Model Mathematics

Component: environment

Component: COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES

RT_over_F=RgasTempFaraday C=Acap1e-3 a1=CVmyoFaraday a2=C2VSSFaraday ddtimeNai=-INa+INab+3INaCa+INaK+IKv14_Naa1 ddtimeKi=-IKr+IKs+IK1+ICaK+i_Stim-2INaK+IKv43+IKv14_Ka1 ddtimeCai=beta_iJxfer-Jup-Jtrpn-ICab-2INaCa+IpCa0.5a1 ddtimeCaSS=beta_SSJrelVJSRVSS-JxferVmyoVSS-ICaa2 ddtimeCaJSR=beta_JSRJtr-Jrel ddtimeCaNSR=JupVmyoVNSR-JtrVJSRVNSR i_tot=INa+ICa+ICaK+IKr+IKs+IK1+INaCa+INaK+Ito1+IpCa+ICab+INab+i_Stim ddtimeV=-i_tot

Component: I_stimulus

past=timestim_periodstim_period i_Stim=stim_amplitudeiftime-paststim_offsettime-paststim_offset+stim_duration0otherwise

Component: COMPUTE_INTRACELLULAR_CALCIUM_FLUXES

fb=CaiKfbNfb rb=CaNSRKrbNrb Jup=KSRvmaxffb-vmaxrrb1+fb+rbifiso=01.5KSRvmaxffb-vmaxrrb1+fb+rbotherwise Jrel=v1O1_RyR+O2_RyRCaJSR-CaSS Jtr=CaNSR-CaJSRtautr Jxfer=CaSS-Caitauxfer

Component: COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS

CSQNtot=15ifRyR2=10.515otherwise dLTRPNCa=kltrpn_plusCai1-LTRPNCa-kltrpn_minusLTRPNCa dHTRPNCa=khtrpn_plusCai1-HTRPNCa-khtrpn_minusHTRPNCa ddtimeLTRPNCa=dLTRPNCa ddtimeHTRPNCa=dHTRPNCa Jtrpn=LTRPNtotdLTRPNCa+HTRPNtotdHTRPNCa beta_SS=11+CMDNtotKmCMDNCaSS+KmCMDN2+EGTAtotKmEGTACaSS+KmEGTA2 beta_JSR=11+CSQNtotKmCSQNCaJSR+KmCSQN2 beta_i=11+CMDNtotKmCMDNCai+KmCMDN2+EGTAtotKmEGTACai+KmEGTA2

Component: COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES

HmaxO1C2=0.2ifCSQN2=10.5otherwise H50C2O1=0.5ifCSQN2=11otherwise klumenC1O1=HmaxC1O1-HmaxC1O1-Hmin1+H50C1O1CaJSRHN klumenO1C2=HmaxO1C2-HmaxO1C2-Hmin1+H50O1C2CaJSRHN klumenC2O1=HmaxC2O1-HmaxC2O1-Hmin1+H50C2O1CaJSRHN dC1_RyR=-kaplusklumenC1O1CaSS1000ncoopkryrC1_RyR+kaminusO1_RyR dO2_RyR=kbplusCaSS1000mcoopkryrO1_RyR-kbminusO2_RyR dC2_RyR=kcplusklumenO1C2O1_RyR-kcminusklumenC2O1C2_RyR dO1_RyR=-dC1_RyR+dO2_RyR+dC2_RyR ddtimeC1_RyR=dC1_RyR ddtimeO2_RyR=dO2_RyR ddtimeC2_RyR=dC2_RyR ddtimeO1_RyR=dO1_RyR

