# Size of variable arrays: sizeAlgebraic = 2 sizeStates = 2 sizeConstants = 9 from math import * from numpy import * def createLegends(): legend_states = [""] * sizeStates legend_rates = [""] * sizeStates legend_algebraic = [""] * sizeAlgebraic legend_voi = "" legend_constants = [""] * sizeConstants legend_voi = "time in component environment (minute)" legend_constants[0] = "PMO in component muscle_autoregulatory_local_blood_flow_control (mmHg)" legend_constants[6] = "PDO in component M_autoregulatory_driving_force (mmHg)" legend_constants[7] = "POE in component M_ST_sensitivity_control (mmHg)" legend_constants[1] = "POM in component parameter_values (dimensionless)" legend_algebraic[0] = "AMM1 in component M_ST_time_delay_and_limit (dimensionless)" legend_constants[2] = "A4K in component parameter_values (minute)" legend_constants[3] = "AMM4 in component parameter_values (dimensionless)" legend_states[0] = "AMM1T in component M_ST_time_delay_and_limit (dimensionless)" legend_constants[8] = "POF in component M_LT_sensitivity_control (mmHg)" legend_constants[4] = "POM2 in component parameter_values (dimensionless)" legend_states[1] = "AMM2 in component M_LT_time_delay (dimensionless)" legend_constants[5] = "A4K2 in component parameter_values (minute)" legend_algebraic[1] = "AMM in component global_M_blood_flow_autoregulation_output (dimensionless)" legend_rates[0] = "d/dt AMM1T in component M_ST_time_delay_and_limit (dimensionless)" legend_rates[1] = "d/dt AMM2 in component M_LT_time_delay (dimensionless)" return (legend_states, legend_algebraic, legend_voi, legend_constants) def initConsts(): constants = [0.0] * sizeConstants; states = [0.0] * sizeStates; constants[0] = 38.0666 constants[1] = 0.04 constants[2] = 0.1 constants[3] = 0.005 states[0] = 1.00269 constants[4] = 2 states[1] = 1.09071 constants[5] = 40000 constants[6] = constants[0]-38.0000 constants[7] = constants[6]*constants[1]+1.00000 constants[8] = constants[4]*constants[6]+1.00000 return (states, constants) def computeRates(voi, states, constants): rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic rates[0] = (constants[7]*1.00000-states[0])/constants[2] rates[1] = (constants[8]*1.00000-states[1])/constants[5] return(rates) def computeAlgebraic(constants, states, voi): algebraic = array([[0.0] * len(voi)] * sizeAlgebraic) states = array(states) voi = array(voi) algebraic[0] = custom_piecewise([less(states[0] , constants[3]), constants[3] , True, states[0]]) algebraic[1] = algebraic[0]*states[1] return algebraic def custom_piecewise(cases): """Compute result of a piecewise function""" return select(cases[0::2],cases[1::2]) def solve_model(): """Solve model with ODE solver""" from scipy.integrate import ode # Initialise constants and state variables (init_states, constants) = initConsts() # Set timespan to solve over voi = linspace(0, 10, 500) # Construct ODE object to solve r = ode(computeRates) r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1) r.set_initial_value(init_states, voi[0]) r.set_f_params(constants) # Solve model states = array([[0.0] * len(voi)] * sizeStates) states[:,0] = init_states for (i,t) in enumerate(voi[1:]): if r.successful(): r.integrate(t) states[:,i+1] = r.y else: break # Compute algebraic variables algebraic = computeAlgebraic(constants, states, voi) return (voi, states, algebraic) def plot_model(voi, states, algebraic): """Plot variables against variable of integration""" import pylab (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends() pylab.figure(1) pylab.plot(voi,vstack((states,algebraic)).T) pylab.xlabel(legend_voi) pylab.legend(legend_states + legend_algebraic, loc='best') pylab.show() if __name__ == "__main__": (voi, states, algebraic) = solve_model() plot_model(voi, states, algebraic)