Location: Bifurcation analysis of the regulatory modules of the mammalian G1/S transition @ cd7badd5a6ad / swat_2004.cellml

Author:
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
Date:
2011-09-02 10:48:33+12:00
Desc:
Edited HTML file
Permanent Source URI:
http://models.cellml.org/w/hnielsen/swat_2004/rawfile/cd7badd5a6ad4a567b2228065cd5c74f56ab6be8/swat_2004.cellml

<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 18/03/2011 at 4:17:40 at p.m. using:

COR (0.9.31.1409) 
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model name="swat_2004" cmeta:id="swat_2004" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="hour">
      <unit units="second" multiplier="3600"/>
   </units>
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="CONC">
      <unit units="mole"/>
      <unit units="litre" exponent="-1"/>
   </units>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="environment">
      <variable name="time" units="hour" public_interface="out"/>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="pRB">
      <variable name="pRB" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="k1" units="dimensionless" public_interface="in"/>
      <variable name="E2F1" units="CONC" public_interface="in"/>
      <variable name="km1" units="dimensionless" public_interface="in"/>
      <variable name="j11" units="dimensionless" public_interface="in"/>
      <variable name="j61" units="dimensionless" public_interface="in"/>
      <variable name="k16" units="dimensionless" public_interface="in"/>
      <variable name="CycDa" units="CONC" public_interface="in"/>
      <variable name="k61" units="dimensionless" public_interface="in"/>
      <variable name="pRBp" units="CONC" public_interface="in"/>
      <variable name="phi_pRB" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pRB</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>k1</ci>
                        <apply>
                           <divide/>
                           <ci>E2F1</ci>
                           <apply>
                              <plus/>
                              <ci>km1</ci>
                              <ci>E2F1</ci>
                           </apply>
                        </apply>
                        <apply>
                           <divide/>
                           <ci>j11</ci>
                           <apply>
                              <times/>
                              <ci>j11</ci>
                              <ci>pRB</ci>
                           </apply>
                        </apply>
                        <apply>
                           <divide/>
                           <ci>j61</ci>
                           <apply>
                              <times/>
                              <ci>j61</ci>
                              <ci>pRBp</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k16</ci>
                        <ci>pRB</ci>
                        <ci>CycDa</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k61</ci>
                     <ci>pRBp</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_pRB</ci>
                  <ci>pRB</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="E2F1">
      <variable name="E2F1" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="kp" units="dimensionless" public_interface="in"/>
      <variable name="k2" units="dimensionless" public_interface="in"/>
      <variable name="a" units="dimensionless" public_interface="in"/>
      <variable name="km2" units="dimensionless" public_interface="in"/>
      <variable name="j12" units="dimensionless" public_interface="in"/>
      <variable name="pRB" units="CONC" public_interface="in"/>
      <variable name="j62" units="dimensionless" public_interface="in"/>
      <variable name="pRBp" units="CONC" public_interface="in"/>
      <variable name="phi_E2F1" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>E2F1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>kp</ci>
                  <apply>
                     <times/>
                     <ci>k2</ci>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <power/>
                              <ci>a</ci>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                           <apply>
                              <power/>
                              <ci>E2F1</ci>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <power/>
                              <ci>km2</ci>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                           <apply>
                              <power/>
                              <ci>E2F1</ci>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>j12</ci>
                        <apply>
                           <plus/>
                           <ci>j12</ci>
                           <ci>pRBp</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>j62</ci>
                        <apply>
                           <plus/>
                           <ci>j62</ci>
                           <ci>pRBp</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_E2F1</ci>
                  <ci>E2F1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="CycDa">
      <variable name="CycDa" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="k34" units="dimensionless" public_interface="in"/>
