Rendering of the source text

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<!--
This CellML file was generated on 11/03/2008 at 16:13:16 using:

COR (0.9.31.897)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->

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<article>
  <articleinfo>
  <title>Mathematical Model Of Action Potentials In The Periphery Of The Sinoatrial Node, 2000</title>
  <author>
    <firstname>Penny</firstname>
          <surname>Noble</surname>
    <affiliation>
      <shortaffil>Oxford University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This version of the CellML model was created by Alan Garny of Oxford University, it has been unit checked and the model runs in both COR and OpenCell to reproduce the published results. The units have been checked and they are consistent.
</para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
ABSTRACT: INTRODUCTION: Cardiac multicellular modeling has traditionally focused on ventricular electromechanics. More recently, models of the atria have started to emerge, and there is much interest in addressing sinoatrial node structure and function. METHODS AND RESULTS: We implemented a variety of one-dimensional sinoatrial models consisting of descriptions of central, transitional, and peripheral sinoatrial node cells, as well as rabbit or human atrial cells. These one-dimensional models were implemented using CMISS on an SGI Origin 2000 supercomputer. Intercellular coupling parameters recorded in experimental studies on sinoatrial node and atrial cell-pairs under-represent the electrotonic interactions that any cardiomyocyte would have in a multidimensional setting. Unsurprisingly, cell-to-cell coupling had to be scaled-up (by a factor of 5) in order to obtain a stable leading pacemaker site in the sinoatrial node center. Further critical parameters include the gradual increase in intercellular coupling from sinoatrial node center to periphery, and the presence of electrotonic interaction with atrial cells. Interestingly, the electrotonic effect of the atrium on sinoatrial node periphery is best described as opposing depolarization, rather than necessarily hyperpolarizing, as often assumed. CONCLUSION: Multicellular one-dimensional models of sinoatrial node and atrium can provide useful insight into the origin and spread of normal cardiac excitation. They require larger than "physiologic" intercellular conductivities in order to make up for a lack of "anatomical" spatial scaling. Multicellular models for more in-depth quantitative studies will require more realistic anatomico-physiologic properties.
</para>

<para>
Note: There is a second variable which varies between models; version.  If version=0 the CellML model behaves like the Zhang et al. 2000 model.  If version=1 the CellML model describes a 0D capable, or suitable for single cell modelling, and if version=2 the CellML model describes a 1D capable, or suitable for multicellular modelling.  By default the CellML model is setup to describe a central SAN cell (dCell=0) suitable for single cell modelling (version=1).
</para>

<para>
The original paper reference is cited below.
</para>

<para>
One-dimensional rabbit sinoatrial node models: benefits and limitations, A. Garny, P. Kohl, P.J. Hunter, M.R. Boyett and D. Noble, 2003, 
            <emphasis>The Journal of Cardiovascular Electrophysiology</emphasis>
          , 14, S121-S132. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10899081&amp;dopt=Abstract">PubMed ID: 14760914</ulink>
</para>

<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the Zhang et al SAN model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="zhang_2000.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Garny <emphasis>et al</emphasis> 2003 'published' and "0D capable' models of the action potentials in the cells of the SA node.  The 1D capable model has one additional current called I_Cap - or a persistant calcium current.</caption>
</informalfigure>


</sect1>
</article>
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            <eq/>
            <ci>tau_m</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0006247</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.832</cn>
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                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.335</cn>
                                    </apply>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">56.7</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.627</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.082</cn>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65.01</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="second">4<sep/>-5</cn>
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                  <apply>
                     <eq/>
                     <ci>Version</ci>
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                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0006247</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8322166</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.33566</cn>
                                    </apply>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">56.7062</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6274</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0823</cn>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">65.0131</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="second">4.569<sep/>-5</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="sodium_current_h_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="h" public_interface="out" units="dimensionless"/>
      <variable name="F_Na" units="dimensionless"/>
      <variable initial_value="0.015905380261" name="h1" units="dimensionless"/>
      <variable initial_value="0.01445216109" name="h2" units="dimensionless"/>
      <variable name="h1_infinity" units="dimensionless"/>
      <variable name="h2_infinity" units="dimensionless"/>
      <variable name="tau_h1" units="second"/>
      <variable name="tau_h2" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>F_Na</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0952</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.063</cn>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34.4</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.66</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.225</cn>
                                    </apply>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">63.7</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0869</cn>
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                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
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               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.09518</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06306</cn>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34.4</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.662</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2251</cn>
                                    </apply>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">63.7</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.08693</cn>
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               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>h</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>F_Na</ci>
                  </apply>
                  <ci>h1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>F_Na</ci>
                  <ci>h2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h1_infinity</ci>
                  <ci>h1</ci>
               </apply>
               <ci>tau_h1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>h2_infinity</ci>
                  <ci>h2</ci>
               </apply>
               <ci>tau_h2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>h1_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">66.1</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>h2_infinity</ci>
            <ci>h1_infinity</ci>
         </apply>
         <apply>
            <eq/>
