function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =1; end % There are a total of 4 entries in each of the rate and state variable arrays. % There are a total of 9 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (day)'); LEGEND_CONSTANTS(:,1) = strpad('s in component uninfected (per_day_mm3)'); LEGEND_CONSTANTS(:,2) = strpad('r in component uninfected (per_day)'); LEGEND_CONSTANTS(:,3) = strpad('T_max in component uninfected (per_mm3)'); LEGEND_CONSTANTS(:,4) = strpad('mu_T in component uninfected (per_day)'); LEGEND_CONSTANTS(:,5) = strpad('k_1 in component latently_infected (mm3_per_day)'); LEGEND_STATES(:,1) = strpad('T_1 in component latently_infected (per_mm3)'); LEGEND_STATES(:,2) = strpad('T_2 in component actively_infected (per_mm3)'); LEGEND_STATES(:,3) = strpad('V in component free_virus_particle (per_mm3)'); LEGEND_STATES(:,4) = strpad('T in component uninfected (per_mm3)'); LEGEND_CONSTANTS(:,6) = strpad('k_2 in component actively_infected (per_day)'); LEGEND_CONSTANTS(:,7) = strpad('mu_b in component actively_infected (per_day)'); LEGEND_CONSTANTS(:,8) = strpad('mu_V in component free_virus_particle (per_day)'); LEGEND_CONSTANTS(:,9) = strpad('N in component free_virus_particle (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('T_tot in component T_cell_population (per_mm3)'); LEGEND_RATES(:,4) = strpad('d/dt T in component uninfected (per_mm3)'); LEGEND_RATES(:,1) = strpad('d/dt T_1 in component latently_infected (per_mm3)'); LEGEND_RATES(:,2) = strpad('d/dt T_2 in component actively_infected (per_mm3)'); LEGEND_RATES(:,3) = strpad('d/dt V in component free_virus_particle (per_mm3)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 10; CONSTANTS(:,2) = 0.03; CONSTANTS(:,3) = 1500; CONSTANTS(:,4) = 0.02; CONSTANTS(:,5) = 2.4E-5; STATES(:,1) = 0; STATES(:,2) = 0; STATES(:,3) = 1.0E-3; STATES(:,4) = 1000; CONSTANTS(:,6) = 3E-3; CONSTANTS(:,7) = 0.24; CONSTANTS(:,8) = 2.4; CONSTANTS(:,9) = 1400; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,4) = ((CONSTANTS(:,1) - CONSTANTS(:,4).*STATES(:,4))+ CONSTANTS(:,2).*STATES(:,4).*(1.00000 - (STATES(:,4)+STATES(:,1)+STATES(:,2))./CONSTANTS(:,3))) - CONSTANTS(:,5).*STATES(:,3).*STATES(:,4); RATES(:,1) = ( CONSTANTS(:,5).*STATES(:,3).*STATES(:,4) - CONSTANTS(:,4).*STATES(:,1)) - CONSTANTS(:,6).*STATES(:,1); RATES(:,2) = CONSTANTS(:,6).*STATES(:,1) - CONSTANTS(:,7).*STATES(:,2); RATES(:,3) = ( CONSTANTS(:,9).*CONSTANTS(:,7).*STATES(:,2) - CONSTANTS(:,5).*STATES(:,3).*STATES(:,4)) - CONSTANTS(:,8).*STATES(:,3); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = STATES(:,4)+STATES(:,1)+STATES(:,2); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end