def model individual_Kr as def import using "units_and_constants/units_BG.cellml" for unit mM using unit mM; unit fmol using unit fmol; unit per_fmol using unit per_fmol; unit J_per_mol using unit J_per_mol; unit fmol_per_sec using unit fmol_per_sec; unit C_per_mol using unit C_per_mol; unit J_per_C using unit J_per_C; unit microm3 using unit microm3; unit fF using unit fF; unit fC using unit fC; unit fA using unit fA; unit per_second using unit per_second; unit millivolt using unit millivolt; unit per_sec using unit per_sec; unit J_per_K_per_mol using unit J_per_K_per_mol; unit fmol_per_L using unit fmol_per_L; unit fmol_per_L_per_sec using unit fmol_per_L_per_sec; unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L; unit uM using unit uM; unit mM_per_sec using unit mM_per_sec; unit uM_per_sec using unit uM_per_sec; unit pL using unit pL; unit m_to_u using unit m_to_u; enddef; def import using "units_and_constants/constants_BG.cellml" for comp constants using comp constants; enddef; def comp environment as var time: second {pub: out}; // initial values var q_K_i: fmol {init: 1e-888, pub: out}; var q_K_o: fmol {init: 1e-888, pub: out}; var q_Sa_Kr: fmol {init: 1e-888, pub: out}; var q_Sb_Kr: fmol {init: 1e-888, pub: out}; var q_Sc_Kr: fmol {init: 1e-888, pub: out}; var q_Sd_Kr: fmol {init: 1e-888, pub: out}; // From submodule var v_Kr: fmol_per_sec {pub: in}; var v_xr10: fmol_per_sec {pub: in}; var v_xr11: fmol_per_sec {pub: in}; var v_xr20: fmol_per_sec {pub: in}; var v_xr21: fmol_per_sec {pub: in}; ode(q_K_i, time) = vvv; ode(q_K_o, time) = vvv; ode(q_Sa_Kr, time) = vvv; ode(q_Sb_Kr, time) = vvv; ode(q_Sc_Kr, time) = vvv; ode(q_Sd_Kr, time) = vvv; enddef; def comp Kr_parameters as var kappa_Kr: fmol_per_sec {init: 2641.62, pub: out}; var kappa_xr10: fmol_per_sec {init: 0.0794844, pub: out}; var kappa_xr11: fmol_per_sec {init: 0.00212813, pub: out}; var kappa_xr20: fmol_per_sec {init: 0.267259, pub: out}; var kappa_xr21: fmol_per_sec {init: 2.18134, pub: out}; var K_K_i: per_fmol {init: 13.8536, pub: out}; var K_K_o: per_fmol {init: 15.7427, pub: out}; var K_Sa_Kr: per_fmol {init: 0.0465841, pub: out}; var K_Sb_Kr: per_fmol {init: 0.00570751, pub: out}; var K_Sc_Kr: per_fmol {init: 1.73989, pub: out}; var K_Sd_Kr: per_fmol {init: 0.213172, pub: out}; enddef; def comp Kr as var time: second {pub: in}; var R: J_per_K_per_mol {pub: in}; var T: kelvin {pub: in}; // parameters var kappa_Kr: fmol_per_sec {pub: in}; var kappa_xr10: fmol_per_sec {pub: in}; var kappa_xr11: fmol_per_sec {pub: in}; var kappa_xr20: fmol_per_sec {pub: in}; var kappa_xr21: fmol_per_sec {pub: in}; var K_K_i: per_fmol {pub: in}; var K_K_o: per_fmol {pub: in}; var K_Sa_Kr: per_fmol {pub: in}; var K_Sb_Kr: per_fmol {pub: in}; var K_Sc_Kr: per_fmol {pub: in}; var K_Sd_Kr: per_fmol {pub: in}; // Input from global environment var q_K_i: fmol {pub: in}; var q_K_o: fmol {pub: in}; var q_Sa_Kr: fmol {pub: in}; var q_Sb_Kr: fmol {pub: in}; var q_Sc_Kr: fmol {pub: in}; var q_Sd_Kr: fmol {pub: in}; // Constitutive parameters var mu_K_i: J_per_mol; var mu_K_o: J_per_mol; var mu_Sa_Kr: J_per_mol; var mu_Sb_Kr: J_per_mol; var mu_Sc_Kr: J_per_mol; var mu_Sd_Kr: J_per_mol; var v_Kr: fmol_per_sec {pub: out}; var v_xr10: fmol_per_sec {pub: out}; var v_xr11: fmol_per_sec {pub: out}; var v_xr20: fmol_per_sec {pub: out}; var v_xr21: fmol_per_sec {pub: out}; mu_K_i = R*T*ln(K_K_i*q_K_i); mu_K_o = R*T*ln(K_K_o*q_K_o); mu_Sa_Kr = R*T*ln(K_Sa_Kr*q_Sa_Kr); mu_Sb_Kr = R*T*ln(K_Sb_Kr*q_Sb_Kr); mu_Sc_Kr = R*T*ln(K_Sc_Kr*q_Sc_Kr); mu_Sd_Kr = R*T*ln(K_Sd_Kr*q_Sd_Kr); v_Kr = ppp; v_xr10 = ppp; v_xr11 = ppp; v_xr20 = ppp; v_xr21 = ppp; enddef; def map between environment and Kr for vars time and time; vars q_K_i and q_K_i; vars q_K_o and q_K_o; vars q_Sa_Kr and q_Sa_Kr; vars q_Sb_Kr and q_Sb_Kr; vars q_Sc_Kr and q_Sc_Kr; vars q_Sd_Kr and q_Sd_Kr; vars v_Kr and v_Kr; vars v_xr10 and v_xr10; vars v_xr11 and v_xr11; vars v_xr20 and v_xr20; vars v_xr21 and v_xr21; enddef; def map between Kr and Kr_parameters for vars kappa_Kr and kappa_Kr; vars kappa_xr10 and kappa_xr10; vars kappa_xr11 and kappa_xr11; vars kappa_xr20 and kappa_xr20; vars kappa_xr21 and kappa_xr21; vars K_K_i and K_K_i; vars K_K_o and K_K_o; vars K_Sa_Kr and K_Sa_Kr; vars K_Sb_Kr and K_Sb_Kr; vars K_Sc_Kr and K_Sc_Kr; vars K_Sd_Kr and K_Sd_Kr; enddef; def map between constants and Kr for vars R and R; vars T and T; enddef; enddef;