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Maly, Wiley, Lauffenburger, 2004
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Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis
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Model Mathematics
Component based math viewer is available
Component: environment
Component: L
∂
∂
time
L
=
DL
L
Component: R
∂
∂
time
R
=
koff
C
-
kon
R
L
Component: C
∂
∂
time
C
=
kon
R
L
+
kdgc
CGrb
+
kdgsc
CGrbSos
-
koff
C
+
kagc
Grb
C
+
kagsc
GrbSos
CGrb
Component: CGrb
∂
∂
time
CGrb
=
kagc
Grb
C
+
kdsc
CGrbSos
-
kdgc
CGrb
+
kasc
Sos
CGrb
Component: CGrbSos
∂
∂
time
CGrbSos
=
kagsc
GrbSos
C
+
kasc
Sos
CGrb
-
kdgsc
CGrbSos
+
kdsc
CGrbSos
Component: Grb
∂
∂
time
Grb
=
kdsg
GrbSos
+
D
Grb
-
kasg
Sos
Grb
Component: Sos
∂
∂
time
Sos
=
D
Sos
+
kdsg
GrbSos
+
kdps
pSos
-
kasg
Sos
Grb
+
kps
ppERK
Sos
Component: GrbSos
∂
∂
time
GrbSos
=
D
GrbSos
+
kasg
Grb
Sos
-
kdsg
GrbSos
Component: pSos
∂
∂
time
pSos
=
D
pSos
+
kps
ppERK
Sos
-
kdps
pSos
Component: pRaf
∂
∂
time
pRaf
=
D
pRaf
-
V2
pRaf
K2
+
pRaf
Component: pMEK
∂
∂
time
pMEK
=
D
pMEK
+
k3
pRaf
MEKtot
-
pMEK
+
ppMEK
K3
+
MEKtot
-
pMEK
+
ppMEK
+
V5
ppMEK
K5
+
ppMEK
-
k4
pRaf
pMEK
K4
+
pMEK
+
V6
pMEK
K6
+
pMEK
Component: ppMEK
∂
∂
time
ppMEK
=
D
ppMEK
+
k4
pRaf
pMEK
K4
+
pMEK
-
V5
ppMEK
K5
+
ppMEK
Component: pERK
∂
∂
time
pERK
=
D
pERK
+
k7
ppMEK
ERKtot
-
pERK
+
ppERK
K7
+
ERKtot
-
pERK
+
ppERK
+
V9
ppERK
K9
+
ppERK
-
k8
ppMEK
pERK
K8
+
pERK
+
V10
pERK
K10
+
pERK
Component: ppERK
∂
∂
time
ppERK
=
D
ppERK
+
k8
ppMEK
pERK
K8
+
pERK
-
V9
ppERK
K9
+
ppERK
Component: parameters
Source
Derived from workspace
Maly, Wiley, Lauffenburger, 2004
at changeset
a650bb380cac
.
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This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis