Location: semantic-annotation @ ade7933153a7 / sneyd_1995.cellml

Author:

AnandR <a.rampadarath@auckland.ac.nz>

Date:

2019-04-05 14:25:01+13:00

Desc:

Added some semgen annotated models (AnandR)

Permanent Source URI:

http://models.cellml.org/workspace/584/rawfile/ade7933153a72bb89e0b02d75db92d6e4be285f5/sneyd_1995.cellml

<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="sneyd_1995" cmeta:id="sneyd_1995">
  <documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <section id="sec_status">
        <title>Model Status</title>
        <para>This CellML model runs in both OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>ABSTRACT:  In response to mechanical stimulation of a single cell, airway epithelial cells in culture exhibit a wave of increased intracellular free Ca2+ concentration that spreads from cell to cell over a limited distance through the culture. We present a detailed analysis of the intercellular wave in a two-dimensional sheet of cells. The model is based on the hypothesis that the wave is the result of diffusion of inositol trisphosphate (IP3) from the stimulated cell. The two-dimensional model agrees well with experimental data and makes the following quantitative predictions: as the distance from the stimulated cells increases, 1) the intercellular delay increases exponentially, 2) the intracellular wave speed decreases exponentially, and 3) the arrival time increases exponentially. Furthermore, 4) a proportion of the cells at the periphery of the response will exhibit waves of decreased amplitude, 5) the intercellular membrane permeability to IP3 must be approximately 2 microns/s or greater, and 6) the ratio of the maximum concentration of IP3 in the stimulated cell to the Km of the IP3 receptor (with respect to IP3) must be approximately 300 or greater. These predictions constitute a rigorous test of the hypothesis that the intercellular Ca2+ waves are mediated by IP3 diffusion.</para>
        <para>The original paper is cited below:</para>
        <para>
          Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model. J. Sneyd, B.T. Wetton, A.C. Charles and M.J. Sanderson, 1995, American Journal of Physiology, 268, C1537-C1545.
          <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=7611375&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 7611375</ulink>
        </para>
        <informalfigure float="0" id="fig_reaction_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>Diagram of model</title>
              </objectinfo>
              <imagedata fileref="sneyd_1995.png" />
            </imageobject>
          </mediaobject>
          <caption>A schematic diagram of the pathway described by the mathematical model.</caption>
        </informalfigure>
      </sect1>
    </article>
  </documentation>
  <units name="per_second">
    <unit exponent="-1.0" units="second" />
  </units>
  <units name="per_sec_square">
    <unit exponent="-2.0" units="second" />
  </units>
  <units name="micromolar">
    <unit prefix="micro" units="mole" />
    <unit exponent="-1.0" units="litre" />
  </units>
  <units name="flux">
    <unit units="micromolar" />
    <unit exponent="-1.0" units="second" />
  </units>
  <units name="micromolar_per_second">
    <unit units="per_second" />
    <unit units="micromolar" />
  </units>
  <units name="micromolar_square_per_second">
    <unit units="per_second" />
    <unit exponent="2.0" units="micromolar" />
  </units>
  <component name="enviroment">
    <variable cmeta:id="enviroment_time" name="time" public_interface="out" units="second" />
  </component>
  <component name="P">
    <variable cmeta:id="P_P" initial_value="0" name="P" public_interface="out" units="micromolar" />
    <variable cmeta:id="P.V_p" initial_value="0.08" name="V_p" units="per_second" />
    <variable cmeta:id="P.k_p" initial_value="1" name="k_p" units="micromolar" />
    <variable cmeta:id="P.IPR_3_flux" initial_value="0.72" name="IPR_3_flux" units="flux" />
    <variable cmeta:id="P.time" name="time" public_interface="in" units="second" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>P</ci>
        </apply>
        <piecewise>
          <piece>
            <apply>
              <minus />
              <ci>IPR_3_flux</ci>
              <apply>
                <divide />
                <apply>
                  <times />
                  <ci>V_p</ci>
                  <ci>P</ci>
                  <ci>k_p</ci>
                </apply>
                <apply>
                  <plus />
                  <ci>k_p</ci>
                  <ci>P</ci>
                </apply>
              </apply>
            </apply>
            <apply>
              <leq />
              <ci>time</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="second">15</cn>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <minus />
                  <ci>V_p</ci>
                </apply>
                <ci>P</ci>
                <ci>k_p</ci>
              </apply>
              <apply>
                <plus />
                <ci>k_p</ci>
                <ci>P</ci>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
    </math>
