- Author:
- Nazanin ebrahimi <nebr002@aucklanduni.ac.nz>
- Date:
- 2014-11-04 17:53:33+13:00
- Desc:
- Fixing the error for *
- Permanent Source URI:
- http://models.cellml.org/workspace/1cd/rawfile/bc9adbefa06e0bd0bf79be3ec6adcb9d007d5dfc/Notch_1_Wang.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model name="NotchPathway_Wang_Annotated"
cmeta:id="Notch"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
>
<units name="per_nM_per_min">
<unit exponent="-1.0" units="nM"/>
<unit exponent="-1.0" units="min"/>
</units>
<units name="nM_per_min">
<unit units="nM" />
<unit exponent="-1.0" units="min"/>
</units>
<units name="per_min">
<unit exponent="-1.0" units="min"/>
</units>
<units name="nM">
<unit prefix="nano" units="mole"/>
<unit exponent="-1.0" units="liter"/>
</units>
<units name="min">
<unit units="second"/>
</units>
<component name="wholecell" cmeta:id="c0">
<rdf:RDF>
<rdf:Description rdf:ID="c0">
<bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/UBERON_0003059"/>
</rdf:Description>
</rdf:RDF>
<variable cmeta:id="v22" initial_value="0.073" name="mLfng_n" units="nM"/>
<variable cmeta:id="v29" initial_value="2" name="h2" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v29">
<dcterms:description>Hill coefficient of transcription of Hes7 induced by the complex of NICD and RBP-j</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v57" initial_value="0.2" name="V_sDll1" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v57">
<dcterms:description>Dll1 synthesis rate</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v48" initial_value="0.635" name="V_MdmHes7_c" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v48">
<dcterms:description>Maximum rate of degradation of Hes7 mRNA in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v19" initial_value="0.001" name="K_dNICD_n" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v19">
<dcterms:description>Michaelis constant for degradation of NICD in the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v59" initial_value="2" name="h_HIH" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v59">
<dcterms:description>Hill coefficient of inhibition by Hes7 protein of Hes7 gene transcription</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v26" initial_value="0.2" name="K_HIH" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v26">
<dcterms:description>Constant of inhibition by Hes7 protein of Hes7 gene transcription in the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v15" initial_value="0.043" name="mLfng_c" units="nM" />
<variable cmeta:id="v39" initial_value="1.035" name="K_c" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v39">
<dcterms:description>Apparent first-order rate constant for Notch cleavage into NICD</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v46" initial_value="0.385" name="V_MdDll1" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v46">
<dcterms:description>Maximum rate of degradation of Dll1</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v53" initial_value="0.1" name="V_MdHes7_c" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v53">
<dcterms:description>Maximum rate of degradation of Hes7 protein in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v41" initial_value="1.5" name="EX_mHes7_n" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v41">
<dcterms:description>Apparent first-order rate constant for Hes7 mRNA exit from the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v20" initial_value="0.15" name="K_ILfng" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v20">
<dcterms:description>Constant of inhibition by Lfng of Notch cleavage into NICD</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v40" initial_value="0.117" name="V_MdLfng" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v40">
<dcterms:description>Maximum rate of degradation of Lfng protein</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v24" initial_value="0.042" name="mHes7_c" units="nM" />
<variable cmeta:id="v38" initial_value="0.01" name="EX_Hes7_n" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v38">
<dcterms:description>Apparent first-order rate constant for Hes7 protein exit from the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v58" initial_value="0.03" name="V_mLfng" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v58">
<dcterms:description>Basal rate of transcription of the Lfng gene</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v35" initial_value="0.01" name="IM_Hes7_c" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v35">
<dcterms:description>First-order rate constant for Hes7 protein entry into nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v0" initial_value="0.768" name="K_dmLfng_c" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v0">
<dcterms:description>Michaelis constant for degradation of Lfng mRNA in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v30" initial_value="1.24" name="V_MsmHes7" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v30">
<dcterms:description>Maximum rate of transcription of Hes7 gene induced by the complex of NICD and RBP-j in nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v3" name="RBPj" units="nM" />
<variable cmeta:id="v8" initial_value="0.041" name="K_smHes7" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v8">
<dcterms:description>Threshold constant for induction by the complex of NICD and RBP-j in nucleus of Hes7 transcription</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v17" initial_value="0.37" name="K_dLfng" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v17">
<dcterms:description>Michaelis constant for degradation of Lfng protein</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v6" initial_value="1.584" name="K_dDll1" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v6">
<dcterms:description>Michaelis constant for degradation of Dll1</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v18" initial_value="1.4" name="K_dNotch" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v18">
<dcterms:description>Michaelis constant for degradation of Notch</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v42" initial_value="0.05" name="K_mHes7" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v42">