            <ci>tau_h1</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="second">3.717<sep/>-6</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2815</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17.11</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.003732</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.3426</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.76</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0005977</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_h2</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="second">3.186<sep/>-8</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.6219</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18.8</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">7.189<sep/>-5</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.6683</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">34.07</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.003556</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable name="Version" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="FCell" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="nanoA"/>
      <variable initial_value="0.0058" name="g_Ca_L_Centre_Published" units="microS"/>
      <variable initial_value="0.0057938" name="g_Ca_L_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.0082" name="g_Ca_L_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.0659" name="g_Ca_L_Periphery_Published" units="microS"/>
      <variable initial_value="0.06588648" name="g_Ca_L_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0659" name="g_Ca_L_Periphery_1DCapable" units="microS"/>
      <variable name="g_Ca_L" units="microS"/>
      <variable initial_value="46.4" name="E_Ca_L" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="d_L" private_interface="in" units="dimensionless"/>
      <variable name="f_L" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Ca_L</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_Ca_L_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_Ca_L_Periphery_Published</ci>
                           <ci>g_Ca_L_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_Ca_L_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_Ca_L_Periphery_0DCapable</ci>
                           <ci>g_Ca_L_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
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               </piece>
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                  <apply>
                     <plus/>
                     <ci>g_Ca_L_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_Ca_L_Periphery_1DCapable</ci>
                           <ci>g_Ca_L_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
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         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <times/>
               <ci>g_Ca_L</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>f_L</ci>
                     <ci>d_L</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.006</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.1</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca_L</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.04804900895" name="d_L" public_interface="out" units="dimensionless"/>
      <variable name="alpha_d_L" units="per_second"/>
      <variable name="beta_d_L" units="per_second"/>
      <variable name="d_L_infinity" units="dimensionless"/>
      <variable name="tau_d_L" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d_L</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>d_L_infinity</ci>
                  <ci>d_L</ci>
               </apply>
               <ci>tau_d_L</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>alpha_d_L</ci>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">28.38</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">84.9</cn>
                           <ci>V</ci>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.208</cn>
                                 </apply>
                                 <ci>V</ci>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">28.39</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">84.9</cn>
                           <ci>V</ci>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.208</cn>
                                 </apply>
                                 <ci>V</ci>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">28.4</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">2.5</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">84.9</cn>
                           <ci>V</ci>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.208</cn>
                                 </apply>
                                 <ci>V</ci>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d_L</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">11.43</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.4</cn>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">11.42</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.4</cn>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d_L</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <apply>
                  <plus/>
                  <ci>alpha_d_L</ci>
                  <ci>beta_d_L</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_L_infinity</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">23.1</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.3</cn>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.8</cn>
                                       <ci>FCell</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.2</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.48779845203" name="f_L" public_interface="out" units="dimensionless"/>
      <variable name="alpha_f_L" units="per_second"/>
      <variable name="beta_f_L" units="per_second"/>
      <variable name="f_L_infinity" units="dimensionless"/>
      <variable name="tau_f_L" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_L</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_L_infinity</ci>
                  <ci>f_L</ci>
               </apply>
               <ci>tau_f_L</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f_L</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">3.75</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">3.12</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f_L</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">30</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">25</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f_L</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                           <ci>FCell</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>alpha_f_L</ci>
                        <ci>beta_f_L</ci>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <ci>alpha_f_L</ci>
                        <ci>beta_f_L</ci>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>f_L_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel">
      <variable name="Version" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="FCell" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="nanoA"/>
      <variable initial_value="0.0043" name="g_Ca_T_Centre_Published" units="microS"/>
      <variable initial_value="0.00427806" name="g_Ca_T_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.0021" name="g_Ca_T_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.0139" name="g_Ca_T_Periphery_Published" units="microS"/>
      <variable initial_value="0.0138823" name="g_Ca_T_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.00694" name="g_Ca_T_Periphery_1DCapable" units="microS"/>
      <variable name="g_Ca_T" units="microS"/>
      <variable initial_value="45" name="E_Ca_T" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="d_T" private_interface="in" units="dimensionless"/>
      <variable name="f_T" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Ca_T</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_Ca_T_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_Ca_T_Periphery_Published</ci>
                           <ci>g_Ca_T_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_Ca_T_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_Ca_T_Periphery_0DCapable</ci>
                           <ci>g_Ca_T_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_Ca_T_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_Ca_T_Periphery_1DCapable</ci>
                           <ci>g_Ca_T_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_Ca_T</ci>
               <ci>d_T</ci>
               <ci>f_T</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca_T</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_d_gate">
      <variable initial_value="0.42074047435" name="d_T" public_interface="out" units="dimensionless"/>
      <variable name="alpha_d_T" units="per_second"/>
      <variable name="beta_d_T" units="per_second"/>