      <variable name="CycDi" units="CONC" public_interface="in"/>
      <variable name="km4" units="dimensionless" public_interface="in"/>
      <variable name="k43" units="dimensionless" public_interface="in"/>
      <variable name="phi_CycDa" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CycDa</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>k34</ci>
                        <ci>CycDi</ci>
                        <ci>CycDa</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>km4</ci>
                        <ci>CycDa</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k34</ci>
                     <ci>CycDa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_CycDa</ci>
                  <ci>CycDa</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="CycDi">
      <variable name="CycDi" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="CycDa" units="CONC" public_interface="in"/>
      <variable name="k3" units="dimensionless" public_interface="in"/>
      <variable name="AP1" units="CONC" public_interface="in"/>
      <variable name="k23" units="dimensionless" public_interface="in"/>
      <variable name="E2F1" units="CONC" public_interface="in"/>
      <variable name="j13" units="dimensionless" public_interface="in"/>
      <variable name="pRB" units="CONC" public_interface="in"/>
      <variable name="j63" units="dimensionless" public_interface="in"/>
      <variable name="pRBp" units="CONC" public_interface="in"/>
      <variable name="k43" units="dimensionless" public_interface="in"/>
      <variable name="k34" units="dimensionless" public_interface="in"/>
      <variable name="km4" units="dimensionless" public_interface="in"/>
      <variable name="phi_CycDi" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CycDi</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>k3</ci>
                        <ci>AP1</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k23</ci>
                        <ci>E2F1</ci>
                        <apply>
                           <divide/>
                           <ci>j13</ci>
                           <apply>
                              <plus/>
                              <ci>j13</ci>
                              <ci>pRB</ci>
                           </apply>
                        </apply>
                        <apply>
                           <divide/>
                           <ci>j63</ci>
                           <apply>
                              <plus/>
                              <ci>j63</ci>
                              <ci>pRBp</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k43</ci>
                        <ci>CycDa</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k34</ci>
                     <ci>CycDi</ci>
                     <apply>
                        <divide/>
                        <ci>CycDa</ci>
                        <apply>
                           <plus/>
                           <ci>km4</ci>
                           <ci>CycDa</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_CycDi</ci>
                  <ci>CycDi</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="AP1">
      <variable name="AP1" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="Fm" units="dimensionless" public_interface="in"/>
      <variable name="k25" units="dimensionless" public_interface="in"/>
      <variable name="E2F1" units="CONC" public_interface="in"/>
      <variable name="j15" units="dimensionless" public_interface="in"/>
      <variable name="pRB" units="CONC" public_interface="in"/>
      <variable name="j65" units="dimensionless" public_interface="in"/>
      <variable name="pRBp" units="CONC" public_interface="in"/>
      <variable name="phi_AP1" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>AP1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>Fm</ci>
                  <apply>
                     <times/>
                     <ci>k25</ci>
                     <ci>E2F1</ci>
                     <apply>
                        <divide/>
                        <ci>j15</ci>
                        <apply>
                           <plus/>
                           <ci>j15</ci>
                           <ci>pRB</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>j65</ci>
                        <apply>
                           <plus/>
                           <ci>j65</ci>
                           <ci>pRBp</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_AP1</ci>
                  <ci>AP1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="pRBp">
      <variable name="pRBp" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="k16" units="dimensionless" public_interface="in"/>
      <variable name="pRB" units="CONC" public_interface="in"/>
      <variable name="CycDa" units="CONC" public_interface="in"/>
      <variable name="k61" units="dimensionless" public_interface="in"/>
      <variable name="k67" units="dimensionless" public_interface="in"/>
      <variable name="CycEa" units="CONC" public_interface="in"/>
      <variable name="k76" units="dimensionless" public_interface="in"/>
      <variable name="pRBpp" units="CONC" public_interface="in"/>
      <variable name="phi_pRBp" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pRBp</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <ci>k16</ci>