  </component>
  <component name="c">
    <variable cmeta:id="c_c" initial_value="0.3" name="c" public_interface="out" units="micromolar" />
    <variable cmeta:id="c.J_flux" name="J_flux" public_interface="in" units="flux" />
    <variable cmeta:id="c.J_pump" name="J_pump" public_interface="in" units="flux" />
    <variable cmeta:id="c.J_leak" name="J_leak" public_interface="in" units="flux" />
    <variable cmeta:id="c.time" name="time" public_interface="in" units="second" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>c</ci>
        </apply>
        <apply>
          <plus />
          <apply>
            <minus />
            <ci>J_flux</ci>
            <ci>J_pump</ci>
          </apply>
          <ci>J_leak</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="J_flux">
    <variable cmeta:id="J_flux_J_flux" name="J_flux" public_interface="out" units="flux" />
    <variable cmeta:id="J_flux.k_flux" initial_value="3" name="k_flux" units="micromolar_per_second" />
    <variable cmeta:id="J_flux.mu" name="mu" public_interface="in" units="dimensionless" />
    <variable cmeta:id="J_flux.h" name="h" public_interface="in" units="dimensionless" />
    <variable cmeta:id="J_flux.b" initial_value="0.11" name="b" units="dimensionless" />
    <variable cmeta:id="J_flux.c" name="c" public_interface="in" units="micromolar" />
    <variable cmeta:id="J_flux.k_1" initial_value="0.7" name="k_1" units="micromolar" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>J_flux</ci>
        <apply>
          <times />
          <ci>k_flux</ci>
          <ci>mu</ci>
          <ci>h</ci>
          <apply>
            <plus />
            <ci>b</ci>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <minus />
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>b</ci>
                </apply>
                <ci>c</ci>
              </apply>
              <apply>
                <plus />
                <ci>k_1</ci>
                <ci>c</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="J_pump">
    <variable cmeta:id="J_pump_J_pump" name="J_pump" public_interface="out" units="flux" />
    <variable cmeta:id="J_pump.c" name="c" public_interface="in" units="micromolar" />
    <variable cmeta:id="J_pump.gamma" initial_value="1" name="gamma" units="micromolar_per_second" />
    <variable cmeta:id="J_pump.k_gamma" initial_value="0.27" name="k_gamma" units="micromolar" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>J_pump</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>gamma</ci>
            <apply>
              <power />
              <ci>c</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>k_gamma</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <power />
              <ci>c</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="J_leak">
    <variable cmeta:id="J_leak_J_leak" name="J_leak" public_interface="out" units="flux" />
    <variable cmeta:id="J_leak.beta" initial_value="0.15" name="beta" units="flux" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>J_leak</ci>
        <ci>beta</ci>
      </apply>
    </math>
  </component>
  <component name="mu">
    <variable cmeta:id="mu.mu" name="mu" public_interface="out" units="dimensionless" />
    <variable cmeta:id="mu.P" name="P" public_interface="in" units="micromolar" />
    <variable cmeta:id="mu.k_mu" initial_value="0.01" name="k_mu" units="micromolar" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>mu</ci>
        <apply>
          <divide />
          <apply>
            <power />
            <ci>P</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>k_mu</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
            </apply>
            <apply>
              <power />
              <ci>P</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="h">
    <variable cmeta:id="h.h" initial_value="1" name="h" public_interface="out" units="dimensionless" />
    <variable cmeta:id="h.c" name="c" public_interface="in" units="micromolar" />
    <variable cmeta:id="h.k_2" initial_value="0.7" name="k_2" units="micromolar" />
    <variable cmeta:id="h.tau_h" initial_value="0.2" name="tau_h" units="second" />
    <variable cmeta:id="h.time" name="time" public_interface="in" units="second" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>h</ci>
        </apply>
        <apply>
          <divide />
          <apply>
            <minus />
            <apply>
              <divide />
              <apply>
                <power />
                <ci>k_2</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <plus />
                <apply>
                  <power />
                  <ci>k_2</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
                <apply>
                  <power />
                  <ci>c</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
            </apply>
            <ci>h</ci>
          </apply>
          <ci>tau_h</ci>
        </apply>
      </apply>
    </math>
  </component>
  <connection>
    <map_components component_1="enviroment" component_2="P" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="J_flux" component_2="c" />