      <variable name="d_T_infinity" units="dimensionless"/>
      <variable name="tau_d_T" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d_T</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>d_T_infinity</ci>
                  <ci>d_T</ci>
               </apply>
               <ci>tau_d_T</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d_T</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1068</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.3</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d_T</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1068</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.3</cn>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d_T</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_d_T</ci>
                  <ci>beta_d_T</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_T_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_f_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.038968420558" name="f_T" public_interface="out" units="dimensionless"/>
      <variable name="alpha_f_T" units="per_second"/>
      <variable name="beta_f_T" units="per_second"/>
      <variable name="f_T_infinity" units="dimensionless"/>
      <variable name="tau_f_T" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f_T</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_T_infinity</ci>
                  <ci>f_T</ci>
               </apply>
               <ci>tau_f_T</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f_T</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">15.3</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71</cn>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0.7</cn>
                                    <ci>FCell</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">83.3</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">15.3</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71.7</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">83.3</cn>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f_T</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">15</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.38</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">15</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71.7</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.38</cn>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f_T</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_f_T</ci>
                  <ci>beta_f_T</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_T_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">71</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="four_AP_sensitive_currents">
      <variable name="Version" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="FCell" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="four_AP_sensitive_currents_i_to" name="i_to" public_interface="out" units="nanoA"/>
      <variable cmeta:id="four_AP_sensitive_currents_i_sus" name="i_sus" public_interface="out" units="nanoA"/>
      <variable initial_value="0.00491" name="g_to_Centre_Published" units="microS"/>
      <variable initial_value="0.004905" name="g_to_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.004905" name="g_to_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.03649" name="g_to_Periphery_Published" units="microS"/>
      <variable initial_value="0.036495" name="g_to_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0365" name="g_to_Periphery_1DCapable" units="microS"/>
      <variable name="g_to" units="microS"/>
      <variable initial_value="6.65e-5" name="g_sus_Centre_Published" units="microS"/>
      <variable initial_value="6.645504e-5" name="g_sus_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.000266" name="g_sus_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.0114" name="g_sus_Periphery_Published" units="microS"/>
      <variable initial_value="0.01138376" name="g_sus_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0114" name="g_sus_Periphery_1DCapable" units="microS"/>
      <variable name="g_sus" units="microS"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="q" private_interface="in" units="dimensionless"/>
      <variable name="r" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_to</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_to_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_to_Periphery_Published</ci>
                           <ci>g_to_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_to_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_to_Periphery_0DCapable</ci>
                           <ci>g_to_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_to_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_to_Periphery_1DCapable</ci>
                           <ci>g_to_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>g_sus</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_sus_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_sus_Periphery_Published</ci>
                           <ci>g_sus_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_sus_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_sus_Periphery_0DCapable</ci>
                           <ci>g_sus_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_sus_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_sus_Periphery_1DCapable</ci>
                           <ci>g_sus_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <ci>q</ci>
               <ci>r</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_sus</ci>
            <apply>
               <times/>
               <ci>g_sus</ci>
               <ci>r</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="four_AP_sensitive_currents_q_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.29760539675" name="q" public_interface="out" units="dimensionless"/>
      <variable name="q_infinity" units="dimensionless"/>
      <variable name="tau_q" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>q</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>q_infinity</ci>
                  <ci>q</ci>
               </apply>
               <ci>tau_q</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>q_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.37</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_q</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0101</cn>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.06517</cn>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.57</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08</cn>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">49</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="second">2.4<sep/>-5</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50.93</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">30.31</cn>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">195.5</cn>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5686</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08161</cn>
                                       </apply>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">39</cn>
                                          <apply>
                                             <times/>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                             <ci>FCell</ci>
                                          </apply>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.7174</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2719</cn>
                                          <apply>
                                             <times/>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1719</cn>
                                             <ci>FCell</ci>
                                          </apply>
                                       </apply>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">1</cn>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.93</cn>
                                          <apply>
                                             <times/>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                             <ci>FCell</ci>
                                          </apply>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.0101</cn>
                     <apply>
                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.06517</cn>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5686</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <apply>
                                       <minus/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08161</cn>
