Rendering of the source text

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This CellML file was generated on 19/02/2009 at 09:31:24 using:

COR (0.9.31.1175)
Copyright 2002-2009 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.CellML.org/
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				<title>The functional role of cardiac T-tubules explored in a model of rat ventricular myocytes</title>
				<author>
					<firstname>Catherine</firstname>
					<surname>Lloyd</surname>
					<affiliation>
						<shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
            This CellML model is known to run in both COR and PCEnv to recreate the published results. The units have been checked and they are consistent. This particular version of the CellML model was translated from the author's original Matlab code and it stabilises at 1Hz.</para>
				<para>Please note that this model is relatively stiff. If you run the model using the default COR settings, you will get a message that reads: "Problem with the CVODE integrator: at t=0.00170178, mxstep steps taken before reaching tout." This basically means that you have to increase the maximum number of steps which is, by default, set to 500. Such a value is sufficient for most ODE problems, but not for ODE problems that have very stiff ODEs, such as the current model. Anyway, you will see that the model runs fine if you increase the value to something like 5000. Note that you also need to set the maximum time step to a sensible value, i.e. the duration of the stimulus which is here 1 ms.</para>
				<para>Regarding PCEnv, it uses a higher value than COR for the maximum number of steps, which is why the model will run in PCEnv without having to change this particular setting. Otherwise, like in COR there is a need to set the maximum time step to a sensible value. PCEnv uses a default value of 1 s for the Pasek model, which is clearly not small enough as can be seen when running the model for 10 s. If one uses 0.001 s, then everything is fine.
          </para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>
ABSTRACT: The morphology of the cardiac transverse-axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. The geometrical characteristics of the TATS, the biophysical characteristics of ion transporters and their distribution between surface and tubular membranes were based on available experimental data. Biophysically realistic values of mean access resistance to the tubular lumen and time constants for ion exchange with the bulk extracellular solution were included. The fraction of membrane in the TATS was set to 56%. The action potentials initiated in current-clamp mode are accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady-state stimulation frequencies of 1-5Hz. Ca2+ depletion increased from 7 to 13.1% with stimulation frequency, while K+ accumulation decreased from 4.1 to 2.7%. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.
</para>
				<para>
The original paper reference is cited below:
</para>
				<para>
					The functional role of cardiac T-tubules explored in a model of rat ventricular myocytes, Michal Pasek, Jiri Simurda, and Georges Christe, 2006, <emphasis>Philosophical Transactions of The Royal Society A</emphasis>, 81, 3029-3051. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=16608703&amp;dopt=Abstract">PubMed ID: 16608703</ulink>
				</para>
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					<pCation>Schematic of a ventricular myocyte. The description of electrical activity of surface (s) and tubular (t) membrane comprises formulation of ion transporters that are labelled in the scheme. The intracellular space contains the subspace, the Ca2+ uptake and Ca2+ release compartments of sarcoplasmic reticulum (NSR, JSR) and the Ca2+ buffers calmodulin (Bcm), troponin (Bltrpn,Bhtrpn) and calsequestrin (Bcs). The small filled rectangles in JSR membrane represent ryanodine receptors. The small bi-directional arrows denote Ca2+ diffusion. The dashed arrow represents ionic diffusion between the tubular and the bulk space. The currents included in the model were: ICa, calcium inward current; IKto, time-dependent transient outward potassium current; IKst, steady-state outward potassium current; IKf, hyperpolarization-activated current; IK1, time-independent inward rectifier potassium current; INab, background sodium current; ICab, background calcium current; IKb, background potassium current; INaCa, Na+/Ca2+ exchanger current; INaK, electrogenic Na+/K+ ATPase pump current; IpCa, sarcolemmal Ca-pump current.</pCation>
				</informalfigure>
				<para>
Note that this model is based on a quantitative description of electrical activity of the rat ventricular myocyte proposed by Pandit et al. (2001), which has also been described in CellML and can be found in the CellML Model Respository.
</para>
				
			</sect1>
		</article>
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         <apply>
            <eq/>
            <ci>gKfs</ci>
            <apply>
               <times/>
               <ci>gKf</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fKft</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKft</ci>
            <apply>
               <times/>
               <ci>gKf</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fKft</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKsts</ci>
            <apply>
               <times/>
               <ci>gKst</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fKstt</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKstt</ci>
            <apply>
               <times/>
               <ci>gKst</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fKstt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gK1s</ci>
            <apply>
               <times/>
               <ci>gK1</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fK1t</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gK1t</ci>
            <apply>
               <times/>
               <ci>gK1</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fK1t</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKbs</ci>
            <apply>
               <times/>
               <ci>gKb</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fKbt</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKbt</ci>
            <apply>
               <times/>
               <ci>gKb</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fKbt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKtos</ci>
            <apply>
               <times/>
               <ci>gKto</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fKtot</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gKtot</ci>
            <apply>
               <times/>
               <ci>gKto</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fKtot</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gNabs</ci>
            <apply>
               <times/>
               <ci>gNab</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fNabt</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gNabt</ci>
            <apply>
               <times/>
               <ci>gNab</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fNabt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gCabs</ci>
            <apply>
               <times/>
               <ci>gCab</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fCabt</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gCabt</ci>
            <apply>
               <times/>
               <ci>gCab</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fCabt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gCas</ci>
            <apply>
               <times/>
               <ci>gCa</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fCat</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gCat</ci>
            <apply>
               <times/>
               <ci>gCa</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fCat</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa_maxs</ci>
            <apply>
               <times/>
               <ci>i_NaCa_max</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fNaCat</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa_maxt</ci>
            <apply>
               <times/>
               <ci>i_NaCa_max</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fNaCat</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK_maxs</ci>
            <apply>
               <times/>
               <ci>i_NaK_max</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fNaKt</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK_maxt</ci>
            <apply>
               <times/>
               <ci>i_NaK_max</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fNaKt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_pCa_maxs</ci>
            <apply>
               <times/>
               <ci>i_pCa_max</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>fpCat</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_pCa_maxt</ci>
            <apply>
               <times/>
               <ci>i_pCa_max</ci>
               <apply>
                  <plus/>
                  <ci>Sms</ci>
                  <ci>Smt</ci>
               </apply>
               <ci>fpCat</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nas">
      <variable cmeta:id="i_Nas_i_Nas" name="i_Nas" public_interface="out" units="microA"/>
      <variable name="E_Nas" public_interface="out" units="millivolt"/>
      <variable name="gNas" public_interface="in" units="milliS"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nae" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Ke" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vms" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Nas</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <ln/>
                     <apply>
                        <divide/>
                        <ci>Nae</ci>
                        <ci>Nai</ci>
                     </apply>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
               <ci>F</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Nas</ci>
            <apply>
               <times/>
               <ci>gNas</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>Vms</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <ln/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>Nae</ci>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                                    <ci>Ke</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>Nai</ci>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                                    <ci>Ki</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                     <ci>F</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nas_m_gate">
      <variable initial_value="2.1832558e-6" name="m" public_interface="out" units="dimensionless"/>
      <variable name="alpha_m" units="per_second"/>
      <variable name="beta_m" units="per_second"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">117.26</cn>
                  <apply>
                     <plus/>
                     <ci>Vms</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.3</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.55</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">3800</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.072</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Vms</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">61</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nas_h_gate">
      <variable initial_value="5.8232781e-1" name="h" public_interface="out" units="dimensionless"/>
      <variable name="alpha_h" units="per_second"/>
      <variable name="beta_h" units="per_second"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">284.4</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0812</cn>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">115.9</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">18.77</cn>
                  <apply>
                     <plus/>
                     <ci>Vms</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">64.4</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.22</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">64.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nat">