<dcterms:description>Apparent first-order rate constant for synthesis of Hes7 protein</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v36" initial_value="0.003" name="V_MdNICD_n" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v36">
<dcterms:description>Maximum rate of degradation of NICD in the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v50" initial_value="0.09" name="K_mLfng" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v50">
<dcterms:description>Apparent first-order rate constant for synthesis of Lfng protein</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v54" name="t" units="min">
<rdf:RDF>
<rdf:Description rdf:ID="v54">
<dcterms:description>time</dcterms:description>
<bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/SBO_0000345" />
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v28" initial_value="0.001" name="K_dNICD_c" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v28">
<dcterms:description>Michaelis constant for degradation of NICD in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v34" initial_value="0.01" name="V_mHes7" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v34">
<dcterms:description>Basal rate of transcription of the Hes7 gene</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v52" initial_value="0.5" name="EX_mLfng_n" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v52">
<dcterms:description>Apparent first-order rate constant for Lfng mRNA exit from the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v5" initial_value="0.35" name="RBPj_t" units="nM" />
<variable cmeta:id="v10" initial_value="0.1" name="K_dHes7_c" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v10">
<dcterms:description>Michaelis constant for degradation of Hes7 protein in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v43" initial_value="0.7" name="V_MdmLfng_c" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v43">
<dcterms:description>Maximum rate of degradation of Lfng mRNA in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v32" initial_value="0.069" name="V_sNotch" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v32">
<dcterms:description>Notch synthesis rate</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v27" initial_value="0.05" name="K_smLfng" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v27">
<dcterms:description>Threshold constant for induction by the complex of NICD and RBP-j in nucleus of Lfng transcription</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v14" initial_value="1" name="K_dmHes7_c" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v14">
<dcterms:description>Michaelis constant for degradation of Hes7 mRNA in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v56" initial_value="0.846" name="V_MdNotch" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v56">
<dcterms:description>Maximum rate of degradation of Notch</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v47" initial_value="0.9" name="V_MsmLfng" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v47">
<dcterms:description>Maximum rate of transcription of Lfng gene induced by the complex of NICD and RBP-j in nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v25" initial_value="0.009" name="NICD_n" units="nM" />
<variable cmeta:id="v49" initial_value="0.03" name="IM_NICD_c" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v49">
<dcterms:description>Apparent first-order rate constant for NICD entry into nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v21" initial_value="2.72" name="Lfng" units="nM" />
<variable cmeta:id="v4" initial_value="0.1" name="K_dHes7_n" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v4">
<dcterms:description>Michaelis constant for degradation of Hes7 protein in the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v2" initial_value="0" name="NICD_c" units="nM" />
<variable cmeta:id="v11" initial_value="0.026" name="NR" units="nM" />
<variable cmeta:id="v23" initial_value="0.013" name="mHes7_n" units="nM" />
<variable cmeta:id="v45" initial_value="0.01" name="V_MdNICD_c" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v45">
<dcterms:description>Maximum rate of degradation of NICD in the cytoplasm</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v1" initial_value="1.71" name="Dll1" units="nM" />
<variable cmeta:id="v31" initial_value="1" name="d_NR" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v31">
<dcterms:description>Bimolecular rate constant for degradation of the complex of NICD and RBP-j</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v51" initial_value="8" name="a_NR" units="per_nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v51">
<dcterms:description>Bimolecular rate constant for binding of NICD to RBP-j</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v16" initial_value="0.12" name="Notch" units="nM" />
<variable cmeta:id="v55" initial_value="2" name="n" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v55">
<dcterms:description>Hill coefficient of inhibition by Lfng of Notch cleavage into NICD</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v13" initial_value="10.66" name="Hes7_c" units="nM" />
<variable cmeta:id="v12" initial_value="1" name="K_Dll1" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v12">
<dcterms:description>Michaelis constant for Notch cleavage into NICD by Dll1</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v7" initial_value="1.24" name="Hes7_n" units="nM" />
<variable cmeta:id="v37" initial_value="2" name="h_HIL" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v37">
<dcterms:description>Hill coefficient of inhibition by Hes7 protein of Lfng gene transcription</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v44" initial_value="2" name="h1" units="dimensionless">
<rdf:RDF>
<rdf:Description rdf:ID="v44">
<dcterms:description>Hill coefficient of transcription of Lfng induced by the complex of NICD and RBP-j</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v60" initial_value="0.03" name="EX_NICD_n" units="per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v60">
<dcterms:description>Apparent first-order rate constant for NICD exit from nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v33" initial_value="0.1" name="V_MdHes7_n" units="nM_per_min">
<rdf:RDF>
<rdf:Description rdf:ID="v33">
<dcterms:description>Maximum rate of degradation of Hes7 protein in the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<variable cmeta:id="v9" initial_value="0.2" name="K_HIL" units="nM">