    <map_variables variable_1="J_flux" variable_2="J_flux" />
  </connection>
  <connection>
    <map_components component_1="enviroment" component_2="h" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="P" component_2="mu" />
    <map_variables variable_1="P" variable_2="P" />
  </connection>
  <connection>
    <map_components component_1="c" component_2="J_pump" />
    <map_variables variable_1="c" variable_2="c" />
  </connection>
  <connection>
    <map_components component_1="J_pump" component_2="c" />
    <map_variables variable_1="J_pump" variable_2="J_pump" />
  </connection>
  <connection>
    <map_components component_1="enviroment" component_2="c" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="c" component_2="J_flux" />
    <map_variables variable_1="c" variable_2="c" />
  </connection>
  <connection>
    <map_components component_1="mu" component_2="J_flux" />
    <map_variables variable_1="mu" variable_2="mu" />
  </connection>
  <connection>
    <map_components component_1="c" component_2="h" />
    <map_variables variable_1="c" variable_2="c" />
  </connection>
  <connection>
    <map_components component_1="h" component_2="J_flux" />
    <map_variables variable_1="h" variable_2="h" />
  </connection>
  <connection>
    <map_components component_1="J_leak" component_2="c" />
    <map_variables variable_1="J_leak" variable_2="J_leak" />
  </connection>
  <rdf:RDF xmlns:vcard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:j.0="http://www.example.org/foo/bar/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns="http://www.cellml.org/metadata/simulation/1.0#" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:j.1="http://www.cellml.org/bqs/1.0#" xmlns:opb="http://bhi.washington.edu/OPB#" xmlns:j.2="http://imc.org/vCard/3.0#">
    <rdf:Description rdf:about="">
      <dc:creator rdf:parseType="Resource">
        <vcard:ORG rdf:parseType="Resource">
          <vcard:Orgname xml:lang="en">The University of Auckland</vcard:Orgname>
        </vcard:ORG>
        <vcard:N rdf:parseType="Resource">
          <vcard:Family xml:lang="en">Liu</vcard:Family>
          <vcard:Given xml:lang="en">Wei</vcard:Given>
        </vcard:N>
        <vcard:EMAIL>
          <j.2:internet>
            <rdf:value xml:lang="en">wliu052@aucklanduni.ac.nz</rdf:value>
          </j.2:internet>
        </vcard:EMAIL>
      </dc:creator>
      <dcterms:created rdf:parseType="Resource">
        <dcterms:W3CDTF xml:lang="en">2009-09-29</dcterms:W3CDTF>
      </dcterms:created>
    </rdf:Description>
    <rdf:Description rdf:about="#J_pump_J_pump">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_6">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#process_1" dcterms:description="">
              <semsim:hasMediatorParticipant>
                <rdf:Description rdf:about="#mediator_1">
                  <semsim:hasPhysicalEntityReference>
                    <rdf:Description rdf:about="#entity_8">
                      <ro:part_of>
                        <rdf:Description rdf:about="#entity_7">
                          <ro:part_of>
                            <rdf:Description rdf:about="#entity_2">
                              <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_74793" />
                            </rdf:Description>
                          </ro:part_of>
                          <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_80352" />
                        </rdf:Description>
                      </ro:part_of>
                      <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/PR_P20020" />
                    </rdf:Description>
                  </semsim:hasPhysicalEntityReference>
                </rdf:Description>
              </semsim:hasMediatorParticipant>
              <semsim:hasSinkParticipant>
                <rdf:Description rdf:about="#sink_1" semsim:hasMultiplier="1.0">
                  <semsim:hasPhysicalEntityReference>
                    <rdf:Description rdf:about="#entity_3">
                      <ro:part_of>
                        <rdf:Description rdf:about="#entity_1">
                          <ro:part_of rdf:resource="#entity_2" />
                          <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
                        </rdf:Description>
                      </ro:part_of>
                      <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29108" />
                    </rdf:Description>
                  </semsim:hasPhysicalEntityReference>
                </rdf:Description>
              </semsim:hasSinkParticipant>
              <semsim:hasSourceParticipant>
                <rdf:Description rdf:about="#source_1" semsim:hasMultiplier="1.0">
                  <semsim:hasPhysicalEntityReference>
                    <rdf:Description rdf:about="#entity_4">
                      <ro:part_of>
                        <rdf:Description rdf:about="#entity_5">
                          <ro:part_of rdf:resource="#entity_2" />
                          <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_63842" />
                        </rdf:Description>
                      </ro:part_of>
