Model Mathematics

Component: environment

Component: Clb2

ddtimeClb2=ks_clbepsilon+Mcm_aM1+MJm+kmihPClb2+kdissTrim+kd_sic+kd_sic_1Cln+kd_sic_2Clb2Trim-kd_clb_1+kd_clb_2Cdh1_a+kd_clb_3Cdc20_aClb2+ksweClb2+kassSic1Clb2

Component: PClb2

ddtimePClb2=ksweClb2+kdissPTrim+kd_sic+kd_sic_1Cln+kd_sic_2Clb2PTrim-kd_clb_1+kd_clb_2Cdh1_a+kd_clb_3Cdc20_aPClb2+kmihPClb2+kassSic1PClb2

Component: Trim

ddtimeTrim=kassSic1Clb2+kmihPTrim-kdissTrim+kd_sic+kd_sic_1Cln+kd_sic_2Clb2Trim+kd_clb_1+kd_clb_2Cdh1_a+kd_clb_3Cdc20_aTrim+ksweTrim

Component: PTrim

ddtimePTrim=ksweTrim+kassSic1PClb2-kdissPTrim+kd_sic+kd_sic_1Cln+kd_sic_2Clb2PTrim+kd_clb_1+kd_clb_2Cdh1_a+kd_clb_3Cdc20_aPTrim+kmihPTrim

Component: Mcm_a

ddtimeMcm_a=-ki_mcmMcm_aJi_mcm+Mcm_a+ka_mcmMcmClb2Ja_mcm+Mcm

Component: Sic1

ddtimeSic1=ks_sic+kdissPTrim+Trim+kd_clb_1+kd_clb_2Cdh1_a+kd_clb_3Cdc20_aPTrim+Trim-kd_sic+kd_sic_1Cln+kd_sic_2Clb2Sic1+kassSic1Clb2+PClb2

Component: Mih1_a

ddtimeMih1_a=-Vi_mihMih1_aJi_mih+Mih1_a+Va_mihClb2Mih1Ja_mih+Mih1

Component: IE_a

ddtimeIE_a=-ki_ieIE_aJi_ie+IE_a+ka_ieClb2IEJa_ie+IE

Component: Cdc20_a

ddtimeCdc20_a=ka_cdc20IE_aCdc20Ja_cdc20+Cdc20-ki_cdc20Cdc20_aJi_cdc20+Cdc20_a+kd_cdc20Cdc20_a

Component: Cdc20

ddtimeCdc20=ks_cdc20_1+ks_cdc20_2Clb24Js_cdc204+Clb24+ki_cdc20Cdc20_aJi_cdc20+Cdc20_a-ka_cdc20IE_aCdc20Ja_cdc20+Cdc20+kd_cdc20Cdc20

Component: Cdh1_a

ddtimeCdh1_a=-ki_cdhClb2+ki_cdh_1ClnCdh1_aJi_cdh+Cdh1_a+ka_cdh_1+ka_cdh_2Cdc20_aCdh1Ja_cdh+Cdh1

Component: Cln

ddtimeCln=ks_clnSBF_a-kd_clnCln

Component: SBF_a

ddtimeSBF_a=-ki_sbf_1+ki_sbf_2Clb2SBF_aJi_sbf+SBF_a+ka_sbf_1M+ka_sbf_2ClnSBFJa_sbf+SBF

Component: Swe1

ddtimeSwe1=ks_sweSBF_a+ks_sweC+khsl1rSwe1M+Va_weePSwe1Ja_wee+PSwe1-khsl1BUDSwe1+Vi_weeClb2Swe1Ji_wee+Swe1+kd_swe_1Swe1

Component: PSwe1

ddtimePSwe1=khsl1rPSwe1M+Vi_weeSwe1Clb2Ji_wee+Swe1-khsl1BUDPSwe1+Va_weePSwe1Ja_wee+PSwe1+kd_swe_1PSwe1

Component: Swe1M

ddtimeSwe1M=khsl1BUDSwe1+Va_weePSwe1MJa_wee+PSwe1M-khsl1rSwe1M+Vi_weeClb2Swe1MJi_wee+Swe1M+kd_swe_1Swe1M

Component: PSwe1M

ddtimePSwe1M=khsl1BUDPSwe1+Vi_weeClb2Swe1MJi_wee+Swe1M-khsl1rPSwe1M+Va_weePSwe1MJa_wee+PSwe1M+kd_swe_2PSwe1M

Component: BE

ddtimeBE=ks_budCln-kd_budBE

Component: M

ddtimeM=muM

Component: IE

IE=IE_total-IE_a

Component: Cdh1

Cdh1=Cdh1_total-Cdh1_a

Component: Mih1

Mih1=Mih1_total-Mih1_a

Component: Mcm

Mcm=Mcm_total-Mcm_a

Component: SBF

SBF=SBF_total-SBF_a

Component: Swe1_total

Swe1_total=Swe1+PSwe1+Swe1M+PSwe1M

Component: BUD

BUD=0ifBE0.6Clb2<0.21otherwise

Component: kinetic_parameters

kmih=kmih_1Mih1_a+kmih_2Mih1 kswe=kswe_1Swe1+kswe_2Swe1M+kswe_3PSwe1