Component: COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES

alpha=41.20.4160.012V-35 beta=40.450.049-0.065V-22 alpha_prime=aLalpha beta_prime=betabL gamma=0.60.09233CaSS omega=0.250.01 C0_to_C1=4alpha C1_to_C2=3alpha C2_to_C3=2alpha C3_to_C4=alpha CCa0_to_CCa1=4alpha_prime CCa1_to_CCa2=3alpha_prime CCa2_to_CCa3=2alpha_prime CCa3_to_CCa4=alpha_prime C1_to_C0=beta C2_to_C1=2beta C3_to_C2=3beta C4_to_C3=4beta CCa1_to_CCa0=beta_prime CCa2_to_CCa1=2beta_prime CCa3_to_CCa2=3beta_prime CCa4_to_CCa3=4beta_prime C0_to_CCa0=gamma C1_to_CCa1=aLC0_to_CCa0 C2_to_CCa2=aLC1_to_CCa1 C3_to_CCa3=aLC2_to_CCa2 C4_to_CCa4=aLC3_to_CCa3 CCa0_to_C0=omega CCa1_to_C1=CCa0_to_C0bL CCa2_to_C2=CCa1_to_C1bL CCa3_to_C3=CCa2_to_C2bL CCa4_to_C4=CCa3_to_C3bL a1_C0=C0_to_C1+C0_to_CCa0C0 a2_C0=C1_to_C0C1+CCa0_to_C0CCa0 ddtimeC0=a2_C0-a1_C0 a1_C1=C1_to_C0+C1_to_C2+C1_to_CCa1C1 a2_C1=C0_to_C1C0+C2_to_C1C2+CCa1_to_C1CCa1 ddtimeC1=a2_C1-a1_C1 a1_C2=C2_to_C1+C2_to_C3+C2_to_CCa2C2 a2_C2=C1_to_C2C1+C3_to_C2C3+CCa2_to_C2CCa2 ddtimeC2=a2_C2-a1_C2 a1_C3=C3_to_C2+C3_to_C4+C3_to_CCa3C3 a2_C3=C2_to_C3C2+C4_to_C3C4+CCa3_to_C3CCa3 ddtimeC3=a2_C3-a1_C3 a1_C4=C4_to_C3+fL+C4_to_CCa4C4 a2_C4=C3_to_C4C3+gLOpen+CCa4_to_C4CCa4 ddtimeC4=a2_C4-a1_C4 ddtimeOpen=fLC4-gLOpen a1_Ca0=CCa0_to_CCa1+CCa0_to_C0CCa0 a2_Ca0=CCa1_to_CCa0CCa1+C0_to_CCa0C0 ddtimeCCa0=a2_Ca0-a1_Ca0 a1_Ca1=CCa1_to_CCa0+CCa1_to_CCa2+CCa1_to_C1CCa1 a2_Ca1=CCa0_to_CCa1CCa0+CCa2_to_CCa1CCa2+C1_to_CCa1C1 ddtimeCCa1=a2_Ca1-a1_Ca1 a1_Ca2=CCa2_to_CCa1+CCa2_to_CCa3+CCa2_to_C2CCa2 a2_Ca2=CCa1_to_CCa2CCa1+CCa3_to_CCa2CCa3+C2_to_CCa2C2 ddtimeCCa2=a2_Ca2-a1_Ca2 a1_Ca3=CCa3_to_CCa2+CCa3_to_CCa4+CCa3_to_C3CCa3 a2_Ca3=CCa2_to_CCa3CCa2+CCa4_to_CCa3CCa4+C3_to_CCa3C3 ddtimeCCa3=a2_Ca3-a1_Ca3 a1_Ca4=CCa4_to_CCa3+CCa4_to_C4CCa4 a2_Ca4=CCa3_to_CCa4CCa3+C4_to_CCa4C4 ddtimeCCa4=a2_Ca4-a1_Ca4 a1_Cainf=0.82 yCa_inf=a1_Cainf1+V+28.57.8+1-a1_Cainf tau_yCa=10.003363362094520.5+V-5.53899874036055+0.00779046570737V-49.51039631160386 ddtimeyCa=yCa_inf-yCatau_yCa

