def model individual_CMDN_buffer as def import using "units_and_constants/units_BG.cellml" for unit mM using unit mM; unit fmol using unit fmol; unit per_fmol using unit per_fmol; unit J_per_mol using unit J_per_mol; unit fmol_per_sec using unit fmol_per_sec; unit C_per_mol using unit C_per_mol; unit J_per_C using unit J_per_C; unit microm3 using unit microm3; unit fF using unit fF; unit fC using unit fC; unit fA using unit fA; unit per_second using unit per_second; unit millivolt using unit millivolt; unit per_sec using unit per_sec; unit J_per_K_per_mol using unit J_per_K_per_mol; unit fmol_per_L using unit fmol_per_L; unit fmol_per_L_per_sec using unit fmol_per_L_per_sec; unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L; unit uM using unit uM; unit mM_per_sec using unit mM_per_sec; unit uM_per_sec using unit uM_per_sec; unit pL using unit pL; unit m_to_u using unit m_to_u; enddef; def import using "units_and_constants/constants_BG.cellml" for comp constants using comp constants; enddef; def comp environment as var time: second {pub: out}; // initial values var q_Ca_i: fmol {init: 1e-888, pub: out}; var q_CMDN: fmol {init: 1e-888, pub: out}; var q_CMDN_Ca: fmol {init: 1e-888, pub: out}; // From submodule var v_b2: fmol_per_sec {pub: in}; ode(q_Ca_i, time) = vvv; ode(q_CMDN, time) = vvv; ode(q_CMDN_Ca, time) = vvv; enddef; def comp CMDN_buffer_parameters as var kappa_b2: fmol_per_sec {init: 355.329, pub: out}; var K_Ca_i: per_fmol {init: 1.54215, pub: out}; var K_CMDN: per_fmol {init: 1.54215, pub: out}; var K_CMDN_Ca: per_fmol {init: 0.19471, pub: out}; enddef; def comp CMDN_buffer as var time: second {pub: in}; var R: J_per_K_per_mol {pub: in}; var T: kelvin {pub: in}; // parameters var kappa_b2: fmol_per_sec {pub: in}; var K_Ca_i: per_fmol {pub: in}; var K_CMDN: per_fmol {pub: in}; var K_CMDN_Ca: per_fmol {pub: in}; // Input from global environment var q_Ca_i: fmol {pub: in}; var q_CMDN: fmol {pub: in}; var q_CMDN_Ca: fmol {pub: in}; // Constitutive parameters var mu_Ca_i: J_per_mol; var mu_CMDN: J_per_mol; var mu_CMDN_Ca: J_per_mol; var v_b2: fmol_per_sec {pub: out}; mu_Ca_i = R*T*ln(K_Ca_i*q_Ca_i); mu_CMDN = R*T*ln(K_CMDN*q_CMDN); mu_CMDN_Ca = R*T*ln(K_CMDN_Ca*q_CMDN_Ca); v_b2 = ppp; enddef; def map between environment and CMDN_buffer for vars time and time; vars q_Ca_i and q_Ca_i; vars q_CMDN and q_CMDN; vars q_CMDN_Ca and q_CMDN_Ca; vars v_b2 and v_b2; enddef; def map between CMDN_buffer and CMDN_buffer_parameters for vars kappa_b2 and kappa_b2; vars K_Ca_i and K_Ca_i; vars K_CMDN and K_CMDN; vars K_CMDN_Ca and K_CMDN_Ca; enddef; def map between constants and CMDN_buffer for vars R and R; vars T and T; enddef; enddef;