      <variable cmeta:id="i_Nat_i_Nat" name="i_Nat" public_interface="out" units="microA"/>
      <variable name="E_Nat" public_interface="out" units="millivolt"/>
      <variable name="gNat" public_interface="in" units="milliS"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nat" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Kt" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vmt" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Nat</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <ln/>
                     <apply>
                        <divide/>
                        <ci>Nat</ci>
                        <ci>Nai</ci>
                     </apply>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
               <ci>F</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Nat</ci>
            <apply>
               <times/>
               <ci>gNat</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <apply>
                  <minus/>
                  <ci>Vmt</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <ln/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>Nat</ci>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                                    <ci>Kt</ci>
                                 </apply>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>Nai</ci>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
                                    <ci>Ki</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                     <ci>F</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nat_m_gate">
      <variable initial_value="2.1832694e-6" name="m" public_interface="out" units="dimensionless"/>
      <variable name="alpha_m" units="per_second"/>
      <variable name="beta_m" units="per_second"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">117.26</cn>
                  <apply>
                     <plus/>
                     <ci>Vmt</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.3</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.55</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.3</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">3800</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.072</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Vmt</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">61</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nat_h_gate">
      <variable initial_value="5.8232717e-1" name="h" public_interface="out" units="dimensionless"/>
      <variable name="alpha_h" units="per_second"/>
      <variable name="beta_h" units="per_second"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">284.4</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0812</cn>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">115.9</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">18.77</cn>
                  <apply>
                     <plus/>
                     <ci>Vmt</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">64.4</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.22</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">64.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Cas">
      <variable cmeta:id="i_Cas_i_Cas" name="i_Cas" public_interface="out" units="microA"/>
      <variable name="E_Cas" public_interface="out" units="millivolt"/>
      <variable initial_value="2.5436465e-6" name="Co" units="dimensionless"/>
      <variable initial_value="9.9994546e-1" name="C1" units="dimensionless"/>
      <variable initial_value="9.9994546e-1" name="C2" units="dimensionless"/>
      <variable name="tauCo" units="second"/>
      <variable initial_value="0.009" name="tauCcast" units="second"/>
      <variable name="tauC1" units="second"/>
      <variable name="tauC2" units="second"/>
      <variable initial_value="9.9570063e-1" name="Ccast" units="dimensionless"/>
      <variable name="Coinf" units="dimensionless"/>
      <variable name="Ccastinf" units="dimensionless"/>
      <variable name="C1inf" units="dimensionless"/>
      <variable name="C2inf" units="dimensionless"/>
      <variable name="gCas" public_interface="in" units="cm3_per_second"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="Cass" public_interface="in" units="millimolar"/>
      <variable name="Cae" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Cas</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <ln/>
                     <apply>
                        <divide/>
                        <ci>Cae</ci>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Coinf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.3</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauCo</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00025</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00305</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt2">0.0045</cn>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00105</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt2">0.002</cn>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <minus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.7</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauC1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.105</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>Vms</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.04</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>Vms</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.015</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C2inf</ci>
            <ci>C1inf</ci>
         </apply>
         <apply>
            <eq/>
            <ci>tauC2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.041</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>Vms</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.08</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>Vms</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">55</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.015</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ccastinf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cass</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.01</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>C1inf</ci>
                  <ci>C1</ci>
               </apply>
               <ci>tauC1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>C2inf</ci>
                  <ci>C2</ci>
               </apply>
               <ci>tauC2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Co</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Coinf</ci>
                  <ci>Co</ci>
               </apply>
               <ci>tauCo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ccast</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ccastinf</ci>
                  <ci>Ccast</ci>
               </apply>
               <ci>tauCcast</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Cas</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>gCas</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>Vms</ci>
                           <apply>
                              <power/>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Cass</ci>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    <ci>Vms</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
                           <ci>Cae</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>Vms</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <ci>Co</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                        <apply>
                           <divide/>
                           <ci>Ccast</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        </apply>
                     </apply>
                     <ci>C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                        <apply>
                           <divide/>
                           <ci>Ccast</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        </apply>
                     </apply>
                     <ci>C2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Cat">
      <variable cmeta:id="i_Cat_i_Cat" name="i_Cat" public_interface="out" units="microA"/>
      <variable name="E_Cat" public_interface="out" units="millivolt"/>
      <variable initial_value="2.543652e-6" name="Co" units="dimensionless"/>
      <variable initial_value="9.9994546e-1" name="C1" units="dimensionless"/>
      <variable initial_value="9.9994546e-1" name="C2" units="dimensionless"/>
      <variable name="tauCo" units="second"/>
      <variable initial_value="0.009" name="tauCcast" units="second"/>
      <variable name="tauC1" units="second"/>
      <variable name="tauC2" units="second"/>
      <variable name="Coinf" units="dimensionless"/>
      <variable initial_value="9.9570063e-1" name="Ccast" units="dimensionless"/>
      <variable name="Ccastinf" units="dimensionless"/>
      <variable name="C1inf" units="dimensionless"/>
      <variable name="C2inf" units="dimensionless"/>
      <variable name="gCat" public_interface="in" units="cm3_per_second"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="Cass" public_interface="in" units="millimolar"/>
      <variable name="Cat" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Cat</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <ln/>
                     <apply>
                        <divide/>
                        <ci>Cat</ci>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Coinf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15.3</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauCo</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00025</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00305</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt2">0.0045</cn>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.00105</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt2">0.002</cn>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <minus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">18</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">26.7</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauC1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.105</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>Vmt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.04</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>Vmt</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.015</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C2inf</ci>
            <ci>C1inf</ci>
         </apply>
         <apply>
            <eq/>
            <ci>tauC2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.041</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <ci>Vmt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47</cn>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">12</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.08</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>Vmt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">55</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.015</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">75</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ccastinf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cass</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.01</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>C1inf</ci>
                  <ci>C1</ci>
               </apply>
               <ci>tauC1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>C2inf</ci>
                  <ci>C2</ci>
               </apply>
               <ci>tauC2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Co</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Coinf</ci>
                  <ci>Co</ci>
               </apply>
               <ci>tauCo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ccast</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ccastinf</ci>
                  <ci>Ccast</ci>
               </apply>
               <ci>tauCcast</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Cat</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>gCat</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>Vmt</ci>
                           <apply>
                              <power/>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>Cass</ci>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    <ci>Vmt</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