Component: COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES

alpha_act43=alphaa0Kv43aaKv43V beta_act43=betaa0Kv43-baKv43V alpha_inact43=alphai0Kv43-aiKv43V beta_inact43=betai0Kv43biKv43V C0Kv43_to_C1Kv43=4alpha_act43 C1Kv43_to_C2Kv43=3alpha_act43 C2Kv43_to_C3Kv43=2alpha_act43 C3Kv43_to_OKv43=alpha_act43 CI0Kv43_to_CI1Kv43=4b1Kv43alpha_act43 CI1Kv43_to_CI2Kv43=3b2Kv43alpha_act43b1Kv43 CI2Kv43_to_CI3Kv43=2b3Kv43alpha_act43b2Kv43 CI3Kv43_to_OIKv43=b4Kv43alpha_act43b3Kv43 C1Kv43_to_C0Kv43=beta_act43 C2Kv43_to_C1Kv43=2beta_act43 C3Kv43_to_C2Kv43=3beta_act43 OKv43_to_C3Kv43=4beta_act43 CI1Kv43_to_CI0Kv43=beta_act43f1Kv43 CI2Kv43_to_CI1Kv43=2f1Kv43beta_act43f2Kv43 CI3Kv43_to_CI2Kv43=3f2Kv43beta_act43f3Kv43 OIKv43_to_CI3Kv43=4f3Kv43beta_act43f4Kv43 C0Kv43_to_CI0Kv43=beta_inact43 C1Kv43_to_CI1Kv43=f1Kv43beta_inact43 C2Kv43_to_CI2Kv43=f2Kv43beta_inact43 C3Kv43_to_CI3Kv43=f3Kv43beta_inact43 OKv43_to_OIKv43=f4Kv43beta_inact43 CI0Kv43_to_C0Kv43=alpha_inact43 CI1Kv43_to_C1Kv43=alpha_inact43b1Kv43 CI2Kv43_to_C2Kv43=alpha_inact43b2Kv43 CI3Kv43_to_C3Kv43=alpha_inact43b3Kv43 OIKv43_to_OKv43=alpha_inact43b4Kv43 a1_C043=C0Kv43_to_C1Kv43+C0Kv43_to_CI0Kv43C0Kv43 a2_C043=C1Kv43_to_C0Kv43C1Kv43+CI0Kv43_to_C0Kv43CI0Kv43 ddtimeC0Kv43=a2_C043-a1_C043 a1_C143=C1Kv43_to_C2Kv43+C1Kv43_to_C0Kv43+C1Kv43_to_CI1Kv43C1Kv43 a2_C143=C2Kv43_to_C1Kv43C2Kv43+CI1Kv43_to_C1Kv43CI1Kv43+C0Kv43_to_C1Kv43C0Kv43 ddtimeC1Kv43=a2_C143-a1_C143 a1_C243=C2Kv43_to_C3Kv43+C2Kv43_to_C1Kv43+C2Kv43_to_CI2Kv43C2Kv43 a2_C243=C3Kv43_to_C2Kv43C3Kv43+CI2Kv43_to_C2Kv43CI2Kv43+C1Kv43_to_C2Kv43C1Kv43 ddtimeC2Kv43=a2_C243-a1_C243 a1_C343=C3Kv43_to_OKv43+C3Kv43_to_C2Kv43+C3Kv43_to_CI3Kv43C3Kv43 a2_C343=OKv43_to_C3Kv43OKv43+CI3Kv43_to_C3Kv43CI3Kv43+C2Kv43_to_C3Kv43C2Kv43 ddtimeC3Kv43=a2_C343-a1_C343 a1_O43=OKv43_to_C3Kv43+OKv43_to_OIKv43OKv43 a2_O43=C3Kv43_to_OKv43C3Kv43+OIKv43_to_OKv43OIKv43 ddtimeOKv43=a2_O43-a1_O43 a1_I043=CI0Kv43_to_C0Kv43+CI0Kv43_to_CI1Kv43CI0Kv43 a2_I043=C0Kv43_to_CI0Kv43C0Kv43+CI1Kv43_to_CI0Kv43CI1Kv43 ddtimeCI0Kv43=a2_I043-a1_I043 a1_I143=CI1Kv43_to_CI2Kv43+CI1Kv43_to_C1Kv43+CI1Kv43_to_CI0Kv43CI1Kv43 a2_I143=CI2Kv43_to_CI1Kv43CI2Kv43+C1Kv43_to_CI1Kv43C1Kv43+CI0Kv43_to_CI1Kv43CI0Kv43 ddtimeCI1Kv43=a2_I143-a1_I143 a1_I243=CI2Kv43_to_CI3Kv43+CI2Kv43_to_C2Kv43+CI2Kv43_to_CI1Kv43CI2Kv43 a2_I243=CI3Kv43_to_CI2Kv43CI3Kv43+C2Kv43_to_CI2Kv43C2Kv43+CI1Kv43_to_CI2Kv43CI1Kv43 ddtimeCI2Kv43=a2_I243-a1_I243 a1_I343=CI3Kv43_to_OIKv43+CI3Kv43_to_C3Kv43+CI3Kv43_to_CI2Kv43CI3Kv43 a2_I343=OIKv43_to_CI3Kv43OIKv43+C3Kv43_to_CI3Kv43C3Kv43+CI2Kv43_to_CI3Kv43CI2Kv43 ddtimeCI3Kv43=a2_I343-a1_I343 a1_OI43=OIKv43_to_OKv43+OIKv43_to_CI3Kv43OIKv43 a2_OI43=OKv43_to_OIKv43OKv43+CI3Kv43_to_OIKv43CI3Kv43 ddtimeOIKv43=a2_OI43-a1_OI43