<rdf:RDF>
<rdf:Description rdf:ID="v9">
<dcterms:description>Constant of inhibition by Hes7 protein of Lfng transcription in the nucleus</dcterms:description>
</rdf:Description>
</rdf:RDF>
</variable>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>RBPj</ci>
<apply>
<minus />
<ci>RBPj_t</ci>
<ci>NR</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>Dll1</ci>
</apply>
<apply>
<minus />
<ci>V_sDll1</ci>
<apply>
<times />
<ci>V_MdDll1</ci>
<apply>
<divide />
<ci>Dll1</ci>
<apply>
<plus />
<ci>K_dDll1</ci>
<ci>Dll1</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>Notch</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<ci>V_sNotch</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>K_c</ci>
<ci>Notch</ci>
<ci>Dll1</ci>
</apply>
<apply>
<plus />
<ci>K_Dll1</ci>
<ci>Dll1</ci>
</apply>
</apply>
<apply>
<power />
<ci>K_ILfng</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_ILfng</ci>
<ci>n</ci>
</apply>
<apply>
<power />
<ci>Lfng</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdNotch</ci>
<ci>Notch</ci>
</apply>
<apply>
<plus />
<ci>K_dNotch</ci>
<ci>Notch</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>NICD_c</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>K_c</ci>
<ci>Notch</ci>
<ci>Dll1</ci>
</apply>
<apply>
<plus />
<ci>K_Dll1</ci>
<ci>Dll1</ci>
</apply>
</apply>
<apply>
<power />
<ci>K_ILfng</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_ILfng</ci>
<ci>n</ci>
</apply>
<apply>
<power />
<ci>Lfng</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>EX_NICD_n</ci>
<ci>NICD_n</ci>
</apply>
</apply>
<apply>
<times />
<ci>IM_NICD_c</ci>
<ci>NICD_c</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdNICD_c</ci>
<ci>NICD_c</ci>
</apply>
<apply>
<plus />
<ci>K_dNICD_c</ci>
<ci>NICD_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>Lfng</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>K_mLfng</ci>
<ci>mLfng_c</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdLfng</ci>
<ci>Lfng</ci>
</apply>
<apply>
<plus />
<ci>K_dLfng</ci>
<ci>Lfng</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>mLfng_c</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>EX_mLfng_n</ci>
<ci>mLfng_n</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdmLfng_c</ci>
<ci>mLfng_c</ci>
</apply>
<apply>
<plus />
<ci>K_dmLfng_c</ci>
<ci>mLfng_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>Hes7_c</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>K_mHes7</ci>
<ci>mHes7_c</ci>
</apply>
<apply>
<times />
<ci>EX_Hes7_n</ci>
<ci>Hes7_n</ci>
</apply>
</apply>
<apply>
<times />
<ci>IM_Hes7_c</ci>
<ci>Hes7_c</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdHes7_c</ci>
<ci>Hes7_c</ci>
</apply>
<apply>
<plus />
<ci>K_dHes7_c</ci>
<ci>Hes7_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>mHes7_c</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>EX_mHes7_n</ci>
<ci>mHes7_n</ci>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdmHes7_c</ci>
<ci>mHes7_c</ci>
</apply>
<apply>
<plus />
<ci>K_dmHes7_c</ci>
<ci>mHes7_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>NICD_n</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>IM_NICD_c</ci>
<ci>NICD_c</ci>
</apply>
<apply>
<times />
<ci>d_NR</ci>
<ci>NR</ci>
</apply>
</apply>
<apply>
<times />
<ci>EX_NICD_n</ci>
<ci>NICD_n</ci>
</apply>
</apply>
<apply>
<times />
<ci>a_NR</ci>
<ci>NICD_n</ci>
<ci>RBPj</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdNICD_n</ci>
<ci>NICD_n</ci>
</apply>
<apply>
<plus />
<ci>K_dNICD_n</ci>
<ci>NICD_n</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>NR</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>a_NR</ci>
<ci>NICD_n</ci>
<ci>RBPj</ci>
</apply>
<apply>
<times />
<ci>d_NR</ci>
<ci>NR</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>Hes7_n</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<ci>IM_Hes7_c</ci>
<ci>Hes7_c</ci>
</apply>
<apply>
<times />
<ci>EX_Hes7_n</ci>
<ci>Hes7_n</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>V_MdHes7_n</ci>
<ci>Hes7_n</ci>
</apply>
<apply>
<plus />
<ci>K_dHes7_n</ci>
<ci>Hes7_n</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>mLfng_n</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>V_mLfng</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>V_MsmLfng</ci>
<apply>
<power />
<ci>NR</ci>
<ci>h1</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_smLfng</ci>
<ci>h1</ci>
</apply>
<apply>
<power />
<ci>NR</ci>
<ci>h1</ci>
</apply>
</apply>
</apply>
<apply>
<power />
<ci>K_HIL</ci>
<ci>h_HIL</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_HIL</ci>
<ci>h_HIL</ci>
</apply>
<apply>
<power />
<ci>Hes7_n</ci>
<ci>h_HIL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>EX_mLfng_n</ci>
<ci>mLfng_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>t</ci>
</bvar>
<ci>mHes7_n</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>V_mHes7</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>V_MsmHes7</ci>
<apply>
<power />
<ci>NR</ci>
<ci>h2</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_smHes7</ci>
<ci>h2</ci>
</apply>
<apply>
<power />
<ci>NR</ci>
<ci>h2</ci>
</apply>
</apply>
</apply>
<apply>
<power />
<ci>K_HIH</ci>
<ci>h_HIH</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>K_HIH</ci>
<ci>h_HIH</ci>
</apply>
<apply>
<power />
<ci>Hes7_n</ci>
<ci>h_HIH</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>EX_mHes7_n</ci>
<ci>mHes7_n</ci>
</apply>
</apply>
</apply>
</math>
</component>
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<rdf:Description rdf:ID="v0">
<semsim:isComputationalComponentFor>
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<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v25">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_17">
<semsim:physicalPropertyOf>
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<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_11">
<ro:contained_in>
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</ro:contained_in>
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</rdf:Description>
</ro:part_of>
<dcterms:description />
<semsim:name>Notch 1 intracellular domain (NICD)</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
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</rdf:Description>
</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v6">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_10">