                           <ci>Cat</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>Vmt</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
               <ci>Co</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.9</cn>
                        <apply>
                           <divide/>
                           <ci>Ccast</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        </apply>
                     </apply>
                     <ci>C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                        <apply>
                           <divide/>
                           <ci>Ccast</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        </apply>
                     </apply>
                     <ci>C2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktos">
      <variable cmeta:id="i_Ktos_i_Ktos" name="i_Ktos" public_interface="out" units="microA"/>
      <variable name="E_Ks" public_interface="out" units="millivolt"/>
      <variable name="gKtos" public_interface="in" units="milliS"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vms" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Ke" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="rs" private_interface="in" units="dimensionless"/>
      <variable name="ss" private_interface="in" units="dimensionless"/>
      <variable name="sss" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ktos</ci>
            <apply>
               <times/>
               <ci>gKtos</ci>
               <ci>rs</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.886</cn>
                     <ci>ss</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.114</cn>
                     <ci>sss</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>Vms</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <ln/>
                     <apply>
                        <divide/>
                        <ci>Ke</ci>
                        <ci>Ki</ci>
                     </apply>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
               <ci>F</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktos_rs_gate">
      <variable initial_value="2.3485072e-3" name="rs" public_interface="out" units="dimensionless"/>
      <variable name="taurs" units="second"/>
      <variable name="rinfs" units="dimensionless"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>rinfs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.6</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.42</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taurs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>rs</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>rinfs</ci>
                  <ci>rs</ci>
               </apply>
               <ci>taurs</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktos_ss_gate">
      <variable initial_value="9.8315843e-1" name="ss" public_interface="out" units="dimensionless"/>
      <variable name="tauss" units="second"/>
      <variable name="sinfs" units="dimensionless"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sinfs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.3</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8841</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauss</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.35</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0666</cn>
                              <apply>
                                 <plus/>
                                 <ci>Vms</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.035</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ss</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>sinfs</ci>
                  <ci>ss</ci>
               </apply>
               <ci>tauss</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktos_sss_gate">
      <variable initial_value="6.748337e-1" name="sss" public_interface="out" units="dimensionless"/>
      <variable name="tausss" units="second"/>
      <variable name="ssinfs" units="dimensionless"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>ssinfs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.3</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8841</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tausss</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">3.7</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0333</cn>
                              <apply>
                                 <plus/>
                                 <ci>Vms</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.035</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>sss</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ssinfs</ci>
                  <ci>sss</ci>
               </apply>
               <ci>tausss</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktot">
      <variable name="i_Ktot" public_interface="out" units="microA"/>
      <variable name="E_Kt" public_interface="out" units="millivolt"/>
      <variable name="gKtot" public_interface="in" units="milliS"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vmt" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Kt" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="rt" private_interface="in" units="dimensionless"/>
      <variable name="st" private_interface="in" units="dimensionless"/>
      <variable name="sst" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Kt</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <ln/>
                     <apply>
                        <divide/>
                        <ci>Kt</ci>
                        <ci>Ki</ci>
                     </apply>
                  </apply>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
               <ci>F</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ktot</ci>
            <apply>
               <times/>
               <ci>gKtot</ci>
               <ci>rt</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.886</cn>
                     <ci>st</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.114</cn>
                     <ci>sst</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>Vmt</ci>
                  <ci>E_Kt</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktot_rt_gate">
      <variable initial_value="2.3485094e-3" name="rt" public_interface="out" units="dimensionless"/>
      <variable name="taurt" units="second"/>
      <variable name="rinft" units="dimensionless"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>rinft</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.6</cn>
                        </apply>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.42</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taurt</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>rt</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>rinft</ci>
                  <ci>rt</ci>
               </apply>
               <ci>taurt</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktot_st_gate">
      <variable initial_value="9.8315865e-1" name="st" public_interface="out" units="dimensionless"/>
      <variable name="taust" units="second"/>
      <variable name="sinft" units="dimensionless"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sinft</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.3</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8841</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taust</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.35</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0666</cn>
                              <apply>
                                 <plus/>
                                 <ci>Vmt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.035</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>st</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>sinft</ci>
                  <ci>st</ci>
               </apply>
               <ci>taust</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ktot_sst_gate">
      <variable initial_value="6.7478532e-1" name="sst" public_interface="out" units="dimensionless"/>
      <variable name="tausst" units="second"/>
      <variable name="ssinft" units="dimensionless"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>ssinft</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">45.3</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8841</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tausst</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">3.7</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0333</cn>
                              <apply>
                                 <plus/>
                                 <ci>Vmt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">70</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">0.035</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>sst</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ssinft</ci>
                  <ci>sst</ci>
               </apply>
               <ci>tausst</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ksts">
      <variable name="i_Ksts" public_interface="out" units="microA"/>
      <variable name="gKsts" public_interface="in" units="milliS"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vms" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <variable name="rsts" private_interface="in" units="dimensionless"/>
      <variable name="ssts" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ksts</ci>
            <apply>
               <times/>
               <ci>gKsts</ci>
               <ci>rsts</ci>
               <ci>ssts</ci>
               <apply>
                  <minus/>
                  <ci>Vms</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ksts_rsts_gate">
      <variable initial_value="3.1079213e-3" name="rsts" public_interface="out" units="dimensionless"/>
      <variable name="taursts" units="second"/>
      <variable name="rstinfs" units="dimensionless"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>rstinfs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.82</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taursts</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">10</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>rsts</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>rstinfs</ci>
                  <ci>rsts</ci>
               </apply>
               <ci>taursts</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Ksts_ssts_gate">
      <variable initial_value="3.0773393e-1" name="ssts" public_interface="out" units="dimensionless"/>
      <variable initial_value="2.1" name="taussts" units="second"/>
      <variable name="sstinfs" units="dimensionless"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sstinfs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">87.5</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.3</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ssts</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>sstinfs</ci>
                  <ci>ssts</ci>
               </apply>
               <ci>taussts</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kstt">
      <variable cmeta:id="i_Kstt_i_Kstt" name="i_Kstt" public_interface="out" units="microA"/>
      <variable name="gKstt" public_interface="in" units="milliS"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vmt" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Kt" public_interface="in" units="millivolt"/>
      <variable name="rstt" private_interface="in" units="dimensionless"/>
      <variable name="sstt" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kstt</ci>
            <apply>
               <times/>
               <ci>gKstt</ci>
               <ci>rstt</ci>
               <ci>sstt</ci>
               <apply>
                  <minus/>
                  <ci>Vmt</ci>
                  <ci>E_Kt</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kstt_rstt_gate">
      <variable initial_value="3.1079241e-3" name="rstt" public_interface="out" units="dimensionless"/>
      <variable name="taurstt" units="second"/>