                           <ci>pRB</ci>
                           <ci>CycDa</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>k61</ci>
                           <ci>pRBp</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k67</ci>
                        <ci>pRBp</ci>
                        <ci>CycEa</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k76</ci>
                     <ci>pRBpp</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_pRBp</ci>
                  <ci>pRBp</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="pRBpp">
      <variable name="pRBpp" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="k67" units="dimensionless" public_interface="in"/>
      <variable name="pRBp" units="CONC" public_interface="in"/>
      <variable name="CycEa" units="CONC" public_interface="in"/>
      <variable name="k76" units="dimensionless" public_interface="in"/>
      <variable name="phi_pRBpp" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>pRBpp</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>k67</ci>
                     <ci>pRBp</ci>
                     <ci>CycEa</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k76</ci>
                     <ci>pRBpp</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_pRBpp</ci>
                  <ci>pRBpp</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="CycEi">
      <variable name="CycEi" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="k28" units="dimensionless" public_interface="in"/>
      <variable name="E2F1" units="CONC" public_interface="in"/>
      <variable name="j18" units="dimensionless" public_interface="in"/>
      <variable name="pRB" units="CONC" public_interface="in"/>
      <variable name="j68" units="dimensionless" public_interface="in"/>
      <variable name="pRBp" units="CONC" public_interface="in"/>
      <variable name="CycEa" units="CONC" public_interface="in"/>
      <variable name="k98" units="dimensionless" public_interface="in"/>
      <variable name="k89" units="dimensionless" public_interface="in"/>
      <variable name="km9" units="dimensionless" public_interface="in"/>
      <variable name="phi_CycEi" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CycEi</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>k28</ci>
                        <ci>E2F1</ci>
                        <apply>
                           <divide/>
                           <ci>j18</ci>
                           <apply>
                              <plus/>
                              <ci>j18</ci>
                              <ci>pRB</ci>
                           </apply>
                        </apply>
                        <apply>
                           <divide/>
                           <ci>j68</ci>
                           <apply>
                              <plus/>
                              <ci>j68</ci>
                              <ci>pRBp</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k98</ci>
                        <ci>CycEa</ci>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k89</ci>
                     <ci>CycEi</ci>
                     <apply>
                        <divide/>
                        <ci>CycEa</ci>
                        <apply>
                           <plus/>
                           <ci>km9</ci>
                           <ci>CycEa</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_CycEi</ci>
                  <ci>CycEi</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="CycEa">
      <variable name="CycEa" units="CONC" initial_value="0" public_interface="out"/>
      <variable name="k89" units="dimensionless" public_interface="in"/>
      <variable name="CycEi" units="CONC" public_interface="in"/>
      <variable name="km9" units="dimensionless" public_interface="in"/>
      <variable name="k98" units="dimensionless" public_interface="in"/>
      <variable name="phi_CycEa" units="dimensionless" public_interface="in"/>
      <variable name="time" units="hour" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CycEa</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>k89</ci>
                     <ci>CycEi</ci>
                     <apply>
                        <divide/>
                        <ci>CycEa</ci>
                        <apply>
                           <plus/>
                           <ci>km9</ci>
                           <ci>CycEa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <ci>k98</ci>
                     <ci>CycEa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>phi_CycEa</ci>
                  <ci>CycEa</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="model_parameters">
      <variable name="k1" units="dimensionless" initial_value="1" public_interface="out"/>
      <variable name="k2" units="dimensionless" initial_value="1.6" public_interface="out"/>
      <variable name="k3" units="dimensionless" initial_value="0.05" public_interface="out"/>
      <variable name="k16" units="dimensionless" initial_value="0.4" public_interface="out"/>
      <variable name="k34" units="dimensionless" initial_value="0.04" public_interface="out"/>
      <variable name="k43" units="dimensionless" initial_value="0.01" public_interface="out"/>
