function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =0; end % There are a total of 7 entries in each of the rate and state variable arrays. % There are a total of 11 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (hour)'); LEGEND_STATES(:,1) = strpad('T in component T (cell_ml)'); LEGEND_CONSTANTS(:,1) = strpad('k1 in component model_parameters (cell_per_ml_molecule2_hour)'); LEGEND_STATES(:,2) = strpad('Lm in component Lm (molecule_cell)'); LEGEND_STATES(:,3) = strpad('RT in component RT (molecule_cell)'); LEGEND_STATES(:,4) = strpad('m in component m (cell_ml)'); LEGEND_STATES(:,5) = strpad('LT in component LT (molecule_cell)'); LEGEND_CONSTANTS(:,2) = strpad('k2 in component model_parameters (molecule_ml2_per_cell3_hour)'); LEGEND_CONSTANTS(:,3) = strpad('k3 in component model_parameters (per_hour)'); LEGEND_CONSTANTS(:,4) = strpad('k4 in component model_parameters (per_hour)'); LEGEND_CONSTANTS(:,5) = strpad('k5 in component model_parameters (ml2_per_cell_molecule_hour)'); LEGEND_STATES(:,6) = strpad('Rm in component Rm (molecule_cell)'); LEGEND_CONSTANTS(:,6) = strpad('k6 in component model_parameters (molecule_per_cell_hour)'); LEGEND_CONSTANTS(:,7) = strpad('k7 in component model_parameters (per_hour)'); LEGEND_CONSTANTS(:,8) = strpad('k8 in component model_parameters (per_molar_per_minute)'); LEGEND_STATES(:,7) = strpad('SL in component SL (molecule_ml)'); LEGEND_CONSTANTS(:,9) = strpad('k10 in component model_parameters (molecule_per_cell_hour)'); LEGEND_CONSTANTS(:,10) = strpad('k11 in component model_parameters (per_hour)'); LEGEND_CONSTANTS(:,11) = strpad('k9 in component model_parameters (per_molar_per_minute)'); LEGEND_RATES(:,1) = strpad('d/dt T in component T (cell_ml)'); LEGEND_RATES(:,5) = strpad('d/dt LT in component LT (molecule_cell)'); LEGEND_RATES(:,3) = strpad('d/dt RT in component RT (molecule_cell)'); LEGEND_RATES(:,4) = strpad('d/dt m in component m (cell_ml)'); LEGEND_RATES(:,2) = strpad('d/dt Lm in component Lm (molecule_cell)'); LEGEND_RATES(:,6) = strpad('d/dt Rm in component Rm (molecule_cell)'); LEGEND_RATES(:,7) = strpad('d/dt SL in component SL (molecule_ml)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = 500.0; CONSTANTS(:,1) = 8.38E-10; STATES(:,2) = 1E3; STATES(:,3) = 1E4; STATES(:,4) = 500.0; STATES(:,5) = 0.0; CONSTANTS(:,2) = 6E-3; CONSTANTS(:,3) = 5.9413; CONSTANTS(:,4) = 0.35; CONSTANTS(:,5) = 2.52E-9; STATES(:,6) = 1E3; CONSTANTS(:,6) = 2.244E3; CONSTANTS(:,7) = 0.35; CONSTANTS(:,8) = 1.92E10; STATES(:,7) = 0.0; CONSTANTS(:,9) = 3.11E3; CONSTANTS(:,10) = 13.9; CONSTANTS(:,11) = 87.3E8; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,1) = - ( 1.00000.*CONSTANTS(:,1).*STATES(:,4).*STATES(:,1).*STATES(:,2).*STATES(:,3)); RATES(:,5) = CONSTANTS(:,2).*STATES(:,1).*STATES(:,4) - ( CONSTANTS(:,3).*STATES(:,5)+ CONSTANTS(:,4).*STATES(:,5)+ CONSTANTS(:,5).*STATES(:,4).*STATES(:,1).*STATES(:,5).*STATES(:,6)); RATES(:,3) = CONSTANTS(:,6) - ( CONSTANTS(:,7).*STATES(:,3)+ 1.00000.*CONSTANTS(:,8).*STATES(:,3).*STATES(:,7)); RATES(:,4) = - ( 1.00000.*CONSTANTS(:,1).*STATES(:,4).*STATES(:,1).*STATES(:,5).*STATES(:,6)); RATES(:,2) = CONSTANTS(:,9) - ( CONSTANTS(:,3).*STATES(:,2)+ CONSTANTS(:,4).*STATES(:,2)+ CONSTANTS(:,5).*STATES(:,4).*STATES(:,1).*STATES(:,2).*STATES(:,3)); RATES(:,6) = CONSTANTS(:,6) - ( CONSTANTS(:,7).*STATES(:,6)+ 1.00000.*CONSTANTS(:,8).*STATES(:,6).*STATES(:,7)); RATES(:,7) = CONSTANTS(:,3).*( STATES(:,2).*STATES(:,4)+ STATES(:,5).*STATES(:,1)) - ( CONSTANTS(:,10).*STATES(:,7)+ 1.00000.*CONSTANTS(:,11).*( STATES(:,6).*STATES(:,4)+ STATES(:,3).*STATES(:,1)).*STATES(:,7)); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end