Location: An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements, Mathieu Cloutier, Fiachra B. Bolger, John P. Lowry and Peter Wellstead, 2009 @ 4af2cb7961fd / cloutier_2009.rdf

Author:
AnandR <a.rampadarath@auckland.ac.nz>
Date:
2019-09-09 13:25:18+12:00
Desc:
curated model with annotations
Permanent Source URI:
http://models.cellml.org/workspace/5af/rawfile/4af2cb7961fd1e93032cb7abdd5cecd9648364f7/cloutier_2009.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
    xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" > 
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    <dcterms:description>Astrocytic metabolism of Phosphoglycerate kinase</dcterms:description>
  </rdf:Description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>glycogen synthase flow rate</dcterms:description>
  </rdf:Description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Lactate dehydrogenase</dcterms:description>
  </rdf:Description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>rate of change in the concentration of Lactate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_34">
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    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:16908"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#GAPg.Vg_pfk">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29101"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose in the neuron.</dcterms:description>
  </rdf:Description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the conc of Nicotinamide adenine dinucleotide reduced in astrocyte.</dcterms:description>
  </rdf:Description>
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    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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    <dcterms:description>Lactate exchange between the astrocyte and the capillary.</dcterms:description>
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    <dcterms:description>Rate of change in the concentration of glucose in the astrocyte.</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Oxygen exchange between capillary and astrocytes</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Mitochondrial oxidation of pyruvate</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCc_GLCc">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose in the capillary.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vc_GLC.GLCc">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_26"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose in the capillary.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vec_LAC.LACc">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Lactate in the capillary.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#CRn.PCrn">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in change in concentration of phosphocreatine in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPg.Vg_pk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Pyruvate kinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vc_CO2.Fin_t">
    <dcterms:description>Blood flow entering the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vc_LAC.LACc">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_33"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Lactate in the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_2">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_3"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29101"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_32">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:24996"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_20">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <semsim:name>Glutamate</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vge_LAC.LACg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_32"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>rate of change in the concentration of Lactate in the astrocyte</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vcg_O2.O2g">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Oxygen in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PCrg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_2"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#PEPg.time">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Glucose exchange between the extracellular space and astrocytes.</dcterms:description>
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    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the neuron of the brain.</dcterms:description>
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    <dcterms:description>Exchange of glucose between the extracellular space and neurons.</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:15361"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of oxygen in the capillary.</dcterms:description>
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    <dcterms:description>Carbon Dioxide exchange between neuron and capillary</dcterms:description>
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    <dcterms:description>Astrocytic metabolism of Phosphoglucose isomerase</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#sink_2">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_5"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADHn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_26"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose in the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pump.NAn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of sodium in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pgk.GAPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glyceraldehyde 3-phosphate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ck.CRn">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADHn_NADHn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_14"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Nicotinamide adenine dinucleotide (reduced) in neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_ck.PCrg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_36"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of phosphocreatine in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_3">
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCe.V_en_GLC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Exchange of glucose between the extracellular space and neurons.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLUg_GLUg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_24"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the intracellular concentration of glutamate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#dAMP_dATPn.ATPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the neuron of the brain.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACn.Vn_ldh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of Lactate dehydrogenase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_41">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:16526"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pk.Vg_pk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Pyruvate kinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#sink_3">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_13"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pg_F6Pg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of fructose-6-phosphate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_40">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:16526"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ATPase.ATPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the neuron of the brain.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#environment_time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_7">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:14314"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_mito.O2g">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_37"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Oxygen in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2n_O2n">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_17"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Oxygen in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pump.Vg_pump">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Sodium exchange from astrocyte to the extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#v_stim.v_stim">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Neuronal Na inflow due to stimulation</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#G6Pn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ck.ADPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_42"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of ADP in neuron during adenylate kinase equilibrium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PYRn.Vn_pk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Pyruvate kinase metabolism in the Neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vce_GLC.GLCe">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose in the extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#sink_4">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_17"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_hk.Vg_hk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Hexokinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#u_n.ATPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the neuron of the brain.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_6">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_3"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:17234"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#CO2c.CO2c">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_39"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Carbon Dioxide in a capillary in the brain.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pn_F6Pn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of fructose-6-phosphate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pgk.ADPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_42"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of ADP in neuron during adenylate kinase equilibrium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ATPase.Vn_ATPase">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of ATPase (excluding Na-ATPase)</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPg.Vg_pgk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Phosphoglycerate kinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Fout_t.Fin_t">