      <variable name="rstinft" units="dimensionless"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>rstinft</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.82</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>taurstt</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">10</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">45.16</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.03577</cn>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">98.9</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                           </apply>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>rstt</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>rstinft</ci>
                  <ci>rstt</ci>
               </apply>
               <ci>taurstt</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kstt_sstt_gate">
      <variable initial_value="3.0773368e-1" name="sstt" public_interface="out" units="dimensionless"/>
      <variable initial_value="2.1" name="tausstt" units="second"/>
      <variable name="sstinft" units="dimensionless"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sstinft</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">87.5</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.3</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>sstt</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>sstinft</ci>
                  <ci>sstt</ci>
               </apply>
               <ci>tausstt</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kfs">
      <variable cmeta:id="i_Kfs_i_Kfs" name="i_Kfs" public_interface="out" units="microA"/>
      <variable name="gKfs" public_interface="in" units="milliS"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vms" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <variable name="E_Nas" public_interface="in" units="millivolt"/>
      <variable name="qs" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kfs</ci>
            <apply>
               <times/>
               <ci>gKfs</ci>
               <ci>qs</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <apply>
                        <minus/>
                        <ci>Vms</ci>
                        <ci>E_Nas</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
                     <apply>
                        <minus/>
                        <ci>Vms</ci>
                        <ci>E_Ks</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kfs_qs_gate">
      <variable initial_value="3.4357356e-3" name="qs" public_interface="out" units="dimensionless"/>
      <variable name="tauqs" units="second"/>
      <variable name="qinfs" units="dimensionless"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>qinfs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vms</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">138.6</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.48</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauqs</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.11885</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vms</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28.37</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5623</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>Vms</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.19</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>qs</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>qinfs</ci>
                  <ci>qs</ci>
               </apply>
               <ci>tauqs</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kft">
      <variable cmeta:id="i_Kft_i_Kft" name="i_Kft" public_interface="out" units="microA"/>
      <variable name="gKft" public_interface="in" units="milliS"/>
      <variable name="time" private_interface="out" public_interface="in" units="second"/>
      <variable name="Vmt" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="E_Kt" public_interface="in" units="millivolt"/>
      <variable name="E_Nat" public_interface="in" units="millivolt"/>
      <variable name="qt" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kft</ci>
            <apply>
               <times/>
               <ci>gKft</ci>
               <ci>qt</ci>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     <apply>
                        <minus/>
                        <ci>Vmt</ci>
                        <ci>E_Nat</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
                     <apply>
                        <minus/>
                        <ci>Vmt</ci>
                        <ci>E_Kt</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kft_qt_gate">
      <variable initial_value="3.4357175e-3" name="qt" public_interface="out" units="dimensionless"/>
      <variable name="tauqt" units="second"/>
      <variable name="qinft" units="dimensionless"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>qinft</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>Vmt</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">138.6</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.48</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tauqt</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.11885</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>Vmt</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">28.37</cn>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5623</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>Vmt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.19</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>qt</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>qinft</ci>
                  <ci>qt</ci>
               </apply>
               <ci>tauqt</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_K1s">
      <variable cmeta:id="i_K1s_i_K1s" name="i_K1s" public_interface="out" units="microA"/>
      <variable name="gK1s" public_interface="in" units="milliS"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Ke" public_interface="in" units="millimolar"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K1s</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>gK1s</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>Vms</ci>
                        <ci>E_Ks</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.73</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.613</cn>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>Vms</ci>
                                 <ci>E_Ks</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.73</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>Ke</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.9988</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.124</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_K1t">
      <variable cmeta:id="i_K1t_i_K1t" name="i_K1t" public_interface="out" units="microA"/>
      <variable name="gK1t" public_interface="in" units="milliS"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Kt" public_interface="in" units="millimolar"/>
      <variable name="E_Kt" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_K1t</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>gK1t</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <ci>Vmt</ci>
                        <ci>E_Kt</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.73</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.613</cn>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>Vmt</ci>
                                 <ci>E_Kt</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.73</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <ci>Kt</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.9988</cn>
                              </apply>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.124</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nabs">
      <variable cmeta:id="i_Nabs_i_Nabs" name="i_Nabs" public_interface="out" units="microA"/>
      <variable name="gNabs" public_interface="in" units="milliS"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="E_Nas" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Nabs</ci>
            <apply>
               <times/>
               <ci>gNabs</ci>
               <apply>
                  <minus/>
                  <ci>Vms</ci>
                  <ci>E_Nas</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Nabt">
      <variable cmeta:id="i_Nabt_i_Nabt" name="i_Nabt" public_interface="out" units="microA"/>
      <variable name="gNabt" public_interface="in" units="milliS"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="E_Nat" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Nabt</ci>
            <apply>
               <times/>
               <ci>gNabt</ci>
               <apply>
                  <minus/>
                  <ci>Vmt</ci>
                  <ci>E_Nat</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Cabs">
      <variable cmeta:id="i_Cabs_i_Cabs" name="i_Cabs" public_interface="out" units="microA"/>
      <variable name="gCabs" public_interface="in" units="milliS"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="E_Cas" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Cabs</ci>
            <apply>
               <times/>
               <ci>gCabs</ci>
               <apply>
                  <minus/>
                  <ci>Vms</ci>
                  <ci>E_Cas</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Cabt">
      <variable cmeta:id="i_Cabt_i_Cabt" name="i_Cabt" public_interface="out" units="microA"/>
      <variable name="gCabt" public_interface="in" units="milliS"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="E_Cat" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Cabt</ci>
            <apply>
               <times/>
               <ci>gCabt</ci>
               <apply>
                  <minus/>
                  <ci>Vmt</ci>
                  <ci>E_Cat</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kbs">
      <variable cmeta:id="i_Kbs_i_Kbs" name="i_Kbs" public_interface="out" units="microA"/>
      <variable name="gKbs" public_interface="in" units="milliS"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <variable name="E_Ks" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kbs</ci>
            <apply>
               <times/>
               <ci>gKbs</ci>
               <apply>
                  <minus/>
                  <ci>Vms</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_Kbt">
      <variable cmeta:id="i_Kbt_i_Kbt" name="i_Kbt" public_interface="out" units="microA"/>
      <variable name="gKbt" public_interface="in" units="milliS"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <variable name="E_Kt" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kbt</ci>
            <apply>
               <times/>
               <ci>gKbt</ci>
               <apply>
                  <minus/>
                  <ci>Vmt</ci>
                  <ci>E_Kt</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaCas">
      <variable cmeta:id="i_NaCas_i_NaCas" name="i_NaCas" public_interface="out" units="microA"/>
      <variable name="i_NaCa_maxs" public_interface="in" units="microA"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nae" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cae" public_interface="in" units="millimolar"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCas</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_NaCa_maxs</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0187</cn>
                              <ci>Vms</ci>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cae</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0187</cn>
                              </apply>
                              <ci>Vms</ci>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nae</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0001</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nae</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cai</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nai</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cae</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaCat">
      <variable cmeta:id="i_NaCat_i_NaCat" name="i_NaCat" public_interface="out" units="microA"/>
      <variable name="i_NaCa_maxt" public_interface="in" units="microA"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nat" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cat" public_interface="in" units="millimolar"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCat</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_NaCa_maxt</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0187</cn>
