C C There are a total of 4 entries in the algebraic variable array. C There are a total of 3 entries in each of the rate and state variable arrays. C There are a total of 25 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is Vm in component membrane (millivolt). C CONSTS(1) is C in component membrane (picoF). C ALGBRC(3) is i_K in component potassium_current (picoA). C ALGBRC(4) is i_R in component repolarising_current (picoA). C STATES(2) is IP3 in component IP3 (nanomolar). C CONSTS(2) is m3IP3 in component IP3 (dimensionless). C CONSTS(3) is m4IP3 in component IP3 (dimensionless). C CONSTS(4) is kIP3 in component IP3 (first_order_rate_constant). C CONSTS(5) is A in component IP3 (dimensionless). C STATES(3) is Ca in component Ca (nanomolar). C CONSTS(6) is m3SR in component Ca (dimensionless). C CONSTS(7) is m4SR in component Ca (dimensionless). C CONSTS(8) is m3PMCA in component Ca (dimensionless). C CONSTS(9) is m4PMCA in component Ca (dimensionless). C CONSTS(10) is kSR_rel in component Ca (flux). C CONSTS(11) is kPMCA in component Ca (flux). C ALGBRC(2) is Jcat in component Jcat (flux). C CONSTS(12) is ECa in component Jcat (millivolt). C CONSTS(13) is Gcat in component Jcat (nanomolar_per_millivolt_second). C CONSTS(14) is m3cat in component Jcat (dimensionless). C CONSTS(15) is m4cat in component Jcat (dimensionless). C CONSTS(16) is Gtot in component potassium_current (picoS). C ALGBRC(1) is PoBKCa in component potassium_current (dimensionless). C CONSTS(17) is PoSKCa in component potassium_current (dimensionless). C CONSTS(18) is E_K in component potassium_current (millivolt). C CONSTS(19) is a in component potassium_current (dimensionless). C CONSTS(20) is b in component potassium_current (dimensionless). C CONSTS(21) is c in component potassium_current (dimensionless). C CONSTS(22) is m3 in component potassium_current (dimensionless). C CONSTS(23) is m4 in component potassium_current (dimensionless). C CONSTS(24) is GR in component repolarising_current (picoS). C CONSTS(25) is Vrest in component repolarising_current (millivolt). C RATES(1) is d/dt Vm in component membrane (millivolt). C RATES(2) is d/dt IP3 in component IP3 (nanomolar). C RATES(3) is d/dt Ca in component Ca (nanomolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -31.1 CONSTS(1) = 1.0 STATES(2) = 1.0 CONSTS(2) = 4.0 CONSTS(3) = 55.0 CONSTS(4) = 0.1733 CONSTS(5) = 0.211 STATES(3) = 50.0 CONSTS(6) = 1.1 CONSTS(7) = 0.3 CONSTS(8) = -6.19 CONSTS(9) = 0.39 CONSTS(10) = 180.0 CONSTS(11) = 0.679 CONSTS(12) = 50.0 CONSTS(13) = 0.66 CONSTS(14) = -6.18 CONSTS(15) = 0.37 CONSTS(16) = 6927 CONSTS(17) = 0.5 CONSTS(18) = -80.0 CONSTS(19) = 53.3 CONSTS(20) = -80.8 CONSTS(21) = -6.4 CONSTS(22) = 1.32E-3 CONSTS(23) = 0.30 CONSTS(24) = 955.0 CONSTS(25) = -31.1 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(2) = CONSTS(5)*(1.00000+ tanh((CONSTS(2) - VOI)/CONSTS(3))) - CONSTS(4)*STATES(2) RATES(3) = (CONSTS(10)/2.00000)*(1.00000+ tanh((STATES(2) - CONSTS(6))/CONSTS(7))) - (CONSTS(11)/2.00000)*(1.00000+ tanh((arbitrary_log(STATES(3), 10) - CONSTS(8))/CONSTS(9))) ALGBRC(1) = 0.500000*(1.00000+ tanh(( (arbitrary_log(STATES(3), 10) - CONSTS(21))*(STATES(1) - CONSTS(20)) - CONSTS(19))/( CONSTS(22)*(STATES(1)+ CONSTS(19)*(arbitrary_log(STATES(3), 10) - CONSTS(21))) - CONSTS(20) ** 2.00000+CONSTS(23)))) ALGBRC(3) = CONSTS(16)*(STATES(1) - CONSTS(18))*( 0.400000*ALGBRC(1)+ 0.600000*CONSTS(17)) ALGBRC(4) = CONSTS(24)*(STATES(1) - CONSTS(25)) RATES(1) = - (1.00000/CONSTS(1))*(ALGBRC(3)+ALGBRC(4)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = 0.500000*(1.00000+ tanh(( (arbitrary_log(STATES(3), 10) - CONSTS(21))*(STATES(1) - CONSTS(20)) - CONSTS(19))/( CONSTS(22)*(STATES(1)+ CONSTS(19)*(arbitrary_log(STATES(3), 10) - CONSTS(21))) - CONSTS(20) ** 2.00000+CONSTS(23)))) ALGBRC(3) = CONSTS(16)*(STATES(1) - CONSTS(18))*( 0.400000*ALGBRC(1)+ 0.600000*CONSTS(17)) ALGBRC(4) = CONSTS(24)*(STATES(1) - CONSTS(25)) ALGBRC(2) = ( CONSTS(13)*(CONSTS(12) - STATES(1)))*( 0.500000*(1.00000+ tanh((arbitrary_log(STATES(3), 10) - CONSTS(14))/CONSTS(15)))) RETURN END