rectifier_current_n_gate (dimensionless)'); LEGEND_CONSTANTS(:,26) = strpad('g_leak in component leak_current (uS)'); LEGEND_CONSTANTS(:,27) = strpad('E_leak in component leak_current (millivolt)'); LEGEND_CONSTANTS(:,28) = strpad('g_T in component LVA_calcium_current (uS)'); LEGEND_CONSTANTS(:,29) = strpad('E_Ca in component LVA_calcium_current (millivolt)'); LEGEND_STATES(:,7) = strpad('m in component LVA_calcium_current_m_gate (dimensionless)'); LEGEND_STATES(:,8) = strpad('h in component LVA_calcium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,30) = strpad('theta_m in component LVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,31) = strpad('sigma_m in component LVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,32) = strpad('theta_1 in component LVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,33) = strpad('sigma_1 in component LVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,34) = strpad('sigma_2 in component LVA_calcium_current_m_gate (millivolt)'); LEGEND_ALGEBRAIC(:,7) = strpad('tau_m in component LVA_calcium_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,19) = strpad('m_infinity in component LVA_calcium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,35) = strpad('theta_h in component LVA_calcium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,36) = strpad('sigma_h in component LVA_calcium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,37) = strpad('theta_1 in component LVA_calcium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,38) = strpad('sigma_1 in component LVA_calcium_current_h_gate (millivolt)'); LEGEND_ALGEBRAIC(:,8) = strpad('tau_h in component LVA_calcium_current_h_gate (millisecond)'); LEGEND_ALGEBRAIC(:,20) = strpad('h_infinity in component LVA_calcium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,39) = strpad('g_N in component N_HVA_calcium_current (uS)'); LEGEND_STATES(:,9) = strpad('m in component N_HVA_calcium_current_m_gate (dimensionless)'); LEGEND_STATES(:,10) = strpad('h in component N_HVA_calcium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,40) = strpad('theta_m in component N_HVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,41) = strpad('sigma_m in component N_HVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,42) = strpad('tau_m in component N_HVA_calcium_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,9) = strpad('m_infinity in component N_HVA_calcium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,43) = strpad('theta_h in component N_HVA_calcium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,44) = strpad('sigma_h in component N_HVA_calcium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,45) = strpad('tau_h in component N_HVA_calcium_current_h_gate (millisecond)'); LEGEND_ALGEBRAIC(:,10) = strpad('h_infinity in component N_HVA_calcium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,46) = strpad('g_P in component P_HVA_calcium_current (uS)'); LEGEND_STATES(:,11) = strpad('m in component P_HVA_calcium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,47) = strpad('theta_m