                      <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29108" />
                    </rdf:Description>
                  </semsim:hasPhysicalEntityReference>
                </rdf:Description>
              </semsim:hasSourceParticipant>
              <semsim:name>Ca2+ flow from ER to cytosol across ER membrane</semsim:name>
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>flux of Ca2+ from ER to portion of cytosol in epithelial cell of trachea through plasma membrane calcium-transporting ATPase 1</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#c.J_pump">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_3">
          <semsim:physicalPropertyOf rdf:resource="#process_1" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>flux of Ca2+ from ER to portion of cytosol in epithelial cell of trachea through plasma membrane calcium-transporting ATPase 1</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#mu.P">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_8">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_0">
              <ro:part_of rdf:resource="#entity_1" />
              <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_131186" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of IP3 in the portion of cytosol in epithelial cell of trachea compartment</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#h.k_2">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_10">
          <semsim:physicalPropertyOf rdf:resource="#entity_4" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of Ca2+ in the endoplasmic reticulum (ER) in epithelial cell of trachea</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#P_P">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_0">
          <semsim:physicalPropertyOf rdf:resource="#entity_0" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of IP3 in the portion of cytosol in epithelial cell of trachea compartment</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#sneyd_1995" semsim:modelName="sneyd_1995" bqmodel:isDescribedBy="7611375">
      <semsim:unknown>The Sneyd et al. 1995 model of intercellular calcium waves@en</semsim:unknown>
      <dc:title xml:lang="en">The Sneyd et al. 1995 model of intercellular calcium waves</dc:title>
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
      <j.1:reference rdf:parseType="Resource">
        <j.1:JournalArticle rdf:parseType="Resource">
          <dc:creator>
            <rdf:Seq>
              <rdf:li rdf:parseType="Resource">
                <j.1:Person rdf:parseType="Resource">
                  <vcard:N rdf:parseType="Resource">
                    <vcard:Family xml:lang="en">Sneyd</vcard:Family>
                    <vcard:Given xml:lang="en">J</vcard:Given>
                  </vcard:N>
                </j.1:Person>
              </rdf:li>
              <rdf:li rdf:parseType="Resource">
                <j.1:Person rdf:parseType="Resource">
                  <vcard:N rdf:parseType="Resource">
                    <vcard:Other xml:lang="en">T</vcard:Other>
                    <vcard:Family xml:lang="en">Wetton</vcard:Family>
                    <vcard:Given xml:lang="en">B</vcard:Given>
                  </vcard:N>
                </j.1:Person>
              </rdf:li>
              <rdf:li rdf:parseType="Resource">
                <j.1:Person rdf:parseType="Resource">
                  <vcard:N rdf:parseType="Resource">
                    <vcard:Other xml:lang="en">C</vcard:Other>
                    <vcard:Family xml:lang="en">Charles</vcard:Family>
                    <vcard:Given xml:lang="en">A</vcard:Given>
                  </vcard:N>
                </j.1:Person>
              </rdf:li>
              <rdf:li rdf:parseType="Resource">
                <j.1:Person rdf:parseType="Resource">
                  <vcard:N rdf:parseType="Resource">
                    <vcard:Other xml:lang="en">J</vcard:Other>
                    <vcard:Family xml:lang="en">Sanderson</vcard:Family>
                    <vcard:Given xml:lang="en">M</vcard:Given>
                  </vcard:N>
                </j.1:Person>
              </rdf:li>
            </rdf:Seq>
          </dc:creator>
          <dc:title xml:lang="en">Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model</dc:title>
          <dcterms:issued rdf:parseType="Resource">
            <dcterms:W3CDTF xml:lang="en">1995-06</dcterms:W3CDTF>
          </dcterms:issued>
          <j.1:volume xml:lang="en">268</j.1:volume>
          <j.1:Journal rdf:parseType="Resource">
            <dc:title xml:lang="en">American Journal of Physiology</dc:title>
          </j.1:Journal>
          <j.1:last_page xml:lang="en">C1545</j.1:last_page>
          <j.1:first_page xml:lang="en">C1537</j.1:first_page>
        </j.1:JournalArticle>
        <j.1:Pubmed_id xml:lang="en">7611375</j.1:Pubmed_id>
      </j.1:reference>
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_63842" />
      <bqmodel:isDescribedBy rdf:resource="https://doi.org/10.1152/ajpcell.1995.268.6.C1537" />
      <semsim:unknown>sneyd_1995</semsim:unknown>
      <semsim:unknown>airway epithelial</semsim:unknown>
