http://models.cellml.org/w/hnielsen/guthke_2006 en-us Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors The kinetics of 18 amino acids, ammonia (NH3) and urea (UREA) in 18 liver cell bioreactor runs were analyzed and simulated by a two-compartment model consisting of a system of 42 differential equations. The model parameters, most of them representing enzymatic activities, were identified and their values discussed with respect to the different liver cell bioreactor performance levels. The nitrogen balance based model was used as a tool to quantify the variability of runs and to describe different kinetic patterns of the amino acid metabolism, in particular with respect to glutamate (GLU) and aspartate (ASP). Added HTML file http://models.cellml.org/w/hnielsen/guthke_2006/@@file/1049f8bf1ee115a66fa1840e9ac9695990eb4d4c Added HTML file Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-08-23 12:23 +1200 Added session file and xul http://models.cellml.org/w/hnielsen/guthke_2006/@@file/ec7bc23c9361a858c08aef259812446fc546a4a1 Added session file and xul Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-08-23 12:15 +1200 added images in ai svg and png format http://models.cellml.org/w/hnielsen/guthke_2006/@@file/eb2cd1d7b6871947a7412266472fffb734d7dc5c added images in ai svg and png format Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-03-25 13:23 +1300 Added RDF tags and metadata to CellML file http://models.cellml.org/w/hnielsen/guthke_2006/@@file/2cc1f61ae20dae88f977618c0a46bb73f2b4a07a Added RDF tags and metadata to CellML file Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-03-11 14:29 +1300 Added metadata to cellML file http://models.cellml.org/w/hnielsen/guthke_2006/@@file/0a58e98cb6b9ef661786d4be6d39880704159581 Added metadata to cellML file Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-03-04 09:55 +1300 Fixed old cellml so model makes curved lines now, still need to chec kagainst paper and add images and session http://models.cellml.org/w/hnielsen/guthke_2006/@@file/b9c5bdab6de081c41ff59c76a76249d603b749e1 Fixed old cellml so model makes curved lines now, still need to chec kagainst paper and add images and session Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-03-02 15:20 +1300 Added two versions of CellML working, neither match paper yet, one has unit issues the other does create graphs but they differ to published paper http://models.cellml.org/w/hnielsen/guthke_2006/@@file/c0aee801a7e891f62ca26adf40c153ebdd25d029 Added two versions of CellML working, neither match paper yet, one has unit issues the other does create graphs but they differ to published paper Hanne Nielsen <hnie010@aucklanduni.ac.nz> 2011-02-02 15:02 +1300