in component P_HVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,48) = strpad('sigma_m in component P_HVA_calcium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,49) = strpad('tau_m in component P_HVA_calcium_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,11) = strpad('m_infinity in component P_HVA_calcium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,50) = strpad('g_SK in component calcium_dependent_potassium_current (uS)'); LEGEND_STATES(:,12) = strpad('z in component calcium_dependent_potassium_current_z_gate (dimensionless)'); LEGEND_CONSTANTS(:,51) = strpad('K1 in component calcium_dependent_potassium_current_z_gate (uM_per_nanocoulomb)'); LEGEND_CONSTANTS(:,52) = strpad('K2 in component calcium_dependent_potassium_current_z_gate (per_ms)'); LEGEND_STATES(:,13) = strpad('Ca_conc in component calcium_dependent_potassium_current_z_gate (uM)'); LEGEND_CONSTANTS(:,53) = strpad('tau_z in component calcium_dependent_potassium_current_z_gate (millisecond)'); LEGEND_ALGEBRAIC(:,12) = strpad('z_infinity in component calcium_dependent_potassium_current_z_gate (dimensionless)'); LEGEND_CONSTANTS(:,54) = strpad('g_A in component fast_transient_potassium_current (uS)'); LEGEND_STATES(:,14) = strpad('m in component fast_transient_potassium_current_m_gate (dimensionless)'); LEGEND_STATES(:,15) = strpad('h in component fast_transient_potassium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,55) = strpad('theta_m in component fast_transient_potassium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,56) = strpad('sigma_m in component fast_transient_potassium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,57) = strpad('theta_1 in component fast_transient_potassium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,58) = strpad('theta_2 in component fast_transient_potassium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,59) = strpad('sigma_1 in component fast_transient_potassium_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,60) = strpad('sigma_2 in component fast_transient_potassium_current_m_gate (millivolt)'); LEGEND_ALGEBRAIC(:,13) = strpad('tau_m in component fast_transient_potassium_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,21) = strpad('m_infinity in component fast_transient_potassium_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,61) = strpad('theta_h in component fast_transient_potassium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,62) = strpad('sigma_h in component fast_transient_potassium_current_h_gate (millivolt)'); LEGEND_CONSTANTS(:,63) = strpad('tau_h in component fast_transient_potassium_current_h_gate (millisecond)'); LEGEND_ALGEBRAIC(:,14) = strpad('h_infinity in component fast_transient_potassium_current_h_gate (dimensionless)'); LEGEND_CONSTANTS(:,64) = strpad('g_H in component hyperpolarization_activated_current (uS)'); LEGEND_CONSTANTS(:,65) = strpad('E_H in component hyperpolarization_activated_current (millivolt)'); LEGEND_STATES(:,16) = strpad('m in component