    <dcterms:description>Blood flow entering the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#process_3">
    <semsim:name>Phosphoglucose isomerase metabolism in the neuron</semsim:name>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#CO2c.Vgc_CO2">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_21"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Carbon Dioxide exchange between astrocyte and capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPg_ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pfk.Vn_pfk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Phosphofructokinase metabolism in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pfk.F6Pg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of fructose-6-phosphate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2c_O2c">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_18"/>
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    <dcterms:description>Rate of change in the concentration of oxygen in the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_18">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_19"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:33263"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#dAMP_dATPg.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
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    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#sink_5">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_21"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#process_4">
    <semsim:name>Phosphofructokinase metabolism in the neuron</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADHg.Vg_ldh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Lactate dehydrogenase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADHg_NADHg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_34"/>
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    <dcterms:description>Rate of change in the conc of Nicotinamide adenine dinucleotide reduced in astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADHg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#AMPg.ADPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of ADP in astrocyte during adenylate kinase equilibrium</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#GLUn_GLUn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_20"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in concentration of glutamate in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_glys.GLYg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_38"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change of glycogen in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pgi.F6Pn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of fructose-6-phosphate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#G6Pg.Vg_pgi">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Phosphoglucose isomerase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPg.Vg_pfk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_14"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Phosphofructokinase metabolism in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#process_20">
    <semsim:hasSinkParticipant rdf:resource="./cloutier_2009.cellml#sink_15"/>
    <semsim:hasSourceParticipant rdf:resource="./cloutier_2009.cellml#source_15"/>
    <semsim:name>CO2 exchange from neuron and capillary.</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_29">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:17138"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACe.Vec_LAC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_19"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Lactate exchange between extracellular space and capillaries.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PCrg.PCrg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_36"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of phosphocreatine in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_17">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:33263"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#sink_6">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_2"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#v_stim.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADg.NADHg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the conc of Nicotinamide adenine dinucleotide reduced in astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_ATPase">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of ATPase (excluding Na-ATPase)</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCc.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACn_LACn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Lactate in the neuron.</dcterms:description>
  </rdf:Description>
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    <semsim:name>Phosphoglycerate kinase metabolism in the neuron</semsim:name>
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    <dcterms:description>Oxygen exchange between capillary and astrocytes</dcterms:description>
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  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2c.Vc_O2">
    <dcterms:description>Blood flow contribution to capillary O2</dcterms:description>
  </rdf:Description>
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    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_mito.PYRg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_31"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in pyruvate in the astrocyte.</dcterms:description>
  </rdf:Description>
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    <semsim:hasSourceParticipant rdf:resource="./cloutier_2009.cellml#source_16"/>
    <semsim:name>CO2 exchange between the astrocyte and capillary.</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_glyp.Vg_glyp">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Glycogen phosphorylase flow rate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#sink_7">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_24"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_16">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:17287"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vge_LAC.Vge_LAC">
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vcg_GLC.GLCg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_25"/>
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  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_28">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:88003"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pk.ADPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_42"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of ADP in neuron during adenylate kinase equilibrium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PCrn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vnc_CO2.Vnc_CO2">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Carbon Dioxide exchange between neuron and capillary</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ldh.LACn">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Lactate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#process_6">
    <semsim:name>Pyruvate kinase metabolism in the Neuron</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PYRn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PEPg_PEPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_30"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in concentration of Phosphoenolpyruvate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_ck.CRg">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_15">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:15422"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_hk.GLCg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_25"/>
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    <dcterms:description>Rate of change in the concentration of glucose in the astrocyte.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ck.PCrn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_16"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in change in concentration of phosphocreatine in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pump.ATPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vc_LAC.Vc_LAC">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Lactate entering the capillary</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Fin_t.Fin_t">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the intracellular concentration of glutamate in the astrocyte.</dcterms:description>
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    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_25"/>
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    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:14314"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_39">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_19"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:16526"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_leak_Na.NAg">
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    <dcterms:description>rate of change in the concentration of sodium in the astrocyte.</dcterms:description>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pg.time">
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  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCn_GLCn">
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    <dcterms:description>Rate of change in the concentration of glucose in the neuron.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#GAPn.Vn_pfk">
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    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_13"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_14">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:16908"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_26">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_19"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:17234"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#V_en_GLC.GLCe">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the conc of Nicotinamide adenine dinucleotide reduced in astrocyte.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#process_11">