      <variable name="k61" units="dimensionless" initial_value="0.3" public_interface="out"/>
      <variable name="k67" units="dimensionless" initial_value="0.7" public_interface="out"/>
      <variable name="k76" units="dimensionless" initial_value="0.1" public_interface="out"/>
      <variable name="k23" units="dimensionless" initial_value="0.3" public_interface="out"/>
      <variable name="k25" units="dimensionless" initial_value="0.9" public_interface="out"/>
      <variable name="k28" units="dimensionless" initial_value="0.06" public_interface="out"/>
      <variable name="k89" units="dimensionless" initial_value="0.07" public_interface="out"/>
      <variable name="k98" units="dimensionless" initial_value="0.01" public_interface="out"/>
      <variable name="a" units="dimensionless" initial_value="0.04" public_interface="out"/>
      <variable name="j11" units="dimensionless" initial_value="0.5" public_interface="out"/>
      <variable name="j12" units="dimensionless" initial_value="5" public_interface="out"/>
      <variable name="j15" units="dimensionless" initial_value="0.001" public_interface="out"/>
      <variable name="j18" units="dimensionless" initial_value="0.6" public_interface="out"/>
      <variable name="j61" units="dimensionless" initial_value="5" public_interface="out"/>
      <variable name="j62" units="dimensionless" initial_value="8" public_interface="out"/>
      <variable name="j65" units="dimensionless" initial_value="6" public_interface="out"/>
      <variable name="j68" units="dimensionless" initial_value="7" public_interface="out"/>
      <variable name="j13" units="dimensionless" initial_value="0.002" public_interface="out"/>
      <variable name="j63" units="dimensionless" initial_value="2" public_interface="out"/>
      <variable name="km1" units="dimensionless" initial_value="0.5" public_interface="out"/>
      <variable name="km2" units="dimensionless" initial_value="4" public_interface="out"/>
      <variable name="km4" units="dimensionless" initial_value="0.3" public_interface="out"/>
      <variable name="km9" units="dimensionless" initial_value="0.005" public_interface="out"/>
      <variable name="kp" units="dimensionless" initial_value="0.05" public_interface="out"/>
      <variable name="phi_pRB" units="dimensionless" initial_value="0.005" public_interface="out"/>
      <variable name="phi_E2F1" units="dimensionless" initial_value="0.1" public_interface="out"/>
      <variable name="phi_CycDi" units="dimensionless" initial_value="0.023" public_interface="out"/>
      <variable name="phi_CycDa" units="dimensionless" initial_value="0.03" public_interface="out"/>
      <variable name="phi_AP1" units="dimensionless" initial_value="0.01" public_interface="out"/>
      <variable name="phi_pRBp" units="dimensionless" initial_value="0.06" public_interface="out"/>
      <variable name="phi_pRBpp" units="dimensionless" initial_value="0.04" public_interface="out"/>
      <variable name="phi_CycEi" units="dimensionless" initial_value="0.06" public_interface="out"/>
      <variable name="phi_CycEa" units="dimensionless" initial_value="0.05" public_interface="out"/>
      <variable name="Fm" units="dimensionless" initial_value="0" public_interface="out"/>
   </component>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="pRB"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="E2F1"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="CycDi"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="CycDa"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="AP1"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="pRBp"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="pRBpp"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="CycEi"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="environment" component_2="CycEa"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRB" component_2="model_parameters"/>
      <map_variables variable_1="k1" variable_2="k1"/>
      <map_variables variable_1="km1" variable_2="km1"/>
      <map_variables variable_1="j61" variable_2="j61"/>
      <map_variables variable_1="j11" variable_2="j11"/>
      <map_variables variable_1="k16" variable_2="k16"/>
      <map_variables variable_1="k61" variable_2="k61"/>
      <map_variables variable_1="phi_pRB" variable_2="phi_pRB"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="E2F1" component_2="model_parameters"/>
      <map_variables variable_1="kp" variable_2="kp"/>
      <map_variables variable_1="k2" variable_2="k2"/>
      <map_variables variable_1="a" variable_2="a"/>
      <map_variables variable_1="km2" variable_2="km2"/>
      <map_variables variable_1="j12" variable_2="j12"/>
      <map_variables variable_1="j62" variable_2="j62"/>
      <map_variables variable_1="phi_E2F1" variable_2="phi_E2F1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDi" component_2="model_parameters"/>
      <map_variables variable_1="k3" variable_2="k3"/>
      <map_variables variable_1="k23" variable_2="k23"/>
      <map_variables variable_1="j13" variable_2="j13"/>
      <map_variables variable_1="j63" variable_2="j63"/>
      <map_variables variable_1="k43" variable_2="k43"/>
      <map_variables variable_1="k34" variable_2="k34"/>
      <map_variables variable_1="km4" variable_2="km4"/>