hyperpolarization_activated_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,66) = strpad('theta_m in component hyperpolarization_activated_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,67) = strpad('sigma_m in component hyperpolarization_activated_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,68) = strpad('theta_1 in component hyperpolarization_activated_current_m_gate (millivolt)'); LEGEND_CONSTANTS(:,69) = strpad('sigma_1 in component hyperpolarization_activated_current_m_gate (millivolt)'); LEGEND_ALGEBRAIC(:,15) = strpad('tau_m in component hyperpolarization_activated_current_m_gate (millisecond)'); LEGEND_ALGEBRAIC(:,22) = strpad('m_infinity in component hyperpolarization_activated_current_m_gate (dimensionless)'); LEGEND_CONSTANTS(:,70) = strpad('i_stimStart in component stimulus_protocol (millisecond)'); LEGEND_CONSTANTS(:,71) = strpad('i_stimEnd in component stimulus_protocol (millisecond)'); LEGEND_CONSTANTS(:,72) = strpad('i_stimAmplitude in component stimulus_protocol (nanoA)'); LEGEND_RATES(:,1) = strpad('d/dt V in component membrane (millivolt)'); LEGEND_RATES(:,3) = strpad('d/dt h in component sodium_current_h_gate (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt m in component sodium_current_m_gate (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt h in component persistent_sodium_current_h_gate (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt m in component persistent_sodium_current_m_gate (dimensionless)'); LEGEND_RATES(:,6) = strpad('d/dt n in component delayed_rectifier_current_n_gate (dimensionless)'); LEGEND_RATES(:,7) = strpad('d/dt m in component LVA_calcium_current_m_gate (dimensionless)'); LEGEND_RATES(:,8) = strpad('d/dt h in component LVA_calcium_current_h_gate (dimensionless)'); LEGEND_RATES(:,9) = strpad('d/dt m in component N_HVA_calcium_current_m_gate (dimensionless)'); LEGEND_RATES(:,10) = strpad('d/dt h in component N_HVA_calcium_current_h_gate (dimensionless)'); LEGEND_RATES(:,11) = strpad('d/dt m in component P_HVA_calcium_current_m_gate (dimensionless)'); LEGEND_RATES(:,13) = strpad('d/dt Ca_conc in component calcium_dependent_potassium_current_z_gate (uM)'); LEGEND_RATES(:,12) = strpad('d/dt z in component calcium_dependent_potassium_current_z_gate (dimensionless)'); LEGEND_RATES(:,14) = strpad('d/dt m in component fast_transient_potassium_current_m_gate (dimensionless)'); LEGEND_RATES(:,15) = strpad('d/dt h in component fast_transient_potassium_current_h_gate (dimensionless)'); LEGEND_RATES(:,16) = strpad('d/dt m in component hyperpolarization_activated_current_m_gate (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = -71.847; CONSTANTS(:,1) = 0.04; CONSTANTS(:,2) = 0.7; CONSTANTS(:,3) = 60; STATES(:,2) = 0.015; STATES(:,3) = 0.981; CONSTANTS(:,4) = 44.1; CONSTANTS(:,5) = 7; CONSTANTS(:,6) = 35; CONSTANTS(:,7) = 4; CONSTANTS(:,8) = 25; CONSTANTS(:,9) = 36; CONSTANTS(:,10) = 8.5; CONSTANTS(:,11) = 0.1; CONSTANTS(:,12) = 0.05; STATES(:,4) = 0.002; STATES(:,5) = 0.797; CONSTANTS(:,13) = 65; CONSTANTS(:,14) = 5; CONSTANTS(:,15) = 150; CONSTANTS(:,16) = 47.1; CONSTANTS(:,17) = 