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_74793" />
      <dcterms:keyword>airway epithelial</dcterms:keyword>
      <ro:modelOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000082" />
      <semsim:unknown>lung</semsim:unknown>
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_9672" />
      <dcterms:keyword>lung</dcterms:keyword>
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_84666" />
      <dcterms:keyword>epithelial cell of trachea</dcterms:keyword>
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_84666" />
      <j.1:reference rdf:parseType="Resource">
        <dc:subject rdf:parseType="Resource">
          <rdf:value>
            <rdf:Bag>
              <rdf:li xml:lang="en">calcium dynamics</rdf:li>
            </rdf:Bag>
          </rdf:value>
          <j.1:subject_type xml:lang="en">keyword</j.1:subject_type>
        </dc:subject>
      </j.1:reference>
      <cmeta:comment rdf:parseType="Resource">
        <dc:creator rdf:parseType="Resource">
          <vcard:FN xml:lang="en">Catherine Lloyd</vcard:FN>
        </dc:creator>
        <rdf:value xml:lang="en">This is the CellML description of Sneyd et al.'s mathematical model of intercellular calcium waves</rdf:value>
      </cmeta:comment>
      <semsim:unknown>epithelial cell of trachea</semsim:unknown>
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_9672" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_63842" />
      <simulation rdf:parseType="Resource">
        <boundIntervals rdf:parseType="Collection">
          <rdf:Description>
            <maximumStepSize xml:lang="en">0.1</maximumStepSize>
            <endingValue xml:lang="en">2</endingValue>
          </rdf:Description>
        </boundIntervals>
      </simulation>
    </rdf:Description>
    <j.0:bazfoo />
    <rdf:Description rdf:about="#c.J_flux">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_2">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#process_0" dcterms:description="">
              <semsim:hasMediatorParticipant>
                <rdf:Description rdf:about="#mediator_0">
                  <semsim:hasPhysicalEntityReference>
                    <rdf:Description rdf:about="#entity_6">
                      <ro:part_of rdf:resource="#entity_7" />
                      <semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/PR_P29994" />
                    </rdf:Description>
                  </semsim:hasPhysicalEntityReference>
                </rdf:Description>
              </semsim:hasMediatorParticipant>
              <semsim:hasSinkParticipant>
                <rdf:Description rdf:about="#sink_0" semsim:hasMultiplier="1.0">
                  <semsim:hasPhysicalEntityReference rdf:resource="#entity_3" />
                </rdf:Description>
              </semsim:hasSinkParticipant>
              <semsim:hasSourceParticipant>
                <rdf:Description rdf:about="#source_0" semsim:hasMultiplier="1.0">
                  <semsim:hasPhysicalEntityReference rdf:resource="#entity_4" />
                </rdf:Description>
              </semsim:hasSourceParticipant>
              <semsim:name>Ca2+ flow from ER to cytosol across IP3 and wall of smooth endoplasmic reticulum</semsim:name>
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>flux of Ca2+ from endoplasmic reticulum (ER) to portion of cytosol in epithelial cell of trachea through inositol 1,4,5-trisphosphate receptor type 1 (rat)</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#J_flux_J_flux">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_4">
          <semsim:physicalPropertyOf rdf:resource="#process_0" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>flux of Ca2+ from endoplasmic reticulum (ER) to portion of cytosol in epithelial cell of trachea through inositol 1,4,5-trisphosphate receptor type 1 (rat)</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#c_c">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_1">
          <semsim:physicalPropertyOf rdf:resource="#entity_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of Ca2+ in the portion of cytosol in epithelial cell of trachea compartment</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#h.c">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_9">
          <semsim:physicalPropertyOf rdf:resource="#entity_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of Ca2+ in the portion of cytosol in epithelial cell of trachea compartment</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#J_flux.c">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_5">
          <semsim:physicalPropertyOf rdf:resource="#entity_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of Ca2+ in the portion of cytosol in epithelial cell of trachea compartment</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#J_pump.c">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_7">
          <semsim:physicalPropertyOf rdf:resource="#entity_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>concentration of Ca2+ in the portion of cytosol in epithelial cell of trachea compartment</dcterms:description>
    </rdf:Description>
  </rdf:RDF>
</model>