Component: COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES

alpha_act14=alphaa0Kv14aaKv14V beta_act14=betaa0Kv14-baKv14V alpha_inact14=alphai0Kv14 beta_inact14=betai0Kv14 C0Kv14_to_C1Kv14=4alpha_act14 C1Kv14_to_C2Kv14=3alpha_act14 C2Kv14_to_C3Kv14=2alpha_act14 C3Kv14_to_OKv14=alpha_act14 CI0Kv14_to_CI1Kv14=4b1Kv14alpha_act14 CI1Kv14_to_CI2Kv14=3b2Kv14alpha_act14b1Kv14 CI2Kv14_to_CI3Kv14=2b3Kv14alpha_act14b2Kv14 CI3Kv14_to_OIKv14=b4Kv14alpha_act14b3Kv14 C1Kv14_to_C0Kv14=beta_act14 C2Kv14_to_C1Kv14=2beta_act14 C3Kv14_to_C2Kv14=3beta_act14 OKv14_to_C3Kv14=4beta_act14 CI1Kv14_to_CI0Kv14=beta_act14f1Kv14 CI2Kv14_to_CI1Kv14=2f1Kv14beta_act14f2Kv14 CI3Kv14_to_CI2Kv14=3f2Kv14beta_act14f3Kv14 OIKv14_to_CI3Kv14=4f3Kv14beta_act14f4Kv14 C0Kv14_to_CI0Kv14=beta_inact14 C1Kv14_to_CI1Kv14=f1Kv14beta_inact14 C2Kv14_to_CI2Kv14=f2Kv14beta_inact14 C3Kv14_to_CI3Kv14=f3Kv14beta_inact14 OKv14_to_OIKv14=f4Kv14beta_inact14 CI0Kv14_to_C0Kv14=alpha_inact14 CI1Kv14_to_C1Kv14=alpha_inact14b1Kv14 CI2Kv14_to_C2Kv14=alpha_inact14b2Kv14 CI3Kv14_to_C3Kv14=alpha_inact14b3Kv14 OIKv14_to_OKv14=alpha_inact14b4Kv14 a1_C0=C0Kv14_to_C1Kv14+C0Kv14_to_CI0Kv14C0Kv14 a2_C0=C1Kv14_to_C0Kv14C1Kv14+CI0Kv14_to_C0Kv14CI0Kv14 ddtimeC0Kv14=a2_C0-a1_C0 a1_C1=C1Kv14_to_C2Kv14+C1Kv14_to_C0Kv14+C1Kv14_to_CI1Kv14C1Kv14 a2_C1=C2Kv14_to_C1Kv14C2Kv14+CI1Kv14_to_C1Kv14CI1Kv14+C0Kv14_to_C1Kv14C0Kv14 ddtimeC1Kv14=a2_C1-a1_C1 a1_C2=C2Kv14_to_C3Kv14+C2Kv14_to_C1Kv14+C2Kv14_to_CI2Kv14C2Kv14 a2_C2=C3Kv14_to_C2Kv14C3Kv14+CI2Kv14_to_C2Kv14CI2Kv14+C1Kv14_to_C2Kv14C1Kv14 ddtimeC2Kv14=a2_C2-a1_C2 a1_C3=C3Kv14_to_OKv14+C3Kv14_to_C2Kv14+C3Kv14_to_CI3Kv14C3Kv14 