4.1; CONSTANTS(:,18) = 0.1; CONSTANTS(:,19) = 1.3; CONSTANTS(:,20) = -80; STATES(:,6) = 0.158; CONSTANTS(:,21) = 30; CONSTANTS(:,22) = 25; CONSTANTS(:,23) = 30; CONSTANTS(:,24) = 40; CONSTANTS(:,25) = 50; CONSTANTS(:,26) = 0.005; CONSTANTS(:,27) = -50; CONSTANTS(:,28) = 0.1; CONSTANTS(:,29) = 40; STATES(:,7) = 0.001; STATES(:,8) = 0.562; CONSTANTS(:,30) = 38; CONSTANTS(:,31) = 5; CONSTANTS(:,32) = 28; CONSTANTS(:,33) = 25; CONSTANTS(:,34) = 70; CONSTANTS(:,35) = 70.1; CONSTANTS(:,36) = 7; CONSTANTS(:,37) = 70; CONSTANTS(:,38) = 65; CONSTANTS(:,39) = 0.05; STATES(:,9) = 0.001; STATES(:,10) = 0.649; CONSTANTS(:,40) = 30; CONSTANTS(:,41) = 6; CONSTANTS(:,42) = 5; CONSTANTS(:,43) = 70; CONSTANTS(:,44) = 3; CONSTANTS(:,45) = 25; CONSTANTS(:,46) = 0.05; STATES(:,11) = 0; CONSTANTS(:,47) = 17; CONSTANTS(:,48) = 3; CONSTANTS(:,49) = 10; CONSTANTS(:,50) = 0.3; STATES(:,12) = 0; CONSTANTS(:,51) = -500; CONSTANTS(:,52) = 0.04; STATES(:,13) = 0.0604; CONSTANTS(:,53) = 1; CONSTANTS(:,54) = 1; STATES(:,14) = 0.057; STATES(:,15) = 0.287; CONSTANTS(:,55) = 27; CONSTANTS(:,56) = 16; CONSTANTS(:,57) = 40; CONSTANTS(:,58) = 74; CONSTANTS(:,59) = 5; CONSTANTS(:,60) = 7.5; CONSTANTS(:,61) = 80; CONSTANTS(:,62) = 11; CONSTANTS(:,63) = 20; CONSTANTS(:,64) = 0.005; CONSTANTS(:,65) = -38.8; STATES(:,16) = 0.182; CONSTANTS(:,66) = 79.8; CONSTANTS(:,67) = 5.3; CONSTANTS(:,68) = 70; CONSTANTS(:,69) = 11; CONSTANTS(:,70) = 10; CONSTANTS(:,71) = 11; CONSTANTS(:,72) = 10; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,3) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,9))./ - CONSTANTS(:,10))); RATES(:,2) = (ALGEBRAIC(:,3) - STATES(:,2))./CONSTANTS(:,11); ALGEBRAIC(:,4) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,13))./CONSTANTS(:,14))); RATES(:,5) = (ALGEBRAIC(:,4) - STATES(:,5))./CONSTANTS(:,15); ALGEBRAIC(:,5) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,16))./CONSTANTS(:,17))); RATES(:,4) = (ALGEBRAIC(:,5) - STATES(:,4))./CONSTANTS(:,18); ALGEBRAIC(:,9) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,40))./CONSTANTS(:,41))); RATES(:,9) = (ALGEBRAIC(:,9) - STATES(:,9))./CONSTANTS(:,42); ALGEBRAIC(:,10) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,43))./CONSTANTS(:,44))); RATES(:,10) = (ALGEBRAIC(:,10) - STATES(:,10))./CONSTANTS(:,45); ALGEBRAIC(:,11) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,47))./CONSTANTS(:,48))); RATES(:,11) = (ALGEBRAIC(:,11) - STATES(:,11))./CONSTANTS(:,49); ALGEBRAIC(:,12) = 1.00000./(1.00000+power(0.00300000./STATES(:,13), 2.00000)); RATES(:,12) = (ALGEBRAIC(:,12) - STATES(:,12))./CONSTANTS(:,53); ALGEBRAIC(:,14) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,61))./CONSTANTS(:,62))); RATES(:,15) = (ALGEBRAIC(:,14) - STATES(:,15))./CONSTANTS(:,63); ALGEBRAIC(:,2) = 3.50000./(exp((STATES(:,1)+CONSTANTS(:,6))./CONSTANTS(:,7))+exp( - (STATES(:,1)+CONSTANTS(:,6))./CONSTANTS(:,8)))+1.00000; ALGEBRAIC(:,17) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,4))./CONSTANTS(:,5))); RATES(:,3) = (ALGEBRAIC(:,17) - STATES(:,3))./ALGEBRAIC(:,2); ALGEBRAIC(:,6) = 