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    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_25"/>
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    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:28087"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_30"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_42"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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    <dcterms:description>Rate of change in the concentration of Lactate in the extracellular space.</dcterms:description>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_8"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_ck.ADPg">
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    <dcterms:description>Neuronal metabolism of Hexokinase</dcterms:description>
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    <semsim:name>Na(1+) leakage from the neuron to the extracellular space.</semsim:name>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_25">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_22"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:17234"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pfk.Vg_pfk">
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    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:33263"/>
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    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:24996"/>
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  &lt;article&gt;&#xD;
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      &lt;title&gt;An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
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      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This CellMl model runs in OpenCell to recreate the published results.  The units are balanced.  Thank you to the original author Mathieu Cloutier for his invaluable help in the final stages of model curation.  We recommend the followin simulation conditions: a duration of 2500 seconds with a an increase in neuronal activity at 200 seconds.&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
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      &lt;para&gt;ABSTRACT: An integrative, systems approach to the modelling of brain energy metabolism is presented. Mechanisms such as glutamate cycling between neurons and astrocytes and glycogen storage in astrocytes have been implemented. A unique feature of the model is its calibration using in vivo data of brain glucose and lactate from freely moving rats under various stimuli. The model has been used to perform simulated perturbation experiments that show that glycogen breakdown in astrocytes is significantly activated during sensory (tail pinch) stimulation. This mechanism provides an additional input of energy substrate during high consumption phases. By way of validation, data from the perfusion of 50 microM propranolol in the rat brain was compared with the model outputs. Propranolol affects the glucose dynamics during stimulation, and this was accurately reproduced in the model by a reduction in the glycogen breakdown in astrocytes. The model's predictive capacity was verified by using data from a sensory stimulation (restraint) that was not used for model calibration. Finally, a sensitivity analysis was conducted on the model parameters, this showed that the control of energy metabolism and transport processes are critical in the metabolic behaviour of cerebral tissue.&lt;/para&gt;&#xD;
      &lt;informalfigure float="0" id="fig_reaction_diagram"&gt;&#xD;
        &lt;mediaobject&gt;&#xD;
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              &lt;title&gt;model diagram&lt;/title&gt;&#xD;
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            &lt;imagedata fileref="cloutier_2009.png" /&gt;&#xD;
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        &lt;caption&gt;Schematic diagram of the model for astrocyte-neuron metabolism&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
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        An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements, Mathieu Cloutier, Fiachra B. Bolger, John P. Lowry and Peter Wellstead, 2009,&#xD;
        &lt;emphasis&gt;Journal of Computational Neuroscience&lt;/emphasis&gt;&#xD;
        , 27, 391-414.&#xD;
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      &lt;/para&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
  </rdf:Description>
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    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_32"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#PCrg.Vg_ck">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
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  </rdf:Description>
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  </rdf:Description>
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  </rdf:Description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_18"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_18"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_hk.Vn_hk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <semsim:hasSourceParticipant rdf:resource="./cloutier_2009.cellml#source_3"/>
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  </rdf:Description>
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    <dcterms:description>Blood flow out of the capillary.</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_glyp.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pgk.GAPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_29"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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    <semsim:hasSinkParticipant rdf:resource="./cloutier_2009.cellml#sink_14"/>
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    <semsim:name>Lactate exchange between extracellular space and capillary.</semsim:name>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#source_13">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_26"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCe.Veg_GLC">
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    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_2"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_pump">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_1"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_42"/>
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    <dcterms:description>Concentration of ADP in neuron during adenylate kinase equilibrium</dcterms:description>
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    <semsim:hasSinkParticipant rdf:resource="./cloutier_2009.cellml#sink_4"/>
    <semsim:hasSourceParticipant rdf:resource="./cloutier_2009.cellml#source_4"/>
    <semsim:name>Oxygen exchange between the capillary and the neurons.</semsim:name>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_7"/>
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  </rdf:Description>
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    <dcterms:description>Blood flow entering the capillary.</dcterms:description>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pump.Vn_pump">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#GLYg_GLYg">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change of glycogen in the astrocyte.</dcterms:description>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#ADPg.ADPg">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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    <semsim:hasSinkParticipant rdf:resource="./cloutier_2009.cellml#sink_5"/>
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    <semsim:name>Na(1+) leak from the extracellular space to the astrocyte.</semsim:name>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#source_14">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_13"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#source_6">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_21"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#source_16">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_41"/>
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    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#CO2c.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_18"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_14"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_16"/>
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  </rdf:Description>
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    <dcterms:description>Blood flow contribution to capillary O2</dcterms:description>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_21"/>
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#ADPn.ATPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#source_7">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_23"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#source_15">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_40"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCe_GLCe">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_6"/>
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    <dcterms:description>Rate of change in the concentration of glucose in the extracellular space.</dcterms:description>
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    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_ldh.Vn_ldh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
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    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_15"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#NAg.Vg_pump">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_10"/>
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  <rdf:Description rdf:about="./cloutier_2009.cellml#Vgc_LAC.Vgc_LAC">