a2_C3=OKv14_to_C3Kv14OKv14+CI3Kv14_to_C3Kv14CI3Kv14+C2Kv14_to_C3Kv14C2Kv14 ddtimeC3Kv14=a2_C3-a1_C3 a1_O=OKv14_to_C3Kv14+OKv14_to_OIKv14OKv14 a2_O=C3Kv14_to_OKv14C3Kv14+OIKv14_to_OKv14OIKv14 ddtimeOKv14=a2_O-a1_O a1_CI0=CI0Kv14_to_C0Kv14+CI0Kv14_to_CI1Kv14CI0Kv14 a2_CI0=C0Kv14_to_CI0Kv14C0Kv14+CI1Kv14_to_CI0Kv14CI1Kv14 ddtimeCI0Kv14=a2_CI0-a1_CI0 a1_CI1=CI1Kv14_to_CI2Kv14+CI1Kv14_to_C1Kv14+CI1Kv14_to_CI0Kv14CI1Kv14 a2_CI1=CI2Kv14_to_CI1Kv14CI2Kv14+C1Kv14_to_CI1Kv14C1Kv14+CI0Kv14_to_CI1Kv14CI0Kv14 ddtimeCI1Kv14=a2_CI1-a1_CI1 a1_CI2=CI2Kv14_to_CI3Kv14+CI2Kv14_to_C2Kv14+CI2Kv14_to_CI1Kv14CI2Kv14 a2_CI2=CI3Kv14_to_CI2Kv14CI3Kv14+C2Kv14_to_CI2Kv14C2Kv14+CI1Kv14_to_CI2Kv14CI1Kv14 ddtimeCI2Kv14=a2_CI2-a1_CI2 a1_CI3=CI3Kv14_to_OIKv14+CI3Kv14_to_C3Kv14+CI3Kv14_to_CI2Kv14CI3Kv14 a2_CI3=OIKv14_to_CI3Kv14OIKv14+C3Kv14_to_CI3Kv14C3Kv14+CI2Kv14_to_CI3Kv14CI2Kv14 ddtimeCI3Kv14=a2_CI3-a1_CI3 a1_OI=OIKv14_to_OKv14+OIKv14_to_CI3Kv14OIKv14 a2_OI=OKv14_to_OIKv14OKv14+CI3Kv14_to_OIKv14CI3Kv14 ddtimeOIKv14=a2_OI-a1_OI

Component: COMPUTE_REVERSAL_POTENTIALS

ENa=RT_over_FlnNaoNai EK=RT_over_FlnKoKi a1=Ko+0.01833Nao a2=Ki+0.01833Nai EKs=RT_over_Flna1a2 ECa=0.5RT_over_FlnCaoCai

Component: COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp

PKv14=1-Kv43FracKvScale4.2986e-7 GKv43=Kv43FracKvScale0.1 INa=GNana6+na7V-ENa fKo=Ko4 IKr=GKrfKoOHergV-EK IKs=GKsO1ks+O2ksV-EK IKv43=GKv43OKv43V-EK VF_over_RT=VRT_over_F VFsq_over_RT=1000FaradayVF_over_RT a1_K=KiVF_over_RT-Ko a2=VF_over_RT-1 IKv14_K=PKv14OKv14VFsq_over_RTa1_Ka2 a1_Na=NaiVF_over_RT-Nao IKv14_Na=0.02PKv14OKv14VFsq_over_RTa1_Naa2 IKv14=IKv14_K+IKv14_Na Ito1=IKv43+IKv14 K1_inf=10.94+1.26RT_over_FV-EK IK1=GK1Ko1K1_infV-EK INab=GNabV-ENa