2.50000./(exp((STATES(:,1)+CONSTANTS(:,23))./CONSTANTS(:,24))+exp( - (STATES(:,1)+CONSTANTS(:,23))./CONSTANTS(:,25)))+0.0100000; ALGEBRAIC(:,18) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,21))./CONSTANTS(:,22))); RATES(:,6) = (ALGEBRAIC(:,18) - STATES(:,6))./ALGEBRAIC(:,6); ALGEBRAIC(:,7) = 5.00000./(exp((STATES(:,1)+CONSTANTS(:,32))./CONSTANTS(:,33))+exp( - (STATES(:,1)+CONSTANTS(:,32))./CONSTANTS(:,34)))+2.00000; ALGEBRAIC(:,19) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,30))./CONSTANTS(:,31))); RATES(:,7) = (ALGEBRAIC(:,19) - STATES(:,7))./ALGEBRAIC(:,7); ALGEBRAIC(:,8) = 20.0000./(exp((STATES(:,1)+CONSTANTS(:,37))./CONSTANTS(:,38))+exp( - (STATES(:,1)+CONSTANTS(:,37))./CONSTANTS(:,38)))+1.00000; ALGEBRAIC(:,20) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,35))./CONSTANTS(:,36))); RATES(:,8) = (ALGEBRAIC(:,20) - STATES(:,8))./ALGEBRAIC(:,8); ALGEBRAIC(:,13) = 1.00000./(exp((STATES(:,1)+CONSTANTS(:,57))./CONSTANTS(:,59))+exp( - (STATES(:,1)+CONSTANTS(:,58))./CONSTANTS(:,60)))+0.370000; ALGEBRAIC(:,21) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,55))./CONSTANTS(:,56))); RATES(:,14) = (ALGEBRAIC(:,21) - STATES(:,14))./ALGEBRAIC(:,13); ALGEBRAIC(:,15) = 1.00000./(exp((STATES(:,1)+CONSTANTS(:,68))./CONSTANTS(:,69))+exp( - (STATES(:,1)+CONSTANTS(:,68))./CONSTANTS(:,69)))+50.0000; ALGEBRAIC(:,22) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,66))./CONSTANTS(:,67))); RATES(:,16) = (ALGEBRAIC(:,22) - STATES(:,16))./ALGEBRAIC(:,15); ALGEBRAIC(:,25) = CONSTANTS(:,28).*STATES(:,7).*STATES(:,8).*(STATES(:,1) - CONSTANTS(:,29)); ALGEBRAIC(:,26) = CONSTANTS(:,39).*STATES(:,9).*STATES(:,10).*(STATES(:,1) - CONSTANTS(:,29)); ALGEBRAIC(:,27) = CONSTANTS(:,46).*STATES(:,11).*(STATES(:,1) - CONSTANTS(:,29)); RATES(:,13) = (1.00000./1000.00).*CONSTANTS(:,51).*(ALGEBRAIC(:,25)+ALGEBRAIC(:,26)+ALGEBRAIC(:,27)) - CONSTANTS(:,52).*STATES(:,13); ALGEBRAIC(:,1) = CONSTANTS(:,2).*power(STATES(:,2), 3.00000).*STATES(:,3).*(STATES(:,1) - CONSTANTS(:,3)); ALGEBRAIC(:,16) = CONSTANTS(:,12).*STATES(:,4).*STATES(:,5).*(STATES(:,1) - CONSTANTS(:,3)); ALGEBRAIC(:,23) = CONSTANTS(:,19).*power(STATES(:,6), 4.00000).*(STATES(:,1) - CONSTANTS(:,20)); ALGEBRAIC(:,24) = CONSTANTS(:,26).*(STATES(:,1) - CONSTANTS(:,27)); ALGEBRAIC(:,28) = CONSTANTS(:,50).*power(STATES(:,12), 2.00000).*(STATES(:,1) - CONSTANTS(:,20)); ALGEBRAIC(:,29) = CONSTANTS(:,54).*STATES(:,14).*STATES(:,15).*(STATES(:,1) - CONSTANTS(:,20)); ALGEBRAIC(:,30) = CONSTANTS(:,64).*STATES(:,16).*(STATES(:,1) - CONSTANTS(:,65)); ALGEBRAIC(:,31) = piecewise({VOI>=CONSTANTS(:,70)&VOI<=CONSTANTS(:,71), CONSTANTS(:,72) }, 0.00000); RATES(:,1) = ( - (ALGEBRAIC(:,1)+ALGEBRAIC(:,16)+ALGEBRAIC(:,23)+ALGEBRAIC(:,24)+ALGEBRAIC(:,25)+ALGEBRAIC(:,26)+ALGEBRAIC(:,27)+ALGEBRAIC(:,28)+ALGEBRAIC(:,29)+ALGEBRAIC(:,30))+ALGEBRAIC(:,31))./CONSTANTS(:,1); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,3) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,9))./ - CONSTANTS(:,10))); ALGEBRAIC(:,4) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,13))./CONSTANTS(:,14))); ALGEBRAIC(:,5) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,16))./CONSTANTS(:,17))); ALGEBRAIC(:,9) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,40))./CONSTANTS(:,41))); ALGEBRAIC(:,10) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,43))./CONSTANTS(:,44))); ALGEBRAIC(:,11) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,47))./CONSTANTS(:,48))); ALGEBRAIC(:,12) = 1.00000./(1.00000+power(0.00300000./STATES(:,13), 2.00000)); ALGEBRAIC(:,14) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,61))./CONSTANTS(:,62))); ALGEBRAIC(:,2) = 3.50000./(exp((STATES(:,1)+CONSTANTS(:,6))./CONSTANTS(:,7))+exp( - (STATES(:,1)+CONSTANTS(:,6))./CONSTANTS(:,8)))+1.00000; ALGEBRAIC(:,17) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,4))./CONSTANTS(:,5))); ALGEBRAIC(:,6) = 2.50000./(exp((STATES(:,1)+CONSTANTS(:,23))./CONSTANTS(:,24))+exp( - (STATES(:,1)+CONSTANTS(:,23))./CONSTANTS(:,25)))+0.0100000; ALGEBRAIC(:,18) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,21))./CONSTANTS(:,22))); ALGEBRAIC(:,7) = 5.00000./(exp((STATES(:,1)+CONSTANTS(:,32))./CONSTANTS(:,33))+exp( - (STATES(:,1)+CONSTANTS(:,32))./CONSTANTS(:,34)))+2.00000; ALGEBRAIC(:,19) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,30))./CONSTANTS(:,31))); ALGEBRAIC(:,8) = 20.0000./(exp((STATES(:,1)+CONSTANTS(:,37))./CONSTANTS(:,38))+exp( - (STATES(:,1)+CONSTANTS(:,37))./CONSTANTS(:,38)))+1.00000; ALGEBRAIC(:,20) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,35))./CONSTANTS(:,36))); ALGEBRAIC(:,13) = 1.00000./(exp((STATES(:,1)+CONSTANTS(:,57))./CONSTANTS(:,59))+exp( - (STATES(:,1)+CONSTANTS(:,58))./CONSTANTS(:,60)))+0.370000; ALGEBRAIC(:,21) = 1.00000./(1.00000+exp( - (STATES(:,1)+CONSTANTS(:,55))./CONSTANTS(:,56))); ALGEBRAIC(:,15) = 1.00000./(exp((STATES(:,1)+CONSTANTS(:,68))./CONSTANTS(:,69))+exp( - (STATES(:,1)+CONSTANTS(:,68))./CONSTANTS(:,69)))+50.0000; ALGEBRAIC(:,22) = 1.00000./(1.00000+exp((STATES(:,1)+CONSTANTS(:,66))./CONSTANTS(:,67))); ALGEBRAIC(:,25) = CONSTANTS(:,28).*STATES(:,7).*STATES(:,8).*(STATES(:,1) - CONSTANTS(:,29)); ALGEBRAIC(:,26) = CONSTANTS(:,39).*STATES(:,9).*STATES(:,10).*(STATES(:,1) - CONSTANTS(:,29)); ALGEBRAIC(:,27) = CONSTANTS(:,46).*STATES(:,11).*(STATES(:,1) - CONSTANTS(:,29)); ALGEBRAIC(:,1) = CONSTANTS(:,2).*power(STATES(:,2), 3.00000).*STATES(:,3).*(STATES(:,1) - CONSTANTS(:,3)); ALGEBRAIC(:,16) = CONSTANTS(:,12).*STATES(:,4).*STATES(:,5).*(STATES(:,1) - CONSTANTS(:,3)); ALGEBRAIC(:,23) = CONSTANTS(:,19).*power(STATES(:,6), 4.00000).*(STATES(:,1) - CONSTANTS(:,20)); ALGEBRAIC(:,24) = CONSTANTS(:,26).*(STATES(:,1) - CONSTANTS(:,27)); ALGEBRAIC(:,28) = CONSTANTS(:,50).*power(STATES(:,12), 2.00000).*(STATES(:,1) - CONSTANTS(:,20)); ALGEBRAIC(:,29) = CONSTANTS(:,54).*STATES(:,14).*STATES(:,15).*(STATES(:,1) - CONSTANTS(:,20)); ALGEBRAIC(:,30) = CONSTANTS(:,64).*STATES(:,16).*(STATES(:,1) - CONSTANTS(:,65)); ALGEBRAIC(:,31) = piecewise({VOI>=CONSTANTS(:,70)&VOI<=CONSTANTS(:,71), CONSTANTS(:,72) }, 0.00000); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end