                              <ci>Vmt</ci>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cat</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0187</cn>
                              </apply>
                              <ci>Vmt</ci>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nat</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0001</cn>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nat</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cai</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nai</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cat</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaKs">
      <variable cmeta:id="i_NaKs_i_NaKs" name="i_NaKs" public_interface="out" units="microA"/>
      <variable name="i_NaK_maxs" public_interface="in" units="microA"/>
      <variable name="Ke" public_interface="in" units="millimolar"/>
      <variable name="Nae" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Vms" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaKs</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>i_NaK_maxs</ci>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <divide/>
                                       <apply>
                                          <times/>
                                          <apply>
                                             <minus/>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                                          </apply>
                                          <ci>Vms</ci>
                                          <ci>F</ci>
                                       </apply>
                                       <apply>
                                          <times/>
                                          <ci>R</ci>
                                          <ci>T</ci>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <exp/>
                                       <apply>
                                          <divide/>
                                          <ci>Nae</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                                       </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <divide/>
                                       <apply>
                                          <times/>
                                          <apply>
                                             <minus/>
                                             <ci>Vms</ci>
                                          </apply>
                                          <ci>F</ci>
                                       </apply>
                                       <apply>
                                          <times/>
                                          <ci>R</ci>
                                          <ci>T</ci>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">10</cn>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Ke</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ke</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1.5</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_NaKt">
      <variable cmeta:id="i_NaKt_i_NaKt" name="i_NaKt" public_interface="out" units="microA"/>
      <variable name="i_NaK_maxt" public_interface="in" units="microA"/>
      <variable name="Kt" public_interface="in" units="millimolar"/>
      <variable name="Nat" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Vmt" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaKt</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <ci>i_NaK_maxt</ci>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <divide/>
                                       <apply>
                                          <times/>
                                          <apply>
                                             <minus/>
                                             <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                                          </apply>
                                          <ci>Vmt</ci>
                                          <ci>F</ci>
                                       </apply>
                                       <apply>
                                          <times/>
                                          <ci>R</ci>
                                          <ci>T</ci>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <exp/>
                                       <apply>
                                          <divide/>
                                          <ci>Nat</ci>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                                       </apply>
                                    </apply>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <divide/>
                                       <apply>
                                          <times/>
                                          <apply>
                                             <minus/>
                                             <ci>Vmt</ci>
                                          </apply>
                                          <ci>F</ci>
                                       </apply>
                                       <apply>
                                          <times/>
                                          <ci>R</ci>
                                          <ci>T</ci>
                                       </apply>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">10</cn>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Kt</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Kt</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1.5</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_pCas">
      <variable cmeta:id="i_pCas_i_pCas" name="i_pCas" public_interface="out" units="microA"/>
      <variable name="i_pCa_maxs" public_interface="in" units="microA"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_pCas</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_pCa_maxs</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0004</cn>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="i_pCat">
      <variable cmeta:id="i_pCat_i_pCat" name="i_pCat" public_interface="out" units="microA"/>
      <variable name="i_pCa_maxt" public_interface="in" units="microA"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_pCat</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_pCa_maxt</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0004</cn>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="t_tubular_ion_fluxes">
      <variable name="JteNa" public_interface="out" units="millimolar_per_second"/>
      <variable name="JteCa" public_interface="out" units="millimolar_per_second"/>
      <variable name="JteK" public_interface="out" units="millimolar_per_second"/>
      <variable initial_value="0.15" name="tauNa" units="second"/>
      <variable initial_value="0.5" name="tauCa" units="second"/>
      <variable initial_value="0.15" name="tauK" units="second"/>
      <variable name="Vt" public_interface="in" units="cm3"/>
      <variable name="Nat" public_interface="in" units="millimolar"/>
      <variable name="Cat" public_interface="in" units="millimolar"/>
      <variable name="Kt" public_interface="in" units="millimolar"/>
      <variable name="Nae" public_interface="in" units="millimolar"/>
      <variable name="Cae" public_interface="in" units="millimolar"/>
      <variable name="Ke" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>JteNa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3">1</cn>
                     <ci>Vt</ci>
                  </apply>
                  <ci>tauNa</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>Nat</ci>
                  <ci>Nae</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>JteCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3">1</cn>
                     <ci>Vt</ci>
                  </apply>
                  <ci>tauCa</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>Cat</ci>
                  <ci>Cae</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>JteK</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3">1</cn>
                     <ci>Vt</ci>
                  </apply>
                  <ci>tauK</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>Kt</ci>
                  <ci>Ke</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="JCaSRup">
      <variable cmeta:id="JCaSRup_JCaSRup" name="JCaSRup" public_interface="out" units="millimolar_per_second"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="CaSRup" public_interface="in" units="millimolar"/>
      <variable name="Vmyo" public_interface="in" units="cm3"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>JCaSRup</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3_second">1</cn>
                  <ci>Vmyo</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.04</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">10</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Cai</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.000168</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.9</cn>
                           <ci>CaSRup</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">3.29</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Cai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.000168</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>CaSRup</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">3.29</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Jtr">
      <variable cmeta:id="Jtr_Jtr" name="Jtr" public_interface="out" units="millimolar_per_second"/>
      <variable initial_value="0.03448" name="tautr" units="second"/>
      <variable name="CaSRrel" public_interface="in" units="millimolar"/>
      <variable name="CaSRup" public_interface="in" units="millimolar"/>
      <variable name="VSRrel" public_interface="in" units="cm3"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Jtr</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3">1</cn>
                     <ci>VSRrel</ci>
                  </apply>
                  <ci>tautr</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>CaSRup</ci>
                  <ci>CaSRrel</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="JCaSRrel">
      <variable cmeta:id="JCaSRrel_JCaSRrel" name="JCaSRrel" public_interface="out" units="millimolar_per_second"/>
      <variable name="kap" units="per_millimolar4_per_second"/>
      <variable initial_value="576" name="kam" units="per_second"/>
      <variable name="kbp" units="per_millimolar3_per_second"/>
      <variable initial_value="1930" name="kbm" units="per_second"/>
      <variable initial_value="18" name="kcp" units="per_second"/>
      <variable initial_value="0.8" name="kcm" units="per_second"/>
      <variable initial_value="6.7606483e-1" name="F1" units="dimensionless"/>
      <variable initial_value="3.8333331e-4" name="F2" units="dimensionless"/>
      <variable initial_value="6.4516879e-11" name="F3" units="dimensionless"/>
      <variable initial_value="3.2355462e-1" name="F4" units="dimensionless"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="VSRrel" public_interface="in" units="cm3"/>
      <variable name="Cass" public_interface="in" units="millimolar"/>
      <variable name="CaSRrel" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>JCaSRrel</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3_second">1800</cn>
               <ci>VSRrel</ci>
               <apply>
                  <plus/>
                  <ci>F2</ci>
                  <ci>F3</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>CaSRrel</ci>
                  <ci>Cass</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>kap</ci>
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         <apply>
            <eq/>
            <ci>kbp</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millimolar3_per_second">4.05<sep/>+9</cn>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>F1</ci>
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            <apply>
               <minus/>
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                  <times/>
                  <ci>F2</ci>
                  <ci>kam</ci>
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               <apply>
                  <times/>
                  <ci>F1</ci>
