Model Mathematics

Component: environment

Component: PI3K

ddtimeR=-kf1RHRG+kb1R_HRGddtimeHRG=-kf1RHRG+kb1R_HRGddtimeR_HRG=kf1RHRG-kb1R_HRG-twokf2R_HRGR_HRG-kb2R_HRG2ddtimeR_HRG2=kf2R_HRGR_HRG-kb2R_HRG2-kf3R_HRG2-kb3RP+V4RPk4+RPddtimeRP=kf3R_HRG2-kb3RP-V4RPk4+RP-kf5RPShc-kb5R_Shc+kf8R_ShP-kb8ShGSRP-kf23RPPI3K-kb23R_PI3K+kf25R_PI3Kstar-kb25RPPI3Kstar-kf34RP-kb34InternalisationddtimeInternalisation=kf34RP-kb34InternalisationddtimeR_Shc=kf5RPShc-kb5R_Shc-kf6R_Shc-kb6R_ShPddtimeShc=-kf5RPShc-kb5R_Shc+V10ShPk10+ShPddtimeR_ShP=kf6R_Shc-kb6R_ShP-kf7R_ShP-kb7R_ShGSddtimeGS=-kf7R_ShP-kb7R_ShGS+kf9ShGS-kb9GSShPddtimeShP=kf9ShGS-kb9GSShP-V10ShPk10+ShPddtimeR_ShGS=kf7R_ShP-kb7R_ShGS-kf8R_ShP-kb8ShGSRPddtimeShGS=kf8R_ShP-kb8ShGSRP-kf9ShGS-kb9GSShPddtimeR_PI3K=kf23RPPI3K-kb23R_PI3K-kf24R_PI3K-kb24R_PI3KstarddtimePI3K=-kf23RPPI3K-kb23R_PI3K+V26PI3Kstark26+PI3KstarddtimeR_PI3Kstar=kf24R_PI3K-kb24R_PI3Kstar-kf25R_PI3Kstar-kb25RPPI3KstarddtimePI3Kstar=kf25R_PI3Kstar-kb25RPPI3Kstar-V26PI3Kstark26+PI3Kstar

Component: RasGDPtoRasGTP

ddtimeRasGDP=-kf11ShGSRasGDPk11+RasGDP+V12RasGTPk12+RasGTPddtimeRasGTP=kf11ShGSRasGDPk11+RasGDP-V12RasGTPk12+RasGTP

Component: RAF

ddtimeRAF=kf14Akt_PIPP+ERAF_stark14+RAF_star-kf13RasGTPRAFk13+RAFddtimeRAF_star=-kf14Akt_PIPP+ERAF_stark14+RAF_star+kf13RasGTPRAFk13+RAF

Component: Akt

ddtimeP=V28PIP3k28+PIP3-kf27PI3KstarPk27+PddtimePIP3=-V28PIP3k28+PIP3+kf27PI3KstarPk27+P-kf29PIP3Akt-kb29Akt_PIP3ddtimeAkt=-kf29PIP3Akt-kb29Akt_PIP3ddtimeAkt_PIP3=kf29PIP3Akt-kb29Akt_PIP3-V30Akt_PIP3k30one+Akt_PIPk32+Akt_PIP3+kf31PP2AAkt_PIPk31one+MEKPk16+MEKPPk18+Akt_PIPPk33+Akt_PIPddtimeAkt_PIP=V30Akt_PIP3k30one+Akt_PIPk32+Akt_PIP3-kf31PP2AAkt_PIPk31one+MEKPk16+MEKPPk18+Akt_PIPPk33+Akt_PIP-V32Akt_PIPk32one+Akt_PIP3k30+Akt_PIP+kf33PP2AAkt_PIPPk33one+MEKPk16+MEKPPk18+Akt_PIPk31+Akt_PIPPddtimeAkt_PIPP=V32Akt_PIPk32one+Akt_PIP3k30+Akt_PIP-kf33PP2AAkt_PIPPk33one+MEKPk16+MEKPPk18+Akt_PIPk31+Akt_PIPP

Component: MEK

ddtimeMEK=-kf15RAF_starMEKk15one+MEKPk17+MEK+kf16PP2AMEKPk16one+MEKPPk18+Akt_PIPk31+Akt_PIPPk33+MEKPddtimeMEKP=kf15RAF_starMEKk15one+MEKPk17+MEK-kf16PP2AMEKPk16one+MEKPPk18+Akt_PIPk31+Akt_PIPPk33+MEKP-kf17RAF_starMEKPk17one+MEKk15+MEKP+kf18PP2AMEKPPk18one+MEKPk16+Akt_PIPk31+Akt_PIPPk33+MEKPPddtimeMEKPP=kf17RAF_starMEKPk17one+MEKk15+MEKP-kf18PP2AMEKPPk18one+MEKPk16+Akt_PIPk31+Akt_PIPPk33+MEKPP

Component: ERK

ddtimeERK=-kf19MEKPPERKk19one+ERKPk21+ERK+kf20MKP3ERKPk20one+ERKPPk22+ERKPddtimeERKPP=kf21MEKPPERKPk21one+ERKk19+ERKP-kf22MKP3ERKPPk22one+ERKPk20+ERKPPddtimeERKP=kf19MEKPPERKk19one+ERKPk21+ERK-kf20MKP3ERKPk20one+ERKPPk22+ERKP-kf21MEKPPERKPk21one+ERKk19+ERKP+kf22MKP3ERKPPk22one+ERKPk20+ERKPP