                                    </apply>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">39</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.7174</cn>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2719</cn>
                                    <apply>
                                       <plus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.93</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="four_AP_sensitive_currents_r_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.064402950262" name="r" public_interface="out" units="dimensionless"/>
      <variable name="r_infinity" units="dimensionless"/>
      <variable name="tau_r" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>r</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>r_infinity</ci>
                  <ci>r</ci>
               </apply>
               <ci>tau_r</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>r_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.93</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">19.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_r</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">2.98</cn>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">15.59</cn>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.037</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.09</cn>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30.61</cn>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.369</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.12</cn>
                                       </apply>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">23.84</cn>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0025</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1.191</cn>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">7.838</cn>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.037</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.09012</cn>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30.61</cn>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.369</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.119</cn>
                                       </apply>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">23.84</cn>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">2.98</cn>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">19.59</cn>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.037</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.09012</cn>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30.61</cn>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.369</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.119</cn>
                                       </apply>
                                       <apply>
                                          <plus/>
                                          <ci>V</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">23.84</cn>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifying_potassium_current">
      <variable name="Version" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="rapid_delayed_rectifying_potassium_current_i_K_r" name="i_K_r" public_interface="out" units="nanoA"/>
      <variable initial_value="0.000797" name="g_K_r_Centre_Published" units="microS"/>
      <variable initial_value="0.00079704" name="g_K_r_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.000738" name="g_K_r_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.016" name="g_K_r_Periphery_Published" units="microS"/>
      <variable initial_value="0.016" name="g_K_r_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0208" name="g_K_r_Periphery_1DCapable" units="microS"/>
      <variable name="g_K_r" units="microS"/>
      <variable name="P_a" units="dimensionless"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="P_af" private_interface="in" units="dimensionless"/>
      <variable name="P_as" private_interface="in" units="dimensionless"/>
      <variable name="P_i" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_r</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_K_r_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_K_r_Periphery_Published</ci>
                           <ci>g_K_r_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_K_r_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_K_r_Periphery_0DCapable</ci>
                           <ci>g_K_r_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_K_r_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_K_r_Periphery_1DCapable</ci>
                           <ci>g_K_r_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_r</ci>
            <apply>
               <times/>
               <ci>g_K_r</ci>
               <ci>P_a</ci>
               <ci>P_i</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_a</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                  <ci>P_af</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.4</cn>
                  <ci>P_as</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifying_potassium_current_P_af_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.13034201158" name="P_af" public_interface="out" units="dimensionless"/>
      <variable name="P_af_infinity" public_interface="out" units="dimensionless"/>
      <variable name="tau_P_af" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_af</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>P_af_infinity</ci>
                  <ci>P_af</ci>
               </apply>
               <ci>tau_P_af</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_af_infinity</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <neq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">13.2</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>tau_P_af</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">37.2</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.96</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.5</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <neq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">37.2</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.96</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.5</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifying_potassium_current_P_as_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.46960956028" name="P_as" public_interface="out" units="dimensionless"/>
      <variable name="P_as_infinity" units="dimensionless"/>
      <variable name="tau_P_as" units="second"/>
      <variable name="P_af_infinity" public_interface="in" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_as</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>P_as_infinity</ci>
                  <ci>P_as</ci>
               </apply>
               <ci>tau_P_as</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_as_infinity</ci>
            <ci>P_af_infinity</ci>
         </apply>
         <apply>
            <eq/>
            <ci>tau_P_as</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.2</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.15</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">21.6</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <neq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4.2</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">17</cn>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.15</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>V</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                    </apply>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">21.6</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifying_potassium_current_P_i_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.87993375273" name="P_i" public_interface="out" units="dimensionless"/>
      <variable name="P_i_infinity" units="dimensionless"/>
      <variable name="tau_P_i" units="second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>tau_P_i</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.002</cn>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.002</cn>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.006</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_i</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>P_i_infinity</ci>
                  <ci>P_i</ci>
               </apply>
               <ci>tau_P_i</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>P_i_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18.6</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifying_potassium_current">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="slow_delayed_rectifying_potassium_current_i_K_s" name="i_K_s" public_interface="out" units="nanoA"/>