      <map_variables variable_1="phi_CycDi" variable_2="phi_CycDi"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDa" component_2="model_parameters"/>
      <map_variables variable_1="k34" variable_2="k34"/>
      <map_variables variable_1="km4" variable_2="km4"/>
      <map_variables variable_1="k43" variable_2="k43"/>
      <map_variables variable_1="phi_CycDa" variable_2="phi_CycDa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="AP1" component_2="model_parameters"/>
      <map_variables variable_1="Fm" variable_2="Fm"/>
      <map_variables variable_1="k25" variable_2="k25"/>
      <map_variables variable_1="j15" variable_2="j15"/>
      <map_variables variable_1="j65" variable_2="j65"/>
      <map_variables variable_1="phi_AP1" variable_2="phi_AP1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRBp" component_2="model_parameters"/>
      <map_variables variable_1="k16" variable_2="k16"/>
      <map_variables variable_1="k61" variable_2="k61"/>
      <map_variables variable_1="k67" variable_2="k67"/>
      <map_variables variable_1="k76" variable_2="k76"/>
      <map_variables variable_1="phi_pRBp" variable_2="phi_pRBp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRBpp" component_2="model_parameters"/>
      <map_variables variable_1="k67" variable_2="k67"/>
      <map_variables variable_1="k76" variable_2="k76"/>
      <map_variables variable_1="phi_pRBpp" variable_2="phi_pRBpp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycEi" component_2="model_parameters"/>
      <map_variables variable_1="k28" variable_2="k28"/>
      <map_variables variable_1="k98" variable_2="k98"/>
      <map_variables variable_1="k89" variable_2="k89"/>
      <map_variables variable_1="km9" variable_2="km9"/>
      <map_variables variable_1="j18" variable_2="j18"/>
      <map_variables variable_1="j68" variable_2="j68"/>
      <map_variables variable_1="phi_CycEi" variable_2="phi_CycEi"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycEa" component_2="model_parameters"/>
      <map_variables variable_1="k98" variable_2="k98"/>
      <map_variables variable_1="k89" variable_2="k89"/>
      <map_variables variable_1="km9" variable_2="km9"/>
      <map_variables variable_1="phi_CycEa" variable_2="phi_CycEa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRB" component_2="E2F1"/>
      <map_variables variable_1="E2F1" variable_2="E2F1"/>
      <map_variables variable_1="pRB" variable_2="pRB"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRB" component_2="CycDa"/>
      <map_variables variable_1="CycDa" variable_2="CycDa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRB" component_2="pRBp"/>
      <map_variables variable_1="pRBp" variable_2="pRBp"/>
      <map_variables variable_1="pRB" variable_2="pRB"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="E2F1" component_2="pRBp"/>
      <map_variables variable_1="pRBp" variable_2="pRBp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDi" component_2="AP1"/>
      <map_variables variable_1="AP1" variable_2="AP1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDi" component_2="E2F1"/>
      <map_variables variable_1="E2F1" variable_2="E2F1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDi" component_2="pRB"/>
      <map_variables variable_1="pRB" variable_2="pRB"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDi" component_2="pRBp"/>
      <map_variables variable_1="pRBp" variable_2="pRBp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycDi" component_2="CycDa"/>
      <map_variables variable_1="CycDi" variable_2="CycDi"/>
      <map_variables variable_1="CycDa" variable_2="CycDa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="AP1" component_2="pRB"/>
      <map_variables variable_1="pRB" variable_2="pRB"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="AP1" component_2="pRBp"/>
      <map_variables variable_1="pRBp" variable_2="pRBp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="AP1" component_2="E2F1"/>
      <map_variables variable_1="E2F1" variable_2="E2F1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRBp" component_2="CycDa"/>
      <map_variables variable_1="CycDa" variable_2="CycDa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRBp" component_2="CycEa"/>
      <map_variables variable_1="CycEa" variable_2="CycEa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRBp" component_2="pRBpp"/>
      <map_variables variable_1="pRBpp" variable_2="pRBpp"/>
      <map_variables variable_1="pRBp" variable_2="pRBp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="pRBpp" component_2="CycEa"/>
      <map_variables variable_1="CycEa" variable_2="CycEa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycEi" component_2="E2F1"/>
      <map_variables variable_1="E2F1" variable_2="E2F1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycEi" component_2="pRB"/>
      <map_variables variable_1="pRB" variable_2="pRB"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycEi" component_2="pRBp"/>
      <map_variables variable_1="pRBp" variable_2="pRBp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="CycEi" component_2="CycEa"/>
      <map_variables variable_1="CycEa" variable_2="CycEa"/>
      <map_variables variable_1="CycEi" variable_2="CycEi"/>
   </connection>
</model>