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    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Lactate exchange between the astrocyte and the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#source_8">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_26"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_19">
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:280996"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GAPn_GAPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glyceraldehyde 3-phosphate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_ldh.LACg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_32"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>rate of change in the concentration of Lactate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLUn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#unitstepSB.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_9">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:17138"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2g_O2g">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_37"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Oxygen in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#u_g.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#source_9">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_6"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#AMPg.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pfk.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#entity_8">
    <bqbiol:isPartOf rdf:resource="./cloutier_2009.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:88003"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pfk.F6Pn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of fructose-6-phosphate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_glys.G6Pg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_27"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose-6-phosphate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_hk.G6Pn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glucose-6-phosphate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vv.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_pfk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Phosphofructokinase metabolism in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vne_LAC.LACe">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_13"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Lactate in the extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pgk.Vg_pgk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Phosphoglycerate kinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pg.Vg_pgi">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Phosphoglucose isomerase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_pk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Pyruvate kinase metabolism in the Neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pk.PEPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_10"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in concentration of phosphoenolpyruvate in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_pgk.NADHn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_14"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Nicotinamide adenine dinucleotide (reduced) in neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pn.Vn_pfk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Phosphofructokinase metabolism in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACg.Vgc_LAC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_16"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Lactate exchange between the astrocyte and the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vcg_GLC.Vcg_GLC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_12"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Glucose exchange between capillary and astrocytes.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLCg.Vg_hk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Hexokinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PYRg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACg_LACg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_32"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>rate of change in the concentration of Lactate in the astrocyte</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACc.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2n.Vcn_O2">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Oxygen exchange between the capillary and the neurons.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Veg_GLU.Veg_GLU">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Glutamate exchange between the extracellular space and the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2c.Vcn_O2">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Oxygen exchange between the capillary and the neurons.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#V_en_GLC.V_en_GLC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Exchange of glucose between the extracellular space and neurons.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_hk.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_ck">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of Creatine kinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_pgk">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Phosphoglycerate kinase metabolism in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLUg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vec_LAC.LACe">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_13"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Lactate in the extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_pk.ADPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of ADP in astrocyte during adenylate kinase equilibrium</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#dHb.Fin_t">
    <dcterms:description>Blood flow entering the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#mediator_3">
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_4"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_ck.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#CRn_CRn">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PYRn.Vn_ldh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of Lactate dehydrogenase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_leak_Na.NAn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of sodium in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2g.Vcg_O2">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_17"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Oxygen exchange between capillary and astrocytes</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vgc_CO2.Vgc_CO2">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_21"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Carbon Dioxide exchange between astrocyte and capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GLUe_GLUe">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_23"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of glutamate in the extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#G6Pg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NADHn.Vn_mito">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of Mitochondrial oxidation of pyruvate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#dHb.O2c">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of oxygen in the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#GAPg.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#mediator_2">
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_4"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#O2n.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vc_CO2.CO2c">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_39"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of Carbon Dioxide in a capillary in the brain.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vce_GLC.Vce_GLC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_18"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Glucose exchange between capillary and extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vv.Fin_t">
    <dcterms:description>Blood flow entering the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vv.Fout_t">
    <dcterms:description>Blood flow out of the capillary.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_ATPase.Vg_ATPase">
    <dcterms:description>Metabolism of ATPase (excluding Na-ATPase) in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vg_mito.ATPg">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_35"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the astrocyte.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#mediator_1">
    <semsim:hasPhysicalEntityReference rdf:resource="./cloutier_2009.cellml#entity_4"/>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Vn_mito.ATPn">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#entity_15"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Rate of change in the concentration of adenosine triphosphate in the neuron of the brain.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#ATPn.Vn_mito">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Neuronal metabolism of Mitochondrial oxidation of pyruvate</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#F6Pn.Vn_pgi">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Phosphoglucose isomerase metabolism in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#PEPg.Vg_pk">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Pyruvate kinase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#Veg_GLC.Veg_GLC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_13"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Glucose exchange between the extracellular space and astrocytes.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACn.Vne_LAC">
    <bqbiol:isPropertyOf rdf:resource="./cloutier_2009.cellml#process_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Lactate exchange between neuron and extracellular space.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#LACg.Vg_ldh">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Astrocytic metabolism of Lactate dehydrogenase</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./cloutier_2009.cellml#NAn.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
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