                  <ci>kap</ci>
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                     <power/>
                     <ci>Cass</ci>
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                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>F2</ci>
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            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>F1</ci>
                     <ci>kap</ci>
                     <apply>
                        <power/>
                        <ci>Cass</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>F3</ci>
                     <ci>kbm</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>F4</ci>
                     <ci>kcm</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>F2</ci>
                  <apply>
                     <plus/>
                     <ci>kam</ci>
                     <apply>
                        <times/>
                        <ci>kbp</ci>
                        <apply>
                           <power/>
                           <ci>Cass</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                     <ci>kcp</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>F3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>F2</ci>
                  <ci>kbp</ci>
                  <apply>
                     <power/>
                     <ci>Cass</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>F3</ci>
                  <ci>kbm</ci>
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            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>F4</ci>
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            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>F2</ci>
                  <ci>kcp</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>F4</ci>
                  <ci>kcm</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="JCad">
      <variable name="JCad" public_interface="out" units="millimolar_per_second"/>
      <variable initial_value="0.003125" name="taud" units="second"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cass" public_interface="in" units="millimolar"/>
      <variable name="Vmyo" public_interface="in" units="cm3"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>JCad</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3">1</cn>
                  <apply>
                     <minus/>
                     <ci>Cass</ci>
                     <ci>Cai</ci>
                  </apply>
                  <ci>Vmyo</ci>
               </apply>
               <ci>taud</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CaSRup">
      <variable initial_value="2.2755058e-1" name="CaSRup" public_interface="out" units="millimolar"/>
      <variable name="JCaSRup" public_interface="in" units="millimolar_per_second"/>
      <variable name="Jtr" public_interface="in" units="millimolar_per_second"/>
      <variable name="VSRup" public_interface="in" units="cm3"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CaSRup</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>JCaSRup</ci>
                  <ci>Jtr</ci>
               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_cm3">1</cn>
                  <ci>VSRup</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CaSRrel">
      <variable initial_value="2.2638169e-1" name="CaSRrel" public_interface="out" units="millimolar"/>
      <variable name="Jtr" public_interface="in" units="millimolar_per_second"/>
      <variable name="JCaSRrel" public_interface="in" units="millimolar_per_second"/>
      <variable name="VSRrel" public_interface="in" units="cm3"/>
      <variable name="time" public_interface="in" units="second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CaSRrel</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">15</cn>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.8</cn>
                           </apply>
                           <apply>
                              <power/>
                              <apply>
                                 <plus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.8</cn>
                                 <ci>CaSRrel</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <ci>Jtr</ci>
                     <ci>JCaSRrel</ci>
                  </apply>
               </apply>
               <ci>VSRrel</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ion_concentrations">
      <variable initial_value="6.9435814e0" name="Nai" public_interface="out" units="millimolar"/>
      <variable initial_value="3.5486498e-5" name="Cai" public_interface="out" units="millimolar"/>
      <variable initial_value="1.3753311e2" name="Ki" public_interface="out" units="millimolar"/>
      <variable initial_value="1.4001386e2" name="Nat" public_interface="out" units="millimolar"/>
      <variable initial_value="1.2271399e0" name="Cat" public_interface="out" units="millimolar"/>
      <variable initial_value="5.3627676e0" name="Kt" public_interface="out" units="millimolar"/>
      <variable initial_value="4.3112114e-5" name="Cass" public_interface="out" units="millimolar"/>
      <variable initial_value="9.2804169e-1" name="BTRH" units="millimolar"/>
      <variable initial_value="3.4317829e-2" name="BTRL" units="millimolar"/>
      <variable name="dBTRH" units="millimolar_per_second"/>
      <variable name="dBTRL" units="millimolar_per_second"/>
      <variable name="Vd" public_interface="in" units="cm3"/>
      <variable name="VSRrel" public_interface="in" units="cm3"/>
      <variable name="VSRup" public_interface="in" units="cm3"/>
      <variable name="Vt" public_interface="in" units="cm3"/>
      <variable name="Vmyo" public_interface="in" units="cm3"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_Stim" public_interface="in" units="microA"/>
      <variable name="i_Nas" public_interface="in" units="microA"/>
      <variable name="i_Cas" public_interface="in" units="microA"/>
      <variable name="i_Nabs" public_interface="in" units="microA"/>
      <variable name="i_NaCas" public_interface="in" units="microA"/>
      <variable name="i_NaKs" public_interface="in" units="microA"/>
      <variable name="i_Kfs" public_interface="in" units="microA"/>
      <variable name="i_Kbs" public_interface="in" units="microA"/>
      <variable name="i_K1s" public_interface="in" units="microA"/>
      <variable name="i_Ktos" public_interface="in" units="microA"/>
      <variable name="i_Ksts" public_interface="in" units="microA"/>
      <variable name="i_pCas" public_interface="in" units="microA"/>
      <variable name="i_Cabs" public_interface="in" units="microA"/>
      <variable name="i_Nat" public_interface="in" units="microA"/>
      <variable name="i_Cat" public_interface="in" units="microA"/>
      <variable name="i_Nabt" public_interface="in" units="microA"/>
      <variable name="i_NaCat" public_interface="in" units="microA"/>
      <variable name="i_NaKt" public_interface="in" units="microA"/>
      <variable name="i_Kft" public_interface="in" units="microA"/>
      <variable name="i_Kbt" public_interface="in" units="microA"/>
      <variable name="i_K1t" public_interface="in" units="microA"/>
      <variable name="i_Ktot" public_interface="in" units="microA"/>
      <variable name="i_Kstt" public_interface="in" units="microA"/>
      <variable name="i_pCat" public_interface="in" units="microA"/>
      <variable name="i_Cabt" public_interface="in" units="microA"/>
      <variable name="JCaSRup" public_interface="in" units="millimolar_per_second"/>
      <variable name="JCaSRrel" public_interface="in" units="millimolar_per_second"/>
      <variable name="JCad" public_interface="in" units="millimolar_per_second"/>
      <variable name="Jtr" public_interface="in" units="millimolar_per_second"/>
      <variable name="JteNa" public_interface="in" units="millimolar_per_second"/>
      <variable name="JteCa" public_interface="in" units="millimolar_per_second"/>
      <variable name="JteK" public_interface="in" units="millimolar_per_second"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>dBTRH</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millimolar_second">20000</cn>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                     <ci>BTRH</ci>
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               </apply>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.07</cn>
                  <ci>BTRH</ci>
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         </apply>
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            <eq/>
            <apply>
               <diff/>
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                  <ci>time</ci>
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               <ci>BTRH</ci>
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            <ci>dBTRH</ci>
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         <apply>
            <eq/>
            <ci>dBTRL</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millimolar_second">40000</cn>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">1</cn>
                     <ci>BTRL</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>BTRL</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">40</cn>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>BTRL</ci>
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            <ci>dBTRL</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>Cass</ci>
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               <times/>
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                  <divide/>
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                  <apply>
                     <plus/>
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                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.05</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.00238</cn>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.00238</cn>
                              <ci>Cass</ci>
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                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>i_Cas</ci>
                              <ci>i_Cat</ci>
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                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>F</ci>
                           <ci>Vd</ci>
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                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                           <ci>JCaSRrel</ci>
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                        <ci>Vd</ci>
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                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                        <ci>JCad</ci>
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                     <ci>Vd</ci>
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               </apply>
            </apply>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>Cai</ci>
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            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.05</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.00238</cn>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.00238</cn>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
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                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <ci>i_NaCas</ci>
                                    <ci>i_NaCat</ci>
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                              </apply>
                              <ci>i_Cabs</ci>
                              <ci>i_Cabt</ci>
                              <ci>i_pCas</ci>
                              <ci>i_pCat</ci>
                           </apply>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              </apply>
                              <ci>F</ci>
                              <ci>Vmyo</ci>
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                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                              <apply>
                                 <minus/>
                                 <ci>JCad</ci>
                                 <ci>JCaSRup</ci>
                              </apply>