      <variable initial_value="0.000518" name="g_K_s_Centre_Published" units="microS"/>
      <variable initial_value="0.0003445" name="g_K_s_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.000345" name="g_K_s_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.0104" name="g_K_s_Periphery_Published" units="microS"/>
      <variable initial_value="0.0104" name="g_K_s_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0104" name="g_K_s_Periphery_1DCapable" units="microS"/>
      <variable name="g_K_s" units="microS"/>
      <variable name="E_K_s" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="xs" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_s</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_K_s_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_K_s_Periphery_Published</ci>
                           <ci>g_K_s_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_K_s_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_K_s_Periphery_0DCapable</ci>
                           <ci>g_K_s_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_K_s_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_K_s_Periphery_1DCapable</ci>
                           <ci>g_K_s_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_s</ci>
            <apply>
               <times/>
               <ci>g_K_s</ci>
               <apply>
                  <power/>
                  <ci>xs</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K_s</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifying_potassium_current_xs_gate">
      <variable initial_value="0.082293827208" name="xs" public_interface="out" units="dimensionless"/>
      <variable name="alpha_xs" units="per_second"/>
      <variable name="beta_xs" units="per_second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_xs</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>xs</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_xs</ci>
                  <ci>xs</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_xs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">14</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_xs</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="hyperpolarisation_activated_current">
      <variable name="Version" private_interface="out" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="hyperpolarisation_activated_current_i_f_Na" name="i_f_Na" public_interface="out" units="nanoA"/>
      <variable cmeta:id="hyperpolarisation_activated_current_i_f_K" name="i_f_K" public_interface="out" units="nanoA"/>
      <variable initial_value="0.000548" name="g_f_Na_Centre_Published" units="microS"/>
      <variable initial_value="0.0005465" name="g_f_Na_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.000437" name="g_f_Na_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.0069" name="g_f_Na_Periphery_Published" units="microS"/>
      <variable initial_value="0.006875" name="g_f_Na_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0055" name="g_f_Na_Periphery_1DCapable" units="microS"/>
      <variable name="g_f_Na" units="microS"/>
      <variable initial_value="0.000548" name="g_f_K_Centre_Published" units="microS"/>
      <variable initial_value="0.0005465" name="g_f_K_Centre_0DCapable" units="microS"/>
      <variable initial_value="0.000437" name="g_f_K_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.0069" name="g_f_K_Periphery_Published" units="microS"/>
      <variable initial_value="0.006875" name="g_f_K_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.0055" name="g_f_K_Periphery_1DCapable" units="microS"/>
      <variable name="g_f_K" units="microS"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_f_Na</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_f_Na_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_f_Na_Periphery_Published</ci>
                           <ci>g_f_Na_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_f_Na_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_f_Na_Periphery_0DCapable</ci>
                           <ci>g_f_Na_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_f_Na_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_f_Na_Periphery_1DCapable</ci>
                           <ci>g_f_Na_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_f_Na</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <ci>g_f_Na</ci>
                     <ci>y</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_Na</ci>
                     </apply>
                  </apply>
                  <apply>
                     <neq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <ci>g_f_Na</ci>
                     <ci>y</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">77.6</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>g_f_K</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_f_K_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_f_K_Periphery_Published</ci>
                           <ci>g_f_K_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_f_K_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_f_K_Periphery_0DCapable</ci>
                           <ci>g_f_K_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_f_K_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_f_K_Periphery_1DCapable</ci>
                           <ci>g_f_K_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_f_K</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <ci>g_f_K</ci>
                     <ci>y</ci>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>E_K</ci>
                     </apply>
                  </apply>
                  <apply>
                     <neq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <ci>g_f_K</ci>
                     <ci>y</ci>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">102</cn>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="hyperpolarisation_activated_current_y_gate">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable initial_value="0.03889291759" name="y" public_interface="out" units="dimensionless"/>
      <variable name="alpha_y" units="per_second"/>
      <variable name="beta_y" units="per_second"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_y</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>y</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_y</ci>
                  <ci>y</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_y</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">78.91</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.62</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">78.91</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.63</cn>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_y</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">1</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75.13</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">21.25</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="sodium_background_current_i_b_Na" name="i_b_Na" public_interface="out" units="nanoA"/>
      <variable initial_value="5.8e-5" name="g_b_Na_Centre_Published" units="microS"/>
      <variable initial_value="5.81818e-5" name="g_b_Na_Centre_0DCapable" units="microS"/>
      <variable initial_value="5.8e-5" name="g_b_Na_Centre_1DCapable" units="microS"/>
      <variable initial_value="0.000189" name="g_b_Na_Periphery_Published" units="microS"/>
      <variable initial_value="0.0001888" name="g_b_Na_Periphery_0DCapable" units="microS"/>
      <variable initial_value="0.000189" name="g_b_Na_Periphery_1DCapable" units="microS"/>
      <variable name="g_b_Na" units="microS"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_b_Na</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_b_Na_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_Na_Periphery_Published</ci>
                           <ci>g_b_Na_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_b_Na_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_Na_Periphery_0DCapable</ci>
                           <ci>g_b_Na_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_b_Na_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_Na_Periphery_1DCapable</ci>
                           <ci>g_b_Na_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_b_Na</ci>
            <apply>
               <times/>
               <ci>g_b_Na</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="potassium_background_current">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="potassium_background_current_i_b_K" name="i_b_K" public_interface="out" units="nanoA"/>
      <variable initial_value="2.52e-5" name="g_b_K_Centre_Published" units="microS"/>
      <variable initial_value="2.523636e-5" name="g_b_K_Centre_0DCapable" units="microS"/>
      <variable initial_value="2.52e-5" name="g_b_K_Centre_1DCapable" units="microS"/>
      <variable initial_value="8.19e-5" name="g_b_K_Periphery_Published" units="microS"/>
      <variable initial_value="8.1892e-5" name="g_b_K_Periphery_0DCapable" units="microS"/>
      <variable initial_value="8.19e-5" name="g_b_K_Periphery_1DCapable" units="microS"/>
      <variable name="g_b_K" units="microS"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_b_K</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_b_K_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_K_Periphery_Published</ci>
                           <ci>g_b_K_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_b_K_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_K_Periphery_0DCapable</ci>
                           <ci>g_b_K_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_b_K_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_K_Periphery_1DCapable</ci>
                           <ci>g_b_K_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_b_K</ci>
            <apply>
               <times/>
               <ci>g_b_K</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="calcium_background_current_i_b_Ca" name="i_b_Ca" public_interface="out" units="nanoA"/>
      <variable initial_value="1.32e-5" name="g_b_Ca_Centre_Published" units="microS"/>
      <variable initial_value="1.3236e-5" name="g_b_Ca_Centre_0DCapable" units="microS"/>
      <variable initial_value="1.323e-5" name="g_b_Ca_Centre_1DCapable" units="microS"/>
      <variable initial_value="4.3e-5" name="g_b_Ca_Periphery_Published" units="microS"/>
      <variable initial_value="4.2952e-5" name="g_b_Ca_Periphery_0DCapable" units="microS"/>
      <variable initial_value="4.29e-5" name="g_b_Ca_Periphery_1DCapable" units="microS"/>
      <variable name="g_b_Ca" units="microS"/>
      <variable name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_b_Ca</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_b_Ca_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_Ca_Periphery_Published</ci>
                           <ci>g_b_Ca_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>g_b_Ca_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_Ca_Periphery_0DCapable</ci>
                           <ci>g_b_Ca_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>g_b_Ca_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>g_b_Ca_Periphery_1DCapable</ci>
                           <ci>g_b_Ca_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_b_Ca</ci>
            <apply>
               <times/>
               <ci>g_b_Ca</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_calcium_exchanger">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="sodium_calcium_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="nanoA"/>
      <variable initial_value="2.7e-6" name="k_NaCa_Centre_Published" units="nanoA"/>
      <variable initial_value="2.7229e-6" name="k_NaCa_Centre_0DCapable" units="nanoA"/>
      <variable initial_value="2.8e-6" name="k_NaCa_Centre_1DCapable" units="nanoA"/>
      <variable initial_value="8.8e-6" name="k_NaCa_Periphery_Published" units="nanoA"/>
      <variable initial_value="8.83584e-6" name="k_NaCa_Periphery_0DCapable" units="nanoA"/>
      <variable initial_value="8.8e-6" name="k_NaCa_Periphery_1DCapable" units="nanoA"/>
      <variable name="k_NaCa" units="nanoA"/>
      <variable initial_value="0.0001" name="d_NaCa" units="dimensionless"/>
      <variable initial_value="0.5" name="gamma_NaCa" units="dimensionless"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>k_NaCa</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>k_NaCa_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>k_NaCa_Periphery_Published</ci>
                           <ci>k_NaCa_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>k_NaCa_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>k_NaCa_Periphery_0DCapable</ci>
                           <ci>k_NaCa_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>k_NaCa_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>k_NaCa_Periphery_1DCapable</ci>
                           <ci>k_NaCa_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>k_NaCa</ci>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <apply>
                                 <power/>
                                 <ci>Na_i</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                              </apply>
                              <ci>Ca_o</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03743</cn>
                                    <ci>V</ci>
                                    <ci>gamma_NaCa</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <apply>
                                 <power/>
                                 <ci>Na_o</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                              </apply>
                              <ci>Ca_i</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0374</cn>
                                    <ci>V</ci>
                                    <apply>
                                       <minus/>
                                       <ci>gamma_NaCa</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                        <apply>
                           <times/>
                           <ci>d_NaCa</ci>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <ci>Ca_i</ci>
                                 <apply>
                                    <power/>
                                    <ci>Na_o</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>Ca_o</ci>
                                 <apply>
                                    <power/>
                                    <ci>Na_i</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>k_NaCa</ci>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <apply>
                                 <power/>
                                 <ci>Na_i</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                              </apply>
                              <ci>Ca_o</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03743</cn>
                                    <ci>V</ci>
                                    <ci>gamma_NaCa</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <apply>
                                 <power/>
                                 <ci>Na_o</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                              </apply>
                              <ci>Ca_i</ci>
                              <apply>
                                 <exp/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03743</cn>
                                    <ci>V</ci>
                                    <apply>
                                       <minus/>
                                       <ci>gamma_NaCa</ci>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                        <apply>
                           <times/>
                           <ci>d_NaCa</ci>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <ci>Ca_i</ci>
                                 <apply>
                                    <power/>
                                    <ci>Na_o</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>Ca_o</ci>
                                 <apply>
                                    <power/>
                                    <ci>Na_i</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable cmeta:id="sodium_potassium_pump_i_p" name="i_p" public_interface="out" units="nanoA"/>
      <variable initial_value="5.64" name="K_m_Na" units="millimolar"/>
      <variable initial_value="0.621" name="K_m_K" units="millimolar"/>
      <variable initial_value="0.0478" name="i_p_max_Centre_Published" units="nanoA"/>
      <variable initial_value="0.04782545" name="i_p_max_Centre_0DCapable" units="nanoA"/>
      <variable initial_value="0.0478" name="i_p_max_Centre_1DCapable" units="nanoA"/>
      <variable initial_value="0.16" name="i_p_max_Periphery_Published" units="nanoA"/>
      <variable initial_value="0.1551936" name="i_p_max_Periphery_0DCapable" units="nanoA"/>
      <variable initial_value="0.16" name="i_p_max_Periphery_1DCapable" units="nanoA"/>