Component: COMPUTE_INaK_INaCa_ICab_IpCa

ICab=GCabV-ECa IpCa=IpCamaxCaiKmpCa+Cai VF_over_RT=VRT_over_F sigma=Nao67.3-17 a1_Na=1+0.1245-0.1VF_over_RT a2_Na=0.0365sigma-1.33VF_over_RT fNaK=1a1_Na+a2_Na a1_K=KoKo+KmKo a2_K=1+KmNaiNai1.5 INaK=INaKmaxfNaKa1_Ka2_K a1_ncx=etaVF_over_RTNai3Cao a2_ncx=eta-1VF_over_RTNao3Cai a3_ncx=1+ksateta-1VF_over_RT a4_ncx=KmCa+Cao a5_ncx=KmNa3+Nao35000 INaCa=kNaCaa1_ncx-a2_ncxa4_ncxa3_ncxa5_ncx

Component: COMPUTE_ICa_ICaK

PK=Pscale4.574e-7 PCa=Pscale2.469e-4ifiso=01.5Pscale2.469e-4otherwise VF_over_RT=VRT_over_F VFsq_over_RT=1000FaradayVF_over_RT a1_Ca=1e-32VF_over_RT-Cao0.341 a2_Ca=2VF_over_RT-1 ICamax=PCa4VFsq_over_RTa1_Caa2_Ca ICa=ICamaxyCaOpen Icabar=0ifICamax0ICamaxotherwise PKprime=PK1+IcabarICahalf a1_K=KiVF_over_RT-Ko a2_K=VF_over_RT-1 ICaK=PKprimeOpenyCaVFsq_over_RTa1_Ka2_K

Component: INa

FoverRT=1RToverF KToverH=1.381e-23TNa6.626e-31 RTNa=RgasTNa RTNaF=RgasTNaFaraday Temp_Scale=1.38862291252871 alpha1=Temp_ScaleKToverH-114007.462700232RTNa+224.114Rgas+0.286374268596235VRTNaF beta1=Temp_ScaleKToverH-272470.273489681RTNa+708.146Rgas+-2.28528417586424VRTNaF gamma1=Temp_ScaleKToverH-196336.575735923RTNa+529.952Rgas+2.78084918596045VRTNaF Delta1=Temp_ScaleKToverH-133689.9304091RTNa+229.205Rgas+-1.55804214553883VRTNaF On=Temp_ScaleKToverH-62123.0784380481RTNa+39.295Rgas+0.288816042743232VRTNaF Of=Temp_ScaleKToverH-97657.8497137015RTNa+1.51Rgas+0.0684861993100685VRTNaF GammaGamma=Temp_ScaleKToverH116431.142142348RTNa+-578.317Rgas+0.764126011745707VRTNaF DeltaDelta=Temp_ScaleKToverH-55700.6624658307RTNa+-130.639Rgas+-3.64981672927078VRTNaF epsilon=Temp_ScaleKToverH-85800.3675578326RTNa+70.078Rgas omega_na=Temp_ScaleKToverH-121955.166154864RTNa+225.175Rgas rho=Temp_ScaleKToverH-147813.990005035RTNa+338.915Rgas+2.1360043702126VRTNaF mu=Temp_ScaleKToverH-121322.143275242RTNa+193.265Rgas+-1.74290267020903VRTNaF Cn=Temp_ScaleKToverH-287913.446530953RTNa+786.217Rgas Cf=Temp_ScaleKToverH-59565.2236284584RTNa+0.00711Rgas parameter_a=1.40042625477401 k12=4alpha1 k23=3alpha1 k34=2alpha1 k45=alpha1 k56=gamma1 k67=epsilon k89=k12parameter_a k910=k23parameter_a k1011=k34parameter_a k1112=k45parameter_a k1213=GammaGamma k57=rho k21=beta1 k32=2beta1 k43=3beta1 k54=4beta1 k65=Delta1 k76=omega_na k98=k21parameter_a k109=k32parameter_a k1110=k43parameter_a k1211=k54parameter_a k1312=DeltaDelta k75=mu k81=Cf k92=k81parameter_a k103=k92parameter_a k114=k103parameter_a k125=k114parameter_a k136=Of k18=Cn k29=k18parameter_a k310=k29parameter_a k411=k310parameter_a k512=k411parameter_a k613=On ddtimena1=-k18+k12na1+k21na2+k81na8 ddtimena2=k12na1-k21+k23+k29na2+k32na3+k92na9 ddtimena3=k23na2-k32+k34+k310na3+k43na4+k103na10 ddtimena4=k34na3-k43+k45+k411na4+k54na5+k114na11 ddtimena5=k45na4-k54+k56+k57+k512na5+k65na6+k75na7+k125na12 ddtimena6=k56na5-k65+k67+k613na6+k76na7+k136na13 ddtimena7=k57na5+k67na6-k75+k76na7 ddtimena8=k18na1-k81+k89na8+k98na9 ddtimena9=k29na2+k89na8-k98+k92+k910na9+k109na10 ddtimena10=k310na3+k910na9-k1011+k103+k109na10+k1110na11 ddtimena11=k411na4+k1011na10-k1110+k114+k1112na11+k1211na12 ddtimena12=k512na5+k1112na11-k1211+k125+k1213na12+k1312na13 ddtimena13=k613na6+k1213na12-k1312+k136na13

