This is the general mathematical model for the AE1 model with modifications to enable simulations which are capable of reproducing Figure 3A in the original paper. See the various views available in the right hand column. The simulation experiment for this model can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation. The results of which are shown below. A rendering of the mathematical model itself is available here.
In Figure 3A, the HCO3-/Cl- flux is computed for a range of internal HCO3- concentration. Internal and external Cl- concentrations are fixed at 29 and 114 mM; external HCO3- concentration is 26 mM; and internal HCO3- concentration is varied from 0 to 60 mM.
A screenshot illustrating the results when the associated SED-ML document is loaded into OpenCOR and the simulation executed.
This can be reproduced directly from the repository by choosing the Launch with OpenCOR link from the Views Available.