C C There are a total of 7 entries in the algebraic variable array. C There are a total of 11 entries in each of the rate and state variable arrays. C There are a total of 57 entries in the constant variable array. C C C VOI is time in component environment (hour). C STATES(1) is Q_Ca_p in component Q_Ca_p (millimole). C CONSTS(1) is J_bp_Ca in component model_fluxes (millimole_per_hour). C ALGBRC(1) is J_pb_Ca in component model_fluxes (millimole_per_hour). C CONSTS(2) is J_pu_Ca in component model_fluxes (millimole_per_hour). C ALGBRC(4) is J_ip_Ca in component model_fluxes (millimole_per_hour). C STATES(2) is Q_P_p in component Q_P_p (millimole). C CONSTS(39) is J_bp_P in component model_fluxes (millimole_per_hour). C ALGBRC(5) is J_pb_P in component model_fluxes (millimole_per_hour). C CONSTS(3) is J_pu_P in component model_fluxes (millimole_per_hour). C CONSTS(49) is J_ip_P in component model_fluxes (millimole_per_hour). C CONSTS(56) is J_pc_P in component model_fluxes (millimole_per_hour). C ALGBRC(7) is J_cp_P in component model_fluxes (millimole_per_hour). C STATES(3) is Q_P_c in component Q_P_c (millimole). C STATES(4) is Q_PTH_p in component Q_PTH_p (millimole). C ALGBRC(2) is S_PTH in component model_fluxes (millimole_per_hour). C CONSTS(4) is C_PTH_p in component model_parameters (millimolar). C CONSTS(5) is k_PTH in component model_parameters (first_order_rate_constant). C STATES(5) is Q_Ca_b in component Q_Ca_b (millimole). C STATES(6) is Q_P_b in component Q_P_b (millimole). C STATES(7) is Q_E_k in component Q_E_k (millimole). C CONSTS(6) is S_E in component model_parameters (millimole_per_hour). C CONSTS(7) is k_E in component model_parameters (first_order_rate_constant). C STATES(8) is Q_D_p in component Q_D_p (millimole). C CONSTS(8) is k_D in component model_parameters (first_order_rate_constant). C STATES(9) is Q_TCa_i in component Q_TCa_i (millimole). C CONSTS(50) is k1_D in component model_parameters (first_order_rate_constant). C CONSTS(51) is k2_D in component model_parameters (first_order_rate_constant). C STATES(10) is Q_C_PT in component Q_C_PT (millimole). C CONSTS(52) is k3_D in component model_parameters (first_order_rate_constant). C CONSTS(53) is k4_D in component model_parameters (first_order_rate_constant). C STATES(11) is Q_TP_k in component Q_TP_k (millimole). C CONSTS(54) is k1_P in component model_parameters (first_order_rate_constant). C CONSTS(9) is k2_P in component model_parameters (first_order_rate_constant). C CONSTS(10) is J_P_ing in component model_fluxes (millimole_per_hour). C CONSTS(11) is Stoic_Ca_P in component model_fluxes (dimensionless). C CONSTS(12) is k_Ca_i in component model_fluxes (first_order_rate_constant). C CONSTS(13) is C_Ca_i in component model_parameters (millimolar). C CONSTS(14) is C_Ca_p in component model_parameters (millimolar). C CONSTS(15) is C_P_p in component model_parameters (millimolar). C CONSTS(16) is k_Ca_b in component model_parameters (first_order_rate_constant). C CONSTS(17) is k3_P in component model_parameters (first_order_rate_constant). C CONSTS(18) is k4_P in component model_parameters (first_order_rate_constant). C CONSTS(40) is Y_Ca_i_2plus in component model_parameters (first_order_rate_constant). C CONSTS(41) is Y_Ca_p_1minus in component model_parameters (first_order_rate_constant). C CONSTS(19) is C_D_p in component model_parameters (picomolar). C CONSTS(55) is Ca_thr in component model_parameters (first_order_rate_constant). C CONSTS(57) is Ca_T in component model_parameters (second_order_rate_constant). C ALGBRC(3) is P_thr in component model_parameters (millimole_per_hour). C ALGBRC(6) is P_T in component model_parameters (litre_per_hour). C CONSTS(42) is Y_i_D_p_1plus in component model_parameters (first_order_rate_constant). C CONSTS(43) is Y_PT_D_p_1plus in component model_parameters (first_order_rate_constant). C CONSTS(44) is Y_k_Jext_1plus in component model_parameters (first_order_rate_constant). C CONSTS(45) is Y_PTH_p_2plus in component model_parameters (first_order_rate_constant). C CONSTS(46) is Y_PTH_p_2minus in component model_parameters (first_order_rate_constant). C CONSTS(47) is Y_i_D_p_1minus in component model_parameters (first_order_rate_constant). C CONSTS(48) is Y_PT_D_p_1minus in component model_parameters (first_order_rate_constant). C CONSTS(20) is Y_Ca_i_2plus_Max in component model_parameters (first_order_rate_constant). C CONSTS(21) is Y_PTH_p_2plus_Max in component model_parameters (first_order_rate_constant). C CONSTS(22) is Y_PTH_p_2minus_Max in component model_parameters (first_order_rate_constant). C CONSTS(23) is Y_Ca_p_1plus_minus_Max in component model_parameters (first_order_rate_constant). C CONSTS(24) is Y_i_D_p_1plus_minus_Max in component model_parameters (first_order_rate_constant). C CONSTS(25) is Y_PT_D_p_1plus_minus_Max in component model_parameters (first_order_rate_constant). C CONSTS(26) is Y_k_Jext_1plus_minus_Max in component model_parameters (first_order_rate_constant). C CONSTS(27) is X_R_PTH_Ca in component model_parameters (millimolar). C CONSTS(28) is X_R_i_Ca in component model_parameters (millimolar). C CONSTS(29) is X_R_PTH_D in component model_parameters (picomolar). C CONSTS(30) is X_R_E_PTH in component model_parameters (picomolar). C CONSTS(31) is X_R_i_D in component model_parameters (picomolar). C CONSTS(32) is X_R_P_k_PTH in component model_parameters (picomolar). C CONSTS(33) is b_PTH_Ca in component model_parameters (litre_per_millimole). C CONSTS(34) is b_PTH_D in component model_parameters (litre_per_picomole). C CONSTS(35) is b_E_PTH in component model_parameters (litre_per_picomole). C CONSTS(36) is b_i_D in component model_parameters (litre_per_picomole). C CONSTS(37) is a in component model_parameters (dimensionless). C CONSTS(38) is d in component model_parameters (dimensionless). C RATES(1) is d/dt Q_Ca_p in component Q_Ca_p (millimole). C RATES(2) is d/dt Q_P_p in component Q_P_p (millimole). C RATES(3) is d/dt Q_P_c in component Q_P_c (millimole). C RATES(4) is d/dt Q_PTH_p in component Q_PTH_p (millimole). C RATES(5) is d/dt Q_Ca_b in component Q_Ca_b (millimole). C RATES(6) is d/dt Q_P_b in component Q_P_b (millimole). C RATES(7) is d/dt Q_E_k in component Q_E_k (millimole). C RATES(8) is d/dt Q_D_p in component Q_D_p (millimole). C RATES(9) is d/dt Q_TCa_i in component Q_TCa_i (millimole). C RATES(10) is d/dt Q_C_PT in component Q_C_PT (millimole). C RATES(11) is d/dt Q_TP_k in component Q_TP_k (millimole). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1.000 CONSTS(1) = 3.3 CONSTS(2) = 0.21 STATES(2) = 1.000 CONSTS(3) = 1.27 STATES(3) = 3226.0 STATES(4) = 1.000 CONSTS(4) = 3.85 CONSTS(5) = 100.0 STATES(5) = 100.0 STATES(6) = 1.000 STATES(7) = 1.000 CONSTS(6) = 1.000 CONSTS(7) = 0.05 STATES(8) = 1.000 CONSTS(8) = 0.1 STATES(9) = 1.000 STATES(10) = 1.000 STATES(11) = 1.000 CONSTS(9) = 1.000 CONSTS(10) = 1.000 CONSTS(11) = 0.464 CONSTS(12) = 1.000 CONSTS(13) = 1.000 CONSTS(14) = 2.4 CONSTS(15) = 1.2 CONSTS(16) = 1.000 CONSTS(17) = 1.000 CONSTS(18) = 51.8 CONSTS(19) = 90.0 CONSTS(20) = 1.000 CONSTS(21) = 1.000 CONSTS(22) = 1.000 CONSTS(23) = 0.02 CONSTS(24) = 0.02 CONSTS(25) = 0.01 CONSTS(26) = 0.01 CONSTS(27) = 1.0 CONSTS(28) = 1.0 CONSTS(29) = 90.0 CONSTS(30) = 3.85 CONSTS(31) = 90.0 CONSTS(32) = 90.0 CONSTS(33) = 0.05 CONSTS(34) = 0.03 CONSTS(35) = 0.55 CONSTS(36) = 0.03 CONSTS(37) = 0.85 CONSTS(38) = 0.15 CONSTS(39) = CONSTS(11)*CONSTS(1) CONSTS(40) = CONSTS(20)*(CONSTS(13)/(CONSTS(13)+CONSTS(28))) CONSTS(41) = CONSTS(23)*( CONSTS(37)*(1.00000 - tanh( CONSTS(33)*(CONSTS(14) - CONSTS(27))))+CONSTS(38)) CONSTS(42) = CONSTS(24)*( CONSTS(37)*(1.00000+ tanh( CONSTS(36)*(CONSTS(19) - CONSTS(31))))+CONSTS(38)) CONSTS(43) = CONSTS(25)*( CONSTS(37)*(1.00000+ tanh( CONSTS(34)*(CONSTS(19) - CONSTS(29))))+CONSTS(38)) CONSTS(44) = CONSTS(26)*( CONSTS(37)*(1.00000+ tanh( CONSTS(35)*( 1.00000*CONSTS(15) - CONSTS(30))))+CONSTS(38)) CONSTS(45) = CONSTS(21)*(CONSTS(4)/(CONSTS(4)+ 1.00000*CONSTS(32))) CONSTS(46) = CONSTS(22)*(CONSTS(32)/( 1.00000*CONSTS(4)+CONSTS(32))) CONSTS(47) = CONSTS(24)*( CONSTS(37)*(1.00000 - tanh( CONSTS(36)*(CONSTS(19) - CONSTS(31))))+CONSTS(38)) CONSTS(48) = CONSTS(25)*( CONSTS(37)*(1.00000 - tanh( CONSTS(34)*(CONSTS(19) - CONSTS(29))))+CONSTS(38)) CONSTS(49) = CONSTS(10) CONSTS(50) = CONSTS(42) CONSTS(51) = CONSTS(47) CONSTS(52) = CONSTS(43) CONSTS(53) = CONSTS(48) CONSTS(54) = CONSTS(44) CONSTS(55) = 1.95000+CONSTS(45) CONSTS(56) = CONSTS(18)*1.00000*CONSTS(15) CONSTS(57) = CONSTS(55)/CONSTS(14) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(7) = CONSTS(6) - CONSTS(7)*STATES(7) RATES(8) = 1.00000*STATES(7) - CONSTS(8)*STATES(8) RATES(9) = (1.00000 - STATES(9))*CONSTS(50) - STATES(9)*CONSTS(51) RATES(10) = (1.00000 - STATES(10))*CONSTS(52) - STATES(10)*CONSTS(53) RATES(11) = (1.00000 - STATES(11))*CONSTS(54) - STATES(11)*CONSTS(9) ALGBRC(2) = 1.00000*CONSTS(41)*( CONSTS(52)*(1.00000 - STATES(10)) - CONSTS(53)*STATES(10)) RATES(4) = ALGBRC(2) - CONSTS(5)*1.00000*CONSTS(4) ALGBRC(1) = CONSTS(16)*STATES(5) RATES(5) = ALGBRC(1) - CONSTS(1) ALGBRC(4) = ( CONSTS(40)*(1.00000 - STATES(9))*1.00000*CONSTS(50)+ CONSTS(12)*1.00000*(CONSTS(13) - CONSTS(14))) - STATES(9)*CONSTS(51) RATES(1) = (CONSTS(1)+ALGBRC(4)) - (ALGBRC(1)+CONSTS(2)) ALGBRC(5) = CONSTS(11)*ALGBRC(1) RATES(6) = ALGBRC(5) - CONSTS(39) ALGBRC(7) = CONSTS(17)*STATES(3) RATES(2) = (CONSTS(39)+CONSTS(49)+ALGBRC(7)) - (ALGBRC(5)+CONSTS(3)+CONSTS(56)) RATES(3) = CONSTS(56) - ALGBRC(7) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 1.00000*CONSTS(41)*( CONSTS(52)*(1.00000 - STATES(10)) - CONSTS(53)*STATES(10)) ALGBRC(1) = CONSTS(16)*STATES(5) ALGBRC(4) = ( CONSTS(40)*(1.00000 - STATES(9))*1.00000*CONSTS(50)+ CONSTS(12)*1.00000*(CONSTS(13) - CONSTS(14))) - STATES(9)*CONSTS(51) ALGBRC(5) = CONSTS(11)*ALGBRC(1) ALGBRC(7) = CONSTS(17)*STATES(3) ALGBRC(3) = CONSTS(46)*STATES(11) ALGBRC(6) = ALGBRC(3)/CONSTS(15) RETURN END