      <variable name="i_p_max" units="nanoA"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_max</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>i_p_max_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>i_p_max_Periphery_Published</ci>
                           <ci>i_p_max_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>i_p_max_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>i_p_max_Periphery_0DCapable</ci>
                           <ci>i_p_max_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>i_p_max_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>i_p_max_Periphery_1DCapable</ci>
                           <ci>i_p_max_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_p</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_p_max</ci>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Na_i</ci>
                        <apply>
                           <plus/>
                           <ci>K_m_Na</ci>
                           <ci>Na_i</ci>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_o</ci>
                        <apply>
                           <plus/>
                           <ci>K_m_K</ci>
                           <ci>K_o</ci>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.6</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="persistent_calcium_current">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="FCell" public_interface="in" units="dimensionless"/>
      <variable name="i_Ca_p" public_interface="out" units="nanoA"/>
      <variable initial_value="0" name="i_Ca_p_max_Centre_Published" units="nanoA"/>
      <variable initial_value="0" name="i_Ca_p_max_Centre_0DCapable" units="nanoA"/>
      <variable initial_value="0.0042" name="i_Ca_p_max_Centre_1DCapable" units="nanoA"/>
      <variable initial_value="0" name="i_Ca_p_max_Periphery_Published" units="nanoA"/>
      <variable initial_value="0" name="i_Ca_p_max_Periphery_0DCapable" units="nanoA"/>
      <variable initial_value="0.03339" name="i_Ca_p_max_Periphery_1DCapable" units="nanoA"/>
      <variable name="i_Ca_p_max" units="nanoA"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_p_max</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <ci>i_Ca_p_max_Centre_Published</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>i_Ca_p_max_Periphery_Published</ci>
                           <ci>i_Ca_p_max_Centre_Published</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <plus/>
                     <ci>i_Ca_p_max_Centre_0DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>i_Ca_p_max_Periphery_0DCapable</ci>
                           <ci>i_Ca_p_max_Centre_0DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <plus/>
                     <ci>i_Ca_p_max_Centre_1DCapable</ci>
                     <apply>
                        <times/>
                        <ci>FCell</ci>
                        <apply>
                           <minus/>
                           <ci>i_Ca_p_max_Periphery_1DCapable</ci>
                           <ci>i_Ca_p_max_Centre_1DCapable</ci>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_p</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_Ca_p_max</ci>
                  <ci>Ca_i</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ca_i</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0004</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ionic_concentrations">
      <variable initial_value="8" name="Na_i" public_interface="out" units="millimolar"/>
      <variable initial_value="140" name="Na_o" public_interface="out" units="millimolar"/>
      <variable initial_value="0.0001" name="Ca_i" public_interface="out" units="millimolar"/>
      <variable initial_value="2" name="Ca_o" public_interface="out" units="millimolar"/>
      <variable initial_value="140" name="K_i" public_interface="out" units="millimolar"/>
      <variable initial_value="5.4" name="K_o" public_interface="out" units="millimolar"/>
   </component>
   <component name="reversal_and_equilibrium_potentials">
      <variable name="Version" public_interface="in" units="dimensionless"/>
      <variable name="E_Na" public_interface="out" units="millivolt"/>
      <variable name="E_K" public_interface="out" units="millivolt"/>
      <variable name="E_K_s" public_interface="out" units="millivolt"/>
      <variable name="E_Ca" public_interface="out" units="millivolt"/>
      <variable name="K_o" public_interface="in" units="millimolar"/>
      <variable name="Na_o" public_interface="in" units="millimolar"/>
      <variable name="K_i" public_interface="in" units="millimolar"/>
      <variable name="Na_i" public_interface="in" units="millimolar"/>
      <variable name="Ca_o" public_interface="in" units="millimolar"/>
      <variable name="Ca_i" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="millijoule_per_mole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Na</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Na_o</ci>
                     <ci>Na_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>K_o</ci>
                     <ci>K_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ca_o</ci>
                     <ci>Ca_i</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K_s</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <ln/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>K_o</ci>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                                 <ci>Na_o</ci>
                              </apply>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>K_i</ci>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                                 <ci>Na_i</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>Version</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                        <ci>F</ci>
                     </apply>
                     <apply>
                        <ln/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>K_o</ci>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.03</cn>
                                 <ci>Na_o</ci>
                              </apply>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>K_i</ci>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.03</cn>
                                 <ci>Na_i</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="sodium_current">
            <component_ref component="sodium_current_m_gate"/>
            <component_ref component="sodium_current_h_gate"/>
         </component_ref>
         <component_ref component="L_type_Ca_channel">
            <component_ref component="L_type_Ca_channel_d_gate"/>
            <component_ref component="L_type_Ca_channel_f_gate"/>
         </component_ref>
         <component_ref component="T_type_Ca_channel">
            <component_ref component="T_type_Ca_channel_d_gate"/>
            <component_ref component="T_type_Ca_channel_f_gate"/>
         </component_ref>
         <component_ref component="four_AP_sensitive_currents">
            <component_ref component="four_AP_sensitive_currents_q_gate"/>
            <component_ref component="four_AP_sensitive_currents_r_gate"/>
         </component_ref>
         <component_ref component="rapid_delayed_rectifying_potassium_current">
            <component_ref component="rapid_delayed_rectifying_potassium_current_P_af_gate"/>
            <component_ref component="rapid_delayed_rectifying_potassium_current_P_as_gate"/>
            <component_ref component="rapid_delayed_rectifying_potassium_current_P_i_gate"/>
         </component_ref>
         <component_ref component="slow_delayed_rectifying_potassium_current">
            <component_ref component="slow_delayed_rectifying_potassium_current_xs_gate"/>
         </component_ref>
         <component_ref component="hyperpolarisation_activated_current">
            <component_ref component="hyperpolarisation_activated_current_y_gate"/>
         </component_ref>
         <component_ref component="sodium_background_current"/>
         <component_ref component="calcium_background_current"/>
         <component_ref component="potassium_background_current"/>
         <component_ref component="sodium_calcium_exchanger"/>
         <component_ref component="sodium_potassium_pump"/>
         <component_ref component="persistent_calcium_current"/>
         <component_ref component="ionic_concentrations"/>
         <component_ref component="reversal_and_equilibrium_potentials"/>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="sodium_current">
         <component_ref component="sodium_current_m_gate"/>
