C C There are a total of 0 entries in the algebraic variable array. C There are a total of 8 entries in each of the rate and state variable arrays. C There are a total of 13 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is Rs in component Rs (number_per_cell). C STATES(2) is L in component L (picomolar). C STATES(3) is Cs in component Cs (number_per_cell). C CONSTS(1) is Vs in component model_parameters (number_per_cell_minute). C CONSTS(11) is kf in component model_parameters (second_order_rate_constant). C CONSTS(2) is kr in component model_parameters (first_order_rate_constant). C CONSTS(3) is kt in component model_parameters (first_order_rate_constant). C CONSTS(4) is ksyn in component model_parameters (first_order_rate_constant). C CONSTS(5) is ke in component model_parameters (first_order_rate_constant). C STATES(4) is Ri in component Ri (number_per_cell). C STATES(5) is Li in component Li (picomolar). C STATES(6) is Ci in component Ci (number_per_cell). C CONSTS(13) is kfe in component model_parameters (second_order_rate_constant). C CONSTS(12) is kre in component model_parameters (first_order_rate_constant). C CONSTS(6) is kh in component model_parameters (first_order_rate_constant). C CONSTS(7) is kx in component model_parameters (first_order_rate_constant). C CONSTS(8) is Ve in component model_parameters (L_per_cell). C CONSTS(9) is NA in component model_parameters (number_per_picomole). C STATES(7) is Ld in component Ld (number_per_cell). C STATES(8) is Y in component Y (cell_per_L). C CONSTS(10) is IL2 in component model_parameters (dimensionless). C RATES(1) is d/dt Rs in component Rs (number_per_cell). C RATES(3) is d/dt Cs in component Cs (number_per_cell). C RATES(4) is d/dt Ri in component Ri (number_per_cell). C RATES(6) is d/dt Ci in component Ci (number_per_cell). C RATES(5) is d/dt Li in component Li (picomolar). C RATES(7) is d/dt Ld in component Ld (number_per_cell). C RATES(2) is d/dt L in component L (picomolar). C RATES(8) is d/dt Y in component Y (cell_per_L). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1500 STATES(2) = 10 STATES(3) = 1 CONSTS(1) = 11 CONSTS(2) = 0.0138 CONSTS(3) = 0.007 CONSTS(4) = 0.0011 CONSTS(5) = 0.04 STATES(4) = 300 STATES(5) = 0.01 STATES(6) = 1 CONSTS(6) = 0.035 CONSTS(7) = 0.15 CONSTS(8) = 1e-14 CONSTS(9) = 6.022e11 STATES(7) = 1 STATES(8) = 2.5e8 CONSTS(10) = 1 CONSTS(11) = TERNRY(CONSTS(10).EQ.1.00000, CONSTS(2)/11.1000, CONSTS(2)/8.20000) CONSTS(12) = TERNRY(CONSTS(10).EQ.1.00000, CONSTS(2)*8.00000, CONSTS(2)*5.00000) CONSTS(13) = TERNRY(CONSTS(10).EQ.1.00000, CONSTS(12)/1000.00, CONSTS(12)/3000.00) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = ( (CONSTS(2)+CONSTS(4))*STATES(3)+CONSTS(1)) - ( CONSTS(11)*STATES(2)*STATES(1)+ CONSTS(3)*STATES(1)) RATES(3) = CONSTS(11)*STATES(2)*STATES(1) - (CONSTS(2)+CONSTS(5))*STATES(3) RATES(4) = ( CONSTS(12)*STATES(6)+ CONSTS(3)*STATES(1)) - ( CONSTS(13)*STATES(5)*STATES(4)+ CONSTS(6)*STATES(4)) RATES(6) = ( CONSTS(13)*STATES(5)*STATES(4)+ CONSTS(5)*STATES(3)) - (CONSTS(12)+CONSTS(6))*STATES(6) RATES(5) = ( CONSTS(12)*STATES(6) - CONSTS(13)*STATES(5)*STATES(4))/( CONSTS(8)*CONSTS(9)) - CONSTS(7)*STATES(5) RATES(7) = CONSTS(6)*STATES(6) RATES(2) = ( (( CONSTS(2)*STATES(3)+ CONSTS(7)*STATES(5)*CONSTS(8)*CONSTS(9)) - CONSTS(11)*STATES(2)*STATES(1))*STATES(8))/CONSTS(9) RATES(8) = TERNRY(( 600.000*STATES(3))/(250.000+STATES(3)) - 200.000.GT.0.00000, (( 600.000*STATES(3))/(250.000+STATES(3)) - 200.000)*1000.00, 0.00000) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END