                           </apply>
                           <ci>Vmyo</ci>
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                     <apply>
                        <times/>
                        <ci>dBTRH</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.14</cn>
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                  <apply>
                     <times/>
                     <ci>dBTRL</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.07</cn>
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            <eq/>
            <apply>
               <diff/>
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                  <ci>time</ci>
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               <ci>Nai</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>i_Nas</ci>
                     <ci>i_Nat</ci>
                     <ci>i_Nabs</ci>
                     <ci>i_Nabt</ci>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>i_NaCas</ci>
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                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>i_NaCat</ci>
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                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>i_NaKs</ci>
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                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>i_NaKt</ci>
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               <apply>
                  <times/>
                  <ci>F</ci>
                  <ci>Vmyo</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>Ki</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <minus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>i_Stim</ci>
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                              <ci>i_Kfs</ci>
                              <ci>i_Kft</ci>
                              <ci>i_Ksts</ci>
                              <ci>i_Kstt</ci>
                              <ci>i_K1s</ci>
                              <ci>i_K1t</ci>
                              <ci>i_Kbs</ci>
                              <ci>i_Kbt</ci>
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                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>i_NaKs</ci>
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                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>i_NaKt</ci>
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                     <ci>i_Ktos</ci>
                     <ci>i_Ktot</ci>
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               <apply>
                  <times/>
                  <ci>F</ci>
                  <ci>Vmyo</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>Nat</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>i_Nat</ci>
                        <ci>i_Nabt</ci>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaCat</ci>
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                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           <ci>i_NaKt</ci>
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                     <ci>F</ci>
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                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                     <ci>JteNa</ci>
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               </apply>
               <ci>Vt</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cat</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                           <ci>i_NaCat</ci>
                        </apply>
                        <ci>i_Cat</ci>
                        <ci>i_Cabt</ci>
                        <ci>i_pCat</ci>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>F</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                     <ci>JteCa</ci>
                  </apply>
               </apply>
               <ci>Vt</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Kt</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>i_Kft</ci>
                              <ci>i_Kstt</ci>
                              <ci>i_K1t</ci>
                              <ci>i_Kbt</ci>
                           </apply>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>i_NaKt</ci>
                           </apply>
                        </apply>
                        <ci>i_Ktot</ci>
                     </apply>
                     <ci>F</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="cm3">1</cn>
                     <ci>JteK</ci>
                  </apply>
               </apply>
               <ci>Vt</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Vms">
      <variable initial_value="-7.9709547e1" name="Vms" public_interface="out" units="millivolt"/>
      <variable name="Cms" public_interface="in" units="microF"/>
      <variable name="i_circ" public_interface="in" units="microA"/>
      <variable name="i_Stim" public_interface="in" units="microA"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="i_Nas" public_interface="in" units="microA"/>
      <variable name="i_Cas" public_interface="in" units="microA"/>
      <variable name="i_Ktos" public_interface="in" units="microA"/>
      <variable name="i_Ksts" public_interface="in" units="microA"/>
      <variable name="i_Kfs" public_interface="in" units="microA"/>
      <variable name="i_K1s" public_interface="in" units="microA"/>
      <variable name="i_Nabs" public_interface="in" units="microA"/>
      <variable name="i_Cabs" public_interface="in" units="microA"/>
      <variable name="i_Kbs" public_interface="in" units="microA"/>
      <variable name="i_NaKs" public_interface="in" units="microA"/>
      <variable name="i_NaCas" public_interface="in" units="microA"/>
      <variable name="i_pCas" public_interface="in" units="microA"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Vms</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA_per_microA">1000</cn>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>i_Stim</ci>
                        <ci>i_circ</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>i_Nas</ci>
                        <ci>i_Cas</ci>
                        <ci>i_Ktos</ci>
                        <ci>i_Ksts</ci>
                        <ci>i_Kfs</ci>
                        <ci>i_K1s</ci>
                        <ci>i_Nabs</ci>
                        <ci>i_Cabs</ci>
                        <ci>i_Kbs</ci>
                        <ci>i_NaKs</ci>
                        <ci>i_NaCas</ci>
                        <ci>i_pCas</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>Cms</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Vmt">
      <variable initial_value="-7.9709536e1" name="Vmt" public_interface="out" units="millivolt"/>
      <variable name="Cmt" public_interface="in" units="microF"/>
      <variable name="i_circ" public_interface="in" units="microA"/>
      <variable name="time" public_interface="in" units="second"/>
      <variable name="i_Nat" public_interface="in" units="microA"/>
      <variable name="i_Cat" public_interface="in" units="microA"/>
      <variable name="i_Ktot" public_interface="in" units="microA"/>
      <variable name="i_Kstt" public_interface="in" units="microA"/>
      <variable name="i_Kft" public_interface="in" units="microA"/>
      <variable name="i_K1t" public_interface="in" units="microA"/>
      <variable name="i_Nabt" public_interface="in" units="microA"/>
      <variable name="i_Cabt" public_interface="in" units="microA"/>
      <variable name="i_Kbt" public_interface="in" units="microA"/>
      <variable name="i_NaKt" public_interface="in" units="microA"/>
      <variable name="i_NaCat" public_interface="in" units="microA"/>
      <variable name="i_pCat" public_interface="in" units="microA"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Vmt</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA_per_microA">1000</cn>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>i_circ</ci>
                        <ci>i_Nat</ci>
                        <ci>i_Cat</ci>
                        <ci>i_Ktot</ci>
                        <ci>i_Kstt</ci>
                        <ci>i_Kft</ci>
                        <ci>i_K1t</ci>
                        <ci>i_Nabt</ci>
                        <ci>i_Cabt</ci>
                        <ci>i_Kbt</ci>
                        <ci>i_NaKt</ci>
                        <ci>i_NaCat</ci>
                        <ci>i_pCat</ci>
                     </apply>
                  </apply>
               </apply>
               <ci>Cmt</ci>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="i_Nas">
         <component_ref component="i_Nas_m_gate"/>
         <component_ref component="i_Nas_h_gate"/>
      </component_ref>
      <component_ref component="i_Ksts">
         <component_ref component="i_Ksts_rsts_gate"/>
         <component_ref component="i_Ksts_ssts_gate"/>
      </component_ref>
      <component_ref component="i_Ktos">
         <component_ref component="i_Ktos_rs_gate"/>
         <component_ref component="i_Ktos_ss_gate"/>
         <component_ref component="i_Ktos_sss_gate"/>
      </component_ref>
      <component_ref component="i_Kfs">
         <component_ref component="i_Kfs_qs_gate"/>
      </component_ref>
      <component_ref component="i_Nat">
         <component_ref component="i_Nat_m_gate"/>
         <component_ref component="i_Nat_h_gate"/>
      </component_ref>
      <component_ref component="i_Kstt">
         <component_ref component="i_Kstt_rstt_gate"/>
         <component_ref component="i_Kstt_sstt_gate"/>
      </component_ref>
      <component_ref component="i_Ktot">
         <component_ref component="i_Ktot_rt_gate"/>
         <component_ref component="i_Ktot_st_gate"/>
         <component_ref component="i_Ktot_sst_gate"/>
      </component_ref>
      <component_ref component="i_Kft">
         <component_ref component="i_Kft_qt_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="i_Stim" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Nas" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Cas" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ksts" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_K1s" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Kfs" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ktos" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Nat" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Cat" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Kstt" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_K1t" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Kft" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="i_Ktot" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="JCaSRrel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="CaSRrel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="CaSRup" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Vms" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Vmt" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ion_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_circ"/>
      <map_variables variable_1="Rst" variable_2="Rst"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="membrane_permeabilities"/>
      <map_variables variable_1="Sms" variable_2="Sms"/>
      <map_variables variable_1="Smt" variable_2="Smt"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="JCaSRup"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Jtr"/>
      <map_variables variable_1="VSRrel" variable_2="VSRrel"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="JCaSRrel"/>
      <map_variables variable_1="VSRrel" variable_2="VSRrel"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="JCad"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="CaSRrel"/>
      <map_variables variable_1="VSRrel" variable_2="VSRrel"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="CaSRup"/>
      <map_variables variable_1="VSRup" variable_2="VSRup"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="ion_concentrations"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Vmyo" variable_2="Vmyo"/>
      <map_variables variable_1="Vd" variable_2="Vd"/>
      <map_variables variable_1="Vt" variable_2="Vt"/>
      <map_variables variable_1="VSRrel" variable_2="VSRrel"/>