Component: IKr

C2H_to_C3H=T_Const_HERG0.02608362043337 C3H_to_C2H=T_Const_HERG0.14832978132145 C1H_to_C2H=T_Const_HERGA0_HERGB0_HERGV C2H_to_C1H=T_Const_HERGA1_HERGB1_HERGV C3H_to_OH=T_Const_HERGA2_HERGB2_HERGV OH_to_C3H=T_Const_HERGA3_HERGB3_HERGV OH_to_IH=T_Const_HERGA4_HERGB4_HERGV IH_to_OH=T_Const_HERGA5_HERGB5_HERGV C3H_to_IH=T_Const_HERGA6_HERGB6_HERGV IH_to_C3H=OH_to_C3HIH_to_OHC3H_to_IHC3H_to_OHOH_to_IH ddtimeC1Herg=C2H_to_C1HC2Herg-C1H_to_C2HC1Herg a1_C2=C1H_to_C2HC1Herg+C3H_to_C2HC3Herg a2_C2=C2H_to_C1H+C2H_to_C3HC2Herg ddtimeC2Herg=a1_C2-a2_C2 a1_C3=C2H_to_C3HC2Herg+OH_to_C3HOHerg+IH_to_C3HIHerg a2_C3=C3H_to_IH+C3H_to_OH+C3H_to_C2HC3Herg ddtimeC3Herg=a1_C3-a2_C3 a1_O=C3H_to_OHC3Herg+IH_to_OHIHerg a2_O=OH_to_C3H+OH_to_IHOHerg ddtimeOHerg=a1_O-a2_O a1_I=C3H_to_IHC3Herg+OH_to_IHOHerg a2_I=IH_to_C3H+IH_to_OHIHerg ddtimeIHerg=a1_I-a2_I

Component: IKs

C0ks_C1ks=0.00795600798004 C1ks_O1ks=0.03966720676071 O1ks_O2ks=0.007672543630630.08662945914655V O1ks_C1ks=0.00700806628929-0.14999754700285V O2ks_O1ks=0.00379737998368-0.01425668126881V C1ks_C0ks=0.2162557589585-0.00001889123021V ddtimeC0ks=-C0ks_C1ksC0ks+C1ks_C0ksC1ks ddtimeC1ks=C0ks_C1ksC0ks-C1ks_C0ks+C1ks_O1ksC1ks+O1ks_C1ksO1ks ddtimeO1ks=C1ks_O1ksC1ks-O1ks_C1ks+O1ks_O2ksO1ks+O2ks_O1ksO2ks ddtimeO2ks=O1ks_O2ksO1ks-O2ks_O1ksO2ks