         <component_ref component="sodium_current_h_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_d_gate"/>
         <component_ref component="T_type_Ca_channel_f_gate"/>
      </component_ref>
      <component_ref component="four_AP_sensitive_currents">
         <component_ref component="four_AP_sensitive_currents_q_gate"/>
         <component_ref component="four_AP_sensitive_currents_r_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifying_potassium_current">
         <component_ref component="rapid_delayed_rectifying_potassium_current_P_af_gate"/>
         <component_ref component="rapid_delayed_rectifying_potassium_current_P_as_gate"/>
         <component_ref component="rapid_delayed_rectifying_potassium_current_P_i_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifying_potassium_current">
         <component_ref component="slow_delayed_rectifying_potassium_current_xs_gate"/>
      </component_ref>
      <component_ref component="hyperpolarisation_activated_current">
         <component_ref component="hyperpolarisation_activated_current_y_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="four_AP_sensitive_currents" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifying_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifying_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarisation_activated_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="four_AP_sensitive_currents"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
      <map_variables variable_1="i_sus" variable_2="i_sus"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="rapid_delayed_rectifying_potassium_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_K_r" variable_2="i_K_r"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="slow_delayed_rectifying_potassium_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_K_s" variable_2="i_K_s"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="hyperpolarisation_activated_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_f_Na" variable_2="i_f_Na"/>
      <map_variables variable_1="i_f_K" variable_2="i_f_K"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_background_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_b_Na" variable_2="i_b_Na"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="potassium_background_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_b_K" variable_2="i_b_K"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_background_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_b_Ca" variable_2="i_b_Ca"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_calcium_exchanger"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_p" variable_2="i_p"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="persistent_calcium_current"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="i_Ca_p" variable_2="i_Ca_p"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="reversal_and_equilibrium_potentials"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="sodium_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="ionic_concentrations" component_2="sodium_current"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="four_AP_sensitive_currents"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="rapid_delayed_rectifying_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="slow_delayed_rectifying_potassium_current"/>
      <map_variables variable_1="E_K_s" variable_2="E_K_s"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="hyperpolarisation_activated_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="sodium_background_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="potassium_background_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="calcium_background_current"/>
      <map_variables variable_1="E_Ca" variable_2="E_Ca"/>
   </connection>
   <connection>
      <map_components component_1="sodium_calcium_exchanger" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
   </connection>
   <connection>
      <map_components component_1="reversal_and_equilibrium_potentials" component_2="ionic_concentrations"/>
      <map_variables variable_1="K_o" variable_2="K_o"/>
      <map_variables variable_1="Na_o" variable_2="Na_o"/>
      <map_variables variable_1="K_i" variable_2="K_i"/>
      <map_variables variable_1="Na_i" variable_2="Na_i"/>
      <map_variables variable_1="Ca_o" variable_2="Ca_o"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
   </connection>
   <connection>
      <map_components component_1="persistent_calcium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ca_i" variable_2="Ca_i"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="sodium_current_m_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="sodium_current" component_2="sodium_current_h_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="d_L" variable_2="d_L"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="f_L" variable_2="f_L"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_d_gate"/>
      <map_variables variable_1="d_T" variable_2="d_T"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_f_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="f_T" variable_2="f_T"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="four_AP_sensitive_currents" component_2="four_AP_sensitive_currents_q_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="FCell" variable_2="FCell"/>
      <map_variables variable_1="q" variable_2="q"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="four_AP_sensitive_currents" component_2="four_AP_sensitive_currents_r_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="r" variable_2="r"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifying_potassium_current" component_2="rapid_delayed_rectifying_potassium_current_P_af_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="P_af" variable_2="P_af"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifying_potassium_current" component_2="rapid_delayed_rectifying_potassium_current_P_as_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="P_as" variable_2="P_as"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifying_potassium_current_P_af_gate" component_2="rapid_delayed_rectifying_potassium_current_P_as_gate"/>
      <map_variables variable_1="P_af_infinity" variable_2="P_af_infinity"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifying_potassium_current" component_2="rapid_delayed_rectifying_potassium_current_P_i_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="P_i" variable_2="P_i"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifying_potassium_current" component_2="slow_delayed_rectifying_potassium_current_xs_gate"/>
      <map_variables variable_1="xs" variable_2="xs"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="hyperpolarisation_activated_current" component_2="hyperpolarisation_activated_current_y_gate"/>
      <map_variables variable_1="Version" variable_2="Version"/>
      <map_variables variable_1="y" variable_2="y"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>



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xml:lang="en">Lei</Family></rdf:Description><rdf:Description rdf:about="rdf:#dee551d1-2252-4bc6-8bf4-b9ee129c52f1"><rdf:value xml:lang="en">alan.garny@dpag.ox.ac.uk</rdf:value><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n6"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n4"/></boundIntervals></rdf:Description><rdf:Description rdf:about="rdf:#44639f26-ec90-48e8-a934-3174d7e81ab8"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">A</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Garny</Family></rdf:Description><rdf:Description rdf:nodeID="n3"><rdf:value><rdf:Description rdf:nodeID="n1"/></rdf:value><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type></rdf:Description><rdf:Description rdf:about="rdf:#9c8f8a7e-206a-4406-8358-eda7523d6a07"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2007-06-14T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#d794b673-c4a7-4f32-9aae-6dbb02840341"><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en"></Other><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Garny</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Alan</Family></rdf:Description></rdf:RDF></model>
Model Curation
  • Curation Status c2
  • JSim c2
  • COR c2
  • OpenCell c2
Source
Derived from workspace Garny, Kohl, Hunter, Boyett, Noble, 2003 at changeset 6ccfa55a2824.
Collaboration
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License

This work is licensed under a Creative Commons Attribution 3.0 Unported License.