      <map_variables variable_1="VSRup" variable_2="VSRup"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="t_tubular_ion_fluxes"/>
      <map_variables variable_1="Vt" variable_2="Vt"/>
      <map_variables variable_1="Nae" variable_2="Nae"/>
      <map_variables variable_1="Ke" variable_2="Ke"/>
      <map_variables variable_1="Cae" variable_2="Cae"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Vms"/>
      <map_variables variable_1="Cms" variable_2="Cms"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Nas"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Nae" variable_2="Nae"/>
      <map_variables variable_1="Ke" variable_2="Ke"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Cas"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cae" variable_2="Cae"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Ktos"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Ke" variable_2="Ke"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_K1s"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Ke" variable_2="Ke"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_NaKs"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Nae" variable_2="Nae"/>
      <map_variables variable_1="Ke" variable_2="Ke"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_NaCas"/>
      <map_variables variable_1="Nae" variable_2="Nae"/>
      <map_variables variable_1="Cae" variable_2="Cae"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="Vmt"/>
      <map_variables variable_1="Cmt" variable_2="Cmt"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Nat"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Cat"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_Ktot"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_K1t"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="model_parameters" component_2="i_NaKt"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Nas"/>
      <map_variables variable_1="gNas" variable_2="gNas"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Cas"/>
      <map_variables variable_1="gCas" variable_2="gCas"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Ksts"/>
      <map_variables variable_1="gKsts" variable_2="gKsts"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_K1s"/>
      <map_variables variable_1="gK1s" variable_2="gK1s"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Kfs"/>
      <map_variables variable_1="gKfs" variable_2="gKfs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Ktos"/>
      <map_variables variable_1="gKtos" variable_2="gKtos"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Nabs"/>
      <map_variables variable_1="gNabs" variable_2="gNabs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Cabs"/>
      <map_variables variable_1="gCabs" variable_2="gCabs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Kbs"/>
      <map_variables variable_1="gKbs" variable_2="gKbs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_NaCas"/>
      <map_variables variable_1="i_NaCa_maxs" variable_2="i_NaCa_maxs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_NaKs"/>
      <map_variables variable_1="i_NaK_maxs" variable_2="i_NaK_maxs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_pCas"/>
      <map_variables variable_1="i_pCa_maxs" variable_2="i_pCa_maxs"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Nat"/>
      <map_variables variable_1="gNat" variable_2="gNat"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Cat"/>
      <map_variables variable_1="gCat" variable_2="gCat"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Kstt"/>
      <map_variables variable_1="gKstt" variable_2="gKstt"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_K1t"/>
      <map_variables variable_1="gK1t" variable_2="gK1t"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Kft"/>
      <map_variables variable_1="gKft" variable_2="gKft"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Ktot"/>
      <map_variables variable_1="gKtot" variable_2="gKtot"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Nabt"/>
      <map_variables variable_1="gNabt" variable_2="gNabt"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Cabt"/>
      <map_variables variable_1="gCabt" variable_2="gCabt"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_Kbt"/>
      <map_variables variable_1="gKbt" variable_2="gKbt"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_NaCat"/>
      <map_variables variable_1="i_NaCa_maxt" variable_2="i_NaCa_maxt"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_NaKt"/>
      <map_variables variable_1="i_NaK_maxt" variable_2="i_NaK_maxt"/>
   </connection>
   <connection>
      <map_components component_1="membrane_permeabilities" component_2="i_pCat"/>
      <map_variables variable_1="i_pCa_maxt" variable_2="i_pCa_maxt"/>
   </connection>
   <connection>
      <map_components component_1="i_circ" component_2="Vms"/>
      <map_variables variable_1="i_circ" variable_2="i_circ"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
   </connection>
   <connection>
      <map_components component_1="i_Stim" component_2="Vms"/>
      <map_variables variable_1="i_Stim" variable_2="i_Stim"/>
   </connection>
   <connection>
      <map_components component_1="i_circ" component_2="Vmt"/>
      <map_variables variable_1="i_circ" variable_2="i_circ"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
   </connection>
   <connection>
      <map_components component_1="JCaSRup" component_2="ion_concentrations"/>
      <map_variables variable_1="JCaSRup" variable_2="JCaSRup"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="CaSRup" component_2="JCaSRup"/>
      <map_variables variable_1="JCaSRup" variable_2="JCaSRup"/>
      <map_variables variable_1="CaSRup" variable_2="CaSRup"/>
   </connection>
   <connection>
      <map_components component_1="Jtr" component_2="ion_concentrations"/>
      <map_variables variable_1="Jtr" variable_2="Jtr"/>
   </connection>
   <connection>
      <map_components component_1="Jtr" component_2="CaSRrel"/>
      <map_variables variable_1="Jtr" variable_2="Jtr"/>
      <map_variables variable_1="CaSRrel" variable_2="CaSRrel"/>
   </connection>
   <connection>
      <map_components component_1="Jtr" component_2="CaSRup"/>
      <map_variables variable_1="Jtr" variable_2="Jtr"/>
      <map_variables variable_1="CaSRup" variable_2="CaSRup"/>
   </connection>
   <connection>
      <map_components component_1="JCaSRrel" component_2="ion_concentrations"/>
      <map_variables variable_1="JCaSRrel" variable_2="JCaSRrel"/>
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   <connection>
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   <connection>
      <map_components component_1="i_Kbt" component_2="i_Ktot"/>
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      <map_variables variable_1="E_Nat" variable_2="E_Nat"/>
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      <map_components component_1="i_Nat" component_2="i_Kft"/>
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   <connection>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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      <map_variables variable_1="Vms" variable_2="Vms"/>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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   <connection>
      <map_components component_1="i_Ktos" component_2="i_Ktos_rs_gate"/>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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   <connection>
      <map_components component_1="i_Ktos" component_2="i_Ktos_ss_gate"/>
      <map_variables variable_1="ss" variable_2="ss"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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   <connection>
      <map_components component_1="i_Ktos" component_2="i_Ktos_sss_gate"/>
      <map_variables variable_1="sss" variable_2="sss"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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   <connection>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vms" variable_2="Vms"/>
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   <connection>
      <map_components component_1="i_Nat" component_2="i_Nat_m_gate"/>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
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   <connection>
      <map_components component_1="i_Nat" component_2="i_Nat_h_gate"/>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
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      <map_components component_1="i_Kstt" component_2="i_Kstt_rstt_gate"/>
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      <map_variables variable_1="Vmt" variable_2="Vmt"/>
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      <map_variables variable_1="rt" variable_2="rt"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
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   <connection>
      <map_components component_1="i_Ktot" component_2="i_Ktot_st_gate"/>
      <map_variables variable_1="st" variable_2="st"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
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   <connection>
      <map_components component_1="i_Ktot" component_2="i_Ktot_sst_gate"/>
      <map_variables variable_1="sst" variable_2="sst"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
   </connection>
   <connection>
      <map_components component_1="i_Kft" component_2="i_Kft_qt_gate"/>
      <map_variables variable_1="qt" variable_2="qt"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Vmt" variable_2="Vmt"/>
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<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#2d54617c-66b6-42ff-9686-752fc7127093"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Auckland Bioengineering Institute</Orgunit></rdf:Description><rdf:Description rdf:about="rdf:#edee11e8-a2c2-4928-a24a-73903ea74e47"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2009-02-09T14:57:12+13:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#40436da7-a3ad-4b0f-9a5c-827f72768411"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#09c57c45-4e0d-43bf-8f25-1973a9481829"/></N></rdf:Description><rdf:Description rdf:about="rdf:#09c57c45-4e0d-43bf-8f25-1973a9481829"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#25c5253f-6e01-4411-8dc7-0b59073433dc"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">16608703</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#036ef0b2-6467-42bd-a3cb-18f820ea6e5c"/></JournalArticle></rdf:Description><rdf:Description rdf:about="rdf:#4d64df0c-6632-4a43-b52a-ee97ebbfc6d4"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#c4cc805a-fb0a-46d4-81d6-86e33b9331e2"/></creator><rdf:value xml:lang="en">This CellML model is known to run in both COR and PCEnv to recreate the published results. The units have been checked and they are consistent. This particular version of the CellML model was translated from the author's original Matlab code.

Please note that this model is relatively stiff. If you run the model using the default COR settings, you will get a message that reads: "Problem with the CVODE integrator: at t=0.00170178, mxstep steps taken before reaching tout." This basically means that you have to increase the maximum number of steps which is, by default, set to 500. Such a value is sufficient for most ODE problems, but not for ODE problems that have very stiff ODEs, such as the current model. Anyway, you will see that the model runs fine if you increase the value to something like 5000. Note that you also need to set the maximum time step to a sensible value, i.e. the duration of the stimulus which is here 1 ms.

Regarding PCEnv, it uses a higher value than COR for the maximum number of steps, which is why the model will run in PCEnv without having to change this particular setting. Otherwise, like in COR there is a need to set the maximum time step to a sensible value. PCEnv uses a default value of 1 s for the Pasek model, which is clearly not small enough as can be seen when running the model for 10 s. If one uses 0.001 s, then everything is fine.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#4928f4e6-928e-4cda-a629-ddab695a2015"><rdf:value xml:lang="en">Recoded the entire model according to the Matlab to CellML automated conversion.  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