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v11">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_21">
<semsim:physicalPropertyOf>
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<ro:contained_in rdf:resource="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_2" />
<dcterms:description />
<semsim:name>The complex of NICD and RBP-j</semsim:name>
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</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v21">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_18">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_12">
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</semsim:physicalPropertyOf>
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</rdf:Description>
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<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_3">
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<ro:part_of>
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<ro:contained_in>
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<semsim:refersTo rdf:resource="http://identifiers.org/go/GO:0005737" />
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</ro:contained_in>
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</ro:part_of>
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</rdf:Description>
</semsim:physicalPropertyOf>
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</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v20">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_4">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v19">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_1">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v26">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_2">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v12">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_26">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_13">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_9">
<dcterms:description />
<semsim:name>Total RBP-j concentration which is assumed to be constant</semsim:name>
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</rdf:Description>
</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_23">
<semsim:physicalPropertyOf>
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<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q61483" />
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</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v22">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_0">
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</ro:part_of>
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</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v16">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_24">
<semsim:physicalPropertyOf>
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<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q01705" />
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</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v9">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_28">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</rdf:Description>
<rdf:Description rdf:ID="v4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_19">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</rdf:Description>
<rdf:Description rdf:ID="v27">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_15">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</rdf:Description>
<rdf:Description rdf:ID="v13">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_25">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_7">
<ro:contained_in rdf:resource="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q8BKT2" />
</rdf:Description>
</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v8">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_8">
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</rdf:Description>
<rdf:Description rdf:ID="v23">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_22">
<semsim:physicalPropertyOf>
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<ro:part_of>
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</ro:part_of>
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</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v17">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_9">
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<rdf:Description rdf:ID="v3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_7">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_8">
<dcterms:description />
<semsim:name>RBP-j protein (dissociative from NR complex)</semsim:name>
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</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v10">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_14">
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<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_27">
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<rdf:Description rdf:ID="v24">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_5">
<semsim:physicalPropertyOf>
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<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:33699" />
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</semsim:physicalPropertyOf>
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</semsim:isComputationalComponentFor>
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<rdf:Description rdf:ID="v28">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_12">
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<rdf:Description rdf:ID="v14">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_16">
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</rdf:Description>
<rdf:Description rdf:ID="v18">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_11">
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_20">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_13">
<ro:part_of>
<rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_14">
<ro:contained_in rdf:resource="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_5" />
<semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q01705" />
</rdf:Description>
</ro:part_of>
<dcterms:description />
<semsim:name>Notch 1 intracellular domain (NICD)</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
</rdf:RDF>
</model>
